JPH10504565A5 - - Google Patents

Info

Publication number
JPH10504565A5
JPH10504565A5 JP1996508101A JP50810196A JPH10504565A5 JP H10504565 A5 JPH10504565 A5 JP H10504565A5 JP 1996508101 A JP1996508101 A JP 1996508101A JP 50810196 A JP50810196 A JP 50810196A JP H10504565 A5 JPH10504565 A5 JP H10504565A5
Authority
JP
Japan
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP1996508101A
Other languages
English (en)
Japanese (ja)
Other versions
JP3741441B2 (ja
JPH10504565A (ja
Filing date
Publication date
Priority claimed from US08/442,575 external-priority patent/US5767144A/en
Application filed filed Critical
Priority claimed from PCT/US1995/009924 external-priority patent/WO1996006095A1/en
Publication of JPH10504565A publication Critical patent/JPH10504565A/ja
Publication of JPH10504565A5 publication Critical patent/JPH10504565A5/ja
Application granted granted Critical
Publication of JP3741441B2 publication Critical patent/JP3741441B2/ja
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

JP50810196A 1994-08-19 1995-08-04 エンドセリン・アンタゴニスト Expired - Lifetime JP3741441B2 (ja)

Applications Claiming Priority (9)

Application Number Priority Date Filing Date Title
US29334994A 1994-08-19 1994-08-19
US33471794A 1994-11-04 1994-11-04
US08/442,575 US5767144A (en) 1994-08-19 1995-05-30 Endothelin antagonists
US49799895A 1995-08-02 1995-08-02
US08/497,998 1995-08-02
US08/293,349 1995-08-02
US08/334,717 1995-08-02
US08/442,575 1995-08-02
PCT/US1995/009924 WO1996006095A1 (en) 1994-08-19 1995-08-04 Endothelin antagonists

Publications (3)

Publication Number Publication Date
JPH10504565A JPH10504565A (ja) 1998-05-06
JPH10504565A5 true JPH10504565A5 (enExample) 2005-07-14
JP3741441B2 JP3741441B2 (ja) 2006-02-01

Family

ID=27501591

Family Applications (1)

Application Number Title Priority Date Filing Date
JP50810196A Expired - Lifetime JP3741441B2 (ja) 1994-08-19 1995-08-04 エンドセリン・アンタゴニスト

Country Status (12)

Country Link
EP (2) EP1186603A3 (enExample)
JP (1) JP3741441B2 (enExample)
KR (2) KR100447000B1 (enExample)
AT (1) ATE219077T1 (enExample)
AU (1) AU711832B2 (enExample)
CA (2) CA2195677C (enExample)
DE (1) DE69527072T2 (enExample)
DK (1) DK0776324T3 (enExample)
ES (1) ES2179881T3 (enExample)
IL (2) IL134905A (enExample)
PT (1) PT776324E (enExample)
WO (1) WO1996006095A1 (enExample)

Families Citing this family (32)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5852046A (en) * 1993-08-03 1998-12-22 Hoechst Aktiengesellschaft Benzo-fused heterocyclic compounds having a 5-membered ring processes for their preparation their use as medicaments their use as diagnostic agents and medicaments containing them
US7208517B1 (en) 1994-08-19 2007-04-24 Abbott Labortories Endothelin antagonists
US6162927A (en) 1994-08-19 2000-12-19 Abbott Laboratories Endothelin antagonists
US5767144A (en) * 1994-08-19 1998-06-16 Abbott Laboratories Endothelin antagonists
NZ330818A (en) * 1996-02-13 2000-05-26 Abbott Lab Benzo-1, 3-dioxolyl- and benzofuranyl substituted pyrrolidine derivatives as endothelin antagonists
AU2763602A (en) * 1996-02-13 2002-05-16 Abbott Laboratories Endothelin antagonists
ES2182029T3 (es) * 1996-02-13 2003-03-01 Abbott Lab Derivados de acido 4-(benzo-1,3-dioxolil) pirrolidin-3-carboxilico como antagonistas de endotelina.
AU781355B2 (en) * 1996-02-13 2005-05-19 Abbott Laboratories Novel benzo-1,3-dioxolyl-and benzofuranyl substituted pyrrolidine derivatives as endothelin antagonists
US5801250A (en) * 1996-12-13 1998-09-01 Abbott Laboratories Process for the stereoselective production of nitro-enamine compounds
US6030975A (en) * 1997-03-14 2000-02-29 Basf Aktiengesellschaft Carboxylic acid derivatives, their preparation and use in treating cancer
HUP0002681A3 (en) * 1997-06-17 2001-09-28 Abbott Lab Pyrrolidine carboxylic acid derivatives as endothelin antagonists and pharmaceutical compositions containing the same
TR200101234T2 (tr) * 1997-08-04 2002-06-21 Abbott Laboratories Endotelin antagonistleri.
US6339087B1 (en) 1997-08-18 2002-01-15 Syntex (U.S.A.) Llc Cyclic amine derivatives-CCR-3 receptor antagonists
IL125658A0 (en) 1997-08-18 1999-04-11 Hoffmann La Roche Ccr-3 receptor antagonists
DE19743681A1 (de) * 1997-10-02 1999-04-08 Knoll Ag Methode zur Verhinderung der Transplantatabstoßung
US6410554B1 (en) 1998-03-23 2002-06-25 Merck & Co., Inc. Combination therapy for the treatment of benign prostatic hyperplasia
AU5478799A (en) 1998-09-14 2000-04-03 Warner-Lambert Company Branched alkyl pyrrolidine-3-carboxylic acids
EP1131290B1 (en) 1998-11-20 2008-02-20 F. Hoffmann-La Roche Ag Piperidine ccr-3 receptor antagonists
WO2002017912A1 (en) * 2000-08-31 2002-03-07 Abbott Laboratories Endothelin antagonists
US8168616B1 (en) 2000-11-17 2012-05-01 Novartis Ag Combination comprising a renin inhibitor and an angiotensin receptor inhibitor for hypertension
GB0327839D0 (en) 2003-12-01 2003-12-31 Novartis Ag Organic compounds
NZ586285A (en) 2004-03-17 2011-12-22 Novartis Ag Use of aliskiren in monotherapy for treating diabetes and metabolic disorder (syndrome X)
CA2904447C (en) 2007-08-22 2017-01-03 Abbvie Deutschland Gmbh & Co Kg Therapy for complications of diabetes
WO2011114103A1 (en) 2010-03-18 2011-09-22 Biolipox Ab Pyrimidinones for use as medicaments
JO2998B1 (ar) 2010-06-04 2016-09-05 Amgen Inc مشتقات بيبيريدينون كمثبطات mdm2 لعلاج السرطان
JP6093770B2 (ja) 2011-09-27 2017-03-08 アムジエン・インコーポレーテツド 癌の治療のためのmdm2阻害剤としての複素環化合物
US11407721B2 (en) 2013-02-19 2022-08-09 Amgen Inc. CIS-morpholinone and other compounds as MDM2 inhibitors for the treatment of cancer
AU2014223547B2 (en) 2013-02-28 2017-11-16 Amgen Inc. A benzoic acid derivative MDM2 inhibitor for the treatment of cancer
JP6377123B2 (ja) 2013-03-14 2018-08-22 アムジエン・インコーポレーテツド 癌の治療のためのmdm2阻害剤としてのヘテロアリール酸モルホリノン化合物
JOP20200296A1 (ar) 2013-06-10 2017-06-16 Amgen Inc عمليات صنع وأشكال بلورية من mdm2 مثبط
US8962675B1 (en) * 2013-09-12 2015-02-24 Abbvie Inc. Atrasentan mandelate salts
KR102091932B1 (ko) 2018-08-16 2020-03-20 장남순 안전하고 간편한 접첩구조를 갖는 접이식 트램펄린

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3342833A (en) * 1964-08-07 1967-09-19 Shell Oil Co Pyrrolidine production from aziridines and olefins
ES2164054T3 (es) * 1991-11-05 2002-02-16 Smithkline Beecham Corp Antagonistas de receptores de endotelina.
JPH07509465A (ja) * 1992-07-17 1995-10-19 スミスクライン・ビーチャム・コーポレイション エンドセリン受容体アンタゴニスト

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