JPH10513185A - ミセル性ナノ粒子 - Google Patents
ミセル性ナノ粒子Info
- Publication number
- JPH10513185A JPH10513185A JP8523735A JP52373596A JPH10513185A JP H10513185 A JPH10513185 A JP H10513185A JP 8523735 A JP8523735 A JP 8523735A JP 52373596 A JP52373596 A JP 52373596A JP H10513185 A JPH10513185 A JP H10513185A
- Authority
- JP
- Japan
- Prior art keywords
- micellar
- nanoparticles
- oil
- initiator
- oils
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/107—Emulsions ; Emulsion preconcentrates; Micelles
- A61K9/1075—Microemulsions or submicron emulsions; Preconcentrates or solids thereof; Micelles, e.g. made of phospholipids or block copolymers
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S977/00—Nanotechnology
- Y10S977/70—Nanostructure
- Y10S977/773—Nanoparticle, i.e. structure having three dimensions of 100 nm or less
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S977/00—Nanotechnology
- Y10S977/902—Specified use of nanostructure
- Y10S977/904—Specified use of nanostructure for medical, immunological, body treatment, or diagnosis
- Y10S977/915—Therapeutic or pharmaceutical composition
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S977/00—Nanotechnology
- Y10S977/902—Specified use of nanostructure
- Y10S977/904—Specified use of nanostructure for medical, immunological, body treatment, or diagnosis
- Y10S977/926—Topical chemical, e.g. cosmetic or sunscreen
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Epidemiology (AREA)
- General Health & Medical Sciences (AREA)
- Dispersion Chemistry (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Biophysics (AREA)
- Animal Behavior & Ethology (AREA)
- Molecular Biology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Cosmetics (AREA)
- Transition And Organic Metals Composition Catalysts For Addition Polymerization (AREA)
- Addition Polymer Or Copolymer, Post-Treatments, Or Chemical Modifications (AREA)
Abstract
Description
Claims (1)
- 【特許請求の範囲】 1.約25〜1000nmの直径を有するミセル性ナノ粒子であって、該ミセル 性ナノ粒子が、油、安定剤及びアルコールベースの開始剤を含み適当な水ベース の溶液で水和された親油相を含み、該安定剤を、ツイーン60、ツイーン80、 ノニルフェノールポリエチレングリコールエーテル及びこれらの混合物よりなる 群から選択する、上記のミセル性ナノ粒子。 2.前記の開始剤を、メタノール、エタノール及びこれらの混合物を含むアルコ ールベースの物質よりなる群から選択する、請求項1に記載のミセル性ナノ粒子 。 3.前記の開始剤を、50%以上のエタノール、メタノール及びこれらの混合物 を含むアルコールベースの物質よりなる群から選択する、請求項2に記載のミセ ル性ナノ粒子。 4.前記の油を、植物油、堅果油、魚油、ラード油、鉱油、スクアラン、トリカ プリリン及びこれらの混合物よりなる群から選択する、請求項1に記載のミセル 性ナノ粒子。 5.前記の水溶液が生理学的に適合性の溶液を含む、請求項1に記載のミセル性 ナノ粒子。 6.前記の水溶液を、水及びリン酸緩衝塩溶液よりなる群から選択する、請求項 8に記載のミセル性ナノ粒子。 7.前記の水相がそれに溶解させ又は懸濁させた活性物質を有する、請求項1に 記載のミセル性ナノ粒子。 8.前記の油がそれに溶解させ又は懸濁させた活性物質を有する、請求項1に記 載のミセル性ナノ粒子。 9.前記の開始剤がそれに溶解させ又は懸濁させた活性物質を有する、請求項1 に記載のミセル性ナノ粒子。 10.前記の活性物質がエストラジオールを含む、請求項9に記載のミセル性ナ ノ粒子。 11.前記のミセル性ナノ粒子が水溶液に分散可能である、請求項1に記載のミ セル性ナノ粒子。 12.前記のミセル性ナノ粒子の直径が0.2mmのフィルターの通過を可能に する、請求項1に記載のミセル性ナノ粒子。 13.下記のステップを含む、ミセル性ナノ粒子の製造方法: 過剰の油を安定剤及び開始剤とブレンドして親油相を形成し、該安定剤は、ツ イーン60、ツイーン80、ノニルフェノールポリエチレングリコールエーテル 及びこれらの混合物よりなる群から選択し; 水溶液ベースを有する稀釈溶液を調製し;そして 過剰の該親油相を該稀釈剤とブレンドして上記のミセル性ナノ粒子を形成する 。 14.前記の開始剤を、メタノール、エタノール及びこれらの混合物を含むアル コールベースの物質よりなる群から選択する、請求項13に記載の方法。 15.前記の開始剤を、50%以上のエタノール、メタノール及びこれらの混合 物を含むアルコールベースの物質よりなる群から選択する、請求項14に記載の 方法。 16.前記の油を、植物油、堅果油、魚油、ラード油、鉱油、スクアラン、トリ カプリリン及びこれらの混合物よりなる群から選択する、請求項13に記載の方 法。 17.前記の水溶液が生理学的に適合性の溶液を含む、請求項16に記載の方法 。 18.前記の水溶液を、水及びリン酸緩衝塩溶液よりなる群から選択する、請求 項17に記載の方法。 19.前記の水相がそれに溶解させ又は懸濁させた活性物質を有する、請求項1 3に記載の方法。 20.前記の油がそれに溶解させ又は懸濁させた活性物質を有する、請求項13 に記載の方法。 21.前記の開始剤がそれに溶解させ又は懸濁させた活性物質を有する、請求項 13に記載の方法。 22.前記の活性物質がエストラジオールを含む、請求項21に記載の方法。 23.前記の親油相と前記の希釈剤とのブレンディングを、約50m/sの相対 速度を用いて、1/18,000インチのオリフィスを通して達成する、請求項 13に記載の方法。 24.前記の親油相の前記の水相に対する比が約4:1である、請求項13に記 載の方法。
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US08/380,942 | 1995-01-31 | ||
US08/380,942 US5629021A (en) | 1995-01-31 | 1995-01-31 | Micellar nanoparticles |
PCT/US1996/001410 WO1996023409A1 (en) | 1995-01-31 | 1996-01-29 | Micellar nanoparticles |
Publications (2)
Publication Number | Publication Date |
---|---|
JPH10513185A true JPH10513185A (ja) | 1998-12-15 |
JP3974170B2 JP3974170B2 (ja) | 2007-09-12 |
Family
ID=23503042
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP52373596A Expired - Fee Related JP3974170B2 (ja) | 1995-01-31 | 1996-01-29 | ミセル性ナノ粒子 |
Country Status (14)
Country | Link |
---|---|
US (1) | US5629021A (ja) |
EP (1) | EP0806894B1 (ja) |
JP (1) | JP3974170B2 (ja) |
KR (1) | KR100482390B1 (ja) |
CN (1) | CN1144583C (ja) |
AU (1) | AU711744B2 (ja) |
BR (1) | BR9606996A (ja) |
CA (1) | CA2211262C (ja) |
DE (1) | DE69627309T2 (ja) |
DK (1) | DK0806894T3 (ja) |
ES (1) | ES2200055T3 (ja) |
PT (1) | PT806894E (ja) |
WO (1) | WO1996023409A1 (ja) |
ZA (1) | ZA96738B (ja) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2009533341A (ja) * | 2006-04-07 | 2009-09-17 | ノババックス,インコーポレイテッド | 抗細菌、抗真菌、抗酵母、および/または抗ウイルス特性を有するナノ構造組成物 |
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- 1996-01-29 ES ES96906271T patent/ES2200055T3/es not_active Expired - Lifetime
- 1996-01-29 DE DE69627309T patent/DE69627309T2/de not_active Expired - Lifetime
- 1996-01-29 KR KR1019970705166A patent/KR100482390B1/ko not_active IP Right Cessation
- 1996-01-29 CN CNB96192912XA patent/CN1144583C/zh not_active Expired - Fee Related
- 1996-01-29 AU AU49709/96A patent/AU711744B2/en not_active Ceased
- 1996-01-29 CA CA002211262A patent/CA2211262C/en not_active Expired - Fee Related
- 1996-01-29 JP JP52373596A patent/JP3974170B2/ja not_active Expired - Fee Related
- 1996-01-29 PT PT96906271T patent/PT806894E/pt unknown
- 1996-01-29 EP EP96906271A patent/EP0806894B1/en not_active Expired - Lifetime
- 1996-01-29 BR BR9606996A patent/BR9606996A/pt not_active Application Discontinuation
- 1996-01-29 WO PCT/US1996/001410 patent/WO1996023409A1/en not_active Application Discontinuation
- 1996-01-29 DK DK96906271T patent/DK0806894T3/da active
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Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
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JP2009533341A (ja) * | 2006-04-07 | 2009-09-17 | ノババックス,インコーポレイテッド | 抗細菌、抗真菌、抗酵母、および/または抗ウイルス特性を有するナノ構造組成物 |
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DE69627309T2 (de) | 2004-03-04 |
KR100482390B1 (ko) | 2005-08-31 |
AU711744B2 (en) | 1999-10-21 |
CN1144583C (zh) | 2004-04-07 |
KR19980701770A (ko) | 1998-06-25 |
MX9705663A (es) | 1998-07-31 |
CN1179698A (zh) | 1998-04-22 |
EP0806894A1 (en) | 1997-11-19 |
CA2211262C (en) | 2005-08-30 |
DK0806894T3 (da) | 2003-08-04 |
EP0806894A4 (en) | 1999-12-15 |
ZA96738B (en) | 1996-09-26 |
CA2211262A1 (en) | 1996-08-08 |
DE69627309D1 (de) | 2003-05-15 |
US5629021A (en) | 1997-05-13 |
ES2200055T3 (es) | 2004-03-01 |
AU4970996A (en) | 1996-08-21 |
JP3974170B2 (ja) | 2007-09-12 |
WO1996023409A1 (en) | 1996-08-08 |
BR9606996A (pt) | 1997-10-28 |
PT806894E (pt) | 2003-08-29 |
EP0806894B1 (en) | 2003-04-09 |
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