JPH10505066A - ジヒドロ−2,3−ベンゾジアゼピン誘導体 - Google Patents
ジヒドロ−2,3−ベンゾジアゼピン誘導体Info
- Publication number
- JPH10505066A JPH10505066A JP8508926A JP50892696A JPH10505066A JP H10505066 A JPH10505066 A JP H10505066A JP 8508926 A JP8508926 A JP 8508926A JP 50892696 A JP50892696 A JP 50892696A JP H10505066 A JPH10505066 A JP H10505066A
- Authority
- JP
- Japan
- Prior art keywords
- phenyl
- compound
- solution
- added
- compound according
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
- C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
- C07D317/44—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D317/46—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems condensed with one six-membered ring
- C07D317/48—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring
- C07D317/50—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to atoms of the carbocyclic ring
- C07D317/58—Radicals substituted by nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
- C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
- C07D493/04—Ortho-condensed systems
Abstract
Description
Claims (1)
- 【特許請求の範囲】 1.一般式: [式中、Rは、水素またはC1−C10アルキルであり; Xは、置換されていないか、またはハロゲン、ヒドロキシ、シアノ、ニトロ、 C1−C6アルキル、C3−C6シクロアルキル、C1−C4アルコキシ、カルボキシ 、C1−C6アルコキシカルボニル、アセチル、ホルミル、カルボキシメチル、ヒ ドロキシメチル、アミノ、アミノメチル、メチレンジオキシおよびトリフルオロ メチルからなる群から選ばれる1個またはそれ以上の基で置換されている、フェ ニル、チエニル、フリル、ピリジル、イミダゾリル、ベンズイミダゾリル、ベン ゾチアゾリルおよびフタラジニルであり; Arylは、p−ニトロフェニル、p−アミノフェニルまたはp−(アミノ保護 )フェニルである] を有する化合物または医薬的に許容され得るそれらの塩。 2.Arylがp−ニトロフェニル、P−(C1−C6)アルカノイルアミノフェニ ルを示すものである、請求項2記載の化合物。 3.Arylがp−アミノフェニルを示すものである、請求項1記載の化合物。 4.Rがメチルを示すものである、請求項1記載の化合物。 5.Xが置換されていないか、またはハロゲン、ヒドロキシ、シアノ、ニトロ 、C1−C6アルキル、C1−C4アルコキシ、カルボキシ、アセチル、ホルミル、 カ ルボキシメチル、ヒドロキシメチル、アミノ、アミノメチルおよびトリフルオロ メチルからなる群から選ばれる1個またはそれ以上の基で置換されている芳香族 基を示すものである、請求項1〜4のいずれか1項記載の化合物。 6.芳香族基がフェニル、チエニル、フリル、ピリジル、イミダゾリルおよび フタラジニルから選ばれるものである、請求項5記載の化合物。 7.Xがフェニル、4−メチルフェニル、2−メチルフェニル、4−メトキシ フェニル、4−(i−プロピル)フェニル、4−シクロペンチルフェニル、4− (t−ブチル)フェニル、4−アセチルフェニル、4−トリフルオロメチルフェ ニル、4−クロロフェニル、2−ブロモフェニル、3−ヨードフェニルまたは3 ,4−(メチレンジオキシ)フェニルを示すものである、請求項1〜4のいずれ か1項記載の化合物。 8.Xがフェニル、2−ピリジル、2−メトキシカルボニルチエン−3−イル 、2−ベンズイミダゾリル、2−ベンゾチアゾリルまたは1−フタラジニルを示 すものである、請求項1〜4のいずれか1項記載の化合物。 9.Xがフェニル、2−ピリジルまたは1−フタラジニルを示すものである、 請求項8記載の化合物。 10.(R)−7−(2−ピリジル)−8,9−ジヒドロ−8−メチル−5− (4−アミノフェニル)−7H−1,3−ジオキソロ[4,5−h][2,3]ベ ンゾジアゼピン、またはそれらの医薬的に許容され得る塩。 11.請求項1に記載の化合物および医薬的に許容され得る希釈剤または担体 を含む医薬組成物。 12.痙攣に対する処置が必要な哺乳動物における痙攣を処置する方法であっ て、請求項1記載の化合物の有効量を投与することを含む方法。 13.AMPA受容体を遮断する処置を必要とする哺乳動物におけるAMPA 受容体を遮断する方法であって、請求項1に記載の化合物の有効量を投与するこ とを含む方法。
Applications Claiming Priority (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US29864594A | 1994-08-31 | 1994-08-31 | |
US08/298,645 | 1994-08-31 | ||
US41302995A | 1995-03-28 | 1995-03-28 | |
US08/413,029 | 1995-03-28 | ||
PCT/US1995/010945 WO1996006606A1 (en) | 1994-08-31 | 1995-08-30 | Dihydro-2,3-benzodiazepine derivatives |
Publications (2)
Publication Number | Publication Date |
---|---|
JPH10505066A true JPH10505066A (ja) | 1998-05-19 |
JP4131987B2 JP4131987B2 (ja) | 2008-08-13 |
Family
ID=26970798
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP50892696A Expired - Fee Related JP4131987B2 (ja) | 1994-08-31 | 1995-08-30 | ジヒドロ−2,3−ベンゾジアゼピン誘導体 |
Country Status (13)
Country | Link |
---|---|
US (1) | US5795886A (ja) |
EP (3) | EP0771198B1 (ja) |
JP (1) | JP4131987B2 (ja) |
AT (2) | ATE212994T1 (ja) |
CA (1) | CA2198751C (ja) |
DE (2) | DE69525342T2 (ja) |
DK (2) | DK0771198T3 (ja) |
ES (2) | ES2170804T3 (ja) |
FI (1) | FI113049B (ja) |
HK (1) | HK1013794A1 (ja) |
NZ (1) | NZ292417A (ja) |
PT (2) | PT1157992E (ja) |
WO (1) | WO1996006606A1 (ja) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2006516647A (ja) * | 2003-02-04 | 2006-07-06 | アイバックス・インスティチュート・フォー・ドラッグ・リサーチ・リミテッド | 新規置換2,3−ベンゾジアゼピン誘導体 |
Families Citing this family (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ZA972746B (en) * | 1996-04-04 | 1998-10-09 | Egyt Gyogyszervegyeszeti Gyar | Novel 2,3-benzodiazepine derivatives |
HUP9701325A1 (hu) * | 1997-07-31 | 2000-08-28 | Gyógyszerkutató Intézet Kft. | Új 2,3-benzodiazepin-származékok |
HU9803014D0 (en) * | 1998-12-23 | 1999-02-01 | Egyt Gyogyszervegyeszeti Gyar | Novel phtalazine derivatives, process for their production and pharmaceutical compositions containing the same |
HU227128B1 (en) * | 1999-07-07 | 2010-07-28 | Egyt Gyogyszervegyeszeti Gyar | New 2,3-benzodiazepine derivatives |
US6649607B2 (en) * | 2001-05-18 | 2003-11-18 | Vela Pharmaceuticals, Inc. | Compositions and methods for treating or preventing convulsions or seizures |
TW200902024A (en) * | 2007-04-02 | 2009-01-16 | Teva Pharma | Novel 2,3-benzodiazepine derivatives and their use as antipsychotic agents |
CU20090172A6 (es) | 2009-10-09 | 2011-10-05 | Facultad De Quimica Universidad De La Habana | Sistemas tricíclicos y tetracíclicos con actividad sobre el sistema nervioso central y vascular |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
HU219778B (hu) * | 1990-12-21 | 2001-07-30 | Gyógyszerkutató Intézet Közös Vállalat | Eljárás N-acil-2,3-benzodiazepin-származékok, savaddíciós sóik és az ezeket tartalmazó gyógyászati készítmények előállítására, valamint a vegyületek egy csoportja, és az ezeket tartalmazó gyógyászati készítmények |
HU206719B (en) * | 1990-12-21 | 1992-12-28 | Gyogyszerkutato Intezet | Process for producing 1-/4-acylamino-phenyl/-7,8-methylenedioxy-5h-2,3-benzodiazepine derivatives, acid addicional salts and pharmaceutical compositions containing them |
HU219777B (hu) * | 1993-07-02 | 2001-07-30 | Gyógyszerkutató Intézet Kft. | Optikailag aktív 1-(4-nitro-fenil)-4-metil-7,8-metiléndioxi-3,4-dihidro-5H-2,3-benzodiazepin és eljárás előállítására |
-
1995
- 1995-08-30 DK DK95930998T patent/DK0771198T3/da active
- 1995-08-30 WO PCT/US1995/010945 patent/WO1996006606A1/en active IP Right Grant
- 1995-08-30 PT PT01114686T patent/PT1157992E/pt unknown
- 1995-08-30 NZ NZ292417A patent/NZ292417A/en not_active IP Right Cessation
- 1995-08-30 JP JP50892696A patent/JP4131987B2/ja not_active Expired - Fee Related
- 1995-08-30 DE DE69525342T patent/DE69525342T2/de not_active Expired - Lifetime
- 1995-08-30 US US08/776,892 patent/US5795886A/en not_active Expired - Fee Related
- 1995-08-30 ES ES95930998T patent/ES2170804T3/es not_active Expired - Lifetime
- 1995-08-30 DE DE69534407T patent/DE69534407T2/de not_active Expired - Lifetime
- 1995-08-30 PT PT95930998T patent/PT771198E/pt unknown
- 1995-08-30 CA CA002198751A patent/CA2198751C/en not_active Expired - Fee Related
- 1995-08-30 EP EP95930998A patent/EP0771198B1/en not_active Expired - Lifetime
- 1995-08-30 EP EP01114686A patent/EP1157992B1/en not_active Expired - Lifetime
- 1995-08-30 EP EP05015260A patent/EP1593683A3/en not_active Withdrawn
- 1995-08-30 DK DK01114686T patent/DK1157992T3/da active
- 1995-08-30 AT AT95930998T patent/ATE212994T1/de not_active IP Right Cessation
- 1995-08-30 AT AT01114686T patent/ATE302779T1/de not_active IP Right Cessation
- 1995-08-30 ES ES01114686T patent/ES2244524T3/es not_active Expired - Lifetime
-
1997
- 1997-02-27 FI FI970833A patent/FI113049B/fi active
-
1998
- 1998-12-23 HK HK98115184A patent/HK1013794A1/xx not_active IP Right Cessation
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2006516647A (ja) * | 2003-02-04 | 2006-07-06 | アイバックス・インスティチュート・フォー・ドラッグ・リサーチ・リミテッド | 新規置換2,3−ベンゾジアゼピン誘導体 |
Also Published As
Publication number | Publication date |
---|---|
FI970833A0 (fi) | 1997-02-27 |
HK1013794A1 (en) | 1999-09-10 |
NZ292417A (en) | 1998-09-24 |
EP1157992A1 (en) | 2001-11-28 |
DE69525342D1 (de) | 2002-03-21 |
CA2198751C (en) | 2006-07-11 |
DE69534407D1 (de) | 2005-09-29 |
EP0771198B1 (en) | 2002-02-06 |
EP1157992B1 (en) | 2005-08-24 |
JP4131987B2 (ja) | 2008-08-13 |
PT771198E (pt) | 2002-06-28 |
FI970833A (fi) | 1997-02-27 |
ES2170804T3 (es) | 2002-08-16 |
DK0771198T3 (da) | 2002-04-22 |
DE69534407T2 (de) | 2006-03-16 |
PT1157992E (pt) | 2005-10-31 |
DK1157992T3 (da) | 2005-10-24 |
ATE212994T1 (de) | 2002-02-15 |
WO1996006606A1 (en) | 1996-03-07 |
EP0771198A4 (ja) | 1997-05-28 |
EP1593683A2 (en) | 2005-11-09 |
DE69525342T2 (de) | 2002-11-07 |
EP1593683A3 (en) | 2006-10-25 |
AU689639B2 (en) | 1998-04-02 |
EP0771198A1 (en) | 1997-05-07 |
ES2244524T3 (es) | 2005-12-16 |
AU3418695A (en) | 1996-03-22 |
ATE302779T1 (de) | 2005-09-15 |
FI113049B (fi) | 2004-02-27 |
CA2198751A1 (en) | 1996-03-07 |
US5795886A (en) | 1998-08-18 |
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