JPH10501792A - カプセル化細胞の宿主への移植方法 - Google Patents
カプセル化細胞の宿主への移植方法Info
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- JPH10501792A JPH10501792A JP7527082A JP52708295A JPH10501792A JP H10501792 A JPH10501792 A JP H10501792A JP 7527082 A JP7527082 A JP 7527082A JP 52708295 A JP52708295 A JP 52708295A JP H10501792 A JPH10501792 A JP H10501792A
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- A61K9/00—Medicinal preparations characterised by special physical form
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- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
- A61K9/0024—Solid, semi-solid or solidifying implants, which are implanted or injected in body tissue
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- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K35/13—Tumour cells, irrespective of tissue of origin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K35/22—Urine; Urinary tract, e.g. kidney or bladder; Intraglomerular mesangial cells; Renal mesenchymal cells; Adrenal gland
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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- A61K9/0048—Eye, e.g. artificial tears
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0085—Brain, e.g. brain implants; Spinal cord
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
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- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/475—Growth factors; Growth regulators
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- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/475—Growth factors; Growth regulators
- C07K14/48—Nerve growth factor [NGF]
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- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0613—Cells from endocrine organs
- C12N5/0614—Adrenal gland
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- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0618—Cells of the nervous system
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0087—Galenical forms not covered by A61K9/02 - A61K9/7023
- A61K9/0092—Hollow drug-filled fibres, tubes of the core-shell type, coated fibres, coated rods, microtubules or nanotubes
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- C12N2500/00—Specific components of cell culture medium
- C12N2500/30—Organic components
- C12N2500/34—Sugars
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Abstract
Description
Claims (1)
- 【特許請求の範囲】 1.宿主に細胞を移植する方法であって: (a) 該細胞を生体適合性カプセルにカプセル化する工程、 (b) 該細胞を1つ以上の制限条件に十分な期間曝して、制限条件(1つま たは複数)に応答する所望の細胞特性を確立する工程、および (c) 該カプセル化細胞を宿主の移植部位で移植する工程であって、該細胞 が移植後実質的に維持される、工程、 を包含する、方法。 2.前記カプセル化細胞がインビトロで制限条件(1つまたは複数)に曝される 、請求項1に記載の方法。 3.レピシエントの移植部位で移植することによって、前記カプセル化細胞がイ ンビボで制限条件(1つまたは複数)に曝される、請求項1に記載の方法。 4.前記細胞が前記宿主に対して異種であり、そして前記カプセルが免疫隔離性 である、請求項1に記載の方法。 5.少なくとも1つの制限条件が、約40mg/デシリットルから約70mg/デシリット ルまでの範囲のグルコース濃度である、請求項1に記載の方法。 6.少なくとも1つの制限条件が、約40mmHgから約65mmHgまでの範囲の酸素濃度 である、請求項1に記載の方法。 7.少なくとも1つの制限条件が、脳脊髄液または脳実質内の生理ドーパンミン 濃度未満のドーパミン濃度である、請求項1に記載の方法。 8.前記細胞が、副腎のクロム親和性細胞、ベビーハムスター腎細胞、およびP C12細胞からなる群より選択される、請求項3に記載の方法。 9.前記細胞が、PC12細胞であって、そして6ヶ月間以上レピシエントに移植さ れる、請求項8に記載の方法。 10.前記細胞が、副腎のクロム親和性細胞であって、そして4ヶ月間以上レピ シエントに移植される、請求項8に記載の方法。 11.前記細胞が、PC12細胞であって、そして3週間以上レピシエントに移植さ れる、請求項8に記載の方法。 12.前記細胞が、神経伝達物質、鎮痛剤、および成長因子からなる群より選択 される生物学的に活性な分子を産生する、請求項1に記載の方法。 13.前記生物学的に活性な分子が、少なくとも1種のカテコールアミンである 、請求項12に記載の方法。 14.前記カプセルが、脳脊髄液および脳実質からなる群より選択される移植部 位で、宿主に移植される請求項1に記載の方法。 15.前記宿主がヒトである、請求項1に記載の方法。 16.制限条件に応答する所望の細胞特性を示す細胞であって、 (a) 細胞を生体適合性カプセルにカプセル化する工程、および (b) 該カプセル化細胞を霊長類レピシエントの移植部位で少なくとも6ヶ 月間移植して、移植部位で起こる制限条件に応答する所望の細胞特性を確立する 工程であって、該細胞がレピシエントに対して異種である、工程、 によって生産される、細胞。 17.前記細胞が、非霊長類の副腎クロム親和性細胞、ベビーハムスター腎細胞 、およびPC12細胞からなる群より選択される、請求項16に記載の細胞。 18.前記細胞が非霊長類の副腎クロム親和性細胞である、請求項17に記載の 細胞。 19.前記細胞がPC12細胞である、請求項17に記載の細胞。 20.前記所望の細胞特性が、前記細胞のカテコールアミン産出量の変化である 、請求項18または19に記載の細胞。 21.前記所望の細胞特性が、前記細胞のカテコールアミン産出量の増加である 、請求項20に記載の細胞。 22.前記カプセルが、脳脊髄液および脳実質からなる群より選択される移植部 位で移植される、請求項16に記載の細胞。 23.前記宿主がヒトである、請求項16に記載の細胞。 24.異種宿主に細胞を移植する方法であって: (a) 2つ以上の制限条件下で該細胞を培養する工程、 (b) 該細胞を生体適合性カプセルにカプセル化し、さらに該カプセル化細 胞を1つ以上の制限条件に十分な期間曝して、制限条件に応答する所望の細胞特 性を確立する工程、および (c) 宿主の移植部位で該カプセル化細胞を移植する工程であって、該細胞 特性が移植後実質的に維持される、工程、 を包含する、方法。
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US08/228,403 US5550050A (en) | 1994-04-15 | 1994-04-15 | Method for implanting encapsulated cells in a host |
US08/228,403 | 1994-04-15 | ||
PCT/US1995/004564 WO1995028166A2 (en) | 1994-04-15 | 1995-04-13 | Method for implanting encapsulated cells in a host |
Related Child Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2005076076A Division JP2005239726A (ja) | 1994-04-15 | 2005-03-16 | カプセル化細胞の宿主への移植方法 |
Publications (1)
Publication Number | Publication Date |
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JPH10501792A true JPH10501792A (ja) | 1998-02-17 |
Family
ID=22857036
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP7527082A Pending JPH10501792A (ja) | 1994-04-15 | 1995-04-13 | カプセル化細胞の宿主への移植方法 |
JP2005076076A Pending JP2005239726A (ja) | 1994-04-15 | 2005-03-16 | カプセル化細胞の宿主への移植方法 |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2005076076A Pending JP2005239726A (ja) | 1994-04-15 | 2005-03-16 | カプセル化細胞の宿主への移植方法 |
Country Status (19)
Country | Link |
---|---|
US (1) | US5550050A (ja) |
EP (2) | EP0756487A1 (ja) |
JP (2) | JPH10501792A (ja) |
CN (1) | CN1146155A (ja) |
AU (1) | AU697600B2 (ja) |
BR (1) | BR9507391A (ja) |
CA (1) | CA2187335A1 (ja) |
CZ (1) | CZ300496A3 (ja) |
EE (1) | EE9600147A (ja) |
FI (1) | FI964124A (ja) |
HU (1) | HUT75661A (ja) |
IL (1) | IL113390A0 (ja) |
IS (1) | IS4368A (ja) |
LV (1) | LV11730B (ja) |
NO (1) | NO964358L (ja) |
PL (1) | PL316845A1 (ja) |
SK (1) | SK131696A3 (ja) |
WO (1) | WO1995028166A2 (ja) |
ZA (1) | ZA953126B (ja) |
Cited By (2)
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JP2009522269A (ja) * | 2005-12-30 | 2009-06-11 | ニューロテック ユーエスエー, インコーポレイテッド | 生物活性分子の送達のための微粒子化デバイスおよびその使用方法 |
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- 1995-04-13 CN CN95192579A patent/CN1146155A/zh active Pending
- 1995-04-13 EE EE9600147A patent/EE9600147A/xx unknown
- 1995-04-13 WO PCT/US1995/004564 patent/WO1995028166A2/en not_active Application Discontinuation
- 1995-04-13 SK SK1316-96A patent/SK131696A3/sk unknown
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- 1995-04-13 JP JP7527082A patent/JPH10501792A/ja active Pending
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1996
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2005
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JP2012072180A (ja) * | 2003-11-13 | 2012-04-12 | Psivida Inc | 生物浸食性マトリクスコア及び生物浸食性スキンを有する注射可能な持続的放出用の送達用デバイス |
JP2009522269A (ja) * | 2005-12-30 | 2009-06-11 | ニューロテック ユーエスエー, インコーポレイテッド | 生物活性分子の送達のための微粒子化デバイスおよびその使用方法 |
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SK131696A3 (en) | 1997-06-04 |
EE9600147A (et) | 1997-04-15 |
AU697600B2 (en) | 1998-10-08 |
MX9604832A (es) | 1998-06-28 |
US5550050A (en) | 1996-08-27 |
ZA953126B (en) | 1996-01-04 |
LV11730A (lv) | 1997-04-20 |
WO1995028166A3 (en) | 1995-11-09 |
CA2187335A1 (en) | 1995-10-26 |
LV11730B (en) | 1998-02-20 |
NO964358D0 (no) | 1996-10-14 |
WO1995028166A2 (en) | 1995-10-26 |
BR9507391A (pt) | 1997-09-16 |
NO964358L (no) | 1996-12-13 |
CN1146155A (zh) | 1997-03-26 |
HU9602850D0 (en) | 1996-12-30 |
EP1632238A1 (en) | 2006-03-08 |
FI964124A0 (fi) | 1996-10-14 |
CZ300496A3 (en) | 1997-03-12 |
AU2382995A (en) | 1995-11-10 |
JP2005239726A (ja) | 2005-09-08 |
IS4368A (is) | 1996-10-01 |
FI964124A (fi) | 1996-10-14 |
PL316845A1 (en) | 1997-02-17 |
EP0756487A1 (en) | 1997-02-05 |
HUT75661A (en) | 1997-05-28 |
IL113390A0 (en) | 1995-07-31 |
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