JPH10273416A - Skin preparation for external use - Google Patents

Abstract

PROBLEM TO BE SOLVED: To obtain the subject highly safe preparation high in moisturizing effect and excellent in skin drying preventive effect, by including an extract from two or more kinds of plants selected from a peony, gardenia, Panax ginseng and mugwort. SOLUTION: This preparation is obtained by compounding (A) 0.001-30 wt.%, preferably, 0.005-15 wt.% of an extract concentrate obtained by distilling the solvent off an extract from two or more kinds of plants selected from a peony, gardenia, Panax ginseng and mugwort, and as necessary, (B) an oily component(s), a U.V. absorbent(s), an antioxidant, a surfactant(s), an antiseptic(s), a perfume(s), etc. The peony extracts solution is an extractant from the root of a peony (a closely related plant) belonging to Paeonia. The gardenia extracts solution is an extract from the fruit of a gardenia belonging to Rubiaceae. The Panax ginseng extracts solution is an extract from the root of Panax ginseng belonging to Araliaceae. The mugwort extracts solution is an extract from the whole grass of mugwort belonging to Compositae. These respective extracts solutions can be obtained by subjecting the above corresponding plants to solvent extraction.

Description

DETAILED DESCRIPTION OF THE INVENTION

[0001]

The present invention relates to an external preparation for skin. More specifically, the present invention relates to an external preparation for skin which has a high moisturizing effect, prevents drying of the skin and is excellent in safety.

[0002]

2. Description of the Related Art Hitherto, it has been essential to maintain moisture in order to maintain healthy skin, and many skin external preparations for moisturizing have been developed.

[0003] In addition, studies on moisturizing agents have been actively conducted, and today, moisturizing agents such as organic acid salts, polyhydric alcohols, and water-soluble polymers are blended into skin external preparations.

[0004]

However, in order to further enhance the moisturizing effect, the amount of these humectants must be increased, and as a result, the system becomes unstable or the usability deteriorates. And had adverse effects on safety.

The present inventors have conducted intensive studies to solve the above problems, and as a result, when an extract of two or more kinds of plants selected from peonies, gardenia, panax ginseng and mugwort is mixed into a skin external preparation, The moisturizing effect increases synergistically,
Further, they have found that a skin external preparation excellent in safety can be obtained, and have completed the present invention.

An object of the present invention is to provide an external preparation for skin which has a high moisturizing effect, an excellent skin drying prevention effect and a high safety.

[0007]

That is, the present invention provides an external preparation for skin, characterized by containing an extract of two or more plants selected from the group consisting of peonies, gardenia, panax ginseng and mugwort. Things.

Further, the present invention provides the above external preparation for skin, characterized in that the plant extract is contained in an amount of 0.001 to 30% by weight based on the total amount of the external preparation for skin. is there.

[0009]

DETAILED DESCRIPTION OF THE PREFERRED EMBODIMENTS The configuration of the present invention will be described below in detail.

The extract of the peony used in the present invention is a peony [Paeonia lactiflora Pallas (Paeonia)
albiflora Pallas var. trichocarpa Bunge)] and the root extract of this closely related plant.

The gardenia extract used in the present invention is a gardenia gardenia [Gardenia jasminoides Ellis (Rubiaceae)].
] Is an extract of the fruit.

The Panax ginseng extract used in the present invention comprises:
Panax ginseng CAMeyer
Root extract.

The mugwort extract used in the present invention is an extract of the whole plant of Artemisia princeps Pampani.

As a method for extracting the above-mentioned extract, a known extraction method can be used.
Solvent extraction with a solvent such as hot water, lower alcohols such as methanol and ethanol or hydrates of these lower alcohols, polyhydric alcohols such as propylene glycol and 1,3-butylene glycol, or hydrates of these polyhydric alcohols. Thus, it is possible to obtain an extract of the plant used in the present invention. In the present invention, commercially available products of each plant extract can be used.

In the present invention, at least two or more extracts of the above-mentioned plants must be blended with the external preparation for skin, and the combination of two or more plant extracts is optional.
Three or all four kinds of extracts may be blended. By blending two or more extracts with the external preparation for skin, the moisturizing effect is synergistically exhibited as compared with the case of blending alone.

The amount of the plant extract in the present invention is as follows:
As an extract concentrate from which the extraction solvent is distilled off, 0.001 to 30% by weight, preferably 0.005% by weight, based on the total amount of the external preparation for skin.
１５15% by weight. If it is less than 0.001% by weight, the moisturizing effect is not exhibited, and if it exceeds 30% by weight, it is not preferable in the production process of the product.

The external preparation for skin of the present invention may contain, in addition to the above essential components, other components usually used in external preparations for skin such as cosmetics and pharmaceuticals, for example, avocado oil, palm oil, peanut oil, beef tallow, rice bran oil , Jojoba oil, carnauba wax, lanolin, liquid paraffin, squalane, oxystearic acid, isostearyl palmitate, isostearyl alcohol, etc., glycerin, sorbitol, polyethylene glycol, collagen, hyaluronic acid and its salts, chondroitin sulfate and its salts, etc. Humectants, UV absorbers such as amyl paradimethylaminobenzoate, urocanic acid, ethyl diisopropylcinnamate, antioxidants such as sodium erysorbate, sage extract, parahydroxyanisole, sodium stearyl sulfate, diethanolamine cetyl sulfate Surfactants such as amine, cetyltrimethylammonium chloride, polyethylene glycol isostearate, glyceryl stearate, preservatives such as ethylparaben and butylparaben, extracts such as oak, spinach, sicon, assembly, birch, loquat, and glycyrrhizic acid derivatives Inflammatory agents such as glycyrrhetinic acid derivatives, salicylic acid derivatives, hinokitiol, zinc oxide, allantoin, placental extracts, glutathione, yukinoshita extracts, arbutin, whitening agents such as ascorbic acid derivatives, aloe, mallow, iris, grapes, yoquinin, hechima , Extract such as lily, royal jelly, photosensitizer, cholesterol derivative, activator such as various amino acids, saffron, senkyu, ginger, hypericum, ononis, rosemary, garlic, etc. Extract, γ
-Blood circulation promoters such as oryzanol, dextran sulfate sodium, etc., sulfur, antiseborrheic agents such as thiantol, fragrances,
Water, an alcohol, a thickener such as a carboxyvinyl polymer, and a coloring agent such as titanium yellow, carsamine, and safflower red can be appropriately blended as necessary, and can be produced by a conventional method.

The dosage form of the external preparation for skin of the present invention is arbitrary,
A wide variety of forms such as a solution system, a solubilizing system, an emulsifying system, an oil-liquid system, a gel system, a powder dispersing system, a water-oil two-layer system, a water-oil-powder three-layer system can be adopted.

The external preparation for skin of the present invention includes cosmetics, pharmaceuticals,
As a quasi-drug, refers to those applied to the hull, its use is optional, for example, lotion, milky lotion, cream,
It can be used for facial cosmetics such as packs, makeup cosmetics such as foundations, lipsticks, eye shadows, etc., body cosmetics, aromatic cosmetics, detergents, ointments and the like.

[0020]

The present invention will be specifically described below with reference to examples. The present invention is not limited by this. The compounding amount is% by weight. In the following examples, a peony extract is a peony extract BG (manufactured by Koshiro Pharmaceutical Co., Ltd.), a gardenia extract is a gardenia silydide (manufactured by Ichimaru Falcos Co., Ltd.), and a panax ginseng extract is a synhongin herring-LV ( E) (Ichimaru Falcos Co., Ltd.), mugwort extract is mugwort liquid SS
(Manufactured by Ichimaru Falcos Co., Ltd.) was used.

First, the moisturizing effect of the present invention was evaluated by the following method. [Test Method by Conductance Measurement] For the samples shown in Table 1, the skin conductance of the chest was measured before application, and 1 hour and 6 hours after application, and the moisturizing effect was evaluated from the rate of change. The rate of change in skin conductance is determined by the following equation (Equation 1), and it is possible to examine the effect of the stratum corneum on water absorption and water retention ability. There is an increase in moisture, and it can be evaluated that the moisturizing effect is high.

[0022]

## EQU1 ## Conductance change rate = (Conductance before application) / (Conductance after application)

The evaluation criteria in Table 1 are as follows. ：: Conductance change rate 0 or more and less than 0.3 △: Conductance change rate 0.3 or more and less than 0.7 ×: Conductance change rate 0.7 or more

[0024]

[Table 1] ---------------------------------------------- ---------------------- Conductance change rate sample 1 hour later 6 hours later ----------------- -------------------------------------------------- -Deionized water × × -------------------------------------------- ------------------------ 10% aqueous solution of 1,3-butylene glycol △ × -------------- -------------------------------------------------- ---- 10% aqueous solution of peony extract ○ △ ------------------------------------- ------------------------------- 10% aqueous solution of gardenia extract ○ △ ---------- -------------------------------------------------- -------- 10% aqueous solution of Panax ginseng extract ○ △ --------------------------------- ----------------------------------- 10% aqueous solution of mugwort extract ○ △ ------ -------------------------------------------------- ------------ 5% aqueous solution of peonies extract △ △ 1,3-butylene glycol 5% aqueous solution --------- -------------------------------------------------- --------- 5% aqueous solution of gardenia extract △ △ 1,3-butylene glycol 5% aqueous solution ---------------------- ---------------------------------------------- Panax ginseng extract 5% aqueous solution △ △ 1,3-butylene glycol 5% aqueous solution ----------------------------------- --------------------------------- ----------------- -------------------------------------------------- -5% aqueous solution of mugwort extract △ △ 1,3-butylene glycol 5% aqueous solution ------------------------------ -------------------------------------- 5% aqueous solution of peonies extract ○ ○ gardenia extract 5% aqueous solution ---------------------------------------------- ---------------------- 5% aqueous solution of peonies extract ○ ○ 5% aqueous solution of Panax ginseng extract ------------ -------------------------------------------------- ------ 5% aqueous solution of peonies extract ○ ○ 5% water of mugwort extract Liquid ------------------------------------------------- ------------------- 5% aqueous solution of Panax ginseng extract ○ ○ 5% aqueous solution of mugwort extract --------------- -------------------------------------------------- --- 5% aqueous solution of gardenia extract ○ ○ 5% aqueous solution of Panax ginseng extract ------------------------------- ------------------------------------- 5% aqueous solution of gardenia extract ○ ○ of mugwort extract 5% aqueous solution ----------------------------------------------- ---------------------

From Table 1, it can be seen that the aqueous solution containing the extract of two or more plants selected from peonies, gardenia, panax ginseng, and mugwort, each containing an aqueous solution alone or in combination with another humectant It can be seen that the moisturizing effect is superior in comparison. In particular, when the extract alone is contained, the conductance change rate after 6 hours is 1
When the extract contains two or more kinds of extracts, the evaluation of the conductance change rate after 6 hours and after 1 hour does not change, indicating that the moisturizing effect functions synergistically. .

Example 1 Cream A. Stearic acid 10.0 Stearyl alcohol 4.0 Butyl stearate 8.0 Monoglycerin stearate 2.0 Perfume 0.4 Ethyl paraben Suitable amount B. Peony extract 5.0 Gardenia extract 5.0 Panax ginseng extract 5.0 Artemisia extract 5.0 Glycerin 4.0 Potassium hydroxide 0.4 Trisodium edetate 0.05 Purified water Residue (Production method) Heat the oil phase of A and the water phase of B to 70 ° C respectively And completely dissolve. Add phase A to phase B and emulsify with an emulsifier. The emulsion was cooled using a heat exchanger to obtain a cream.

Example 2 Cream A. Cetanol 6.0 Vaseline 7.0 Isopropyl myristate 8.0 Squalane 15.0 Monoglycerin stearate 2.2 Polyoxyethylene (20) sorbitan monostearate 2.8 Fragrance 0.3 Parahydroxyanisole Appropriate butylparaben Appropriate B. Glycerin 10.0 Peony extract 3.0 Panax ginseng extract 2.0 Artemisia extract 1.0 Dipropylene glycol 4.0 Disodium edetate 0.01 Purified water Residue (Preparation method) A cream was obtained according to Example 1.

Example 3 Emulsion A. Squalane 5.0 Oleyl oleate 3.0 Vaseline 2.0 Sorbitan sesquioleate 0.8 Polyoxyethylene oleyl ether 1.2 Fragrance 0.3 Ethyl paraben Suitable amount B. 1,3-butylene glycol 4.5 Peony extract 1.5 Mugwort extract 3.5 Ethanol 3.0 Carboxyvinylporimer 0.2 Potassium hydroxide 0.1 Sodium hexametaphosphate 0.05 Purified water Residue (Production method) The oil phase of A and the aqueous phase of B are each 70 Dissolve completely by heating to ° C. Add phase A to phase B and emulsify with an emulsifier. The emulsion was cooled to obtain an emulsion.

“Example 4 Foundation” A. Cetanol 3.5 Deodorized lanolin 4.0 Jojoba oil 5.0 Vaseline 2.0 Squalane 6.0 Monoglycerin stearate 2.5 Polyoxyethylene (60) hydrogenated castor oil 1.5 Polyoxyethylene (20) cetyl ether 1.0 Ethyl paraben Suitable amount Fragrance 0.3 B. Propylene glycol 10.0 Gardenia extract 0.1 Panax ginseng extract 0.2 Mixture powder 12.0 Trisodium edetate 0.2 Purified water Residue (Preparation method) Heat the oil phase of A and the aqueous phase of B to 70 ° C respectively to completely dissolve. Add phase A to phase B and emulsify with an emulsifier. The emulsion was cooled to obtain a foundation.

Example 5 Lotion A. Ethanol 5.0 polyoxyethylene oleyl alcohol ether 2.0 2-ethylhexyl-P-dimethylaminobenzoate 0.18 fragrance 0.05 B. 1,3-butylene glycol 9.5 Peony extract 1.0 Gardenia extract 2.0 Nicotinamide 0.3 glycerin 5.0 Purified water Residue (Preparation method) The alcohol phase of A was added to the aqueous phase of B and solubilized to obtain a lotion.

“Example 6 Pack” (1) Polyvinyl alcohol 10.0 (2) Polyethylene glycol (molecular weight 400) 0.4 (3) Glycerin 3.0 (4) Ethanol (95%) 8.0 (5) Artemisia extract 0.1 (6) Panax ginseng Extract 0.5 (7) Ethylparaben 0.1 (8) Fragrance 0.1 (9) Purified water residue (Preparation method) (4) (7) (8) was mixed and dissolved at room temperature, and (1) (2) (3) and ( 5) (6) and (9) were mixed and dissolved at 80 ° C., and the mixture was stirred and added, and then allowed to cool to room temperature to obtain a pack.

Example 7 Detergent (1) polyoxyethylene (12) diisostearate 5 (2) polyoxyethylene (5) lauryl ether 10 triethanolamine sulfate (3) coconut fatty acid amidopropyl acetate betaine 10 (4) Lauryl diethanolamide 2 (5) Glycerol 5 (6) Peony extract 0.3 (7) Panax ginseng extract 0.7 (8) Perfume 0.2 (9) Purified water residue (Preparation method) 5), (6) and (7) are dissolved, (2), (3) and (4)
After mixing, (1) and (8) were added to obtain a detergent.

The skin external preparations of Examples 1 to 7 each had a high moisturizing effect and were excellent in safety.

[0034]

According to the present invention, it is possible to provide a skin external preparation which has a high moisturizing effect, prevents drying of the skin, and is excellent in safety.

Claims (2)

[Claims] An external preparation for skin comprising an extract of two or more plants selected from the group consisting of peonies, gardenia, panax ginseng and mugwort. 2. The external preparation for skin according to claim 1, wherein the extract of the plant is contained in an amount of 0.001 to 30% by weight based on the total amount of the external preparation for skin.