JPH10508850A - 活性物質の促進された電気移送投与のための組成物、デバイスならびに方法 - Google Patents
活性物質の促進された電気移送投与のための組成物、デバイスならびに方法Info
- Publication number
- JPH10508850A JPH10508850A JP8516122A JP51612296A JPH10508850A JP H10508850 A JPH10508850 A JP H10508850A JP 8516122 A JP8516122 A JP 8516122A JP 51612296 A JP51612296 A JP 51612296A JP H10508850 A JPH10508850 A JP H10508850A
- Authority
- JP
- Japan
- Prior art keywords
- alcohol
- composition
- administration
- electrotransport
- skin
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
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- A61K9/0009—Galenical forms characterised by the drug release technique; Application systems commanded by energy involving or responsive to electricity, magnetism or acoustic waves; Galenical aspects of sonophoresis, iontophoresis, electroporation or electroosmosis
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- A61N1/20—Applying electric currents by contact electrodes continuous direct currents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A61P29/02—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID] without antiinflammatory effect
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Abstract
Description
Claims (1)
- 【特許請求の範囲】 1.組成物が下記の組合わせで特徴づけられる、電気移送投与に適した形態を とった活性物質を含む、経皮電気移送組成物: 少くも一つのC8−C14の直鎖、分枝または環状アルコールまたはこれらの不飽 和誘導体またはこれらの混合物、および 少くとも一つのC2−C4アルコールまたはその不飽和誘導体またはその混合物。 2.さらに水溶性の溶媒を含む請求項1の組成物。 3.C8−C14アルコールまたはその不飽和誘導体の存在量が約0.01から1 00mMであり;またC2−C4アルコールまたはその不飽和誘導体の存在量が約0 .5から30%(v/v)である、請求項2の組成物。 4.C8−C14アルコールまたはその不飽和誘導体の存在量が約1から50mM であり;またC2−C4アルコールまたはその不飽和誘導体の存在量が約1から20 %(v/v)である、請求項2の組成物。 5.C2−C4アルコールがエタノールを含む、請求項1の組成物。 6.C8−C14アルコールがドデカノールを含む、請求項1の組成物。 7.ドデカノールが1−ドデカノールを含む、請求項6の組成物。 8.電気移送投与に適した活性物質が有益な、薬学的に許容できる活性物質で ある、請求項1の組成物。 9.貯留槽(16,18)をもつ電極の少くも一つが請求項1の組成物を含む、電 源(24)と電気的に接続した供与および対向電極(12,16;14,18)を含む、電 気移送投与デバイス(10)。 10.供与電極(12,16)が請求項1の組成物を含み、また電気移送投与に適し た活性物質が有益な薬学的に許容できる活性物質である、請求項9のデバイス。 11.さらに水溶性の溶媒を含む、請求項9のデバイス。 12.C8−C14アルコールまたはその不飽和誘導体の存在量が約0.01から10 0mM;およびC2−C4アルコールまたはその不飽和誘導体の存在量が約0.5か ら30%(v/v)である、請求項9のデバイス。 13.C8−C14アルコールまたはその誘導体の存在量が約1から50mMであり ;およびC2−C4アルコールまたはその誘導体の存在量が約1から20%(v/v)で あ る、請求項9のデバイス。 14.C2−C4アルコールがエタノールを含む、請求項9のデバイス。 15.C8−C14アルコールがドデカノールを含む、請求項9のデバイス。 16.ドデカノールが1−ドデカノールを含む、請求項9のデバイス。
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US339,092 | 1994-11-14 | ||
US08/339,092 US5861439A (en) | 1994-11-14 | 1994-11-14 | Method for enhanced electrotransport agent delivery |
PCT/US1995/014175 WO1996014870A1 (en) | 1994-11-14 | 1995-11-01 | Composition, device, and method for enhanced electrotransport agent delivery |
Publications (2)
Publication Number | Publication Date |
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JPH10508850A true JPH10508850A (ja) | 1998-09-02 |
JP3950169B2 JP3950169B2 (ja) | 2007-07-25 |
Family
ID=23327470
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP51612296A Expired - Fee Related JP3950169B2 (ja) | 1994-11-14 | 1995-11-01 | 活性物質の促進された電気移送投与のための組成物、デバイスならびに方法 |
Country Status (8)
Country | Link |
---|---|
US (3) | US5861439A (ja) |
EP (1) | EP0792164B1 (ja) |
JP (1) | JP3950169B2 (ja) |
AT (1) | ATE258068T1 (ja) |
CA (1) | CA2202137C (ja) |
DE (1) | DE69532477T2 (ja) |
ES (1) | ES2214513T3 (ja) |
WO (1) | WO1996014870A1 (ja) |
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-
1994
- 1994-11-14 US US08/339,092 patent/US5861439A/en not_active Expired - Lifetime
-
1995
- 1995-11-01 WO PCT/US1995/014175 patent/WO1996014870A1/en active IP Right Grant
- 1995-11-01 ES ES95941351T patent/ES2214513T3/es not_active Expired - Lifetime
- 1995-11-01 CA CA002202137A patent/CA2202137C/en not_active Expired - Fee Related
- 1995-11-01 EP EP95941351A patent/EP0792164B1/en not_active Expired - Lifetime
- 1995-11-01 DE DE69532477T patent/DE69532477T2/de not_active Expired - Lifetime
- 1995-11-01 JP JP51612296A patent/JP3950169B2/ja not_active Expired - Fee Related
- 1995-11-01 AT AT95941351T patent/ATE258068T1/de not_active IP Right Cessation
-
1997
- 1997-04-28 US US08/846,225 patent/US5883135A/en not_active Expired - Lifetime
-
1998
- 1998-12-14 US US09/211,463 patent/US6083190A/en not_active Expired - Lifetime
Also Published As
Publication number | Publication date |
---|---|
DE69532477D1 (de) | 2004-02-26 |
EP0792164B1 (en) | 2004-01-21 |
WO1996014870A1 (en) | 1996-05-23 |
CA2202137A1 (en) | 1996-05-23 |
US6083190A (en) | 2000-07-04 |
CA2202137C (en) | 2008-02-12 |
ATE258068T1 (de) | 2004-02-15 |
US5861439A (en) | 1999-01-19 |
ES2214513T3 (es) | 2004-09-16 |
US5883135A (en) | 1999-03-16 |
JP3950169B2 (ja) | 2007-07-25 |
EP0792164A1 (en) | 1997-09-03 |
DE69532477T2 (de) | 2004-11-25 |
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