JPH102900A - サンプル液体中の分析物を検出する方法、試薬キット及び反応容器 - Google Patents
サンプル液体中の分析物を検出する方法、試薬キット及び反応容器Info
- Publication number
- JPH102900A JPH102900A JP9064277A JP6427797A JPH102900A JP H102900 A JPH102900 A JP H102900A JP 9064277 A JP9064277 A JP 9064277A JP 6427797 A JP6427797 A JP 6427797A JP H102900 A JPH102900 A JP H102900A
- Authority
- JP
- Japan
- Prior art keywords
- matrix
- reaction
- reaction vessel
- analyte
- reagent
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 238000006243 chemical reaction Methods 0.000 title claims abstract description 122
- 239000003153 chemical reaction reagent Substances 0.000 title claims abstract description 55
- 239000007788 liquid Substances 0.000 title claims abstract description 36
- 239000012491 analyte Substances 0.000 title claims abstract description 32
- 238000000034 method Methods 0.000 title claims description 42
- 239000011159 matrix material Substances 0.000 claims abstract description 84
- 230000005484 gravity Effects 0.000 claims abstract description 10
- 239000000427 antigen Substances 0.000 claims description 31
- 102000036639 antigens Human genes 0.000 claims description 30
- 108091007433 antigens Proteins 0.000 claims description 30
- 230000004523 agglutinating effect Effects 0.000 claims description 24
- 230000004520 agglutination Effects 0.000 claims description 22
- 238000005119 centrifugation Methods 0.000 claims description 13
- 239000011521 glass Substances 0.000 claims description 13
- 238000001514 detection method Methods 0.000 claims description 11
- 238000005259 measurement Methods 0.000 claims description 7
- 230000002776 aggregation Effects 0.000 claims description 6
- 239000011148 porous material Substances 0.000 claims description 6
- 238000004220 aggregation Methods 0.000 claims description 4
- 239000007795 chemical reaction product Substances 0.000 claims description 4
- 102000008394 Immunoglobulin Fragments Human genes 0.000 claims description 2
- 108010021625 Immunoglobulin Fragments Proteins 0.000 claims description 2
- 230000000694 effects Effects 0.000 claims description 2
- 239000012634 fragment Substances 0.000 claims description 2
- 239000004033 plastic Substances 0.000 claims description 2
- 238000005054 agglomeration Methods 0.000 claims 2
- 210000004369 blood Anatomy 0.000 abstract description 13
- 239000008280 blood Substances 0.000 abstract description 13
- 210000003743 erythrocyte Anatomy 0.000 abstract description 10
- 239000003550 marker Substances 0.000 abstract description 4
- 239000011541 reaction mixture Substances 0.000 abstract description 4
- 230000003311 flocculating effect Effects 0.000 abstract 2
- 239000008394 flocculating agent Substances 0.000 abstract 1
- 238000000926 separation method Methods 0.000 abstract 1
- 239000000523 sample Substances 0.000 description 22
- 239000002245 particle Substances 0.000 description 15
- 210000005239 tubule Anatomy 0.000 description 9
- 238000011049 filling Methods 0.000 description 8
- 238000012360 testing method Methods 0.000 description 8
- 238000003556 assay Methods 0.000 description 7
- 239000000203 mixture Substances 0.000 description 7
- 239000000725 suspension Substances 0.000 description 7
- 239000000872 buffer Substances 0.000 description 6
- 239000000243 solution Substances 0.000 description 6
- 210000004027 cell Anatomy 0.000 description 5
- 210000002966 serum Anatomy 0.000 description 5
- 238000004519 manufacturing process Methods 0.000 description 4
- 238000004062 sedimentation Methods 0.000 description 4
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 description 3
- 239000000969 carrier Substances 0.000 description 3
- 238000010438 heat treatment Methods 0.000 description 3
- 238000011534 incubation Methods 0.000 description 3
- 239000004816 latex Substances 0.000 description 3
- 229920000126 latex Polymers 0.000 description 3
- 238000011533 pre-incubation Methods 0.000 description 3
- 239000000047 product Substances 0.000 description 3
- 239000000126 substance Substances 0.000 description 3
- XMTQQYYKAHVGBJ-UHFFFAOYSA-N 3-(3,4-DICHLOROPHENYL)-1,1-DIMETHYLUREA Chemical compound CN(C)C(=O)NC1=CC=C(Cl)C(Cl)=C1 XMTQQYYKAHVGBJ-UHFFFAOYSA-N 0.000 description 2
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 2
- BLRPTPMANUNPDV-UHFFFAOYSA-N Silane Chemical compound [SiH4] BLRPTPMANUNPDV-UHFFFAOYSA-N 0.000 description 2
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 2
- 241000700605 Viruses Species 0.000 description 2
- 238000004458 analytical method Methods 0.000 description 2
- 239000007853 buffer solution Substances 0.000 description 2
- 239000008121 dextrose Substances 0.000 description 2
- 239000012153 distilled water Substances 0.000 description 2
- 239000005293 duran Substances 0.000 description 2
- -1 for example Substances 0.000 description 2
- 230000035931 haemagglutination Effects 0.000 description 2
- 238000002372 labelling Methods 0.000 description 2
- 210000000265 leukocyte Anatomy 0.000 description 2
- 230000007774 longterm Effects 0.000 description 2
- 239000013610 patient sample Substances 0.000 description 2
- 238000007789 sealing Methods 0.000 description 2
- 229910000077 silane Inorganic materials 0.000 description 2
- 238000003860 storage Methods 0.000 description 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 2
- 229920000936 Agarose Polymers 0.000 description 1
- 241000894006 Bacteria Species 0.000 description 1
- 102000004506 Blood Proteins Human genes 0.000 description 1
- 108010017384 Blood Proteins Proteins 0.000 description 1
- 241000542448 Cavea Species 0.000 description 1
- 206010028980 Neoplasm Diseases 0.000 description 1
- 238000010521 absorption reaction Methods 0.000 description 1
- 230000004913 activation Effects 0.000 description 1
- 230000006978 adaptation Effects 0.000 description 1
- 238000013019 agitation Methods 0.000 description 1
- 239000013566 allergen Substances 0.000 description 1
- 239000003708 ampul Substances 0.000 description 1
- QZPSXPBJTPJTSZ-UHFFFAOYSA-N aqua regia Chemical compound Cl.O[N+]([O-])=O QZPSXPBJTPJTSZ-UHFFFAOYSA-N 0.000 description 1
- 239000012736 aqueous medium Substances 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 210000001124 body fluid Anatomy 0.000 description 1
- 239000010839 body fluid Substances 0.000 description 1
- 239000007767 bonding agent Substances 0.000 description 1
- QXJJQWWVWRCVQT-UHFFFAOYSA-K calcium;sodium;phosphate Chemical compound [Na+].[Ca+2].[O-]P([O-])([O-])=O QXJJQWWVWRCVQT-UHFFFAOYSA-K 0.000 description 1
- 238000004040 coloring Methods 0.000 description 1
- 238000004590 computer program Methods 0.000 description 1
- 239000005289 controlled pore glass Substances 0.000 description 1
- 238000009826 distribution Methods 0.000 description 1
- 238000011156 evaluation Methods 0.000 description 1
- 208000006454 hepatitis Diseases 0.000 description 1
- 231100000283 hepatitis Toxicity 0.000 description 1
- 239000005556 hormone Substances 0.000 description 1
- 229940088597 hormone Drugs 0.000 description 1
- 230000008105 immune reaction Effects 0.000 description 1
- 238000009776 industrial production Methods 0.000 description 1
- 238000011068 loading method Methods 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 239000002609 medium Substances 0.000 description 1
- 239000012528 membrane Substances 0.000 description 1
- 239000002207 metabolite Substances 0.000 description 1
- 238000002156 mixing Methods 0.000 description 1
- 244000052769 pathogen Species 0.000 description 1
- 210000002381 plasma Anatomy 0.000 description 1
- 229920000642 polymer Polymers 0.000 description 1
- 229920001184 polypeptide Polymers 0.000 description 1
- 102000004196 processed proteins & peptides Human genes 0.000 description 1
- 108090000765 processed proteins & peptides Proteins 0.000 description 1
- 238000012545 processing Methods 0.000 description 1
- 239000013049 sediment Substances 0.000 description 1
- 230000035945 sensitivity Effects 0.000 description 1
- 230000008961 swelling Effects 0.000 description 1
- LFQCEHFDDXELDD-UHFFFAOYSA-N tetramethyl orthosilicate Chemical compound CO[Si](OC)(OC)OC LFQCEHFDDXELDD-UHFFFAOYSA-N 0.000 description 1
- 238000003466 welding Methods 0.000 description 1
Classifications
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
- B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
- B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
- B01L3/5021—Test tubes specially adapted for centrifugation purposes
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
- G01N33/54313—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals the carrier being characterised by its particulate form
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Immunology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Hematology (AREA)
- Engineering & Computer Science (AREA)
- Analytical Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Urology & Nephrology (AREA)
- Molecular Biology (AREA)
- Biomedical Technology (AREA)
- Cell Biology (AREA)
- Physics & Mathematics (AREA)
- Microbiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Clinical Laboratory Science (AREA)
- Food Science & Technology (AREA)
- Medicinal Chemistry (AREA)
- Biotechnology (AREA)
- Biochemistry (AREA)
- General Physics & Mathematics (AREA)
- Pathology (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Automatic Analysis And Handling Materials Therefor (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP96104283A EP0797097B1 (de) | 1996-03-18 | 1996-03-18 | Partikel-Immunoassay mit kompakter Matrix |
| DE96104283.5 | 1996-03-18 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPH102900A true JPH102900A (ja) | 1998-01-06 |
| JPH102900A5 JPH102900A5 (https=) | 2005-02-17 |
Family
ID=8222571
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP9064277A Pending JPH102900A (ja) | 1996-03-18 | 1997-03-18 | サンプル液体中の分析物を検出する方法、試薬キット及び反応容器 |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US5869347A (https=) |
| EP (1) | EP0797097B1 (https=) |
| JP (1) | JPH102900A (https=) |
| AT (1) | ATE210829T1 (https=) |
| DE (1) | DE59608443D1 (https=) |
| DK (1) | DK0797097T3 (https=) |
| ES (1) | ES2168402T3 (https=) |
| PT (1) | PT797097E (https=) |
Cited By (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2003107091A (ja) * | 2001-09-28 | 2003-04-09 | Olympus Optical Co Ltd | 生物学的検査のための分離体および検査方法 |
| JP2007519938A (ja) * | 2004-02-02 | 2007-07-19 | メディオン ダイアグノスティクス アクチェンゲゼルシャフト | 凝集反応の可視化と分離により分析物を検出するための装置と方法 |
| JP2008224317A (ja) * | 2007-03-09 | 2008-09-25 | Olympus Corp | 凝集判定装置 |
| JP2008224318A (ja) * | 2007-03-09 | 2008-09-25 | Olympus Corp | 多層型凝集判定容器 |
| JP2012513596A (ja) * | 2008-12-23 | 2012-06-14 | シンビオン・メディカル・システムズ・ソシエテ・ア・レスポンサビリテ・リミテ | 凝集検査を行うための装置および分析システム |
| JP2012194181A (ja) * | 2011-03-15 | 2012-10-11 | Siemens Healthcare Diagnostics Products Gmbh | 血小板機能を決定するための装置及び方法 |
| WO2014203693A1 (ja) * | 2013-06-19 | 2014-12-24 | オリンパス株式会社 | 光学計測用容器 |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2005257337A (ja) * | 2004-03-09 | 2005-09-22 | Brother Ind Ltd | 検査対象受体、検査装置、及び検査方法 |
| JP5008899B2 (ja) | 2006-06-05 | 2012-08-22 | ベックマン コールター， インコーポレイテッド | 粒子凝集判定用容器 |
| EP2372366B1 (en) * | 2010-03-30 | 2019-07-03 | Symbion Medical Systems Sàrl | Analysis station with incubation system |
| CN102608336B (zh) * | 2011-01-19 | 2014-12-24 | 刘大基 | 一次性输血交叉配血实验组合器 |
| EP2859948A1 (en) * | 2013-10-09 | 2015-04-15 | Yantai AusBio Laboratories Co., Ltd. | Method for determining the result of an agglutination reaction and microplate for determining products of agglutination reactions |
| US12366506B2 (en) | 2020-03-09 | 2025-07-22 | Idexx Laboratories, Inc. | Method for removing interfering components of a liquid sample prior to dispensing same on a chemical reagent test slide |
| JP7625614B2 (ja) * | 2020-03-09 | 2025-02-03 | アイデックス ラボラトリーズ インコーポレイテッド | 液体サンプルの成分を除去するために使用されるマトリックスならびに関連のサンプルカップまたは混合カップ |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS5933228B2 (ja) * | 1978-12-25 | 1984-08-14 | 武田薬品工業株式会社 | 妊娠診断反応用被検液の前処理方法ならびに前処理剤 |
| DE3342627A1 (de) * | 1983-11-25 | 1985-06-05 | Boehringer Mannheim Gmbh, 6800 Mannheim | Immunchemischer schnelltest |
| FR2577321B1 (fr) * | 1985-02-08 | 1989-04-28 | Lapierre Yves | Dispositif et procede de mise en evidence d'agglutinats erythrocytaires |
| US5073344A (en) * | 1987-07-17 | 1991-12-17 | Porex Technologies Corp. | Diagnostic system employing a unitary substrate to immobilize microspheres |
| JPH087215B2 (ja) * | 1987-08-24 | 1996-01-29 | シュティフツング・フュア・ディアグノスティッシュ・フォルシュンク | 抗原および／又は抗体の検出方法および検出用の試験キット |
| ATE153138T1 (de) * | 1990-09-26 | 1997-05-15 | Akers Lab Inc | Verbessertes bestimmungsverfahren für liganden |
| GR1002306B (el) * | 1990-11-09 | 1996-05-08 | Ortho Diagnostic Systems Inc. | Αναλυση και διαταξη συγκολλησεως στηλης. |
-
1996
- 1996-03-18 DE DE59608443T patent/DE59608443D1/de not_active Expired - Lifetime
- 1996-03-18 AT AT96104283T patent/ATE210829T1/de active
- 1996-03-18 DK DK96104283T patent/DK0797097T3/da active
- 1996-03-18 ES ES96104283T patent/ES2168402T3/es not_active Expired - Lifetime
- 1996-03-18 PT PT96104283T patent/PT797097E/pt unknown
- 1996-03-18 EP EP96104283A patent/EP0797097B1/de not_active Expired - Lifetime
-
1997
- 1997-03-17 US US08/822,158 patent/US5869347A/en not_active Expired - Lifetime
- 1997-03-18 JP JP9064277A patent/JPH102900A/ja active Pending
Cited By (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2003107091A (ja) * | 2001-09-28 | 2003-04-09 | Olympus Optical Co Ltd | 生物学的検査のための分離体および検査方法 |
| JP2007519938A (ja) * | 2004-02-02 | 2007-07-19 | メディオン ダイアグノスティクス アクチェンゲゼルシャフト | 凝集反応の可視化と分離により分析物を検出するための装置と方法 |
| JP2008224317A (ja) * | 2007-03-09 | 2008-09-25 | Olympus Corp | 凝集判定装置 |
| JP2008224318A (ja) * | 2007-03-09 | 2008-09-25 | Olympus Corp | 多層型凝集判定容器 |
| JP2012513596A (ja) * | 2008-12-23 | 2012-06-14 | シンビオン・メディカル・システムズ・ソシエテ・ア・レスポンサビリテ・リミテ | 凝集検査を行うための装置および分析システム |
| JP2012194181A (ja) * | 2011-03-15 | 2012-10-11 | Siemens Healthcare Diagnostics Products Gmbh | 血小板機能を決定するための装置及び方法 |
| WO2014203693A1 (ja) * | 2013-06-19 | 2014-12-24 | オリンパス株式会社 | 光学計測用容器 |
| JPWO2014203693A1 (ja) * | 2013-06-19 | 2017-02-23 | オリンパス株式会社 | 光学計測用容器 |
Also Published As
| Publication number | Publication date |
|---|---|
| US5869347A (en) | 1999-02-09 |
| DK0797097T3 (da) | 2002-04-15 |
| ES2168402T3 (es) | 2002-06-16 |
| EP0797097B1 (de) | 2001-12-12 |
| ATE210829T1 (de) | 2001-12-15 |
| PT797097E (pt) | 2002-06-28 |
| EP0797097A1 (de) | 1997-09-24 |
| DE59608443D1 (de) | 2002-01-24 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20040311 |
|
| A621 | Written request for application examination |
Free format text: JAPANESE INTERMEDIATE CODE: A621 Effective date: 20040311 |
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| A977 | Report on retrieval |
Free format text: JAPANESE INTERMEDIATE CODE: A971007 Effective date: 20040728 |
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| A131 | Notification of reasons for refusal |
Free format text: JAPANESE INTERMEDIATE CODE: A131 Effective date: 20040804 |
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| A02 | Decision of refusal |
Free format text: JAPANESE INTERMEDIATE CODE: A02 Effective date: 20050107 |