JP3093353B2 - External preparation for skin - Google Patents

Description

DETAILED DESCRIPTION OF THE INVENTION

[0001]

BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to an external preparation for skin, and more particularly, to an external preparation for skin which has a high moisturizing effect and prevents drying of the skin.

[0002]

2. Description of the Related Art Moisture retention is essential for maintaining healthy skin, and many skin external preparations for moisturizing are commercially available. Research on humectants has also been actively conducted, and organic acid salts, polyhydric alcohols, water-soluble polymers and the like are widely used today.

[0003]

However, these humectants must be added in an increased amount in order to enhance their effects, and as a result, the system becomes unstable or the usability deteriorates. There were also problems such as adversely affecting safety.

[0004]

Means for Solving the Problems The inventors of the present invention have made intensive studies to solve the above problems, and as a result, when an extract of a plant belonging to the genus Melissa belonging to the genus Melissa is combined with pyrrolidonecarboxylic acid and / or a salt thereof, a synergistic effect is obtained. It was found that the moisturizing effect was increased and the safety was excellent. That is, the present invention provides an external preparation for skin characterized by blending an extract of a plant belonging to the genus Melissa in the Labiatae with pyrrolidonecarboxylic acid and / or a salt thereof. Hereinafter, the configuration of the present invention will be described in detail. The Lamiaceae Melissa genus plant used in the present invention is Melissa or the like. These generally use leaves,
Fruit and bark are also used. The extraction method of the Labiatae melissa genus plant extract used in the present invention may be performed according to a conventional method. One example is as follows.

The extraction method can be obtained by heating and refluxing a plant belonging to the genus Melissa belonging to the genus Melissa with a solvent such as water, a polyhydric alcohol such as dipropylene glycol or 1,3-butylene glycol, or a mixture thereof, Generally, this extract is used after being concentrated. As another method, an extract obtained by fractionating the extract obtained by the above-described method using adsorption-based chromatography such as silica gel chromatography can also be used.

[0006] In the present invention, when a plant of the genus Melissa belonging to the genus Melissa is blended as an extract or as a fractionated extract, the blending amount is 0.0001 to 30% by weight, preferably 0.005 to 15% by weight, based on the total amount of the external preparation for skin. %. If the amount is less than 0.0001% by weight, the effect is not exhibited, and if it exceeds 30% by weight, it is not preferable in the production process of the product.

The pyrrolidonecarboxylic acid used in the present invention includes sodium salts, triethanolamine salts and the like. The amount of the pyrrolidonecarboxylic acid and / or salt thereof in the present invention is not particularly limited, but is preferably 0.001 to 20% by weight, more preferably 0.01 to 5% by weight, based on the total amount of the external preparation for skin.

[0008] In addition to the above essential components, the skin external preparation of the present invention also contains other components usually used in skin external preparations such as cosmetics and pharmaceuticals, such as avocado oil, palm oil, peanut oil, tallow, rice bran oil, jojoba oil. Moisturizing oils such as oil, carnauba wax, lanolin, liquid paraffin, squalane, oxystearic acid, isostearyl palmitate, isostearyl alcohol, glycerin, sorbitol, polyethylene glycol, collagen, hyaluronic acid and its salts, chondroitin sulfate and its salts, etc. Agents, UV absorbers such as amyl paradimethylaminobenzoate, urocanic acid and ethyl diisopropylcinnamate; antioxidants such as sodium erythorbate, sage extract and parahydroxyanisole; sodium stearyl sulfate; diethanol cetyl sulfate; , Cetyltrimethylammonium chloride, surfactants such as polyethylene glycol isostearate and glyceryl stearate, preservatives such as ethylparaben and butylparaben, extracts such as oak, spinach, sicon, peonies, assembly, birch, loquat, and glycyrrhizin Acid derivatives, glycyrrhetinic acid derivatives, salicylic acid derivatives, hinokitiol, zinc oxide,
Anti-inflammatory agents such as allantoin, placenta extract, glutathione,
Saxinosita extract, arbutin, whitening agents such as ascorbic acid derivatives, carrots, aloe, mallow, iris, grapes, yoquinin, loofah, extracts such as lilies, royal jelly, photosensitizers, cholesterol derivatives, activators such as various amino acids, Saffron, Senkyu, Ginger, Hypericum, Ononis, Rosemary, Extracts such as garlic, γ-oryzanol, dextran sulfate sodium, etc., blood circulation promoters, sulfur, antiseborrheic agents such as Thiantol, fragrance, water, alcohol, Thickeners such as carboxyvinyl polymers and coloring agents such as titanium yellow, carsamine, and safflower red can be appropriately compounded as necessary.

[0009] The dosage form of the external preparation for skin of the present invention is optional,
Any dosage form, such as a solution system, a solubilizing system, an emulsifying system, a powder dispersion system, a water-oil two-layer system, a water-oil-powder three-layer system, may be used. The use of the external preparation for skin of the present invention is also optional. Facial cosmetics such as lotions, emulsions, creams, packs and the like, makeup cosmetics such as foundations, lipsticks, eye shadows, etc., body cosmetics, aromatic cosmetics, cleaning Paints, ointments and the like.

[0010]

EXAMPLES Next, the present invention will be specifically described with reference to examples. The present invention is not limited by this. The compounding amount is% by weight. Prior to the examples, the effects of the present invention were measured by the following method. [Testing Method by Moisture Evaporation Rate Measurement] Filter paper cut into 2 cm square (Toyo Filter Paper N
o. 2) Take 10 μl of the sample, leave it at 25 ° C. and 50% relative humidity, and examine the change in weight with a balance.
Assuming that the evaporation of water proceeds by a linear equation, the water evaporation rate constant of each sample is obtained. Assuming that the weight of the sample at time t is w, the evaporation rate of water is It is represented by When this equation is integrated, ln w = −kt + c (c is a constant) (2) wn at time tn is measured, and ln is calculated according to equation (2).
nwn is plotted against tn, and the water evaporation rate constant k is determined from the slope of the linear function line. The greater the moisture evaporation rate constant k, the greater the volatility of moisture. The smaller the k, the more difficult it is for moisture to evaporate, and the higher the moisture retention effect. The results are shown in Table I.

[0011]

[Table I]

From Table I, it can be seen that when the Melissa extract of the present invention and sodium pyrrolidone carboxylate are used in combination, the moisturizing effect is superior to each other alone or in combination with other moisturizing agents.

EXAMPLE 1 Cream A. Stearic acid 10.0 Stearyl alcohol 4.0 Butyl stearate 8.0 Monoglycerin stearate 2.0 Perfume 0.4 Ethyl paraben Suitable amount B. Melissa extract * 25.0 Sodium pyrrolidone carboxylate 5.0 Glycerin 4.0 Potassium hydroxide 0.4 Trisodium edetate 0.05 Purified water Residue The oil phase of A and the aqueous phase of B are each heated to 70 ° C and completely dissolved. Add phase A to phase B and emulsify with an emulsifier. The emulsion was cooled using a heat exchanger to obtain a cream. * Production method 100g of Melissa leaves are washed thoroughly with water and 50% 1,3-
Add 1.2 kg of butylene glycol aqueous solution and 2.4 g of methyl parahydroxybenzoate, and immerse at room temperature for 10 days. This extract is filtered to obtain a Melissa extract.

Example 2 Cream A. Cetanol 6.0 Vaseline 7.0 Isopropyl myristate 8.0 Squalane 15.0 Monoglycerin stearate 2.2 Polyoxyethylene (20) sorbitan monostearate 2.8 Fragrance 0.3 Parahydroxyanisole Appropriate butylparaben Appropriate B. Glycerin 10.0 Melissa extract 0.02 Dipropylene glycol 4.0 Sodium pyrrolidonecarboxylate 1.0 Disodium edetate 0.01 Purified water Residue A cream was obtained according to Example 1.

Example 3 Emulsion A. Squalane 5.0 Oleyl oleate 3.0 Vaseline 2.0 Sorbitan sesquioleate 0.8 Polyoxyethylene oleyl ether 1.2 Fragrance 0.3 Ethyl paraben Suitable amount B. 1,3-butylene glycol 4.5 Melissa extract 1.5 Sodium pyrrolidonecarboxylate 2.0 Ethanol 3.0 Carboxyvinylporlimer 0.2 Potassium hydroxide 0.1 Sodium hexametaphosphate 0.05 Purified water Residue The oil phase of A and the aqueous phase of B are each brought to 70 ° C. Heat to completely dissolve. Add phase A to phase B and emulsify with an emulsifier. The emulsion was cooled to obtain an emulsion.

Example 4 Foundation A. Cetanol 3.5 Deodorized lanolin 4.0 Jojoba oil 5.0 Vaseline 2.0 Squalane 6.0 Monoglycerin stearate 2.5 Polyoxyethylene (60) hydrogenated castor oil 1.5 Polyoxyethylene (20) cetyl ether 1.0 Ethyl paraben Suitable amount Fragrance 0.3 B. Propylene glycol 10.0 Melissa extract 0.1 Sodium pyrrolidonecarboxylate 1.0 Compound powder 12.0 Trisodium edetate 0.2 Purified water Residue The oil phase of A and the aqueous phase of B are each heated to 70 ° C and completely dissolved. Add phase A to phase B and emulsify with an emulsifier. The emulsion was cooled to obtain a foundation.

Example 5 Lotion A. Ethanol 5.0 polyoxyethylene oleyl alcohol ether 2.0 2-ethylhexyl-P-dimethylaminobenzoate 0.18 fragrance 0.05 B. 1,3-butylene glycol 9.5 pyrrolidone carboxylic acid 3.0 Melissa extract 5.0 nicotinamide 0.3 glycerin 5.0 purified water Residue The alcohol phase of A was added to the aqueous phase of B and solubilized to obtain a lotion.

Example 6 Pack (1) Polyvinyl alcohol 10.0 (2) Polyethylene glycol (molecular weight 400) 0.4 (3) Glycerin 3.0 (4) Ethanol (95%) 8.0 (5) Melissa extract 0.1 (6) Pyrrolidone carboxylic acid Sodium 0.5 (7) Ethyl paraben 0.1 (8) Fragrance 0.1 (9) Purified water residue Mix and dissolve (4) (7) (8) at room temperature, and mix (1) (2) (3) and (5)
(6) After mixing and dissolving (9) at 80 ° C., the mixture was stirred and then allowed to cool to room temperature to obtain a pack.

[0019]

The external preparation for skin of the present invention exhibits an excellent moisturizing effect by blending an extract of a plant belonging to the genus Melissa belonging to the genus Melissa and pyrrolidonecarboxylic acid and / or a salt thereof, and has excellent safety. I have.

[Table 1]

──────────────────────────────────────────────────続 き Continuation of the front page (56) References JP-A-3-157334 (JP, A) JP-A-2-49711 (JP, A) JP-A-63-230625 (JP, A) JP-A-61-1986 180705 (JP, A) JP-A-55-149369 (JP, A) JP-A-4-305512 (JP, A) Compilation of well-known and conventional techniques (cosmetics and similar products) edited by the Japan Patent Office (Showa 59-8) -21) p. 22 (58) Field surveyed (Int. Cl. ⁷ , DB name) A61K ^7/ 00-7/50 CA (STN)

Claims (1)

(57) [Claims] 1. An extract comprising a plant of the genus Melissa belonging to the Labiatae family and pyrrolidonecarboxylic acid and / or a salt thereof as an active ingredient.
An external preparation for moisturizing skin, characterized in that it is blended together.