JPH08507080A - B型肝炎のウイルスに対する細胞障害性tリンパ球の応答を誘発するペプチド - Google Patents
B型肝炎のウイルスに対する細胞障害性tリンパ球の応答を誘発するペプチドInfo
- Publication number
- JPH08507080A JPH08507080A JP51934194A JP51934194A JPH08507080A JP H08507080 A JPH08507080 A JP H08507080A JP 51934194 A JP51934194 A JP 51934194A JP 51934194 A JP51934194 A JP 51934194A JP H08507080 A JPH08507080 A JP H08507080A
- Authority
- JP
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- Prior art keywords
- leu
- peptide
- seq
- phe
- ile
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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Abstract
Description
Claims (1)
- 【特許請求の範囲】 1.次の配列: HBenv183−191(配列識別番号:1) Phe−Leu−Leu−Thr−Arg−Ile−Leu−Thr−Ile を含んでなるCTL誘発ペプチド。 2.ペプチドが、また、Tヘルパーエピトープを含有する、請求の範囲1のC TL誘発ペプチド。 3.免疫原性脂質キャリヤーに接合された、請求の範囲1のペプチド。 4.8〜13アミノ酸を含んでなり、ここでアミノ酸の少なくとも過半数が配 列: HBenv248−260(配列識別番号:2) Phe−Ile−Leu−Leu−Leu−Cys−Leu−Ile−Phe− Leu−Leu−Val−Leu を有するHBenvの対応する部分に対して相同性である、CTL誘発ペプチド 。 5.9〜11アミノ酸を含んでなる、請求の範囲4のCTL誘発ペプチド。 6. HBenv248−257(配列識別番号:3) Phe−Ile−Leu−Leu−Leu−Cys−Leu−Ile−Phe− Leu; HBenv249−257(配列識別番号:4) Ile−Leu−Leu−Leu−Cys−Leu−Ile−Phe−Leu; HBenv249−258(配列識別番号:5) Ile−Leu−Leu−Leu−Cys−Leu−Ile−Phe−Leu− Leu; HBenv250−258(配列識別番号:6) Leu−Leu−Leu−Cys−Leu−Ile−Phe−Leu−Leu; HBenv251−259(配列識別番号:7) Leu−Leu−Cys−Leu−Ile−Phe−Leu−Leu−Val; または HBenv251−260(配列識別番号:8) Leu−Leu−Cys−Leu−Ile−Phe−Leu−Leu−Val− Leu; を含んでなる、請求の範囲4のCTL誘発ペプチド。 7.9〜11アミノ酸を含んでなり、ここでアミノ酸の少なくとも過半数が配 列: HBenv334−344(配列識別番号:) Trp−Leu−Ser−Leu−Leu−Val−Pro−Phe−Val を有するHBenvの対応する部分に対して相同性である、CTL誘発ペプチド 。 8. HBenv335−343(配列識別番号:10) Trp−Leu−Ser−Leu−Leu−Val−Pro−Phe−Val; HBenv334−343(配列識別番号:15) Ser−Trp−Leu−Ser−Leu−Leu−Val−Pro−Phe− Val;または HBenv335−344(配列識別番号:16) Trp−Leu−Ser−Leu−Leu−Val−Pro−Ph e−Val−Gln; を含んでなる、請求の範囲7のCTL誘発ペプチド。 9.免疫原性リポタンパク質キャリヤーに接合された、請求の範囲8のペプチ ド。 10.リポソームを含んでなる製剤学的に許容されうる担体の中に懸濁された 、請求の範囲9のペプチド。 11.有効量のペプチドをHLA−A2ハプロタイプを有する宿主に投与する ことからなり、ここで前記ペプチドは、次の配列: HBenv183−191(配列識別番号:1) Phe−Leu−Leu−Thr−Arg−Ile−Leu−Thr−Ile を含んでなるCTL誘発ペプチドである、B型肝炎の感染を処置または予防する 方法。 12.有効量のペプチドをHLA−A2ハプロタイプを有する宿主に投与する ことを含んでなり、ここで前記ペプチドは8〜13アミノ酸からなるCTL誘発 ペプチドであり、ここでアミノ酸の少なくとも過半数が配列: HBenv248−260(配列識別番号:2) Phe−Ile−Leu−Leu−Leu−Cys−Leu−Ile−Phe− Leu−Leu−Val−Leu、または HBenv335−343(配列識別番号:10) Trp−Leu−Ser−Leu−Leu−Val−Pro−Phe−Val、 を有するHBenvの対応する部分に対して相同性である、B型肝炎の感染を処 置または予防する方法。 13.CTL誘発ペプチドが、 HBenv248−257(配列識別番号:3) Phe−Ile−Leu−Leu−Leu−Cys−Leu−Ile−Phe− Leu; HBenv249−257(配列識別番号:4) Ile−Leu−Leu−Leu−Cys−Leu−Ile−Phe−Leu; HBenv249−258(配列識別番号:5) Ile−Leu−Leu−Leu−Cys−Leu−Ile−Phe−Leu− Leu; HBenv250−258(配列識別番号:6) Leu−Leu−Leu−Cys−Leu−Ile−Phe−Leu−Leu; HBenv251−259(配列識別番号:7) Leu−Leu−Cys−Leu−Ile−Phe−Leu−Leu−Val; または HBenv251−260(配列識別番号:8) Leu−Leu−Cys−Leu−Ile−Phe−Leu−Leu−Val− Leu; を含んでなる、請求の範囲12の方法。 14.宿主が慢性B型肝炎の感染を有するか、あるいはB型肝炎の保菌者であ る、請求の範囲13の方法。 15.CTL誘発ペプチドが、 HBenv335−343(配列識別番号:10) Trp−Leu−Ser−Leu−Leu−Val−Pro−Phe−Val; HBenv334−343(配列識別番号:15) Ser−Trp−Leu−Ser−Leu−Leu−Val−Pro−Phe− Val;または HBenv335−344(配列識別番号:16) Trp−Leu−Ser−Leu−Leu−Val−Pro−Phe−Val− Gln; である、請求の範囲12の方法。 16.宿主が急性B型肝炎の感染を有する、請求の範囲12の方法。 17.CTL誘発ペプチドを予防的に投与する、請求の範囲12の方法。 18.宿主が慢性B型肝炎の感染を有するか、あるいはB型肝炎の保菌者であ る、請求の範囲13の方法。 19.CTL誘発ペプチドをHBVに対するTヘルパーの応答を誘発する第2 ペプチドとともに宿主に投与する、請求の範囲12の方法。 20.CTL誘発ペプチドおよびTヘルパー誘発ペプチドが連鎖されている、 請求の範囲19の方法。
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US2412093A | 1993-02-26 | 1993-02-26 | |
US08/024,120 | 1993-02-26 | ||
PCT/US1994/002195 WO1994019011A1 (en) | 1993-02-26 | 1994-02-25 | Peptides for inducing cytotoxic t lymphocyte responses to hepatitis b virus |
Related Child Applications (1)
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JP2004000504A Division JP3616390B2 (ja) | 1993-02-26 | 2004-01-05 | B型肝炎のウイルスに対する細胞障害性tリンパ球の応答を誘発するペプチド |
Publications (2)
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JPH08507080A true JPH08507080A (ja) | 1996-07-30 |
JP3657603B2 JP3657603B2 (ja) | 2005-06-08 |
Family
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Application Number | Title | Priority Date | Filing Date |
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JP51934194A Expired - Fee Related JP3657603B2 (ja) | 1993-02-26 | 1994-02-25 | B型肝炎のウイルスに対する細胞障害性tリンパ球の応答を誘発するペプチド |
JP2004000504A Expired - Fee Related JP3616390B2 (ja) | 1993-02-26 | 2004-01-05 | B型肝炎のウイルスに対する細胞障害性tリンパ球の応答を誘発するペプチド |
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JP2004000504A Expired - Fee Related JP3616390B2 (ja) | 1993-02-26 | 2004-01-05 | B型肝炎のウイルスに対する細胞障害性tリンパ球の応答を誘発するペプチド |
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Country | Link |
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US (1) | US5788969A (ja) |
EP (2) | EP1375511B1 (ja) |
JP (2) | JP3657603B2 (ja) |
KR (1) | KR960700745A (ja) |
CN (1) | CN1118573A (ja) |
AT (1) | ATE359089T1 (ja) |
AU (1) | AU695261B2 (ja) |
DE (2) | DE69434954T2 (ja) |
ES (1) | ES2204912T3 (ja) |
NZ (1) | NZ263030A (ja) |
WO (1) | WO1994019011A1 (ja) |
Cited By (2)
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JP2012229225A (ja) * | 2006-02-07 | 2012-11-22 | Nec Corp | Hla結合性ペプチド、それをコードするdna断片および組み換えベクター |
US8324345B2 (en) | 2006-10-12 | 2012-12-04 | Nec Corporation | HLA-binding peptide, precursor thereof, DNA fragment and recombinant vector encoding the same |
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US6607727B1 (en) | 1991-08-26 | 2003-08-19 | The Scripps Research Institute | Peptides for inducing cytotoxic T lymphocyte responses to hepatitus B virus |
US7611713B2 (en) * | 1993-03-05 | 2009-11-03 | Pharmexa Inc. | Inducing cellular immune responses to hepatitis B virus using peptide compositions |
US20110097352A9 (en) * | 1992-01-29 | 2011-04-28 | Pharmexa Inc. | Inducing cellular immune responses to hepatitis B virus using peptide and nucleic acid compositions |
US6689363B1 (en) | 1992-01-29 | 2004-02-10 | Epimmune Inc. | Inducing cellular immune responses to hepatitis B virus using peptide and nucleic acid compositions |
US6235288B1 (en) * | 1992-08-26 | 2001-05-22 | The Scripps Research Institute | Peptides for inducing cytotoxic T lymphocyte responses to hepatitis B virus |
DE69820486D1 (de) * | 1998-01-19 | 2004-01-22 | Mogam Biotechnology Res Inst Y | Liposomen, enthaltend peptidantigene, welche vom x-protein aus hepatitis b virus abstammen |
EP1078092B1 (en) * | 1998-05-13 | 2011-08-03 | Epimmune Inc. | Expression vectors for stimulating an immune response and methods of using the same |
US20070020327A1 (en) * | 1998-11-10 | 2007-01-25 | John Fikes | Inducing cellular immune responses to prostate cancer antigens using peptide and nucleic acid compositions |
CA2394741A1 (en) * | 1999-12-21 | 2001-06-28 | Epimmune Inc. | Inducing cellular immune responses to prostate cancer antigens using peptide and nucleic acid compositions |
KR100455902B1 (ko) * | 2001-07-18 | 2004-11-12 | 주식회사 펩트론 | B형 간염 바이러스 표면단백질 프리에스-1 유래의 펩타이드 |
CN1305527C (zh) * | 2003-11-21 | 2007-03-21 | 薛平 | 乙型肝炎治疗疫苗及其制备方法 |
WO2006097682A1 (en) * | 2005-03-18 | 2006-09-21 | Ucl Business Plc | Mechano growth factor peptides and their use |
US20110110974A1 (en) * | 2007-10-29 | 2011-05-12 | Erik Depla | Methods and kits for inducing a ctl response using a prime boost regimen |
WO2010086294A2 (en) | 2009-01-28 | 2010-08-05 | Epimmune Inc. | Pan-dr binding polypeptides and uses thereof |
US10076570B2 (en) | 2009-08-07 | 2018-09-18 | Transgene S.A. | Composition for treating HBV infection |
JP5897464B2 (ja) | 2009-08-07 | 2016-03-30 | トランジェーヌ、ソシエテ、アノニムTransgene S.A. | Hbv感染を治療するための組成物 |
TWI623618B (zh) | 2011-07-12 | 2018-05-11 | 傳斯堅公司 | Hbv聚合酶突變體 |
EP3522920A2 (en) | 2016-10-10 | 2019-08-14 | Transgene SA | Immunotherapeutic product and mdsc modulator combination therapy |
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US4816564A (en) * | 1986-01-31 | 1989-03-28 | Merck & Co., Inc. | Method for producing hepatitis B virus proteins in yeast |
EP0293201A3 (en) * | 1987-05-26 | 1990-02-28 | The Wistar Institute | Method of vaccination for hepatitis b virus |
EP0326111A3 (en) * | 1988-01-29 | 1989-12-27 | New York Blood Center, Inc. | Peptide derivatives rendered immunogenic when administered with alum as an adjuvant |
KR960700739A (ko) * | 1993-03-05 | 1996-02-24 | 카린 이스텀 | Hla-a2. 1 결합 펩티드 및 그의 용도(hla-a2. 1 binding peptides and their uses) |
JP3795914B2 (ja) * | 1993-04-27 | 2006-07-12 | ユナイテッド・バイオメディカル・インコーポレイテッド | ワクチン用免疫原性lhrhペプチド構築体および合成普遍免疫刺激器 |
AU7478394A (en) * | 1993-08-06 | 1995-02-28 | Cytel Corporation | Methods for (ex vivo) therapy using peptide-loaded antigen presenting cells for the activation of ctl |
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1994
- 1994-02-25 KR KR1019950703607A patent/KR960700745A/ko not_active Application Discontinuation
- 1994-02-25 DE DE1994634954 patent/DE69434954T2/de not_active Expired - Lifetime
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- 1994-02-25 CN CN94191295A patent/CN1118573A/zh active Pending
- 1994-02-25 AU AU63559/94A patent/AU695261B2/en not_active Ceased
- 1994-02-25 JP JP51934194A patent/JP3657603B2/ja not_active Expired - Fee Related
- 1994-02-25 AT AT03010010T patent/ATE359089T1/de not_active IP Right Cessation
- 1994-02-25 EP EP20030010010 patent/EP1375511B1/en not_active Expired - Lifetime
- 1994-02-25 NZ NZ263030A patent/NZ263030A/en not_active IP Right Cessation
- 1994-02-25 ES ES94910791T patent/ES2204912T3/es not_active Expired - Lifetime
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Cited By (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2012229225A (ja) * | 2006-02-07 | 2012-11-22 | Nec Corp | Hla結合性ペプチド、それをコードするdna断片および組み換えベクター |
US9045531B2 (en) | 2006-02-07 | 2015-06-02 | Nec Corporation | HLA-binding peptide, precursor thereof, and DNA fragment and recombinant vector coding for said HLA-binding peptide |
US8324345B2 (en) | 2006-10-12 | 2012-12-04 | Nec Corporation | HLA-binding peptide, precursor thereof, DNA fragment and recombinant vector encoding the same |
Also Published As
Publication number | Publication date |
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AU6355994A (en) | 1994-09-14 |
DE69434954T2 (de) | 2007-12-20 |
US5788969A (en) | 1998-08-04 |
DE69433007T2 (de) | 2004-06-09 |
EP0687182A1 (en) | 1995-12-20 |
JP2004161778A (ja) | 2004-06-10 |
EP0687182B1 (en) | 2003-08-06 |
EP0687182A4 (en) | 1997-03-12 |
NZ263030A (en) | 1997-10-24 |
JP3657603B2 (ja) | 2005-06-08 |
KR960700745A (ko) | 1996-02-24 |
AU695261B2 (en) | 1998-08-13 |
JP3616390B2 (ja) | 2005-02-02 |
EP1375511A2 (en) | 2004-01-02 |
EP1375511A3 (en) | 2005-03-02 |
DE69433007D1 (de) | 2003-09-11 |
EP1375511B1 (en) | 2007-04-11 |
DE69434954D1 (de) | 2007-05-24 |
ES2204912T3 (es) | 2004-05-01 |
WO1994019011A1 (en) | 1994-09-01 |
CN1118573A (zh) | 1996-03-13 |
ATE359089T1 (de) | 2007-05-15 |
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