JPH0987148A - Hair growing composition - Google Patents

Abstract

PROBLEM TO BE SOLVED: To obtain a composition excellent in hair growing effect. SOLUTION: This hair growing composition is obtained by blending 0.001-10% minoxidil with an extract of Jatova (a leguminous plant, Hymenaea courbaril) and/or an extract of Betula in an amount of 0.001-10% expressed in terms of dried solid material. The minoxidil has a chemical name of 2,4-diamino-6- piperidinopyrimidine-3-oxide and is commercialized as an agent for treating hypertension and hirsutism phenomenon is known as adverse effect of minoxidil. Jatova is Hymenaea courbaril which is a leguminous plant grown in Brazil and Betula is Betula alnoides which is a betulaceous plant grown in Thailand. These crude medicines are each used by extracting these plants with an aqueous or organic solvent (e.g. ethanol). These crude medicines are each blended with a base such as lotion, tonic, cream, ointment or aerosol and the resultant preparation is used by applying to scalp once or several times daily.

Description

Detailed Description of the Invention

[0001]

TECHNICAL FIELD The present invention relates to a hair-growing composition, and more particularly, to hair-growing by using minoxidil in combination with an extract of the Brazilian drug Jatoba and / or a Thai drug Vetula. The present invention relates to a hair growth composition having an enhanced effect.

[0002]

2. Description of the Related Art In recent years, there has been growing interest in hair, and along with this, it is said that more than 100 kinds of hair growth agents such as hair agents, hair growth agents and hair nourishing agents are commercially available. The hair-growth agent can be used for assisting hair growth in androgenetic alopecia and various alopecia.

Conventionally, as one of the causes of male pattern baldness, an excessive action of male hormone has been mentioned. Especially,
It is known that the main body of androgen activity in organs such as hair roots and sebaceous glands is 5α-dihydrotestosterone produced by reducing testosterone by testosterone-5α-reductase in these target organs. Therefore, various studies have been conducted on naturally-occurring substances having an inhibitory action on testosterone-5α-reductase (JP-A-3-188013, JP-A-4-18026, JP-A-4-308523, JP-A-4-330008, JP-A-4-342
535, etc.). Japanese Patent Application No. 6-92820 describes that Brazil-produced drug Jatoba and Thai-produced drug Vetula have a testosterone-5α-reductase inhibitory action.

On the other hand, minoxidil, which has a chemical name of 2,4-diamino-6-piperidinopyrimidine-3-oxide, is used as a therapeutic agent for hypertension by oral administration due to its remarkable vasodilating effect, but side effects. It is known that the phenomenon of hirsutism occurs. From this finding, it has been reported that topical application of minoxidil externally is effective in treating hair loss (J. ROYAL. So.
c. Med. , Vol. 75, p963, (198
2), British Med. J. , Vol. 28
7, p1015, (1983), J. Invest. D
ermatol. , Vol. 82, p515, (198
4), J. Invest. Dermatol. , Vo
l. 82, p90, (1984)).

[0005]

However, when minoxidil is used as a hair-growth agent, the larger the amount is, the greater the hair-growth effect is, but when used in a large amount, side effects such as skin irritation may occur. Therefore, it has been desired to develop a composition having a small amount of minoxidil and having an excellent hair-growth effect.

[0006]

[Means for Solving the Problems] As a result of intensive studies to solve the above problems, the present inventors have found that minoxidil and an extract of Brazilian crude drug Jatoba and / or an extract of Thai crude drug Vetula. The inventors have found that the hair growth effect is synergistically enhanced by the combined use of and, and completed the present invention.

Jatoba used in the present invention is a plant of the leguminous family Hymenaea cobalvalil.
urbaril). Vetula is a plant of the family Birchaceae, Bethula a
lnoides).

The extract used in the present invention can be obtained by extracting these crude drugs with an aqueous or organic solvent. The solvent used is not particularly limited as long as the active ingredient can be effectively extracted, but water,
Acetone or methanol, ethanol, propanol,
It is preferable to use lower alcohols such as isopropanol, butanol, pentanol and hexanol, or a mixed solution thereof, ethyl acetate and the like.

At the time of extraction, the crude drug can be obtained by directly extracting it with a solvent, but in order to improve extraction efficiency, it is preferable to cut these raw materials into fine pieces and then extract with a solution. The extraction is preferably carried out for 1 to 1 month, preferably 2 to 5 days, using 5 to 100 ml, preferably 10 to 20 ml of solvent for 1 g of the finely cut raw material.

If desired, the extract thus obtained is further subjected to means such as concentration, liquid-liquid partitioning, adsorption chromatography, normal phase or reverse phase chromatography in order to enhance the active ingredient in the extract. It is also possible.

The blending amount of these crude drug extracts in the hair restorer of the present invention is preferably determined in consideration of the dosage form, etc., but generally 0.001 to 10% in terms of dry solid matter,
Preferably 0.01 to 5% is blended.

On the other hand, minoxidil is usually used as a therapeutic agent for hypertension, but commercially available minoxidil (manufactured by Sigma) can be used in the present invention.

The blending amount of minoxidil in the hair restorer of the present invention is preferably determined in consideration of its dosage form and the like, but is generally 0.001 to 10%, preferably 0.01 to 10.
7% is blended.

The hair-growing agent containing the composition of the present invention is prepared according to a conventional method by blending with a usual external preparation for skin application, for example, a base such as lotion, tonic agent, cream, ointment, aerosol and the like. can do.

The hair-growth agent of the present invention is applied to the scalp once to several times a day for use.

[0016]

BEST MODE FOR CARRYING OUT THE INVENTION First, the extracts of Jatoba and Vetula used in the present invention are prepared. In the present invention, minoxidil used was manufactured by Sigma.

10 g of Jatoba (available from Brazilian crude drug dealer) was finely cut, 100 ml of 30% ethanol was added, and the mixture was extracted at room temperature for 48 hours. The solution was distilled off by concentration under reduced pressure from 91 ml of the extract obtained by removing the solid matter by filtration (extract 1) to obtain an extract. The extract yield was 1.00 g.

10 g of betula (available from Thai crude drug dealer) was finely cut, 100 ml of 50% ethanol was added, and the mixture was extracted at room temperature for 48 hours. The solution was distilled off by vacuum concentration from 90 ml of the extract obtained by removing the solid matter by filtration (extract 2) to obtain an extract. The yield of extract is
It was 1.13 g.

Next, in order to confirm the effect of the composition of the present invention, the hair growth effect is measured by the following method. C57BL
The back hair of the mouse is lightly shaved with an electric hair clipper, and then completely depilated with a depilatory cream. Each of the test substances shown in Table 1 was added to a 50% ethanol solution and applied daily from the day after the treatment, and the hair regrowth process was observed. Table 1 shows the ratio of regenerated hair on the 21st day after application.

[0020]

[Table 1]

Sample 1 was prepared by using only a 50% ethanol solution used as a solvent, and even if it was applied, no inhibitory effect on hair regrowth was observed.
When sample 2 is applied, the proportion of regenerated hair drops sharply.
The application of Sample 3 does not show a hair-growth effect.
This is probably because the amount of minoxidil added was small. It can be said that Sample 4 and Sample 5 have a hair-growth effect to some extent as compared with Sample 2, but they are not satisfactory. However, the mice coated with Sample 6 and Sample 7 showed excellent hair-growth effect. That is, it was confirmed that the hair-growth effect is enhanced by applying minoxidil together with the above crude drug extract.

Then, various hair restorers comprising the composition of the present invention were prepared. Example 1 Hair-Growing Agent (1) To 62.5 parts by weight of ethanol, 5 parts by weight of propylene glycol, 0.5 parts by weight of minoxidil, 10 parts by weight of Extract 1 and 22 parts by weight of purified water were added and dissolved by stirring to obtain a lotion type. A hair restorer was prepared.

Example 2 Hair Growth Agent (2) Carboxyvinyl polymer ( 0.1% ) was added to 47.7 parts by weight of purified water.
4 parts by weight were dispersed with stirring. To this, a solution prepared by stirring and dissolving 40 parts by weight of ethanol, 1 part by weight of propylene glycol, 5 parts by weight of glycerin, 0.5 parts by weight of minoxidil, 5 parts by weight of Extract 1, and 0.4 parts by weight of diisopropanolamine was added. Then, the mixture was stirred and mixed to prepare a gel type hair restorer.

Example 3 Hair Growth Agent (3) Polyoxyethylene (20) Sorbitan monostearate 5 parts by weight, sorbitan monostearate 3 parts by weight, cetanol 2 parts by weight, stearyl alcohol 2 parts by weight, liquid paraffin 10 parts by weight. The mixture was dissolved while heating.
Separately, 1 part by weight of minoxidil, 5 parts by weight of extract 1, 0.5 parts by weight of pantotenyl ethyl ether, 0.1 part by weight of methyl paraoxybenzoate, 1 part of propylene glycol.
A solution in which 0 parts by weight and 61.4 parts by weight of purified water were stirred and dissolved while heating was added, and the mixture was cooled to room temperature with stirring and mixing to prepare a cream type hair restorer.

Example 4 Hair Growth Agent (4) 0.5 parts by weight of minoxidil, 10 parts by weight of Extract 2, 5 parts by weight of propylene glycol, polyoxyethylene (2
0) 5 parts by weight of monooleate, 47.5 parts by weight of ethanol, and 28 parts by weight of purified water were dissolved by stirring. This liquid was put in an aerosol can and pressurized with 4 parts by weight of liquefied petroleum gas to prepare an aerosol type hair restorer.

Example 5 Hair-restoring agent (5) Carboxyvinyl polymer ( 0.1% ) was added to 48.7 parts by weight of purified water.
4 parts by weight were dispersed with stirring. To this, a solution prepared by stirring and dissolving 40 parts by weight of ethanol, 5 parts by weight of propylene glycol, 0.5 part by weight of minoxidil, 5 parts by weight of Extract 2 and 0.4 part by weight of diisopropanolamine was added, and the mixture was stirred and mixed. To prepare a gel type hair restorer.

Example 6 Hair Growth Agent (6) Minoxidil 0.5 part by weight, Extract 2 10 parts by weight,
1,3-butanediol 2 parts by weight, propylene glycol 4 parts by weight, polyoxyethylene (20) polyoxypropylene (6) decyl tetradecyl ether 3 parts by weight,
A lotion type hair restorer was prepared by dissolving 52.5 parts by weight of ethanol and 28 parts by weight of purified water with stirring.

[0028]

INDUSTRIAL APPLICABILITY Minoxidil, Jatoba extract and / or
Alternatively, by using the Vetula extract in combination, a hair growth composition having excellent effects can be provided.

Claims (1)

[Claims] 1. A hair-growth composition comprising the following components (A) and (B) (A) minoxidil (B) Jatoba extract and / or Vetula extract.