JPH0930943A - Composition for oral cavity - Google Patents

Abstract

PROBLEM TO BE SOLVED: To obtain a composition for the oral cavity, useful for preventing dental caries and periodontosis and causing a low level of discoloration with time. SOLUTION: This composition for the oral cavity is obtained by blending 0.1-20wt.% polyoxyethylene hardened castor oil and 0.01-2wt.% metallic salt of copper chlorophyllin (e.g. sodium copper chlorophyllin) in a composition for the oral cavity containing 0.001-5wt.% green tea extract. The green tea extract is prepared by pulverfzing a dried green tea leaf, extracting the pulverized and dried green tea leaf with water or an alcohol at ambient temperature, distilling away the solvent from the extract solution, then adding water thereto, dissolving the resultant residue, reextracting the obtained solution with a nonpolar organic solvent (e.g. ethyl acetate) and drying and powdering the resultant extract solution separated with the nonpolar organic solvent. Furthermore, usually used various additives are suitably blended therewith according to the kind of the composition for the oral cavity and prepared into a dentifrice, a mouthwash, a refreshing agent in the mouth, a troche, a pasta agent, a chewing gum, a candy, etc.

Description

Detailed Description of the Invention

[0001]

TECHNICAL FIELD The present invention relates to a stable oral composition which is effective for the prevention of dental caries and periodontal disease, and whose discoloration over time is suppressed.

[0002]

2. Description of the Related Art It is disclosed in JP-A-64-90124 that polyphenol compounds obtained from water or alcoholic extract of tea leaves have antibacterial activity against oral bacteria Streptococcus mutans. The oral composition containing the above extract is useful for the prevention of dental caries and periodontal disease, but such an oral composition tends to discolor over time, which is a drawback of impairing commercial value in appearance. There is.

[0003]

SUMMARY OF THE INVENTION An object of the present invention is to provide an oral composition which is useful for the prevention of dental caries and periodontal disease and has a low degree of discoloration over time.

[0004]

[Means for Solving the Problems] As a result of intensive studies conducted by the present inventors in order to achieve the above object, the composition for oral cavity containing the tea leaf extract was treated with polyoxyethylene hydrogenated castor oil and copper chlorophyllin. It has been found that by further blending a metal salt, it is possible to prevent discoloration over time without impairing the anti-caries and anti-periodontal disease effects of the above extract, and completed the present invention. Therefore, the present invention is an oral composition containing a tea leaf extract, which is characterized by containing polyoxyethylene hydrogenated castor oil and a metal salt of copper chlorophyllin. The oral composition described in the present specification is a dentifrice, mouthwash, mouth freshener, troche, pasta, chewing gum, candy, and the like, and their shapes are liquid, solid, powder and paste. It is in the form of gel, gel or the like and is not particularly limited.

[0005]

BEST MODE FOR CARRYING OUT THE INVENTION The tea leaf extract used in the present invention means a solvent (distilled water) extracted from a dried tea (Camellia sinensis) leaf dried product with water or alcohol, and then dissolved by adding water. The organic solvent extract was extracted again with a polar organic solvent, and the organic solvent extract was dried and powdered. More specifically, it can be prepared as follows. Tea (Camellia sin
The dried leaves of ensis) are generally known as, for example, green tea. As the extraction raw material, it is preferable to use a pulverized product of dried tea leaves, and the extraction can be performed by a known method. That is, tea leaves are extracted at room temperature with a sufficient amount of water or alcohol. After extraction, the residue is separated by a known method to obtain an extract. As the alcohol used for extraction, methyl alcohol, ethyl alcohol, n-propyl alcohol, isopropyl alcohol, butyl alcohol and the like can be used.
The solvent is distilled off from the extract obtained as described above, water is added to the residue to dissolve it, and the residue is extracted with a nonpolar organic solvent.
Examples of the non-polar organic solvent used here include ethyl acetate, hexane, chloroform and the like. The obtained non-polar organic solvent extract is dried and powdered to obtain a tea leaf extract.
The above-mentioned operations such as extraction, evaporation of the solvent, and dry powderization can be carried out according to ordinary methods. Such tea leaf extracts are commercially available, and market products can be used in the present invention. The powdered tea leaf extract can be used as it is for the production of the oral composition. Further, the powdery tea leaf extract can be redissolved in, for example, ethanol to be in a liquid state, or can be processed into a gel or granular form for use.

The tea leaf extract, polyoxyethylene hydrogenated castor oil, and metal salt of copper chlorophyllin thus obtained are blended according to a conventional method according to the kind of the intended oral composition, and the respective oral compositions are prepared. It can be manufactured. The amount of the tea leaf extract to be added to the oral composition of the present invention is generally 0.001 based on the total weight of the oral composition.
Is about 5% by weight, more preferably 0.01-2% by weight. If the blending amount exceeds 5% by weight, the oral composition may feel astringent, which is not preferable. Also 0.0
If it is less than 01% by weight, a sufficient effect cannot be achieved. The blending amount of polyoxyethylene hydrogenated castor oil can be appropriately changed depending on the type of the oral composition, but is generally 0.1 to 20% by weight based on the total weight of the composition.
Is suitable, and more preferably 0.5 to 10% by weight. If it exceeds 20% by weight, the commercial value may be impaired in properties, and if it is less than 0.1% by weight, the desired effect may not be achieved sufficiently.

The amount of the metal salt of copper chlorophyllin is suitably 0.001-2% by weight, more preferably 0.005-0.1% by weight, based on the total weight of the oral composition. Even if the amount is more than 2% by weight, the effect is not improved, and if it is less than 0.001% by weight, the desired effect is not sufficiently achieved. The metal salt of polyoxyethylene hydrogenated castor oil and copper chlorophyllin may be those commercially available. Examples of the metal salt of copper chlorophyllin include sodium salts, potassium salts, alkali metal salts such as lithium salts, alkaline earth metal salts such as magnesium salts and calcium salts, and most commonly sodium salts, that is, copper chlorophyllin sodium. Is used.

In addition to the above-mentioned components, the oral composition of the present invention can be appropriately blended with various additives usually used depending on the kind of the oral composition. For example, in the case of toothpaste, abrasives such as calcium hydrogen phosphate, aluminum hydroxide, calcium pyrophosphate, silicic acid anhydride, calcium carbonate, etc., wetting agents such as glycerin, sorbit, propylene glycol, polyethylene glycol, maltitol, lauriu sulfate. Sodium, foaming agents such as sodium lauroyl sarcosine, adhesive agents such as carrageenan, sodium carboxymethyl cellulose, hydroxyethyl cellulose, sodium polyacrylate, xanthan gum, preservatives such as paraben, benzoic acid, alkyldiaminoethylglycine hydrochloride, sodium saccharin, stevia extract, etc. Sweeteners, peppermint oil, spearmint oil, mixed flavors, menthol, flavoring agents such as carvone, other fluorine, tocopherol acetate, glycyrrhizic acid and salts thereof, Sodium, allantoin derivatives, isopropyl methylphenol, epi-dihydro cholesterol, guaiazulene and salts thereof, chlorhexidine compound, edetate may be blended with sodium hydrogen carbonate.

The present invention is described in detail below with reference to reference examples, examples and comparative examples, but the present invention is not limited to these. Reference Example Preparation of Tea Leaf Extract A dried product of 1 kg of tea (Camellia sinensis) was crushed to prepare. To this, 10 kg of water was added and immersed, and then filtered. The obtained filtrate was concentrated under reduced pressure by a conventional method. About 1 kg of this concentrated solution was extracted with ethyl acetate according to a conventional method. About 5 kg of the obtained ethyl acetate extract was dried and powdered to obtain 40 g of a dried tea leaf extract.

[0010]

【Example】

Comparative Examples and Examples 1 to 15 A dry toothpaste extract obtained above was blended to prepare a toothpaste with the following composition according to a conventional method, and the tube was filled into the tube. The evaluation was carried out by storing at 5 ° C. and 40 ° C. for 1 month and 3 months, respectively, and then observing the degree of discoloration at 40 ° C. using a 5 ° C. stored product having no color change as a control. The evaluation criteria are as follows. Table 1 shows the blending amounts of polyoxyethylene hydrogenated castor oil and sodium copper chlorophyllin and the results of evaluation in the toothpastes of Comparative Examples and Examples. [Composition of toothpaste] Calcium hydrogen phosphate 40.0 g Silicic acid anhydride 5.0 g Sodium carboxymethyl cellulose 1.0 g Glycerin 15.0 g Sorbitol liquid 10.0 g Sodium lauryl sulfate 1.5 g Dry product of tea leaf extract 0.5 g Polyoxyethylene hydrogenated castor oil See Table 1 Copper chlorophyllin sodium See Table 1 Paraben 0.1g Perfume 0.9g Purified water Total amount 100.0g

[Evaluation Criteria] x: Discolored and impaired commercial value △: Slightly discolored but not impaired commercial value ○: Slightly discolored ◎: Not discolored

[0012]

[Table 1] ─────────────────────────────────── Polyoxyethylene Copper chlorophyllin Na Evaluation example Cured castor Oil (g) (g) 1 month later 3 months later ─────────────────────────────────── Comparative Example − − × × Example 1 0.5 0.02 △ △ 〃 2 1.0 0.02 ○ △ 〃 3 2.0 0.02 ○ ○ 〃 4 3.0 0.02 ○ ○ 〃 5 4.0 0.02 ◎ ◎ 〃 6 5.0 0.02 ◎ ◎ 〃 7 6.0 0.02 ◎ ◎ 〃 8 0.5 0.04 △ △ 〃 9 1.0 0.04 ○ ○ 〃 10 2.0 0.04 ◎ ○ 〃 11 3.0 0.04 ◎ ◎ 〃 12 0.5 0.08 ○ ○ 〃 13 1.0 0.08 ◎ ○ 〃 14 2.0 0.08 ◎ ◎ ◎ 〃 15 3.0 0.08 ◎ ◎ ───────────────────────────────────

Example 16 A mouthwash having the following composition was prepared by a conventional method. Example 1
Observe discoloration after storage at 40 ° C for 3 months in the same manner as 15.
As a result, discoloration was not recognized. Ethanol 5.0 g Flavor 0.1 g Saccharin sodium 0.05 g Paraben 0.1 g Dry tea leaf extract 0.5 g Polyoxyethylene hydrogenated castor oil 3.0 g Copper chlorophyllin sodium 0.02 g Purified water Suitable total amount 100.00 g

Example 17 A lozenge composition having the following composition was prepared by a conventional method. Discoloration after storage at 40 ° C. for 3 months was observed in the same manner as in Examples 1 to 15, and as a result, discoloration was not observed. Gum arabic 5.0 g Glucose 65.0 g Perfume 0.2 g Dried tea leaf extract 1.5 g Polyoxyethylene hydrogenated castor oil 2.0 g Copper sodium chlorophyllin 0.005 g Purified water Total amount 100.0 g

Example 18 An oral cooling agent having the following composition was prepared according to a conventional method. Discoloration after storage at 40 ° C. for 3 months was observed in the same manner as in Examples 1 to 15, and as a result, discoloration was not observed. 1-Menthol 0.1g Dry leaf extract 1.0g Polyoxyethylene hydrogenated castor oil 2.0g Copper chlorophyllin sodium 0.02g Perfume 0.1g Purified white sugar Suitable amount Total 100.0g

[0016]

The present invention provides a composition for oral cavity which is effective in preventing caries and periodontal disease, in which discoloration over time is suppressed without impairing the anti-carious and anti-periodontal disease effects of the tea leaf extract.

 ─────────────────────────────────────────────────── ─── Continuation of the front page (72) Inventor Hidetaka Matsuda 3-12-2 Rokkakubashi, Kanagawa-ku, Yokohama-shi, Kanagawa Prefecture (72) Inventor Shinji Sugiyama 5-13-1-201, Atio, Atsugi-shi, Kanagawa (72) Invention Person Yoshihiro Shitaki 1-6-3 Hamamatsucho, Minato-ku, Tokyo Taiyo Kagaku Co., Ltd.

Claims (1)

[Claims] 1. An oral composition containing a tea leaf extract, which comprises polyoxyethylene hydrogenated castor oil and a metal salt of copper chlorophyllin.