JPH10152428A - Skin preparation for external use - Google Patents
Skin preparation for external useInfo
- Publication number
- JPH10152428A JPH10152428A JP8325975A JP32597596A JPH10152428A JP H10152428 A JPH10152428 A JP H10152428A JP 8325975 A JP8325975 A JP 8325975A JP 32597596 A JP32597596 A JP 32597596A JP H10152428 A JPH10152428 A JP H10152428A
- Authority
- JP
- Japan
- Prior art keywords
- extract
- oil
- skin
- external preparation
- group
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Landscapes
- Cosmetics (AREA)
- Medicines Containing Plant Substances (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
Description
【０００１】[0001]
【発明の属する技術分野】本発明は皮膚外用剤に関す
る。更に詳しくは、荒れ肌改善効果に優れ、かつ低温安
定性にも優れた皮膚外用剤に関する。The present invention relates to an external preparation for skin. More specifically, the present invention relates to an external preparation for skin which has an excellent effect of improving rough skin and has excellent low-temperature stability.
【０００２】[0002]
【従来の技術および発明が解決しようとする課題】尿素
を配合した皮膚外用剤は塗布後、皮膚の水分含量を増加
させる作用を持ち、そのことにより荒れ肌を改善する効
果がある。しかしながら、尿素は乳化物中では安定性が
悪く、製剤化が困難である。これまでにも、尿素を有効
成分とする皮膚外用剤として高級脂肪酸をアルカリで中
和することによる石鹸乳化製剤が提案されている（特開
昭６２−０００７号公報）。2. Description of the Related Art A skin external preparation containing urea has an effect of increasing the moisture content of the skin after application, and has an effect of improving rough skin. However, urea has poor stability in emulsions and is difficult to formulate. A soap emulsifying preparation prepared by neutralizing a higher fatty acid with an alkali has been proposed as an external preparation for skin containing urea as an active ingredient (JP-A-62-0007).
【０００３】しかし、石鹸乳化製剤は室温以下の温度に
おいて、経時的に結晶が析出し易く、このため外観が悪
くなる、感触も悪くなるなどの欠点が生じてくる。本発
明は、このような実情からみてなされたものであって、
優れた荒れ肌改善効果を持つと共に、かつ低温安定性に
も優れた皮膚外用剤を提供することを目的とするもので
ある。[0003] However, in a soap emulsion preparation, crystals tend to precipitate with the lapse of time at a temperature lower than room temperature, so that defects such as poor appearance and poor touch are caused. The present invention has been made in view of such circumstances,
It is an object of the present invention to provide an external preparation for skin that has an excellent effect of improving rough skin and has excellent low-temperature stability.
【０００４】[0004]
【課題を解決するための手段】上記の目的を達成するた
めに、本発明の皮膚外用剤は次のような構成をとる。す
なわち、「（ａ）尿素を必須成分とし、（ｂ）高級脂肪
酸、高級アルコール、有機アミンと、（ｃ）オリーブ
油、マカデミアナッツ油、オリーブスクワラン、ホホバ
油、ヒマシ油、紅花油、ヒマワリ油の群から選ばれる植
物油の一種または二種以上と、（ｄ）多価アルコール
と、（ｅ）桃、アロエ、カミツレ、ハイビスカス、セー
ジ、ビワ、キュウカンバー、セイヨウキズタ、ウコン、
スギナ、ローズマリー、ニンジン、茶、シャクヤク、セ
ンブリ、ヘチマ、カノコソウ、オウゴン、ゲンチアナ、
ゲンノショウコ、ゴボウ、サンザシ、シイタケ、ソウハ
クヒ、タイソウ、チンピ、トウキ、ブクリョウ、マツカ
サ、ヨクイニン、シナノキ、シラカバ、、オレンジ、ト
ウキンセンカ、トマト、ヘンナ、ボダイジュ、ホップ、
ユリ、リンゴ、ローズマリーの群から選ばれる植物抽出
物の一種または二種以上を含有する」ことを特徴とする
皮膚外用剤である。Means for Solving the Problems In order to achieve the above object, the external preparation for skin of the present invention has the following constitution. That is, "from the group of (a) urea as an essential component, (b) higher fatty acids, higher alcohols, organic amines, and (c) olive oil, macadamia nut oil, olive squalane, jojoba oil, castor oil, safflower oil, sunflower oil. One or more selected vegetable oils, (d) a polyhydric alcohol, and (e) peach, aloe, chamomile, hibiscus, sage, loquat, cucumber, edible turmeric, turmeric,
Horsetail, rosemary, carrot, tea, peonies, assembly, loofah, valerian, ogon, gentian,
Gennoshoko, burdock, hawthorn, shiitake mushroom, somakuhaku, daisy, chimpanzee, touki, bakuryo, matsukasa, yokunin, linden, birch, orange, toukinsenka, tomato, henna, bodaiju, hop,
It contains one or more plant extracts selected from the group consisting of lilies, apples, and rosemaries. "
【０００５】[0005]
【０００６】以下、本発明の実施の形態を詳述する。Hereinafter, embodiments of the present invention will be described in detail.
【０００７】本発明の皮膚外用剤に用いられる尿素の配
合量は、外用剤（組成物）の総量を基準として０．１〜
２０重量％（以下、ｗｔ％と略す）である。[0007] The amount of urea used in the external preparation for skin of the present invention is from 0.1 to 0.1 based on the total amount of the external preparation (composition).
20% by weight (hereinafter abbreviated as wt%).
【０００８】本発明の皮膚外用剤に用いられる高級脂肪
酸としては、ステアリン酸、イソステアリン酸、オレイ
ン酸、ミリスチン酸が挙げられる。高級脂肪酸の配合量
は、外用剤（組成物）の総量を基準として０．０１〜５
ｗｔ％である。The higher fatty acids used in the external preparation for skin of the present invention include stearic acid, isostearic acid, oleic acid and myristic acid. The blending amount of the higher fatty acid is 0.01 to 5 based on the total amount of the external preparation (composition).
wt%.
【０００９】本発明の皮膚外用剤に用いられる高級アル
コールとしては、セチルアルコール、セトステアリルア
ルコールが挙げられる。高級アルコールの配合量は、外
用剤（組成物）の総量を基準として０．０１〜８ｗｔ％
である。The higher alcohol used in the external preparation for skin of the present invention includes cetyl alcohol and cetostearyl alcohol. The blending amount of the higher alcohol is 0.01 to 8% by weight based on the total amount of the external preparation (composition).
It is.
【００１０】本発明の皮膚外用剤に用いられる有機アミ
ンとしては、トリエタノールアミン、ジイソプロパノー
ルアミンが挙げられる。有機アミンの配合量は、外用剤
（組成物）の総量を基準として０．０５〜５ｗｔ％であ
る。The organic amine used in the external preparation for skin of the present invention includes triethanolamine and diisopropanolamine. The compounding amount of the organic amine is 0.05 to 5 wt% based on the total amount of the external preparation (composition).
【００１１】本発明の皮膚外用剤に用いられる植物油と
しては、オリーブ油、マカデミアナッツ油、オリーブス
クワラン、ホホバ油、ヒマシ油、紅花油、ヒマワリ油が
挙げられ、これらは一種または二種以上を含有すること
ができる。植物油の配合量は、外用剤（組成物）の総量
を基準として０．１〜１０ｗｔ％である。The vegetable oil used in the external preparation for skin of the present invention includes olive oil, macadamia nut oil, olive squalane, jojoba oil, castor oil, safflower oil, and sunflower oil. Can be. The blending amount of the vegetable oil is 0.1 to 10% by weight based on the total amount of the external preparation (composition).
【００１２】本発明の皮膚外用剤に用いられる多価アル
コールとしては、ジプロピレングリコール、１，３−ブ
チレングリコール、グリセリンが挙げられる。多価アル
コールの配合量は、外用剤（組成物）の総量を基準とし
て１０〜３０ｗｔ％である。この範囲であると、低温安
定性が充分に得られる。The polyhydric alcohol used in the external preparation for skin of the present invention includes dipropylene glycol, 1,3-butylene glycol and glycerin. The blending amount of the polyhydric alcohol is 10 to 30% by weight based on the total amount of the external preparation (composition). Within this range, sufficient low-temperature stability can be obtained.
【００１３】本発明の皮膚外用剤に用いられる、桃、ア
ロエでは葉、カミツレ、ハイビスカスでは花、セージは
全草、ビワは葉、キュウカンバーはキュウリの果実、セ
イヨウキズタは茎及び葉、ウコンは根及び茎、スギナは
全草、ローズマリーは葉または花、ニンジンは根、茶は
葉または実、シャクヤクは根、センブリは全草、ヘチマ
は地上部、カノコソウは根、オウゴンはコガネバナの
根、ゲンチアナは根及び根茎、ゲンノショウコは地上
部、ゴボウは根、サンザシは花・葉・実、シイタケは地
上部、ソウハクヒは桑の根、タイソウは果実、チンピは
ミカンの果皮、トウキは根、ブクリョウは菌核、マツカ
サは球果、ヨクイニンは種子、シナノキは花または葉、
シラカバは葉・芽・樹皮、オレンジは果実、トウキンセ
ンカは花、トマトは果実、ヘンナは葉及び幹、ボダイジ
ュは花、ホップは雌花穂果、ユリは球根、リンゴは果
実、ローズマリーは葉または花を、多価アルコール、ア
ルコール、水またはそれらの混合溶媒を用いて熱抽出し
たものであり、これらの群から選ばれる植物抽出物の一
種または二種以上を含有することができる。植物抽出物
の配合量は、外用剤（組成物）の総量を基準として、溶
媒を除いた蒸発残留物換算で、０．０００１〜５．０ｗ
ｔ％である。これらの内で、多価アルコールを用いて抽
出したものが好ましい。その理由として、抽出されたエ
キス中の成分量はごく微量であるが、植物抽出物本来の
効果・作用の他に、上記多価アルコールと同一の効果を
現し、低温安定性も得られる。Peach, aloe leaves, chamomile and hibiscus flowers, sage is whole plant, loquat is leaf, cucumber is cucumber fruit, eucalyptus is stem and leaf, and turmeric is used in the skin external preparation of the present invention. Roots and stems, horsetail is whole plant, rosemary is leaf or flower, carrot is root, tea is leaf or fruit, peonies are root, assembly is whole plant, loofah is above ground, valerian root, ogon is root of koganebana, Gentians are roots and rhizomes, genoshoes are above-ground parts, burdock is roots, hawthorn is flowers / leaves / fruits, shiitake is above-ground parts, soybean mushrooms are mulberry roots, daisies are fruits, chimpis are peels of mandarin, tokyo are roots, and bokuryou are Sclerotium, pine cone, cones, yoquinin seeds, linden flowers or leaves,
Birch is a leaf, bud, bark, orange is a fruit, calendula is a flower, tomato is a fruit, henna is a leaf and a stem, bodhiju is a flower, hop is a female ear, lily is a bulb, apple is a fruit, rosemary is a leaf or The flower is obtained by heat extraction using polyhydric alcohol, alcohol, water or a mixed solvent thereof, and may contain one or more plant extracts selected from these groups. The amount of the plant extract is 0.0001 to 5.0 w in terms of evaporation residue excluding the solvent, based on the total amount of the external preparation (composition).
t%. Among them, those extracted using a polyhydric alcohol are preferred. The reason for this is that although the amount of components in the extracted extract is very small, it exhibits the same effects as the above-mentioned polyhydric alcohols in addition to the inherent effects and actions of the plant extract, and also provides low-temperature stability.
【００１４】本発明の皮膚外用剤は、例えば、ローショ
ン類，乳液類，クリーム類，パック類等に適用すること
ができる。なお、本発明の皮膚外用剤には上記の他に流
動パラフィンなどの液状油、油脂類、色素、香料、防腐
剤、界面活性剤、ビタミン類、アミノ酸、顔料、抗酸化
剤等を本発明の目的を達成する範囲内で適宜配合するこ
とができる。The external preparation for skin of the present invention can be applied to, for example, lotions, emulsions, creams, packs and the like. The external preparation for skin of the present invention includes liquid oils such as liquid paraffin, oils and fats, pigments, fragrances, preservatives, surfactants, vitamins, amino acids, pigments, antioxidants and the like in addition to the above. It can be appropriately blended within the range for achieving the object.
【００１５】[0015]
【実施例】以下、実施例及び比較例に基づいて本発明を
詳細に説明する。なお、実施例に記載の低温安定性測
定方法、荒れ肌改善効果の測定試験法は下記の通りで
ある。The present invention will be described below in detail based on examples and comparative examples. In addition, the low-temperature stability measurement method and the measurement test method of the rough skin improvement effect described in the examples are as follows.
【００１６】低温安定性測定方法 サンプルをガラス瓶に充填し、０℃の恒温槽で１カ月保
存後の状態を、目視により下記の判定基準で判定した。 − ：正常 ＋ ：乳化状態悪化、析出ありLow Temperature Stability Measurement Method A sample was filled into a glass bottle, and the state after storage in a thermostat at 0 ° C. for one month was visually judged according to the following criteria. -: Normal +: Deterioration of emulsified state, with precipitation
【００１７】荒れ肌改善効果の測定試験法 下脚に荒れ肌を持つ中高年被験者２０名を対象として４
週間連続塗布効果を調べた。被験者の左側脚試験部位に
１日２回約１g の試料を塗布し、試験開始前および終了
後の皮膚の状態を、目視により下記の判定基準で判定し
た。右側下脚は試料を塗布せず対照とした。 皮膚乾燥度の判定基準 − ：正常 ± ：軽微乾燥、落屑なし ＋ ：乾燥、落屑軽度 ＋＋ ：乾燥、落屑中等度 ＋＋＋：乾燥、落屑顕著 試験前後の試験部位と対照部位の判定結果を比較し、皮
膚乾燥度が２段階以上改善された場合（例えば＋→−，
＋＋→±）を「有効」、１段階改善された場合を「やや
有効」、変化がなかった場合を「無効」とした。試験結
果は「有効」、「やや有効」となった被験者の人数で示
した。Measurement Test Method for Improving Rough Skin Efficacy For 20 middle-aged subjects with rough skin on lower legs
Weekly continuous application effect was examined. About 1 g of the sample was applied to the test site of the left leg of the subject twice a day, and the condition of the skin before and after the start of the test was visually judged according to the following criteria. The lower right leg served as a control without the application of the sample. Evaluation criteria for skin dryness −: Normal ±: Slightly dry, no desquamation +: Dry, desquamation mild ++: Dry, moderate desquamation +++: Dry, desquamation remarkable Compare the test results before and after the test with the control site, When the skin dryness is improved by two or more steps (for example, + →-,
++ → ±) was regarded as “valid”, the case where the signal was improved by one step was “slightly valid”, and the case where there was no change was “invalid”. The test results were indicated by the number of subjects who became “effective” and “slightly effective”.
【００１８】実施例１〜３、比較例１〜４［スキンクリ
ーム］Examples 1-3, Comparative Examples 1-4 [Skin cream]
【００１９】尿素、ステアリン酸、セチルアルコール、
トリエタノールアミン、オリーブスクワラン、１，３−
ブチレングリコール及び３０重量／容量％（以下、ｗ／
ｖ％と略す）１，３−ブチレングリコール水溶液により
抽出された、蒸発残留物換算で１．７ｗｔ％の桃の葉抽
出物を表１に記載の通りに配合し、下記の組成で各々の
スキンクリームを調製し、前記の諸実験を実施した。Urea, stearic acid, cetyl alcohol,
Triethanolamine, olive squalane, 1,3-
Butylene glycol and 30% w / v (hereinafter referred to as w /
v%), a peach leaf extract of 1.7 wt% in terms of evaporation residue extracted with an aqueous solution of 1,3-butylene glycol was blended as shown in Table 1, and each skin had the following composition. A cream was prepared and the above experiments were performed.
【００２０】（１）組成(1) Composition
【００２１】[0021]
【表１】 [Table 1]
【００２２】（２）調製法 （Ａ）成分及び（Ｂ）成分を各々８０℃に加熱溶解した
後、混合して、攪拌しつつ３０℃迄冷却して各スキンク
リームを調製した。(2) Preparation Method Components (A) and (B) were each heated and dissolved at 80 ° C., mixed, and cooled to 30 ° C. with stirring to prepare each skin cream.
【００２３】（３）特性 各スキンクリームの諸試験を実施した結果を、表１に併
せて記載した。表１に示すように、比較例１〜４のスキ
ンクリームは諸特性において充分なる効果は得られなか
った。これに対し、本発明の実施例１〜３のスキンクリ
ームは諸特性において顕著な効果が見られ、荒れ肌改善
試験では試料塗布後１〜２ケ月で優れた美肌効果を示し
た。また、桃の葉１，３−ブチレングリコール抽出物の
配合量が増すと、荒れ肌が改善された人数が増えたこと
は、抽出物中の成分の効果によることが示唆された。(3) Characteristics The results of various tests performed on each skin cream are shown in Table 1. As shown in Table 1, the skin creams of Comparative Examples 1 to 4 did not provide sufficient effects in various properties. On the other hand, the skin creams of Examples 1 to 3 of the present invention showed remarkable effects in various properties, and showed an excellent skin effect 1 to 2 months after application of the sample in the rough skin improvement test. In addition, it was suggested that an increase in the amount of the peach leaf 1,3-butylene glycol extract increased the number of persons with improved rough skin due to the effect of the components in the extract.
【００２４】実施例４〜６〔スキンクリーム〕 ３０ｗ／ｖ％１，３−ブチレングリコール水溶液により
抽出された、蒸発残留物換算で１．５ｗｔ％のハイビス
カス抽出物及び原料成分を表２に記載の通り配合し、実
施例１〜３と同様の調製法で各々のスキンクリームを作
り、前記荒れ肌改善効果を試験した。Examples 4 to 6 [Skin cream] A hibiscus extract of 1.5 wt% in terms of evaporation residue extracted with a 30 w / v% aqueous 1,3-butylene glycol solution and raw material components are shown in Table 2. Each skin cream was prepared by the same preparation method as in Examples 1 to 3, and the effect of improving the rough skin was tested.
【００２５】[0025]
【表２】 [Table 2]
【００２６】各スキンクリームの諸試験を実施した結果
を、表２に併せて記載した。表２に示すように、本発明
の実施例４〜６のスキンクリームは、試料塗布後１〜２
ケ月で優れた荒れ肌改善効果を示した。ハイビスカス抽
出物が桃の葉抽出物と同様に、優れた荒れ肌改善効果を
示したことは、本発明の必須成分である尿素との相乗効
果と相まって、荒れ肌改善効果をより強調したことが示
唆される。The results of various tests conducted on each skin cream are also shown in Table 2. As shown in Table 2, the skin creams of Examples 4 to 6 of the present invention were obtained after the sample was applied.
It showed an excellent effect of improving rough skin in a month. The fact that the hibiscus extract exhibited an excellent rough skin improving effect similarly to the peach leaf extract suggests that the synergistic effect with urea, which is an essential component of the present invention, further emphasized the rough skin improving effect. You.
【００２７】[0027]
【発明の効果】以上記載のように、本発明が、荒れ肌改
善効果に優れ、かつ低温安定性にも優れた皮膚外用剤を
提供することは明らかである。As described above, it is apparent that the present invention provides an external preparation for skin which is excellent in improving rough skin and also excellent in low-temperature stability.
───────────────────────────────────────────────────── フロントページの続き (51)Int.Cl.6 識別記号 ＦＩ Ａ６１Ｋ 35/78 Ａ６１Ｋ 35/78 Ｈ Ｃ ──────────────────────────────────────────────────続 き Continued on the front page (51) Int.Cl. 6 Identification code FI A61K 35/78 A61K 35/78 HC
Claims (1)
脂肪酸、高級アルコール、有機アミンと、（ｃ）オリー
ブ油、マカデミアナッツ油、オリーブスクワラン、ホホ
バ油、ヒマシ油、紅花油、ヒマワリ油の群から選ばれる
植物油の一種または二種以上と、（ｄ）多価アルコール
と、（ｅ）桃、アロエ、カミツレ、ハイビスカス、セー
ジ、ビワ、キュウカンバー、セイヨウキズタ、ウコン、
スギナ、ローズマリー、ニンジン、茶、シャクヤク、セ
ンブリ、ヘチマ、カノコソウ、オウゴン、ゲンチアナ、
ゲンノショウコ、ゴボウ、サンザシ、シイタケ、ソウハ
クヒ、タイソウ、チンピ、トウキ、ブクリョウ、マツカ
サ、ヨクイニン、シナノキ、シラカバ、、オレンジ、ト
ウキンセンカ、トマト、ヘンナ、ボダイジュ、ホップ、
ユリ、リンゴ、ローズマリーの群から選ばれる植物抽出
物の一種または二種以上を含有することを特徴とする皮
膚外用剤。1. An essential component of (a) urea, (b) higher fatty acids, higher alcohols and organic amines, and (c) olive oil, macadamia nut oil, olive squalane, jojoba oil, castor oil, safflower oil, sunflower oil. One or more vegetable oils selected from the group, (d) a polyhydric alcohol, and (e) peach, aloe, chamomile, hibiscus, sage, loquat, cucumber, eucalyptus, turmeric,
Horsetail, rosemary, carrot, tea, peonies, assembly, loofah, valerian, ogon, gentian,
Gennoshoko, burdock, hawthorn, shiitake mushroom, somakuhashi, daisy, chimpanzee, touki, bakuryo, matsukasa, yokuninin, linden, birch, orange, toukinsenka, tomato, henna, bodaiju, hop,
An external preparation for skin, comprising one or more plant extracts selected from the group consisting of lilies, apples and rosemary.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP32597596A JP4083831B2 (en) | 1996-11-20 | 1996-11-20 | Skin preparation |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP32597596A JP4083831B2 (en) | 1996-11-20 | 1996-11-20 | Skin preparation |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPH10152428A true JPH10152428A (en) | 1998-06-09 |
| JP4083831B2 JP4083831B2 (en) | 2008-04-30 |
Family
ID=18182689
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP32597596A Expired - Lifetime JP4083831B2 (en) | 1996-11-20 | 1996-11-20 | Skin preparation |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JP4083831B2 (en) |
Cited By (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2147161A1 (en) * | 1999-01-26 | 2000-08-16 | Solano Jose Sanmartin | Skin burn treatment composition consists of virgin olive oil and alcohol with addition of rosemary |
| JP2000319122A (en) * | 1999-04-30 | 2000-11-21 | Zenzaburo Hara | Cell proliferation promoting cosmetic |
| FR2829694A1 (en) * | 2001-09-14 | 2003-03-21 | Jacques Andhrel | Cosmetic antiradical compositions useful for skin care comprise hibiscus, may lily and jujube extracts |
| ES2187253A1 (en) * | 2001-11-05 | 2003-05-16 | Talamillo M Angeles Cuetara | Pomade is for burns, herpes, eczema and other cutaneous affections and is based on leaves of male ivy of which 100 grams are poured into recipient of boiling olive oil whose contents are one deciliter |
| EP1319396A1 (en) * | 2001-12-17 | 2003-06-18 | ZECA S.r.l. | Cosmetic bath composition based on herbs and a foaming agent, and packaging containing the said composition |
| KR100426265B1 (en) * | 2000-01-06 | 2004-04-13 | 김용준 | salt of rosemary |
| WO2005027949A1 (en) * | 2003-09-17 | 2005-03-31 | Lequio Fharma Co., Ltd. | Turmeric-containing composition |
| JP2006290766A (en) * | 2005-04-07 | 2006-10-26 | Lucia:Kk | Hair-fostering/growing agent |
| JP2006290767A (en) * | 2005-04-07 | 2006-10-26 | Lucia:Kk | Hair-fostering/growing agent |
| US7270835B2 (en) | 2001-06-20 | 2007-09-18 | Metaproteomics, Llc | Compositions that treat or inhibit pathological conditions associated with inflammatory response |
| US7332185B2 (en) | 2001-06-20 | 2008-02-19 | Metaproteomics, Llc | Complex mixtures exhibiting selective inhibition of cyclooxygenase-2 |
| US7718198B2 (en) | 2001-06-20 | 2010-05-18 | Metaproteomics, Llc | Treatment modalities for autoimmune diseases |
| US7919125B2 (en) * | 2001-06-20 | 2011-04-05 | Metaproteomics, Llc | Modulation of inflammation by hops fractions and derivatives |
| US8142819B2 (en) * | 2002-10-21 | 2012-03-27 | Metaproteomics, Llc | Synergistic compositions that treat or inhibit pathological conditions associated with inflammatory response |
| US8158160B2 (en) | 2001-11-13 | 2012-04-17 | Eric Hauser Kuhrts | Anti-inflammatory cyclooxygenase inhibitors |
| WO2012058711A2 (en) * | 2010-11-02 | 2012-05-10 | Maureen Patricia Macnicol | Composition |
| WO2021182419A1 (en) | 2020-03-09 | 2021-09-16 | 高砂香料工業株式会社 | Ceramide growth promoting agent |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS5913709A (en) * | 1982-07-16 | 1984-01-24 | Lion Corp | Moisturizer |
| JPS649908A (en) * | 1987-07-02 | 1989-01-13 | Kao Corp | Cosmetic, cosmetic set and make-up method |
| JPH02243632A (en) * | 1989-03-16 | 1990-09-27 | Ichimaru Pharcos Co Ltd | Peroxide lipid formation inhibitor comprising vegetable oil extract |
-
1996
- 1996-11-20 JP JP32597596A patent/JP4083831B2/en not_active Expired - Lifetime
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS5913709A (en) * | 1982-07-16 | 1984-01-24 | Lion Corp | Moisturizer |
| JPS649908A (en) * | 1987-07-02 | 1989-01-13 | Kao Corp | Cosmetic, cosmetic set and make-up method |
| JPH02243632A (en) * | 1989-03-16 | 1990-09-27 | Ichimaru Pharcos Co Ltd | Peroxide lipid formation inhibitor comprising vegetable oil extract |
Cited By (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2147161A1 (en) * | 1999-01-26 | 2000-08-16 | Solano Jose Sanmartin | Skin burn treatment composition consists of virgin olive oil and alcohol with addition of rosemary |
| JP2000319122A (en) * | 1999-04-30 | 2000-11-21 | Zenzaburo Hara | Cell proliferation promoting cosmetic |
| KR100426265B1 (en) * | 2000-01-06 | 2004-04-13 | 김용준 | salt of rosemary |
| US7270835B2 (en) | 2001-06-20 | 2007-09-18 | Metaproteomics, Llc | Compositions that treat or inhibit pathological conditions associated with inflammatory response |
| US7919125B2 (en) * | 2001-06-20 | 2011-04-05 | Metaproteomics, Llc | Modulation of inflammation by hops fractions and derivatives |
| US7718198B2 (en) | 2001-06-20 | 2010-05-18 | Metaproteomics, Llc | Treatment modalities for autoimmune diseases |
| US7431948B2 (en) | 2001-06-20 | 2008-10-07 | Metaproteomics, Llc | Compositions that treat or inhibit pathological conditions associated with inflammatory response |
| US7332185B2 (en) | 2001-06-20 | 2008-02-19 | Metaproteomics, Llc | Complex mixtures exhibiting selective inhibition of cyclooxygenase-2 |
| FR2829694A1 (en) * | 2001-09-14 | 2003-03-21 | Jacques Andhrel | Cosmetic antiradical compositions useful for skin care comprise hibiscus, may lily and jujube extracts |
| ES2187253A1 (en) * | 2001-11-05 | 2003-05-16 | Talamillo M Angeles Cuetara | Pomade is for burns, herpes, eczema and other cutaneous affections and is based on leaves of male ivy of which 100 grams are poured into recipient of boiling olive oil whose contents are one deciliter |
| US8158160B2 (en) | 2001-11-13 | 2012-04-17 | Eric Hauser Kuhrts | Anti-inflammatory cyclooxygenase inhibitors |
| US8846115B2 (en) | 2001-11-13 | 2014-09-30 | Metaproteomics, Inc. | Anti-inflammatory cyclooxygenase inhibitors |
| US6800597B2 (en) | 2001-12-17 | 2004-10-05 | Zeca S.R.L. | Cosmetic bath composition based on herbs and a foaming agent, and packaging containing the said composition |
| EP1319396A1 (en) * | 2001-12-17 | 2003-06-18 | ZECA S.r.l. | Cosmetic bath composition based on herbs and a foaming agent, and packaging containing the said composition |
| US8142819B2 (en) * | 2002-10-21 | 2012-03-27 | Metaproteomics, Llc | Synergistic compositions that treat or inhibit pathological conditions associated with inflammatory response |
| WO2005027949A1 (en) * | 2003-09-17 | 2005-03-31 | Lequio Fharma Co., Ltd. | Turmeric-containing composition |
| JP2006290767A (en) * | 2005-04-07 | 2006-10-26 | Lucia:Kk | Hair-fostering/growing agent |
| JP2006290766A (en) * | 2005-04-07 | 2006-10-26 | Lucia:Kk | Hair-fostering/growing agent |
| WO2012058711A2 (en) * | 2010-11-02 | 2012-05-10 | Maureen Patricia Macnicol | Composition |
| WO2012058711A3 (en) * | 2010-11-02 | 2012-11-29 | Maureen Patricia Macnicol | Composition comprising macadamia and calendula for promoting hair growth |
| WO2021182419A1 (en) | 2020-03-09 | 2021-09-16 | 高砂香料工業株式会社 | Ceramide growth promoting agent |
Also Published As
| Publication number | Publication date |
|---|---|
| JP4083831B2 (en) | 2008-04-30 |
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