JPH10182415A - Cosmetic composition - Google Patents

Abstract

PROBLEM TO BE SOLVED: To obtain a cosmetic composition capable of improving spots, dullness and roughness of the skin and useful for inhibiting onsets of allergic skin inflammations, etc., by blending a raw sugar-extract with a Scuetellariae radix- extract, an enzyme and/or a yeast extract as essential ingredients. SOLUTION: This cosmetic composition is obtained by adding 0.0001-5% of a mixture consisting of a raw sugar-extract (3,4-dimethoxyphenyl-O-D-glucose, etc.), a Scuetellariae radix-extract (containing baicaline and/or baicalein, which are flavone derivatives extracted from Scutellaria baicalensis GEORGI of Labiatae), an enzyme (a kind of protease obtained from papaya) and a yeast extract (concentrated and dried product of a solution obtained from a Saccharomyces yeast) in a compositional ratio of 1:1:0.5:0.5, 1:1:1:0 or 1:1:0:1.

Description

DETAILED DESCRIPTION OF THE INVENTION

[0001]

BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention provides a cosmetic composition which is effective in improving skin spots, dark spots, rough skin, etc. caused by various causes, and also effective in suppressing the onset of allergic dermatitis and the like.

[0002]

BACKGROUND OF THE INVENTION In recent years, with the spread of gender equality in Japan, social life has changed, and girls have more opportunities to participate in outdoor sports. Some situations have not been able to adapt. Due to changes in food and living environment, the skin is easily damaged, causing skin spots, dark spots, and rough skin. According to the Cosmetic Report of the Japan Cosmetic Industry Association, 80% of Japanese women felt "dull skin and rough skin" in a survey of Japanese women's awareness of "dull skin and rough skin". It can be said that the effect of the change in the living environment described above is how great it is for modern Japanese women. Particularly recently, young women have more opportunities to be exposed to sunlight and ultraviolet rays due to the increase in sports heat, and in addition, the excess lipid intake in the body due to excessive dietary intake due to the establishment of a diet with a predominant western diet has increased lipid peroxide in the body. The external environment that causes skin spots and dark spots, rough skin, aging, and allergies has become commonplace. Under such circumstances, the role of cosmetics is growing more and more,
Skin spots, dark spots, rough skin caused by various causes,
The development of a cosmetic composition for beautiful skin that can sufficiently respond to the prevention and improvement of the onset of skin allergies, etc. has been awaited.

[0003]

2. Description of the Related Art Conventionally, many plant components have been used as cosmetic components for beautiful skin and skin conditioning. Among them, there is a so-called brown sugar soap using brown sugar for a long time. However, the sugar component in the brown sugar precipitates at the stage of production, and it is rough and unpleasant when used, and its skin effect is not always sufficient.

[0004] The skin constantly secretes sebum from sebaceous glands and sweat from sweat glands, and constantly renews skin keratin by metabolism. However, excessive sebum secretion causes old keratin to be left on the sweat glands and skin as a soil on the skin for a long period of time, worsens makeup, and sometimes causes seborrhea and acne and damages the skin. Conventionally, for such old aging exfoliation,
Although keratinous solvents such as salicylic acid, sulfur, and urea or soaps and alkaline substances have been used, these are highly irritating to the skin and have the drawback that they are not suitable as cosmetic materials that require strong safety. Was.

[0005] Also, as social life changes in the near future,
More and more people complain of allergic diseases such as atopic dermatitis, and the allergic eczema symptom, especially on the face, is the biggest factor that afflicts women at the age of makeup. In general, allergy is understood as a biological reaction caused by the release of chemical mediators such as SRS-A, histamine, and bradykinin from mast cells in response to an allergen, and these substances damage surrounding tissues. Therefore, if the generation of these chemical mediators is suppressed in any way, the onset of allergy can be prevented. Among these chemical mediators, methods for suppressing the generation of histamine and bradykinin are already known, but none of SRS-A can be expected to have a sufficient inhibitory effect.

[0006]

In view of the above circumstances, the present inventor asked what the active ingredient of the above-mentioned brown sugar is, and how to use it as a suitable cosmetic. After intensive studies, the active ingredient in brown sugar is a pigment component in brown sugar, which is chemically identified as phenyl glucose (more specifically, 3,4-dimethoxyphenyl-OD-glucose or 3 , 4,6-
(A compound comprising trimethoxyphenyl) (hereinafter, this substance is referred to as a specific brown sugar extract (brown sugar oligo)). At the same time, it has been found that this substance can be extracted from brown sugar, for example, by the following method.

[0007] 1. Dissolve crude sugar (brown sugar) in water and treat with adsorbent. As the adsorbent used here, a porous cross-linked polystyrene resin adsorbent having a huge network structure,
For example, Amberlite XAD-1 is suitable. 2. The adsorbent is washed with water to remove sugar, leaving only the pigment component adsorbed. 3. Next, the dye component is desorbed from the adsorbent, preferably by using hydrous alcohol having an alcohol concentration of 20% or more. Specifically, most of the dye components are eluted with, for example, about 20 to 30% ethanol, and then completely eluted with about 95% ethanol. 4. The eluate is evaporated to dryness under reduced pressure, and the residue is dried at 60 ° C. or lower to obtain the product as a colorless powder having no sweetness.

In the present invention, papain is preferably used for removing the dead skin cells. Papain is an enzyme abundantly contained in milk obtained from immature fruits of papaya, and hydrolyzes protein and peptone. The aging keratin and the like,
Since the cause of soil on the skin surface is caused by secreted fat, protein and carbohydrate, it is completely decomposed by papain, which is a proteolytic enzyme having properties suitable for decomposing these, and disappears from the skin surface. Papain is also suitable in this aspect because it has no skin irritation and is excellent in safety.

As described above, an allergic disease such as atopic dermatitis is a biological reaction caused by a chemical transmitter in the body damaging surrounding tissues.
RS-A is a substance having 5-HETE, a metabolite of arachidonic acid, as a precursor. Therefore, by suppressing the production of 5-HETE, many allergic diseases such as atopic dermatitis can be prevented. As a result of earnest research, the inventor
Ogon (Scutellaria: Scutellaria ba)
icalensis GEORGI)
Baicalin and / or baicalakei
It has been found that an extract containing n) (hereinafter referred to as a specific pentagon extract) has such an effect, which has led to the present invention.

[00010]

DETAILED DESCRIPTION OF THE INVENTION One of the constituents of the present invention, a brown sugar extract, is a pigment component in brown sugar and is chemically a phenylglucose compound, more specifically 3,4-dimethoxyphenyl-OD-. Glucose or 3,4,6-
It is a specific brown sugar extract (brown sugar oligo) which is a compound composed of trimethoxyphenyl. Another component of the extract of the pentagon is a Labiatae family pentagon (Scutellaria baica).
The specific flora extract containing baicalin and / or baicalein, a flavone derivative extracted from C.lensis GEORGI). Still another component, an enzyme, is a kind of protease protease obtained from the emulsion of papaya immature fruit. Yeast extract is obtained from yeast belonging to Saccharomyces by autolysis or acid hydrolysis. The obtained liquid was concentrated and dried to obtain a yeast extract (Saccharomyces yeasts).
t extract).

In the present invention, these three to four types of constituents are used as a cosmetic composition, and their constituent ratios are approximately the specific brown sugar extract 1, the specific pentagon extract 1, papain 0.5, and yeast extract 0. .5, or papain or yeast extract, one of which is 1;
0.0001 to 5%, preferably 0.001 to 5%
It is blended into cosmetics with a blending ratio of 1.00%. The cosmetics applied in the present invention are not limited to creams, lotions, emulsions, and other forms of cosmetics.

[0012]

The cosmetic composition of the present invention thus obtained has an effect of remarkably improving skin spots, blemishes and rough skin, and has an effect of suppressing the onset of allergy.

[0013]

EXAMPLES Examples of the case where the cosmetic composition of the present invention is used in a cosmetic cream will be described below. However, these are merely examples, and the present invention is not limited by these.

Example 1 (Cream containing 1: 1: 1 specific brown sugar extract, specific Japanese pentagon extract, and yeast extract) Specific brown sugar extract 0.01% by weight Specific Japanese pentagon extract 0.01 yeast extract 0.01 Stearic acid 5.00 Glyarin 6.0 Polyoxyethylene monolaurate 3.0 1.3 Butylene glycol 10.00 Lanolin derivative 2.0 Propylene glycol 10.0 Dense wax 3.0 Cetanol 6.0 Squalane 8.0 Perfume 0.5 Purified water 46.47

Example 2 (Cream in which specific brown sugar extract, specific pentagon extract, and enzyme are combined in a ratio of 1: 1: 1) Specific brown sugar extract 0.01% by weight Specific pentagon extract 0.01 enzyme ( Papain) 0.01 Stearic acid 5.00 Glycerin 6.0 Polyoxyethylene monolaurate 3.0 1.3 Butylene glycol 10.00 Lanolin derivative 2.0 Propylene glycol 10.0 Dense wax 3.0 Cetanol 6. 0 Squalane 8.0 Fragrance 0.5 Purified water 46.47

(Effects of Use of Example) Everyday, stain on skin,
Twenty women with dull skin and rough skin were selected to use this cream twice a day before breakfast and before going to bed. One month later, the effect was investigated. The survey results are shown in Tables 1 and 2.

The evaluation criteria were divided into the following five stages according to the degree of symptoms, and the degree of improvement was judged by the degree of the increase in the evaluation stage before and after use, and is shown in Tables 3 and 4.

(Evaluation Criteria) Stain 5. The face is clearly stained and its color is dark. 4. You can see clear spots on the face, but they are not noticeable if you apply makeup. 3. There is a spot on the face, but the outline is not so clear. 2. I have spots on my face but I don't know unless I look closely. 1. I can hardly see the face stains.

Kusumi 5. Dark wrinkles spread over the skin and the entire face and are clearly visible. 4. The skin and face are firm and dark, with dark spots. 3. I'm worried that the skin remains around my face, especially around my eyes. 2. There are dark spots around my eyes and around my face, but I can't tell unless I look closely. 1. Kusumi is almost invisible on the skin and face.

Rough skin 5. The skin looks dull and the makeup is not applied. 4. The skin is not shiny and the makeup is not very good. 3. The gloss of the skin is not particularly good or bad. 2. Skin color and make-up are getting better. 1. The skin is irritated, the face is brighter, the makeup is better, and it spreads well.

[0021]

[Test Examples] In order to clarify the effect of the present invention on suppressing the onset of allergic diseases, test examples are described below, and the test results are shown in Table 5. Or Table 6. Shown in (Test Example) Using a Wistar rat, the intraperitoneal polynuclear leukocytes of the rat were subjected to HEPS-saline buffer (pH 7.0).
Washed in 4), suspended in the same buffer and subjected to ultrasonic treatment, were used as an oxygen solution for arachidonic acid metabolism. Samples of this platelet pomodinate, baicalein, and baicalein were adjusted in various ways as shown in the table, respectively, and kept at 37 ° C. for 5 minutes. Thereafter, [ ^1-14C ] arachidonic acid (0.05
μCi) was added and incubated for 5 minutes. After the end,
The reaction was stopped with formic acid (pH 3), and arachidonic acid metabolites were extracted with ethyl acetate and separated and quantified by silica gel thin layer chromatography (TLC). (Developing liquid: petroleum ether: ether: acetic acid = 50: 50: 1, V / V, TL
C is Merck 5748). The radioactive substance was detected by autoradiography, the spot was cut out, and the radioactivity was quantified with a liquid scintillation counter. In addition,
12-Hydroxyheptadecatrienoic acid (HHT) shown in Tables 5 and 6 is metabolized via cyclooxygenase, while the other is 5-hydroxyeicosatetraenoic acid (5-HET) which is metabolized via lipoxygenase.
E). HHT was identified by comparison with known HHT, and 5-HETE was identified by GC-MS.

[0022]

[Effects of the Invention in the Examples and Test Examples] As is clear from the above Examples and Test Examples, a cosmetic comprising the specific brown sugar extract and the specific Japanese goug extract, the enzyme and / or the yeast extract according to the present invention as essential components. The additive composition has a remarkable effect on improving skin spots, dark spots, rough skin, and the like, and also has an effect of suppressing the onset of allergy.

[Table 1]

[Table 2]

[Table 3]

[Table 4]

[Table 5]

[Table 6]

Claims (2)

[Claims] [1] A cosmetic composition comprising a brown sugar extract, a gougon extract, an enzyme and / or yeast as essential components. 2. The brown sugar extract is a specific brown sugar extract (brown sugar oligo) which is a phenylglucose compound, and the orchid extract is an orgon (koganebana: cu).
tellaria baicalensis GEOR
Baicalin extracted from GI)
And / or baicalein-containing extract, wherein the enzyme is papain, and the yeast extract is a hydrolytic yeast extract (Saccharomyces) based on Saccharomyces.
2. The cosmetic composition according to claim 1, wherein the cosmetic composition is a yeast extract.