JPH10339732A - Automatic analytical device and its supporting system - Google Patents

Abstract

PROBLEM TO BE SOLVED: To easily report to an operator and allow each analysis unit to execute calibration or precise management accurately by displaying the analysis item name and analysis unit name of a corresponding state when it becomes necessary to allow the analysis unit to execute calibration or precise management. SOLUTION: For example, a calibration now display block 402 blinks, when there are analysis items where the time interval of calibration passed. Analysis item names and analysis unit names for performing calibration are displayed at the columns of a test 411 and an A unit 412, while the effective time of lapse time/calibration is displayed at the columns of a blank 413 and a span 414. The effective time of the lapse time/calibration is displayed at the column of a two-points 415 in the case of calibration using two types of standard liquids with a known concentration. An effective time is displayed at the column of a full 416 in the case of calibration using at least three types of standard liquids with a known concentration.

Description

DETAILED DESCRIPTION OF THE INVENTION

[0001]

BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to an automatic analyzer for analyzing components in a biological sample and a support system therefor, and more particularly to an efficient operation and management of calibration and accuracy control in the automatic analyzer.

[0002]

2. Description of the Related Art In an automatic analyzer for analyzing components in a biological sample such as blood or urine using a reagent, at the beginning of the analysis process or at a predetermined time determined according to each reagent during the analysis process. , Or as needed during the analysis process,
Calibration, which is a calibration curve calibration operation, and accuracy control for keeping the automatic analyzer in a good state must be performed.

[0003] Calibration is performed using a standard solution having a predetermined concentration according to each analysis item. The quality control is performed by using a control sample having a predetermined concentration according to each analysis item. Calibration and quality control have a valid time according to each analysis item. Therefore, after the expiration of the valid time, it is necessary to perform calibration and accuracy management again. Also,
If the result of calibration or accuracy control is not within the predetermined range, it is determined as failure,
Calibration and quality control must be performed again. Also, for each analysis item, calibration must be performed again when a reagent is taken out of a new reagent bottle.

[0004] US Patent No. 4,678,755 teaches an automatic chemical analyzer that can perform a calibration. In this prior art, a calibration time interval is stored for each analysis item, and warning data can be displayed on a display device by the control means for an analysis item for which the effective time of the calibration curve has elapsed. . Also,
When the display device outputs the calibration menu screen, a list of all analysis items handled by the analyzer is displayed, and an alarm symbol is attached only to the analysis items that have passed the effective time.

On the other hand, Japanese Patent Application Laid-Open No. Hei 7-92171 discloses a method in which a plurality of analyzers are arranged along a container transport line, and the number of containers corresponding to the analytical processing capacity of each analyzer is sequentially assigned to the plurality of analyzers. Teaches a transport system for distributing to
However, this prior art does not describe anything about calibration and quality control.

Although the apparatus described in Japanese Patent Application Laid-Open No. 7-92171 is effective for analyzing a large number of samples, the number of types of analysis items to be handled is extremely large. Therefore, when trying to use an automatic analyzer having a plurality of analysis units similar to that of JP-A-7-92171, the method described in U.S. Pat. No. 4,678,755 can be applied as it is. In addition, the operation of performing calibration or quality control becomes complicated.

[0007]

SUMMARY OF THE INVENTION An object of the present invention is to provide a method for easily informing an operator that it is necessary to perform calibration or quality control for each of a plurality of analysis units, thereby enabling accurate calibration. Another object of the present invention is to provide an automatic analyzer capable of causing each analysis unit to perform quality control and a support system therefor.

Another object of the present invention is to provide a storage medium storing an operation program for causing an automatic analyzer to execute calibration or quality control.

Another object of the present invention is to provide an automatic analyzer having a configuration capable of repeatedly supplying a sample of known concentration used for calibration or quality control to a plurality of analysis units. is there.

A further object of the present invention is to provide an automatic analyzer operating method capable of easily executing calibration or accuracy control when efficiently operating a plurality of analysis units in the analyzer. is there.

[0011]

An automatic analyzer support system according to the present invention is applied to an automatic analyzer in which a plurality of analysis units are arranged along a transport line. This support system includes a display request unit for displaying a state check screen for calibration or accuracy management, and a plurality of classification headings provided corresponding to the classification of a plurality of states related to calibration or accuracy management in accordance with the display request. Screen display means for causing a state check screen to appear, and an instruction button for instructing the display of detailed information corresponding to each classification heading, and an analysis item name of a corresponding state when an instruction is given by the instruction button And a control unit for controlling the name of the analysis unit to be calibrated or the quality management of the analysis item to be executed on the status inspection screen.

In a preferred embodiment of the present invention, the display mode of the corresponding category heading is changed with the occurrence of a state corresponding to any one of the plurality of category headings. Also, when the occurrence of a condition requiring two or more calibrations or quality control for the same analysis item is notified by two or more classification headings, 1
As the calibration or quality control corresponding to one classification heading is performed, the notification by the remaining other classification headings is canceled.

In the automatic analyzer according to the present invention, a plurality of analysis units are arranged along a transport line for transporting a sample, and the analysis unit selected according to an analysis item is transferred to the analysis unit via the transport line. Is configured to stop by, a specific sample rack holding a specific sample that is repeatedly measured at predetermined intervals, and the specific sample rack is kept on standby to execute calibration or quality control. A rack standby unit that sends out a specific sample rack to the transport line along with, and an analysis that requires calibration or accuracy control via the transport line for the specific sample rack output from a predetermined position on the rack standby unit Control to control the operation of the transport line so that the unit stops at the unit and then returns the specific sample rack to the specified position on the rack standby unit. It includes a stage, a.

An automatic analyzer operating method according to the present invention comprises:
The same specific analysis item is assigned to each of two or more analysis units, and calibration or accuracy management is executed when a state requiring calibration or accuracy management for an automatic analyzer occurs. This is a method of accepting an instruction to be performed and performing calibration or quality control based on the execution instruction in each of two or more analysis units for a specific analysis item.

[0015]

DESCRIPTION OF THE PREFERRED EMBODIMENTS An embodiment of the present invention will be described with reference to FIGS.

First, the configuration of an example of an automatic analyzer to which the present invention is applied will be described.

FIG. 1 is a schematic block diagram of an automatic analyzer capable of analyzing serum, plasma or urine as a biological sample. In the automatic analyzer of FIG. 1, an analyzer for supplying a reagent by a dispenser method as shown in FIG. 2 and an analyzer for supplying a reagent by a pipettor method as shown in FIG. 3 are mixed. The analysis units 3A, 3F and 3G of FIG.
This is a dispenser-type analyzer having a fixed analysis channel and a plurality of reagent ejection nozzles dedicated to each reagent. The analyzers 3B, 3C, 3D, and 3E are pipetter-type analyzers in which the analysis channels are randomly accessed without being fixed, and the reagents corresponding to the analysis items are sequentially dispensed with one reagent pipetting nozzle.

In FIG. 1, analysis units 3A to 3G for analyzing and processing serum include racks such as a patient sample rack 1, a standard solution rack 74, and a control sample rack 77 taken in from the main transport line 20 at sampling positions. After being positioned, the sampling lines 4A to 4G, which are transport paths having a function of returning to the main transport line 20, and identification information of racks provided for each sampling line and identification information of each sample container on the rack. And a reaction unit 5A for performing, for example, optical measurement of a reaction solution by advancing a reaction according to an analysis item between a patient sample or a standard solution or a control sample and a reagent in a reaction container. ~ 5G and reagent supply unit 26
29 to 32 and 34 to 34, respectively. Of the reagent supply units of each analyzer, 26, 27, 28 and 29 are of a pipettor type, and 32, 33 and 34 are of a dispenser type.

The patient sample rack sending section 17 has an area in which a number of patient sample racks 1 can be set, and has a sending mechanism for sending the patient sample racks 1 one by one toward the main transport line 20. The rack collection unit 18 has an area for collecting the patient sample rack 1 containing a sample that has been analyzed by one of the analysis units, and has an alignment mechanism for arranging the sample racks in an orderly manner. The temporary storage unit 22 temporarily stores the patient sample rack 1 sampled by the analyzer until a measurement result is output, and re-transfers the sample rack again via the return line 25 when re-examination is necessary. The sample is sent out so as to be conveyed by the line 20, and if the retest is not required, the sample rack is collected by the rack collection unit 1.
Send to 8.

A standby unit 70 for a specific sample rack used repeatedly, such as a standard solution rack and a control sample rack, is provided with a standard solution rack 74 and a control sample rack 77 input by an operator through a rack input port 75. Rack ID identification device 7 for reading identification information
1, the standard solution rack 74 and the control sample rack 77 whose identification information has been read by the rack ID identification device 71.
For transporting the standard solution rack 74 and the control sample rack 77 that have been transported, and a sensor 72 for detecting the holding position of the standard solution rack 74 and the control sample rack 77 on the rotor 76. And a driving means 73 for rotating the rotor 76. When the execution of the calibration is instructed by the overall control computer 40, the rotor 76 is rotated by the driving means 73, and the standard solution containing the analytical items of the known concentration necessary for the execution of the calibration is used. The rack 74 accommodating the containers is positioned in the delivery passage 80, and the standard liquid rack 74 drawn from a predetermined position of the rotor 76 is delivered to the main transport line 20 through the delivery passage 80.

The main transport line 20 selectively brings the standard solution rack 74 to an analysis unit requiring calibration for the analysis item. The sampling mechanism in the analysis unit pipets a predetermined amount of the standard solution from the standard solution rack to the reaction container of the analysis unit.

When an instruction to execute the quality control is given by the overall control computer 40, the rotor 76 is rotated by the driving means 73 in the same manner, and then the analysis necessary for the execution of the quality control is performed. The rack 77 containing the control sample containing the item is sent out so as to be transported by the main transport line 20. The standard solution rack 74 for which the sampling for calibration has been completed and the control sample rack 77 for which the sampling for quality control has been completed include the sampling line 4A of the analysis unit.
~ 4G to the main transport line 20, then transported to the standby unit 70 via the return line 25,
It is stored in the original holding position on the rotor 76. The stored racks 74 and 77 wait in the rotor 76 until a command for calibration or accuracy control is issued thereafter. The standby unit 70 is maintained at a predetermined temperature so that the standard solution and the control sample do not deteriorate. Here, the configuration is such that the rotor 76 is used, but other configurations such as an elevator-type holding unit may be used instead of the rotor.

The control device is a computer 40 for overall control.
And an analysis unit side computer 6A to 6G provided corresponding to each analysis unit, and a floppy disk memory 41 which is a medium portable external storage device. The analysis unit computers 6A to 6G share processing of output signals from the photometer of each analysis unit. The overall control computer 40 connected to the computers 6A to 6G controls the operation of each analysis unit, the operation of the rack transport system, and the operation of necessary parts in the system, and also performs the arithmetic and control necessary for various information processing. Execute The role assignment between the computers is not limited to this, and can be changed to various modes according to the necessity of the configuration, or the analysis unit side computer can be made unnecessary by using only the overall control computer 40. It is. The overall control computer 40 includes a storage unit 45, an operation unit 42 for data input, a CRT 43 that is a display device for displaying information on a screen, and a printer 4 that can output measurement results and the like.
4 are connected. As the storage unit 45, for example,
A built-in hard disk can be used.

Note that a program is installed in each computer in advance. Each computer executes processing such as control according to the installed program. The program is provided in a state stored in a storage medium such as a floppy disk, a CD-ROM, or the like. As the program, in addition to the control program for executing the analysis, a program for supporting the operation of the analysis of the present invention and the like are installed.

The patient sample rack 1 comprises a box-shaped container holder into which a plurality of, for example, five patient sample containers 2 each containing a patient sample are loaded, as shown in the example of FIG. Various things other than a shape can be used. As shown in the example of FIG. 2, the standard solution rack 74 and the control sample rack 77 also include a plurality of, for example, five control sample containers 79 each containing a standard solution or a control sample container 79 containing a control sample. It consists of a box-shaped container holder to be loaded, but various things other than this shape can be used. Patient sample rack 1, standard solution rack 7
4. An identification information medium indicating rack identification information is provided on the outer wall of the control sample rack 77, and the patient sample container 2,
An identification information medium indicating the internal solution identification information is provided on the outer wall of the standard solution container 78 or the control sample container 79.
Barcode labels, magnetic recording media, and the like are used as these identification information media. The barcodes provided on the patient sample rack 1, the standard solution rack 74, and the control sample rack 77 have information on the rack number and the sample type. The barcode provided on the patient sample container 2 has information on each sample, for example, information such as a reception number, a reception date, a patient name, a patient number, a sample type, and a sample request analysis item. The standard solution container 78 or the control sample container 79 has information on each standard solution or control sample, for example, information such as a standard solution name or control sample name, ID, and manufacturing lot number.

The identification information reading device 50 shown in FIG. 1 inputs the result of reading the identification information (barcode) of the rack and the sample container before being transported by the main transport line 20 to the computer 40. The identification information reading device 58 provided in the temporary storage unit 22 reads the barcodes of the rack and the sample container when the rack enters and exits the temporary storage unit 22 and transmits the barcode to the entire computer 40. Here, the rack refers to the patient sample rack 1, the standard solution rack 74, and the control sample rack 77.
Here, the sample container refers to the sample container 2, the standard solution container 78, and the control sample container 79.

Reagent bottles 12 and 12A for various analysis items stored in the reagent supply sections of the respective analysis units 3A to 3G.
12B, reagent identification information is displayed on the outer wall thereof in the form of a barcode or the like. Reagent identification information includes reagent manufacturing lot number, reagent bottle size, usable reagent volume,
It has an expiration date, a sequence number that differs for each bottle, and an analysis item code. Such reagent identification information is read by a barcode reading device, is associated with each of the analysis units 3A to 3G, and is calculated from the set position of the reagent bottle in the reagent supply unit, the usable liquid amount, and the single dispensed amount. The number of possible analyzes of the reagent to be performed, the type of analysis item, the number of the analysis unit in which the reagent is stored, and the like are stored in the storage unit 45.
Registered in.

The main transport line 20 includes a patient sample rack 1,
A transport belt for mounting the standard solution rack 74 or the control sample rack 77 and a belt driving motor (both not shown) are provided.
4 or the control unit controls the control sample rack 77 to continuously transfer it to a desired position. Each of the sampling lines 4A to 4G can intermittently move the conveyor belt so as to stop the rack at the rack retraction position, the dispensing position, and the rack delivery position. Patient sample rack 1 and standard solution rack 7 transported by main transport line 20
4, or the control sample rack 77 is moved along the row of the analysis units, stopped in front of the analysis unit designated by the control device, and immediately moved to the rack retraction position of the sampling line by the rack moving mechanism (not shown). Moved. And it is dispensed by the dispenser described later at the dispensing position. The patient sample rack 1, the standard solution rack 74, or the control sample rack 77 for which the dispensing operation has been completed is
The rack is transferred from the rack sending position of the sampling line onto the main transport line 20 by the rack transfer mechanism. As the rack transfer mechanism, a transfer robot having a rack gripping arm, a mechanism having an extruding lever for pushing the rack from one of the main transfer line and the sampling line to the other, or the like is used.

A configuration example of a dispenser type analysis unit will be described with reference to FIG. The reaction unit 5A of the analysis unit 3A is provided with two concentric rows of reaction vessels each having a translucent reaction vessel 46a, and splits the light transmitted through the reaction vessel 46a from the light source 14a for each reaction vessel row. A multi-wavelength photometer 15a for receiving a wavelength is provided. A dispenser 48a having a pipette nozzle connected to a sample pipettor pump 47a and a first reagent nozzle group connected to a reagent dispenser pump 60 are provided near the reaction section 5A so as to act on each reaction vessel row. Holding section 64 and second reagent nozzle group holding section 66, first stirring mechanism 65 and second stirring mechanism 67
And a reaction vessel cleaning mechanism 19a. In the reagent cool box 62, reagent bottles 12 of a first reagent and a second reagent (only for necessary analysis items) for a plurality of analysis items are provided.
Are arranged and cooled to a predetermined temperature. The reagent solution in each reagent bottle 12 is supplied to a corresponding reagent discharge nozzle on the reaction vessel row by a reagent dispenser pump 60 via a tube. In this case, the dispenser-type reagent supply unit 32 of the analysis unit 3A shown in FIG. 1 includes the reagent dispenser pump 60 of FIG.
It includes a second reagent nozzle group holding unit 66 and the like.

The individual patient sample racks 1 supplied from the rack sending section 17 are transported by the main transport line 20 and are transferred to the sampling line 4A of the analysis unit 3A when the analysis processing by the analysis unit 3A is necessary. Is done. The patient sample on the patient sample rack 1 that has come to the dispensing position is supplied to the reaction container 4 by the pipette nozzle of the dispenser 48a.
A predetermined amount is pipetted to 6a. This reaction vessel 46
In a, the reagent corresponding to the analysis item is discharged at a predetermined position on the reaction vessel row, and the reaction proceeds. After a predetermined time, the optical characteristics of the reaction solution in the reaction vessel 46a are measured by the multi-wavelength photometer 15a. The signal output from the multi-wavelength photometer 15a is processed by the logarithmic converter 30a and the analog-to-digital converter 31a under the control of the analysis unit side computer 6A.
Sent to.

Each of the standard liquid racks 74 supplied from the standby unit 70 is transported by the main transport line 20 and is transferred to the sampling line 4A of the analysis unit 3A when calibration in the analysis unit 3A is necessary. You. Here, calibration is
This is an operation to measure a sample (standard solution) of known concentration and create a calibration curve.

The standard solution on the standard solution rack 74 that has reached the dispensing position is pipetted and dispensed in a predetermined amount into the reaction vessel 46a by the pipette nozzle of the dispenser 48a. The reagent corresponding to the analysis item is discharged into the reaction container at a predetermined position on the reaction container row, and the reaction proceeds. After a predetermined time, the optical characteristics of the reaction solution in the reaction vessel 46a are measured by the multi-wavelength photometer 15a.

The signal output from the multi-wavelength photometer 15a is converted into a logarithmic converter 30a and an analog / digital converter 31a under the control of the analysis unit computer 6A.
Process. Based on this data, the computer 6A determines the equation of the calibration curve, creates a calibration curve, determines the success or failure of the calibration, and transmits the success or failure to the overall control computer 40. Here, successful calibration means that a calibration curve is created, and the created calibration curve does not greatly deviate from the calibration curve obtained empirically in the past. It means that no calibration curve is created, or that the created calibration curve deviates greatly from the calibration curve obtained empirically in the past. The analysis unit computer 6A is provided with calibration curve data obtained empirically in the past and data on the allowable deviation range, and determines the success or failure of calibration based on the data.

The analysis unit computer 6A
Transmits the information on the equation of the obtained calibration curve to the overall control computer 40 without performing the determination of the success or failure of the calibration.
The data of the calibration curve obtained empirically in the past and the data relating to the allowable deviation range may be provided to determine the success or failure of the calibration.

The individual control sample racks 77 supplied from the standby unit 70 are transported by the main transport line 20, and when accuracy control in the analysis unit 3A is required, the sampling line 4 of the analysis unit 3A is required.
Transferred to A. Here, quality control refers to measuring a sample (control sample) having a known concentration and determining whether or not the measurement result falls within a predetermined range. This is the task of checking whether the state is maintained.

Control sample rack 7 that has reached the dispensing position
The control sample on 7 is pipetted and dispensed in a predetermined amount into the reaction container 46a by the pipette nozzle of the dispenser 48a. The reagent corresponding to the analysis item is discharged into the reaction container 46a at a predetermined position on the reaction container row, and the reaction proceeds. After a predetermined time, the optical characteristics of the reaction solution in the reaction vessel 46a are measured by the multi-wavelength photometer 15a.

The signal output from the multi-wavelength photometer 15a is converted into a logarithmic converter 30a and an analog / digital converter 31a under the control of the analysis unit computer 6A.
Process. Based on this data, the success or failure of quality control is determined in the analysis unit computer 6A. Here, the success of quality control means that the precision is measured,
This refers to a state where the measured accuracy maintains a predetermined accuracy.
Quality control failure means that the accuracy is not measured or
A state in which the measured accuracy does not maintain a predetermined accuracy. The success or failure of the determined quality control is transmitted to the overall control computer 40.

The analysis unit side computer 6A does not judge the success or failure of the quality control, and transmits only information on whether or not measurement was possible or not, and information on the measured value when measurement was possible to the overall control computer 40, The control computer 40 may determine whether the quality management is successful or not.

The dispenser type analysis units 3F and 3G have the same configuration as the analysis unit 3A.

Next, an example of the configuration of the pipetting type analysis unit will be described with reference to FIG. In the reaction container 46b arranged in the reaction section 5B of the analysis unit 3B, the reaction between the sample and the reagent related to a predetermined analysis item proceeds. The patient sample rack 1 moved from the main transport line 20 to the sampling line 4B (FIG. 1) is positioned at the dispensing position, and the sample indicated by the pipette nozzle of the dispenser 48b is collected and transferred to the reaction container 46b. A predetermined amount of the sample is ejected. The dispenser 48b has a pipettor pump 47b. The reaction unit 5B is maintained at a constant temperature (for example, 37 ° C.) by a constant temperature liquid supplied from the constant temperature bath 10.

The pipettor-type reagent supply section 26 of the analysis unit shown in FIG. 3 has two reagent disks 26A and 26B for the first reagent and the second reagent. Reagent bottle 12 containing various reagents prepared for many types of analysis items
In A and 12B, reagent identification information is displayed by bar codes on their outer wall surfaces. After the reagent bottles 12A and 12B are placed on the reagent disks 26A and 26B, the reagent identification information of each reagent bottle is read by the barcode readers 23A and 23B, and the information is set at the set position of the reagent bottle on the reagent disk. , Corresponding analysis items,
The reagent bottle is registered in the storage unit 45 together with the analysis unit number set therein. Reagent dispensers 8A and 8B
Has a reagent pipette pump 11 connected to each of the pipettor nozzles that can rotate and move up and down.

The row of the reaction containers 46b into which the patient sample has been dispensed is rotated and moved from the reagent bottle 12A positioned at the reagent suction position according to the type of the analysis item to the reagent dispenser 8A.
As a result, a predetermined amount of the reagent solution is sucked, and the first reagent is discharged to the reaction container 46b at the reagent addition position. After the contents are agitated by the agitating mechanism 13A at the agitating position, the reaction vessel row is transported a plurality of times, and when the reaction vessel 46b reaches the second reagent adding position, the reagent dispenser 8B operates the reagent in accordance with the analysis item. The reagent solution is sucked from the reagent bottle 12B positioned at the suction position, and the reagent is discharged into the reaction container. Next, the contents of the reaction vessel are stirred by the stirring mechanism 13B. Thereafter, the reaction vessel 4 is rotated with the rotation of the reaction vessel row.
6b passes the light beam from the light source 14b and
The light transmitted through the reaction solution is detected by the multi-wavelength photometer 15b.

The signal of the wavelength corresponding to the analysis item is processed by the logarithmic converter 30b and the analog / digital converter 31b controlled by the computer 6B on the analysis unit side, and the digital signal is transmitted to the computer 40 for overall control. The measured reaction vessel 46b is cleaned by the cleaning mechanism 19b and reused.

When calibration in the analysis unit 3B is necessary, the standard solution rack 74 is transferred to the sampling line 4B of the analysis unit 3B. The standard solution rack 74 is positioned at the dispensing position and the dispenser 48b
The standard solution indicated by the pipette nozzle is sampled, and a predetermined amount of the standard solution is discharged to the reaction container 46b. The reaction of this standard solution proceeds in the same manner as the reaction of the patient sample described above. The signal of the wavelength of the reaction solution is supplied to a logarithmic converter 30b controlled by the analysis unit computer 6B.
And an analog / digital converter 31b. Based on this data, the analytical unit computer 6B calculates the equation of the calibration curve to create a calibration curve,
The success or failure of the calibration is determined, and the success or failure is transmitted to the overall control computer 40. The analysis unit computer 6B is provided with calibration curve data obtained empirically in the past and data on the allowable deviation range, and determines the success or failure of the calibration based on the data.

The analysis unit side computer 6B does not judge the success or failure of the calibration, and transmits the information on the obtained equation of the calibration curve to the overall control computer 40B.
And the overall control computer 40 may be provided with calibration curve data obtained empirically in the past and data on the allowable deviation range to determine the success or failure of the calibration.

When accuracy control in the analysis unit 3B is required, the control sample rack 77 is transferred to the sampling line 4B of the analysis unit 3B. The control sample rack 77 is positioned at the dispensing position, the control sample indicated by the pipette nozzle of the dispenser 48b is collected, and a predetermined amount of the control sample is discharged to the reaction container 46b. The reaction of this control sample proceeds in the same manner as the reaction of the patient sample described above.

The signal of the wavelength of the reaction solution is processed by a logarithmic converter 30b and an analog / digital converter 31b controlled by the analysis unit computer 6B. Based on this data, the analyzer-side computer 6
It is determined whether the predetermined accuracy is maintained in A,
The result is transmitted to the overall control computer 40.

The analysis unit computer 6A does not judge whether the predetermined accuracy is maintained, but transmits only the measured values to the overall control computer 40, and the predetermined accuracy is maintained in the overall control computer 40. A determination may be made as to whether or not there is an error.

The analysis units 3C, 3D and 3E have the same configuration as the analysis unit 3B.

Next, the operation of the embodiment of FIG. 1 will be described.

Before the sample rack 1 is set in the rack sending section 17, and before the standard solution rack 74 and the control sample rack 77 are set in the standby unit 70, an inspection instruction request is issued from each requester to each sample. The analysis item is
The information is registered in advance in the overall control computer 40 from the operation unit 42 together with each sample number. The analysis condition information of each analysis item, information on calibration, and information on accuracy management are stored in the floppy disk memory 41. When the same analysis item is assigned to two or more analysis units, analysis condition information to be commonly used by a plurality of analysis units is a reagent to be used, a measurement wavelength in a photometer, a sample collection amount, and the like. .

The information on the calibration includes a calibration time interval, a calibration execution format (standard solution or calibrator to be used), a method of preparing a calibration curve, information on a permissible range of the calibration curve, and calibration execution conditions (what kind of calibration execution conditions). Whether to execute calibration in this case). The information on the quality control includes a quality control time interval, a quality control execution format (control sample to be used), information on the allowable range of the quality, a quality management execution condition (when to perform the quality control), and the like. . Among them, the method of creating the calibration curve, the information on the allowable range of the calibration curve, and the information on the allowable range of the accuracy are also stored in storage means (not shown) of the analysis unit computers 6A to 6G.

Among the analysis condition information, the information stored corresponding to each reagent bottle includes the necessary number of reagents from the first reagent to the fourth reagent, the code of the reagent bottle consisting of a five-digit number, and the reagent number. This includes the dispensed amount and the number of tests that can be analyzed per reagent bottle.

The reagent supply unit 2 of each of the analysis units 3A to 3G
As the reagent bottles are stored in 6 to 29 and 32 to 34, the reagent identification information of each reagent bottle is registered in the overall control computer 40 in association with the analysis unit number. In this case, reagents for the same type of analysis item are stored in a plurality of analyzers of the same group that handle the same sample type. Here, it is assumed that the serum sample is handled in all the analysis units 3A to 3G. Among them, the reagent supply unit 32 of the analysis unit 3A stores, for example, GOT and GPT as liver function test items and calcium as urgent test items,
Reagent bottles for UA and BUN are stored. In the reagent supply section 26 of the analysis unit 3B, for example, reagent bottles for GOT, GPT, which are liver function test items, and other analysis items with a small number of test requests are stored. The reagent supply unit 27 of the analysis unit 3C stores, for example, calcium, UA, and BUN, which are urgent test items, and reagent bottles for other analytical items with a small number of test requests. Therefore, the liver function test item can be analyzed and processed by the two analysis units 3A and 3B. Further, the urgent inspection item can be analyzed and processed by the two analysis units 3A and 3C. The number of analysis units and the number of analysis item reagents to be stored in an overlapping manner are determined by the operator according to the actual conditions of the examination room in each facility.

As each of the reagent bottles 12, 12A, and 12B is stored in each reagent supply unit, the reagent identification information provided on the reagent bottle is read, and the reagent bottle code is used as a key and the analysis condition information is already used. The registered information is searched, and the analysis item corresponding to the reagent bottle, the size of the bottle, the number of tests that can be analyzed, the set position of the reagent bottle, and the like are associated with each other and registered in the overall control computer 40. . At the same time, the maximum number of times of analysis based on the total number of reagent bottles for the same type of analysis item in a plurality of analysis units capable of performing the same type of analysis is also registered and displayed on the CRT 43 as necessary.

After the corresponding reagents for the analysis items necessary for each analysis unit are stored, prior to the sample analysis processing, calibration for all the analysis items that can be analyzed by the analysis unit is performed for each analysis unit. Are respectively executed. The analysis unit side computer determines the success or failure of the calibration. When the same analysis item is assigned to each of two or more analysis units, the same standard solution is sampled by stopping at those analysis units.

When the execution of the calibration is completed successfully, the fact that the calibration was successful and the equation of the calibration curve obtained as the calibration result are expressed as follows.
It is stored in the storage unit 45 of the overall control computer 40. The calibration result is used for the concentration calculation when the corresponding analysis item is analyzed in each analysis unit.

When the execution of the calibration has been failed and ended, the computer on the analysis unit side sends a message to the control computer 40 indicating that the calibration has failed. The overall control computer 40 displays that the calibration has failed on a calibration support screen (described later) of the CRT 43. On the calibration support screen, a button is displayed as an area for inputting an instruction to display information on an analysis item for which calibration has failed, and the operator issues a display instruction for this button via the operation unit 42. Is input, information on the failed analysis item is displayed, and a process for re-executing the failed calibration is started.

When the execution of the calibration for all the analysis items in all the analysis units is completed successfully, the quality control for all the analysis items that can be analyzed by the analysis unit is performed for each of the analysis units. Are respectively executed. The analysis unit side computer determines the success or failure of the quality control, and transmits the determined success or failure to the overall control computer 40.

When the execution of the accuracy management has ended due to a failure, the overall control computer 40 displays on the accuracy management support screen (described later) of the CRT 43 that the accuracy management has failed. On this quality control support screen, a button is displayed as an area for inputting an instruction to display information on an analysis item for which quality control has failed, and the operator
When a display instruction is input for this button via the operation unit 42, information on the failed analysis item is displayed, and the failed accuracy management is executed again.

When the execution of the quality control in all the analysis units is completed successfully, the analysis process of the analysis items that can be analyzed by the analysis unit is started for each analysis unit.

When the analysis process is started, the rack sending section 1
As one of the detection racks 1 placed on the sample rack 7 is pushed out toward the main transport line 20, the sample rack 1
Or the identification information of the sample container 2 is read by the identification information reading device 50. The sample type on the sample rack 1 is determined by the overall control computer 40 based on the read information, and an analysis unit group that is set in advance for the sample type is selected. One of the analysis unit groups is determined as the sample transport destination. Here, for example, it is assumed that a serum sample is determined, and a group of the analysis units 3A, 3B, and 3C to which the sample rack is to be transported is selected.

Further, with the reading of the sample identification information, the registration status of the sample number and the analysis item is collated, and the analysis item designated for measurement for each sample on the sample rack 1 is determined. The analysis items are analysis units 3A and 3B
And 3C should be analyzed by
The determination is made by the overall control computer 40. In this case, the overall control computer 40 monitors the number of analysis items for which analysis processing has already been instructed for each analysis unit and how long it takes to finish dispensing those samples. In particular, for a specific analysis item that can be analyzed by a plurality of analysis units, it is determined which analysis unit is more efficient to perform the analysis process on the analysis item. For example, regarding the specific analysis items GOT and GPT, it is determined whether the analysis unit with the smallest number of samples waiting to be processed is 3A or 3B at that time, and the one with the shorter waiting time is designated as the designated analysis unit.

In addition to such a method of automatically designating an analysis unit to be subjected to analysis processing of a specific analysis item according to the degree of busyness among a plurality of analysis units, the operator can preliminarily select each analysis item from the operation unit 42. It is also possible to specify the priority order of the analysis units to be used for the processing.

A sample rack 1 having a sample to be analyzed for a specific analysis item and having a transport destination (for example, the analysis unit 3B) determined is transferred from the main transport line 2 to the designated analysis unit 3B.
It is continuously transported by 0 and stopped before the entrance of the analysis unit 3B to the sampling line 4B. Next, the sample rack 1 is moved to the sampling line 4B, and after a predetermined sample is dispensed to the reaction section 5B by the sample dispenser 48b at the dispensing position, the sample rack 1 is returned to the main transport line 20. When analysis items to be analyzed by another analysis unit 3C remain in the sample on the sample rack 1, the sample rack 1 is moved to the analysis unit 3C by the main transport line 20.
The sample is transferred to the sampling line 4C and dispensed.

The amount of the reagent remaining in the reagent bottle for each analysis item in each analysis unit is determined by the overall control computer 40.
Being monitored by As a method of monitoring the remaining amount of the reagent, a method based on detecting the reagent liquid level in the reagent bottle when dispensing the reagent by a liquid level detector provided in the reagent pipette nozzle, or dispensing the reagent Each time is used, a method of subtracting the number of analyzable times input in advance is adopted. In either case, whether or not the amount of reagent for the analysis item is insufficient is determined by determining by the overall control computer 40 whether or not the remaining number of analyzable times has reached a predetermined value. You. In this case, the predetermined value is set such that the remaining number is small, such as zero, one, or two.

Also, for example, G of the designated analysis unit 3B
When it is determined that the OT reagent is insufficient, the analysis processing of the GOT by the analysis unit 3B is stopped, and at the same time, the analysis is performed so that the analysis processing of the GOT by the analysis unit 3A in which the GOT reagent is sufficiently left is enabled. The unit switching operation is controlled. Therefore, a sample to be subjected to GOT analysis processing thereafter is conveyed to another analysis unit 3A having the next priority, and GOT analysis processing is performed.

The control device in the embodiment of FIG. 1 knows which analysis unit is instructing the analysis processing, calibration, and quality control of each analysis item, and stores the data in the storage unit 45. Have been. The overall control computer 40 stores information on which analysis unit is performing analysis processing, calibration, and quality control of each analysis item in a memory table. The information is made into a list and the drawing is displayed on the CRT 43.

In the apparatus of the embodiment shown in FIG.
A to 3G can be instructed to start and stop the respective operations by a key operation of the operation unit 42, and the overall control computer 40 is stopped based on the instruction information from the operation unit. The sample rack 1 from the rack sending unit 17 is transported via the main transport line 20 only to the remaining analysis units except the analysis unit. Especially,
During night hours, when the number of requested samples is small and the urgent sample testing is the main task, only the minimum necessary analysis units are put into operation and the remaining analysis units are stopped. it can. During the time period when the number of requested samples increases, the plurality of stopped analysis units are restarted.

In the apparatus of the embodiment shown in FIG. 1, when an abnormal situation occurs in one of the analysis units and the analysis processing by the analysis unit becomes impossible, the same analysis processing is replaced by another analysis unit. Thus, the control device instructs the transport of the sample rack to another analysis unit and the analysis processing by another analysis unit. For example, by setting reagents for a plurality of analysis items in duplicate in the two analysis units 3B and 3C, the analysis processing can be performed without interrupting the analysis operation for the plurality of analysis items.

During the analysis process in the automatic analyzer as described above, at predetermined time intervals predetermined for each analysis item, or at a predetermined number of samples,
Calibration and quality control must be performed. Also, when a reagent in a reagent bottle is consumed and a reagent bottle is added, it may be necessary to perform calibration on the reagent in the added reagent bottle.

The automatic analyzer support system according to the present invention provides an automatic analyzer having
Alternatively, this is a support system for performing calibration and accuracy management during analysis processing in the automatic analyzer. This support system will be described below.

First, the calibration support screen displayed by the present support system on the CRT 43 of the automatic analyzer will be described. This support screen functions as a check screen of the calibration state.

FIG. 4 shows an example of the calibration support screen. When the operator presses the Calibration button 423, which is a button integrated with display input on the screen, the display of the Calibration button 423 is inverted and the calibration support screen is displayed.
On this screen, the display part as the inspection screen of the calibration state is a part including the display area 400 and the display area 410, and these display areas will be described first.

When the Calibration button 423 is instructed by the operator and the calibration support screen is displayed, the display in the display area 410 has not been performed yet. On the calibration support screen,
A display other than the display area 410 is displayed.

In the display area 400, a plurality of classification headings provided corresponding to the classification of a plurality of states of calibration, that is, display blocks 401 to 401, which are a plurality of indices that preliminarily classify and symbolize the state of the analyzer. 404 is displayed. Further, in the display area 400, instruction buttons or reception buttons 405 to 408 provided corresponding to the display blocks and receiving a display instruction are displayed. Display blocks 401 to 40 as classification headings
4 respectively, when the state of the analyzer includes an event symbolized by the display block, its own display mode is changed.

A Pre-Setting display block 401 in the display area 400 indicates that an analysis item corresponding to a calibration that needs to be performed regularly, such as a calibration to be performed prior to the analysis processing in the automatic analyzer, is registered. Blinks. Pre-Setting display block 40
When 1 flashes, when the operator instructs button 405, the display area 410 displays the analysis item name of the calibration that needs to be performed regularly, and starts the calibration of the displayed analysis item. Is done.

The Calib.Now display block 402 in the display area 400 blinks when there is an analysis item whose calibration time interval has passed. When the Calib.Now display block 402 flashes, the operator
When the user designates 6, the corresponding analysis item name is displayed in the display area 410, and the calibration of the displayed analysis item is started.

The Calib.Failed display block 403 in the display area 400 blinks when there is an analysis item in which calibration has failed. When the Calib.Failed display block 403 blinks, the operator
When 07 is designated, the corresponding analysis item name is displayed in the display area 410, and calibration of the displayed analysis item is started.

The Change Over display block 404 in the display area 400 blinks when there is an analysis item for which the necessity of the calibration accompanying the addition of the reagent bottle is present. When the change over display block 404 flashes and the operator designates the button 408, the display area 410 displays the name of the analysis item to which the new reagent has been added, and the calibration of the displayed analysis item is performed. Is activated.

Next, the contents displayed in display area 410 will be described. In the column of Test 411, an analysis item name to be calibrated is displayed. A.Unit41
Column 2 shows the name of the analysis unit to be calibrated. In the column of Blank 413, when calibration to be performed is calibration using one type of standard solution having a concentration of 0, elapsed time / calibration interval (valid time) is displayed. The column of Span 414 displays elapsed time / calibration interval (valid time) when the calibration to be performed is a calibration using one type of standard solution having a known concentration other than zero. In the column of 2 Points 415, when calibration to be performed is calibration using two types of standard solutions having known concentrations, elapsed time / calibration interval (valid time) is displayed. Fu
In the column of ll416, the calibration to be performed is
In the case of calibration using three or more types of standard solutions having known concentrations, elapsed time / calibration interval (effective time) is displayed.

In FIG. 4, the analysis items AST, AL
T, calibration of ALP, analysis unit 3D
In this example, it is necessary to use one type of standard solution having a concentration of 0, and the elapsed time / calibration interval is set to 10/100 for AST, ALT, and ALP. It is necessary to calibrate the analysis item LDH in the analysis unit 3E using one type of standard solution having a concentration of 0, and the elapsed time / calibration interval is 15/100.
Is displayed. Further, the calibration of the analysis item TP is performed in the analysis unit 3E by 1
It is necessary to use a standard solution with a non-concentration of 0 or two standard solutions with a known concentration. 15 / when using
When 100 or two kinds of standard solutions having known concentrations are used, it is indicated that the ratio is 115/200. further,
The calibration of the analysis item UN is performed in the analysis unit 3
In F, it is necessary to use one type of standard solution having a concentration of 0, and it is displayed that the elapsed time / calibration interval is 15/100. Furthermore, it is necessary to calibrate the analysis item CRE in the analysis unit 3F using one type of standard solution having a known concentration other than 0 or two types of standard solutions having a known concentration. Is 15/100 when one type of standard solution having a known concentration other than 0 is used, and 115/200 when two types of standard solutions are used. . Further, the calibration of the analysis item CRP needs to be performed in the analysis unit 3D using two types of standard solutions of known concentration or three or more types of standard solutions of known concentration. Indicates that the ratio is 50/100 when two standard solutions with known concentrations are used, and 50/200 when three or more standard solutions with known concentrations are used.

When one of the buttons 405 to 408 is instructed, a list of analysis items in a corresponding state is displayed on the display area 410, and at the same time, information on the standard solution necessary for calibration of each analysis item is displayed. The data may be output from the printer 44 in association with each analysis item.

When the number of analysis items displayed in the display area 410 is large and cannot be displayed all at once, the analysis items can be displayed by scrolling with the buttons 451 and 452. .

Next, other buttons displayed on the calibration support screen will be described. Work P
When the lace button 421 is instructed by the operator, a function screen is displayed. When the Reagent button 422 is instructed by the operator, a management screen for the reagent bottle is displayed. When the quality control button 424 is instructed by the operator, a quality management support screen (this will be described later) is displayed. When the Utility button 425 is instructed by the operator, a system setting screen for performing basic settings for operating the apparatus is displayed.
When a Caliburation Trace button 431 is instructed by the operator, the history of calibration performed in the past is displayed. When the Instrument Factor button 432 is instructed by the operator, a factor for correcting the bias of each analysis unit is displayed. When the Reaction Monitor button 433 is instructed by the operator, data for checking the state of the reaction for each analysis item is displayed. When the Working Information button 434 is instructed by the operator, detailed information of the calibration result is displayed. When the Save button 435 is instructed by the operator, the list displayed on the screen is saved. He
When the operator presses the lp button 436, help information is displayed.

The Stop button 441 is a button for stopping the automatic analyzer. Log off button 442
This button is used to exit from the display screen. The S.Stop button 443 is a button for stopping sampling, and the Alarm button 444 is a button for notifying an abnormality of the device. System Overview button 445
This button is used to display the movement of the rack in order to know whether the rack is flowing normally. A Print button 446 is a button for instructing printing, and
The button 447 is a button for activating the automatic analyzer.

Next, a description will be given of an accuracy management support screen displayed on the CRT 43 of the automatic analyzer by the present support system. This support screen functions as an inspection screen of the quality control state.

FIG. 5 shows an example of the accuracy management support screen. Qualit, a button that integrates display and input on the screen
When the y Control button 524 is instructed by the operator, the display of the Quality Control button 524 is inverted and the quality management support screen is displayed. On this screen, the display part as the inspection screen of the quality control state is a part including the display area 500 and the display area 510.
These display areas will be described.

When the quality control button 524 is instructed by the operator and the quality management support screen is displayed, the display in the display area 510 has not been made yet. The display other than the display area 510 is displayed on the quality management support screen.

In the display area 500, there are provided a plurality of classification headings provided corresponding to a plurality of classifications of the quality control, that is, display blocks 501 to 501 which are a plurality of indices for classifying and symbolizing states of the analyzer in advance. 503 is displayed, and further, an instruction button or an accept button 50 provided corresponding to those display blocks to accept a display instruction.
5 to 407 are displayed. Each of the display blocks 501 to 503 as a classification heading changes its own display mode when the state of the analyzer includes an event symbolized by the display block.

[0091] The Pre-Setting display block 501 in the display area 500 indicates that an analysis item corresponding to accuracy management that must be performed regularly, such as accuracy management to be performed prior to analysis processing in the automatic analyzer, is registered. Blinks. When the operator designates a button 505 when the Pre-Setting display block 501 blinks, analysis items for quality control that need to be performed constantly are displayed in the display area 510, and the displayed analysis items are displayed. Quality control is activated.

The Time-over display block 502 in the display area 500 blinks when the validity period of the accuracy management has passed. When the Time-over display block 502 blinks,
When the operator designates button 506, display area 51 is displayed.
Within 0, the analysis items of the quality management that need to be performed are displayed, and the quality management of the displayed analysis items is started.

The QC.Failed display block 503 in the display area 500 blinks when a failure in quality control occurs. When the QC.Failed display block 503 blinks,
When the operator designates button 507, display area 51 is displayed.
Within 0, the analysis items of the quality management that need to be performed are displayed, and the quality management of the displayed analysis items is started.

Next, the contents displayed in the display area 410 will be described. In the column of Test 511, analysis items for which quality control is to be performed are displayed. A. In the column of Unit 512,
The name of the analysis unit for which quality control is to be performed is displayed. Cont
In the column of rol 513, the name of the control sample used for quality control to be performed is displayed. In the column of Type 514, a type that defines the type of concentration of the control sample to be used for quality control is displayed. Lot515
Column displays the production lot number of the control sample to be used for quality control. In the column of Time Out 516, the elapsed time of accuracy management to be performed / interval (effective time) of accuracy management are displayed.

In FIG. 5, the analysis items AST, AL
The quality control of T and ALP is performed in the analysis unit 3D.
It must be performed using a control sample of lot number X970400 with the name Ctrl-1 and the type Ser / Pl.
It is displayed that both ALT and ALP are 10/100. In addition, it is necessary to perform the accuracy control of the analysis item LDH in the analysis unit 3E using the control sample of the lot number S668795 with the name of Ctrl-2 and the type of Ser / Pl. , 50/60. Furthermore, it is necessary to control the accuracy of the analysis item TP in the analysis unit 3E using the control sample of the lot number S668795 with the name of Ctrl-2 and the type of Ser / Pl. ,
50/60 is displayed. Further, the quality control of the analysis item UN is performed in the analysis unit 3F by Ct.
Lot number V8 with name rl-U and type Urin
Must be performed using 46852 control samples, elapsed time / quality control interval is 10/60
Is displayed. Furthermore, the analysis item CRE
In the analysis unit 3F, the quality control of the lot number S668795 in the name of Ctrl-2 and the type of Ser / Pl
It is necessary to use the control sample of No., and the interval of elapsed time / quality control is displayed as 50/60. Furthermore, it is necessary to control the accuracy of the analysis item CRP in the analysis unit 3D using the control sample of the name Ctrl-M and the type of Ser / Pl and the lot number M970123, and the elapsed time / interval of the accuracy control is 10/60 is displayed.

When one of buttons 505 to 507 is instructed, a list of analysis items is displayed in display area 510, and at the same time, information on control samples necessary for quality control of each analysis item is associated with each analysis item. Let me
Output may be made from the printer 44.

If the number of analysis items displayed in display area 510 is large and cannot be displayed all at once, buttons 551 and 552 can be used to scroll and display analysis items. .

Next, other buttons displayed on the accuracy management support screen will be described. Select button 53
When 1 is instructed by the operator, the list displayed on the screen can be edited. When the Select button 531 is instructed by the operator, the list displayed on the screen can be edited. When a Save button 532 is instructed by the operator, the list displayed on the screen is saved. When the Help button 533 is instructed by the operator, help information is displayed.

Next, the operation of the present support system will be described. A program that defines the operation of the present support system is stored in the storage unit 45, and the operation of the present support system is performed by reading and executing the program by the overall control computer 40.

FIG. 6 is a flowchart showing the outline of the operation of the present support system. The support system first calls a calibration presetting processing routine in step 610. Next, at step 620, a quality control presetting processing routine is called. Thereafter, in step 630, the analysis monitoring processing routine is called and executed, and the processing ends.

FIGS. 7 and 8 are detailed flowcharts of the calibration presetting processing routine started in step 610. First, the calibration presetting processing routine is performed in step 7
At 10, an input of a calibration presetting item, which is an analysis item to be calibrated on a regular basis, is accepted. The calibration presetting items are input from the operation unit 42 by the operator.

If the calibration presetting items are not changed every day, the items once input may be updated. Further, if there is a change such as increase or decrease in some of the items, the input may be performed only for the item, and the others may be updated.

Next, in step 720, the input calibration presetting items are stored in the storage unit 45. When the calibration presetting items are stored in the storage unit 45, the Pre-setting display block 401 on the calibration support screen in FIG. Next, in step 740, it is determined whether or not the operator has issued an instruction on the button 405 (display instruction of a calibration presetting item). If it is determined in step 740 that the operator has not instructed the button 405, the process waits for input of a display instruction. When it is determined in step 740 that the button 405 has been instructed by the operator, the process proceeds to step 750 to display the calibration presetting items in the display area 410 on the calibration support screen of FIG.

Next, in step 810, an instruction is issued to execute one of the calibration presetting items. Then, in step 820, it is determined whether or not the calibration (the calibration instructed to be executed in step 810) is successful. If it is determined in step 820 that the calibration has failed, the process proceeds to step 870, calls and executes a calibration failure processing routine, and then returns to step 820. If it is determined in step 820 that the calibration has been successful,
Proceeding to step 830, the calibration time stored in the storage unit 45 for the analysis item of the calibration is reset.

Next, in step 840, among the calibration presetting items displayed in the display area 410 on the calibration support screen in FIG.
The display about the analysis item of the calibration is deleted. Next, in step 850, of the presetting items stored in the storage unit 45, the storage of the analysis items of the calibration is deleted.

Next, in step 860, it is determined whether or not the calibration has been completed for all the analysis items out of the calibration presetting items. In step 860, among the presetting items,
If it is determined that there is an analysis item for which calibration has not yet been completed, the process returns to step 810.
If it is determined in step 860 that the calibration has been completed for all the analysis items among the presetting items, the process returns.

Next, FIG. 9 is a detailed flowchart of the calibration failure processing routine started in step 870 in the calibration presetting processing routine. In the calibration failure processing routine, first, in step 910, the analysis item for which the calibration has failed is stored in the storage unit 45 as a calibrated fail item. Next, in step 920,
The Calib.Failed display block 403 on the calibration support screen in FIG. 4 blinks. Next, step 930
Then, the instruction of the button 407 by the operator (CALIB.
It is determined whether or not there is a display instruction of a fail item). If it is determined in step 930 that the operator has not instructed the button 407, the process waits for a display instruction input. If it is determined in step 930 that the button 407 has been instructed by the operator, the process proceeds to step 940 to display the Carib / Fail item in the display area 410 on the calibration support screen in FIG. Next, in step 950, an instruction is issued to execute calibration of the Caribbean fail item. Thereafter, the process proceeds to step 960, where the analysis item of the calibration is deleted from the display of the calibration item in the display area 410 on the calibration support screen in FIG. Next, in step 970, the storage of the analysis item of the calibration among the calibration items stored in the storage unit 45 is deleted, and the process returns.

FIGS. 10 and 11 are detailed flowcharts of the accuracy management presetting processing routine started in step 620 in the flowchart of FIG. 6 showing the outline of the operation of the present support system. The quality control presetting processing routine first includes a step 101
At 0, an input of a quality control presetting item, which is an analysis item for which quality control is to be performed on a regular basis, is accepted. The quality control presetting items are input from the operation unit 42 by the operator.

Next, in step 1020, the input accuracy management presetting item is stored in the storage unit 45.
When the accuracy management presetting items are stored in the storage unit 45, the Pre-setting display block 501 on the accuracy management support screen in FIG. Next, at step 1040, the button 50
Instruction 5 (Instruction to display quality control presetting items)
Is determined. If it is determined in step 1040 that the operator has not instructed the button 505, the process waits for a display instruction input. Step 1
If it is determined in 040 that the operator has instructed the button 505, the process proceeds to step 1050, and the display area 510 on the accuracy management support screen in FIG.
Displays quality control presetting items.

Next, in step 1110, an instruction is given to execute one of the accuracy management presetting items. Then, in step 1120, it is determined whether or not the accuracy management (the accuracy management instructed to be executed in step 1110) is successful. If it is determined in step 1120 that the accuracy management has failed, the process proceeds to step 1170, calls and executes the accuracy management failure processing routine, and then returns to step 1120. If it is determined in step 1120 that the quality management has been successful, the process proceeds to step 1130, and the quality management time stored in the storage unit 45 for the analysis item of the quality management is reset. Next, in step 1140, among the quality management presetting items displayed in the display area 510 on the quality management support screen of FIG. 5, the display of the analysis item of the quality management is deleted. Next, in step 1150, of the quality control presetting items stored in the storage unit 45, the storage of the quality control analysis items is deleted.

Next, at step 1160, it is determined whether or not the quality control has been completed for all the analysis items among the quality control presetting items. Step 116
If it is determined at 0 that there is an analysis item for which quality management has not yet been completed among the quality management presetting items, the process returns to step 1110. Step 1160
If it is determined that the accuracy management has been completed for all the analysis items among the accuracy management presetting items, the process returns.

Next, FIG. 12 is a detailed flowchart of the accuracy management failure processing routine started at step 1170 in the accuracy management presetting processing routine. The quality control failure processing routine first includes a step 12
In step 10, the analysis item whose quality control has failed is stored in the storage unit 45 as a QC fail item. Next, in step 1220, the QCFailed display block 503 on the quality management support screen in FIG. Next, step 1230
Then, it is determined whether or not an instruction of the button 507 (display instruction of the QC fail item) has been made by the operator. In step 1230, the operator presses the button 507.
If it is determined that the instruction has not been issued, an input of a display instruction is waited. If it is determined in step 1230 that the operator has instructed the button 507,
Proceeding to step 1240, the QC fail item is displayed in the display area 510 on the quality management support screen of FIG.

Next, in step 1250, an instruction is given to execute the quality control of the QC fail item. Thereafter, the process proceeds to step 1260, and the analysis item of the quality control is deleted from the display of the QC fail items displayed in the display area 510 on the quality management support screen of FIG. Next, in step 1270, the storage of the quality control analysis items among the QC fail items stored in the storage unit 45 is deleted, and the process returns.

FIG. 13 is a flowchart showing the operation of the present support system in FIG.
7 is a detailed flowchart of an analysis monitoring processing routine started at 0. First, in step 13010, the analysis monitoring processing routine instructs each analysis unit of the automatic analyzer to execute the analysis processing. Next, in step 13020, it is determined whether or not there is an analysis item for which the effective time of the quality control has elapsed. If it is determined in step 13020 that there is an analysis item for which the validity time of the quality control has elapsed, the process proceeds to step 13060 to call and execute a quality control validity time over processing routine.

Next, in step 13070, it is determined whether or not the accuracy management executed in the accuracy management effective time over processing routine was successful. If it is determined in step 13070 that the accuracy management executed in the accuracy management effective time over processing routine is successful, the process proceeds to step 13
The process proceeds to 090, and the quality control time of the quality control analysis item stored in the storage unit 45 is reset. Thereafter, the flow returns to step 13010. Step 13070
If it is determined that the accuracy management executed in the accuracy management effective time over processing routine has failed, the process proceeds to step 13080, calls and executes the above-described accuracy management failure processing routine, and then returns to step 13070. .
If it is determined in step 13020 that there is no analysis item for which the validity time of the quality control has elapsed, the process proceeds to step 13020.
Proceed to 30.

In step 13030, it is determined whether or not there is any analysis item for which the effective time of the calibration has elapsed. If it is determined in step 13030 that there is an analysis item for which the effective time of the calibration has elapsed, the process proceeds to step 13100, where a calibration effective time over processing routine is called to execute the calibration of the analysis item.

Next, in step 13110, it is determined whether or not the calibration executed in the calibration valid time over processing routine has been successful. If it is determined in step 13110 that the calibration performed in the calibration valid time over processing routine has been successful, the process proceeds to step 13130, where the analysis items of the calibration stored in the storage unit 45 are described. Reset the calibration time. Thereafter, the flow returns to step 13010. Step 13
If it is determined in step 110 that the calibration executed in the calibration valid time over processing routine has failed, the process proceeds to step 13120. After the above-described calibration failure processing routine is called and executed, the process proceeds to step 13110. Return. Step 130
If it is determined in step 30 that there is no analysis item for which the effective time of the calibration has elapsed, step 13
Proceeding to 040, it is determined whether a reagent shortage has occurred and it is necessary to add a reagent bottle.

If it is determined in step 13040 that addition of a reagent bottle is not necessary, step 1305
The process proceeds to 0, and it is determined whether or not all the analysis processes have been completed. If it is determined in step 13050 that there is still an analysis process to be executed, step 13020
Return to If it is determined in step 13050 that all the analysis processes have been completed, the process returns. If it is determined in step 13040 that the addition of a reagent bottle is necessary, the process proceeds to step 13140 and the CRT 43
The upper display screen indicates that a reagent bottle needs to be added.

Next, in step 13150, it is determined whether a reagent bottle has been added. Step 13150
If it is determined that the reagent bottle has not been added, the process returns to step 13140. Step 13150
If it is determined that the reagent bottle has been added, the process proceeds to step 13160 to determine whether or not it is necessary to execute the calibration accompanying the addition of the reagent bottle based on the information stored in the storage unit 45. Judgment. Step 1
If it is determined in 3160 that there is no need to execute the calibration accompanying the addition of the reagent bottle, the process returns to step 13010. If it is determined in step 13160 that it is necessary to execute the calibration accompanying the addition of the reagent bottle, the process proceeds to step 13170,
After calling and executing the changeover processing routine, the process proceeds to step 13110.

Next, FIG. 14 is a detailed flowchart of the accuracy management effective time over processing routine called at step 13060 in the analysis monitoring processing routine. First, the quality control effective time over processing routine
In step 1410, the analysis item whose validity time of the quality control has elapsed is stored in the storage unit 45 as a time-over item. Next, in step 1420, the Time-over display block 502 on the accuracy management support screen of FIG. Next, in step 1430, it is determined whether or not an instruction of the button 506 (display instruction of a time-over item) has been made by the operator. At step 1430,
If it is determined that the operator has not instructed the button 506, the process waits for a display instruction. Step 14
If it is determined in step 30 that the instruction of the button 506 has been made by the operator, the process proceeds to step 1440, and the display area 510 on the accuracy management support screen in FIG.
Display time-over items. Next, step 14
At 50, an instruction is given to execute the accuracy management of the time-over item. Thereafter, the process proceeds to step 1460, and the analysis item of the quality control is erased from the display of the time-over item displayed in the display area 510 on the quality management support screen of FIG. Next, in step 1470, the storage unit 4
Then, the storage of the quality control analysis items among the time-over items stored in 5 is deleted, and the process returns.

Next, FIG. 15 is a detailed flowchart of the calibration valid time over processing routine started at step 13100 in the analysis monitoring processing routine. In the calibration effective time over processing routine, first, in step 1510, the analysis item whose calibration effective time has elapsed is stored in the storage unit 45 as a calib now item. Next, step 1
At 520, Cali on the calibration support screen of FIG.
b. Make the Now display block 402 blink. Next, in step 1530, it is determined whether or not the operator has issued an instruction on the button 406 (display instruction on the Caribou Now item). If it is determined in step 1530 that the operator has not instructed the button 406,
Wait for display instruction input.

If it is determined in step 1530 that the instruction of the button 406 has been made by the operator, the process proceeds to step 1540, and the calibration now item is displayed in the display area 410 on the calibration support screen of FIG. . Next, in step 1550, an instruction is issued to execute the calibration of the calibrated now item.
Thereafter, the process proceeds to step 1560, and the calibration analysis item in the display of the calibration now item displayed in the display area 410 on the calibration support screen in FIG. 4 is deleted. Next, at step 1570,
The storage unit 45 deletes the storage of the analysis items of the calibration from the calibration / now items stored in the storage unit 45 and returns.

Next, FIG. 16 is a detailed flowchart of the change-over processing routine started in step 13170 in the analysis monitoring processing routine. The change-over processing routine first includes a step 16
At 10, the storage unit 45 stores the analysis items for which the calibration needs to be executed in accordance with the addition or update of the reagent bottles, as the change-over items. next,
In step 1620, the Change Over display block 404 on the calibration support screen of FIG.
Next, in step 1630, the button 4
It is determined whether or not there has been an instruction 08 (an instruction to display a changeover item). At step 1630,
If it is determined that the operator has not instructed the button 408, input of a display instruction is waited. Step 16
If it is determined in step 30 that the operator has instructed the button 408, the process proceeds to step 1640, and the display area 4 on the calibration support screen in FIG.
In 10, a change item is displayed. Next, in step 1650, an instruction is issued to execute calibration of the changeover item. Thereafter, the process proceeds to step 1660, where the analysis item of the calibration in the display of the changeover item displayed in the display area 410 on the calibration support screen of FIG. 4 is deleted. Next, in step 1670, the storage of the analysis item of the calibration among the changeover items stored in the storage unit 45 is deleted, and the process returns.

FIG. 17 is a flowchart showing details of the calibration execution processing in step 810 in FIG. 8, step 950 in FIG. 9, step 1550 in FIG. 15, and step 1650 in FIG.

First, the calibration execution process is performed as follows.
In step 1710, an instruction to start the automatic analyzer is issued.
Next, at step 1720,
The standard solution rack 74 required for the calibration of the analysis item to be executed is specified from the data in which each analysis item and the information on the standard solution necessary for the calibration of the analysis item are stored in correspondence. The storage unit 45
The standard solution rack 74 necessary for the calibration of the analysis item to be executed is obtained from the data in which the respective standard solution racks and the positions (addresses) of the standard solution racks on the rotor 76 are stored. To the address on the rotor 76.

Next, in step 1730, the rotor 76 is rotated by the driving means 73 while detecting the position with the sensor 72, and the standard liquid rack 74 at the above address is stopped before the inlet to the main transport line 20. . Next, in step 1740, the standard solution rack 74 is moved to the main transport line 20.
Tell them to throw them up. Next, step 1750
Then, it is determined which analysis unit performs the calibration of the analysis item to be executed based on the data stored in the storage unit 45.

Next, in step 1760, the standard solution rack 7 is loaded into the analyzer determined to perform calibration.
The main transport line 20 is controlled so that the transport line 4 is transported. When the standard solution rack 74 is transported to the analysis unit determined to perform the calibration, step 177 is performed.
0 instructs the relevant analysis unit to perform calibration using the standard solution on the standard solution rack 74. Upon receiving this instruction, the analysis unit
Execute the calibration of the analysis item to be executed.

FIG. 18 shows step 1110 of FIG. 11, step 1250 of FIG. 12, and step 14 of FIG.
It is a flowchart in 50 which shows the detail of the execution process of quality control. In the quality control execution process, first, in step 1810, an instruction to start the automatic analyzer is issued. next,
In step 1820, the data stored in the storage unit 45 in which the analysis items and the information on the control samples required for the accuracy management of the analysis items are stored in correspondence with each other, the accuracy management of the analysis items to be executed is performed. The control sample rack 77 required for the operation is specified. Also, based on the data stored in the storage unit 45 in which each control sample rack and the position (address) of the control sample rack on the rotor 76 are stored in correspondence with each other, it is necessary to manage the accuracy of the analysis items to be executed. The address on the rotor 76 of the control sample rack 77 is obtained.

Next, in step 1830, the rotor 76 is rotated by the driving means 73 while detecting the position with the sensor 72, and the control sample rack 77 at the above address is rotated.
Is stopped just before the entrance to the main transport line 20. Next, in step 1840, an instruction is given to load the control sample rack 77 onto the main transport line 20.
Next, in step 1850, the storage unit 4 determines which analysis unit performs the quality control of the analysis item to be performed.
5 is determined based on the data stored in. Next, in step 1860, the main transport line 20 is controlled so that the control sample rack 77 is transported to the analysis unit determined to perform the quality control. When the control sample rack 77 is transported to the analysis unit determined to perform the quality control, in step 1870, the control unit executes the quality control using the control sample on the control sample rack 77 in the analysis unit. To instruct. Upon receiving this instruction, the analysis unit executes the accuracy management of the analysis item to be executed.

Display blocks 401 to 404 in FIG.
And display blocks 501 to 503 in FIG. 5 are classification headings corresponding to the state of necessity of calibration or quality control. Display blocks 401 to 404 in FIG.
Of the display blocks 501 to 503 in FIG. 5, the display block located at the top of the screen is set to have a higher priority than the display block located at the bottom.

When two or more classification states requiring calibration or quality control occur for the same analysis item, the corresponding two or more display blocks blink. When the execution of the calibration or the accuracy management is instructed from the reception button corresponding to one display block having a high priority among the blinking display blocks, the automatic analyzer executes the instruction. This eliminates the need for calibration or accuracy management corresponding to the display blocks with low priority, so that the blinking state of the remaining display blocks that have not been instructed also disappears, and the storage information regarding the occurrence of the necessity is lost. Will be erased.

In the description of the operation of the support system, analysis items to be set as presetting items, calib now items, carib fail items, change over items, time over items, and QC fail items are stored. When the stored analysis item is hit, the presetting item, the calib now item, the calib fail item, the change over item, the time over item, and the QC fail item are stored. You may do so.

Next, the structure of the data stored in the storage unit 45 to realize the operation of the support system will be described. FIG. 19 shows the structure of this data. As shown in FIG. 19, the storage unit 45 stores calibration information 1900 and quality management information 1910. The calibration information 1900 includes, for each analysis item, a calibration time interval, an elapsed time from the last execution of the calibration of the analysis item (or the time of the last execution of the calibration of the analysis item), and a calibration execution format. (Name of standard solution used for calibration, calibration method, etc.), calibration parameters (information on calibration curve formula), calibration execution conditions (information on when to execute calibration), etc. Stored. Also, quality control information 1910
For each analysis item, the quality control time interval, the time elapsed since the last execution of the quality control for that analysis item (or the time of the last execution of the quality control for that analysis item), and the quality management execution format ( Name of control sample to be used,
And a quality management execution condition (information on when to execute the quality management), and the like. The overall control computer 40 may execute the calibration information 1900 and the quality management information 1
Calibration and accuracy management are performed with reference to 910.

FIG. 20 shows the interrelationship between the calibration data generated with the operation of the support system and stored in the storage unit 45.

First, regarding the interrelationship of the above data,
A first example is shown.

As the pre-set data 2020 of the calibration items, the analysis items for which calibration is to be performed regularly are set in advance by the operator.
Expiration data 2030 of calibration item
As an example, when the time interval of the calibration has elapsed, the analysis item for re-executing the calibration is set in advance by the operator. As the calibration failure data 2040, an analysis item for re-executing the calibration when the calibration has failed is set in advance by the operator. As the calibration execution data 2050 due to the reagent shortage,
When a reagent bottle is added, an analysis item for re-executing calibration is set in advance by the operator.

When the automatic analyzer is in a state of executing the calibration that is performed constantly, the present support system reads the preset data 2020 of the calibration item, and reads the preset data of the calibration item. By referring to the calibration information 1900 (see FIG. 19) relating to the analysis item set as 2020, a calibration execution item list 2010 storing the analysis item to be calibrated and the standard solution in association with each other is generated. The calibration is executed based on the calibration execution item list 2010.

[0138] In the case where a calibration has occurred in which the time interval as the valid time has elapsed, the present support system determines whether or not the analysis item of the calibration is set as validity time out data 2030 of the calibration item. Is determined. If it is determined that the analysis item of the calibration is set as the expired data 2030 of the calibration item, the calibration information 19 on the analysis item is determined.
Referring to FIG. 19 (see FIG. 19), a calibration execution item list 2010 in which the analysis items to be calibrated and the standard solution are stored in correspondence with each other is generated, and the calibration is performed based on the calibration execution item list 2010. Run. If it is determined that the analysis item of the calibration is not set as the expired data 2030 of the calibration item, the generation of the calibration execution item list 2010 is not performed.

If the calibration has failed,
The present support system determines whether or not the analysis item of the calibration is set as the calibration failure data 2040. When it is determined that the analysis item of the calibration is set as the calibration failure data 2040, the analysis to be performed with reference to the calibration information 1900 (see FIG. 19) related to the analysis item is performed. A calibration execution item list 2010 in which items and standard solutions are stored in association with each other is generated, and calibration is executed based on the calibration execution item list 2010. The analysis item of the calibration is
If it is determined that the data is not set as the calibration failure data 2040, the generation of the calibration execution item list 2010 is not performed.

When a reagent bottle is added or replaced,
In this support system, the analysis item of the calibration is the calibration execution data 20 associated with the reagent shortage.
It is determined whether 50 has been set. When it is determined that the analysis item of the calibration is set as the calibration execution data 2050 associated with the reagent shortage, the calibration is performed by referring to the calibration information 1900 (see FIG. 19) relating to the analysis item. Execution item list 2010 in which the analysis items to be subjected and the standard solution are stored in association with each other.
And a calibration execution item list 2010
The calibration is executed based on. When it is determined that the analysis item of the calibration is not set as the calibration execution data 2050 due to the shortage of the reagent, the calibration execution item list 2
010 is not generated.

Next, a second example of the interrelationship of the calibration data will be described.

As the preset data 2020 of the calibration items, the presetting items accepted in step 710 of the calibration presetting process shown in FIG. 7 are stored. The validity time expiration data 2030 of the calibration item is the calibration now item stored in step 1510 of the calibration validity time over process shown in FIG. The calibration failure data 2040 is a calibration fail item stored in step 910 of the calibration failure process shown in FIG. The calibration execution data 2050 associated with the reagent shortage is the changeover item stored in step 1610 of the changeover process shown in FIG. When the pre-set data 2020 of the calibration item, the expired data 2030 of the calibration item, the calibration failure data 2040, and the calibration execution data 2050 due to the shortage of the reagent are generated, the overall control computer 40 executes the calibration. By referring to the information 1900, a calibration execution item list 2010 in which the analysis items to be calibrated and the standard solution are stored in correspondence with each other is generated, and the calibration is executed based on the calibration execution item list 2010.

FIG. 21 shows the interrelationship of data relating to quality control, which is generated in association with the operation of the support system and stored in the storage unit 45.

First, regarding the interrelationship of the above data,
A first example is shown.

As the pre-set data 2120 of the quality control items, the analysis items for which the quality control is constantly performed are set in advance by the operator. As the validity time expiration data 2130 of the quality control item, an analysis item for re-executing the quality control when the validity time of the quality control has elapsed has been set in advance by the operator. As the quality control failure data 2140, an analysis item for re-executing the quality control when the quality control fails is set in advance by the operator.

When the automatic analyzer is in a state of executing the quality control which is performed regularly, the support system reads the preset data 2120 of the quality control item, and reads the preset data of the quality control item. With reference to the quality management information 1910 (see FIG. 19) relating to the analysis item set as 2120, a quality management execution item list 2110 in which the analysis item to be subjected to quality control and the control sample are stored in association with each other is generated. The quality management is performed based on the quality management execution item list 2110.

[0147] When the accuracy management after the valid time has elapsed occurs, the present support system determines whether or not the analysis item of the quality control is set as the validity time out data 2130 of the quality management item. . When it is determined that the analysis item of the quality control is set as the validity time-out data 2130 of the quality control item, the quality management is performed by referring to the quality management information 1910 (see FIG. 19) relating to the analysis item. Quality control execution item list 211 in which analysis items to be performed and control samples are stored in association with each other.
0 is generated and quality management is performed based on the quality management execution item list 2110. If it is determined that the analysis item of the quality management is not set as the validity time out data 2130 of the quality management item, the quality management execution item list 2110 is not generated.

If the quality control has failed, the present support system determines whether or not the analysis item of the quality control is set as the quality control failure data 2140. When it is determined that the analysis item of the quality control is set as the quality control failure data 2140, the quality control information 1910 (see FIG. 19) related to the quality control item is referred to, and the analysis to be performed for the quality control is performed. Quality control execution item list 211 storing items and control samples in association with each other
0 is generated and quality management is performed based on the quality management execution item list 2110. When it is determined that the analysis item of the quality management is not set as the quality management failure data 2140, the quality management execution item list 2110 is not generated.

Next, a second example of the interrelationship of data for quality control will be described.

As the preset data 2120 of the quality control item, the presetting item accepted in step 1010 of the quality control presetting process shown in FIG. 10 is stored. The validity time expiration data 2130 of the quality control item is a time-over item stored in step 1410 of the quality control valid time-over process shown in FIG. The quality control failure data 2140 is a QC field item stored in step 1210 of the quality control failure process shown in FIG. When the pre-set data 2120 of the quality control item, the validity time out data 2130 of the quality control item, and the quality control failure data 2140 occur, the overall control computer 40 refers to the quality control information 1910 to perform the quality control. A quality control execution item list 2110 in which analysis items to be performed and control samples are stored in association with each other is generated, and quality control is performed based on the quality control execution item list 2110.

Further, the name of the standard solution, the number of the standard solution rack, the position of the standard solution container in the standard solution rack, the identification information (ID) of the standard solution, and the lot number of the standard solution are stored in association with each other. When a calibration to be performed occurs, a standard solution name required for the calibration,
The number of the standard solution rack, the position of the standard solution container in the standard solution rack, identification information (ID) of the standard solution, and the lot number of the standard solution may be displayed on the display screen of the CRT 43.
Similarly, the control sample name, the control sample rack number, the position of the control sample container in the control sample rack, the identification information (ID) of the control sample,
The lot number of the control sample is stored in association with the lot number. When the quality control to be executed occurs, the control sample name, the control sample rack number, the position of the control sample container in the control sample rack, the control sample identification information (I
D), the lot number of the control sample may be displayed on the display screen of the CRT 43.

An example of such a display screen of the CRT 43 is shown in FIG. In FIG. 22, for example, when the Pre-Setting button 2201 is touched by the operator, the standard solution name required for executing the calibration of the pre-setting data 2020 of the calibration item in FIG. In the column of Rack 2212, the number of the standard solution rack, the position of the standard solution container in the standard solution rack in the column of Pos2213, and the identification information (ID) of the standard solution
In the column of ID2214 and the lot number of the standard solution in LOT221.
Reason 22 shows the reason for performing calibration in column 5.
These are displayed in the 16 columns. At the same time, the name of the control sample necessary for executing the quality control of the pre-set data 2120 of the quality control item in FIG. 21 is entered in the column of Name 2217, the number of the control sample rack is entered in the column of Rack 2218, and the control sample container in the control sample rack is displayed. Is displayed in the column of Pos 2219, the identification information (ID) of the control sample is displayed in the column of ID 2220, the lot number of the control sample is displayed in the column of LOT 2221, and the reason for executing the quality control is displayed in the column of REASON 2222. If the number of standard solutions and control samples for which information is to be displayed is large, buttons 2241, 2242, and 224
3. The display screen can be scrolled by the button 2244.

[0153]

According to the automatic analyzer and the support system therefor according to the present invention, the analysis items to be calibrated or whose quality should be controlled can be easily notified to the operator through the display screen for each cause of necessity. Predetermined calibration or quality control can be accurately executed for a specific analysis unit in which a problem has occurred.

According to the automatic analyzer of the present invention, the standard sample or the quality control sample can be transported by the transport line whenever necessary, so that the analysis unit which has become necessary among the plurality of analysis units is required. In contrast, it becomes easy to repeatedly execute the calibration or the quality control process of an appropriate analysis item.

According to the automatic analyzer operating method of the present invention,
Calibration or accuracy management when efficiently operating a plurality of analysis units can be easily performed.

[Brief description of the drawings]

FIG. 1 is a diagram showing a schematic configuration of an automatic analyzer according to one embodiment of the present invention.

FIG. 2 is a diagram for explaining an example of a dispenser-type analyzer in the embodiment of FIG. 1;

FIG. 3 is a diagram for explaining an example of a pipettor type analyzer in the embodiment of FIG. 1;

FIG. 4 is a diagram for explaining a calibration support screen of the present invention.

FIG. 5 is a diagram for explaining an accuracy management support screen of the present invention.

FIG. 6 is a flowchart showing an outline of the operation of the support system of the present invention.

FIG. 7 is a flowchart showing a calibration presetting process of the support system of the present invention.

FIG. 8 is a flowchart showing a calibration presetting process of the support system of the present invention.

FIG. 9 is a flowchart showing a calibration failure process of the support system of the present invention.

FIG. 10 is a flowchart showing a quality management presetting process of the support system of the present invention.

FIG. 11 is a flowchart showing a quality management presetting process of the support system of the present invention.

FIG. 12 is a flowchart illustrating accuracy management failure processing of the support system of the present invention.

FIG. 13 is a flowchart showing an analysis monitoring process of the support system of the present invention.

FIG. 14 is a flowchart showing an accuracy management effective time over process of the support system of the present invention.

FIG. 15 is a flowchart showing a calibration effective time over process of the support system of the present invention.

FIG. 16 is a flowchart showing a change-over process of the support system of the present invention.

FIG. 17 is a flowchart showing a calibration execution instruction process of the support system of the present invention.

FIG. 18 is a flowchart showing a quality management execution instruction process of the support system of the present invention.

FIG. 19 is a diagram for explaining the structure of data stored in the support system of the present invention.

FIG. 20 is a diagram for explaining a mutual relationship of data stored in the support system of the present invention.

FIG. 21 is a diagram for explaining a mutual relationship of data stored in the support system of the present invention.

FIG. 22 is a diagram for explaining an example of a display screen displayed by the support system of the present invention.

[Explanation of symbols]

1: patient sample rack, 2: patient sample container, 3A to 3G ...
Analysis unit, 4A-4G ... sampling line, 5A
~ 5G ... reaction part, 12,12A, 12B ... reagent bottle,
15a, 15b: multi-wavelength photometer, 17: rack sending section,
18: Rack collection unit, 20: Main transfer line, 26A, 2
6B: reagent disk, 26-29, 32-34: reagent supply unit, 40: computer for overall control, 50-58: identification information reading device, 70: standby unit, 72: sensor,
73: drive device, 74: standard solution rack, 75: standard solution rack / control sample rack inlet, 76: rotor, 77: control sample rack.

 ──────────────────────────────────────────────────続 き Continuing from the front page (72) Inventor Kazumitsu Kawase, 882-Momo, Oaza-shi, Hitachinaka-shi, Ibaraki Pref. Inside the Measuring Instruments Division, Hitachi, Ltd. Hitachi, Ltd.Measuring Instruments Division

Claims (10)

[Claims] An automatic analyzer support system applied to an automatic analyzer in which a plurality of analysis units for measuring an analysis target in each analysis unit are arranged along a transport line for transporting a sample rack. A requesting means for displaying a state check screen for calibration or accuracy control, a plurality of classification headings provided corresponding to a plurality of state classifications related to calibration or quality control in accordance with the display request, and An instruction button for instructing the display of detailed information corresponding to the classification heading, a screen display means for causing a state inspection screen to appear, and when an instruction is given by the instruction button, an analysis item name of the corresponding state; and The name of the analysis unit for which calibration or quality control of the analysis item is to be executed is displayed on the status check screen. Control means for controlling the
An automatic analyzer support system comprising: 2. The automatic analyzer support system according to claim 1, wherein the display requesting means is a display requesting means for displaying a calibration status check screen, and the plurality of classification headings are the progress since the previous calibration execution. The heading indicates the state in which there is an analysis item whose time has passed the calibration time interval, the heading indicates the state in which there is an analysis item for which the calibration that has been performed has failed, and the calibration has been performed because a new reagent has been added. A heading indicating a state in which an analysis item that needs to be executed is present. 3. The automatic analyzer support system according to claim 1, wherein the display requesting means is a display requesting means for a quality control status inspection screen, and wherein the plurality of classification headings are the progress since the last execution of the quality control. An automatic analyzer that includes a heading indicating a state in which an analysis item whose time has passed the quality control time interval and a heading indicating a state in which an analysis item for which quality control has failed have been performed. Support system. 4. The automatic analyzer support system according to claim 1, wherein a display mode of the corresponding category heading is changed in accordance with occurrence of a state corresponding to any one of the plurality of category headings. An automatic analyzer support system characterized in that: 5. The automatic analyzer support system according to claim 1, wherein two or more calibrations or accuracy control states for the same analysis item are generated by two or more classification headings. An automatic analyzer support system characterized in that when notified, the calibration or accuracy management corresponding to one classification heading is executed, and the notification based on the remaining classification headings is canceled. 6. A storage medium storing an operation program for a support system that supports execution of calibration or accuracy management in an automatic analyzer that analyzes a plurality of analysis items, wherein the program comprises: (a) A step of displaying a request button for requesting a display of a state inspection screen for calibration or quality control on the screen display device; (b) When a display request is issued, calibration or quality control is required Displaying a status inspection screen having a plurality of classification headings corresponding to the status and a display instruction button for detailed information on the screen display device; (c) a status corresponding to at least one of the classification headings has occurred; And (d) changing the mode of the corresponding classification heading according to the above. The analysis item name in the appropriate state as well as displayed on the screen display device, a storage medium characterized by comprising the step of performing a calibration or accuracy management of the analysis items displayed. 7. A plurality of analysis units are arranged along a transport line for transporting a sample, and the sample is stopped by an analysis unit selected according to an analysis item via the transport line. In the configured automatic analyzer, a specific sample rack holding a specific sample repeatedly measured at a predetermined interval, and the specific sample rack is put on standby to perform calibration or quality control. And a rack standby unit for sending the specific sample rack toward the transport line, and calibration or accuracy control of the specific sample rack output from a predetermined position on the rack standby unit via the transport line. Drop by the required analysis unit, and then return the specific sample rack to the predetermined position on the rack standby unit, An automatic analyzer, comprising: a control unit that controls an operation of the transport line. 8. The automatic analyzer according to claim 7, wherein a plurality of classification headings corresponding to a state requiring calibration or accuracy management are displayed, and the analysis item is in a state corresponding to one or more classification headings. An automatic analyzer comprising a display means for displaying a name. 9. An operating method of an automatic analyzer in which each of a plurality of analysis units in the automatic analyzer measures a sample, wherein the same specific analysis item is assigned to each of two or more analysis units. Assigned, and received an instruction to execute calibration or accuracy management in response to the occurrence of a state requiring calibration or accuracy management for the automatic analyzer, and for the specific analysis items, A method for operating an automatic analyzer, wherein calibration or accuracy management based on the instruction is executed in each of the analysis units. 10. The method for operating an automatic analyzer according to claim 9, wherein the instruction to execute the calibration or the accuracy management is a plurality of classification headings requiring the calibration or the accuracy management and the execution of the calibration or the accuracy management. A method for operating an automatic analyzer, characterized in that the screen display device displays a status check screen having a button for instructing the operation.