JPH08502474A - トコリティックオキシトシンレセプターアンタゴニスト - Google Patents

トコリティックオキシトシンレセプターアンタゴニスト

Info

Publication number
JPH08502474A
JPH08502474A JP6509222A JP50922293A JPH08502474A JP H08502474 A JPH08502474 A JP H08502474A JP 6509222 A JP6509222 A JP 6509222A JP 50922293 A JP50922293 A JP 50922293A JP H08502474 A JPH08502474 A JP H08502474A
Authority
JP
Japan
Prior art keywords
alkyl
hydrogen
compound
mmol
effective amount
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP6509222A
Other languages
English (en)
Japanese (ja)
Inventor
エバンス，ベン・イー
ホツブス，ダグラス・ダブリユ
ポーリユツクジイツク，ジヨゼフ・エム
ペテイーボーン，ダグラス・ジエイ
リトル，ケネス・イー
ウイリアムズ，ピーター・デイー
Original Assignee
メルク エンド カンパニー インコーポレーテッド
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by メルク エンド カンパニー インコーポレーテッド filed Critical メルク エンド カンパニー インコーポレーテッド
Publication of JPH08502474A publication Critical patent/JPH08502474A/ja
Pending legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D221/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
    • C07D221/02—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
    • C07D221/20—Spiro-condensed ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Urology & Nephrology (AREA)
  • Endocrinology (AREA)
  • Reproductive Health (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Plural Heterocyclic Compounds (AREA)
JP6509222A 1992-10-07 1993-09-27 トコリティックオキシトシンレセプターアンタゴニスト Pending JPH08502474A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US95793892A 1992-10-07 1992-10-07
US957.938 1992-10-07
PCT/US1993/009152 WO1994007496A1 (fr) 1992-10-07 1993-09-27 Antagonistes recepteurs d'oxytocine tocolytique

Publications (1)

Publication Number Publication Date
JPH08502474A true JPH08502474A (ja) 1996-03-19

Family

ID=25500372

Family Applications (1)

Application Number Title Priority Date Filing Date
JP6509222A Pending JPH08502474A (ja) 1992-10-07 1993-09-27 トコリティックオキシトシンレセプターアンタゴニスト

Country Status (5)

Country Link
EP (1) EP0663827A4 (fr)
JP (1) JPH08502474A (fr)
AU (1) AU5292393A (fr)
CA (1) CA2143117A1 (fr)
WO (1) WO1994007496A1 (fr)

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2010513384A (ja) * 2006-12-22 2010-04-30 エフ．ホフマン−ラ ロシュ アーゲー スピロ−ピペリジン誘導体
JP2010513385A (ja) * 2006-12-22 2010-04-30 エフ．ホフマン−ラ ロシュ アーゲー スピロ−ピペリジン誘導体
WO2011111875A1 (fr) * 2010-03-11 2011-09-15 Dainippon Sumitomo Pharma Co., Ltd. Dérivé d'amine n-acyle cyclique ou son sel pharmaceutiquement acceptable
JP2013075894A (ja) * 2011-09-14 2013-04-25 Dainippon Sumitomo Pharma Co Ltd Ｎ−アシル環状アミン誘導体またはその医薬上許容される塩からなる医薬
WO2014024993A1 (fr) * 2012-08-09 2014-02-13 国立大学法人京都大学 Dérivé de pipérazine et utilisation de celui-ci

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0714299B1 (fr) * 1993-07-16 2002-04-24 Merck & Co. Inc. Benzoxazinone et benzopyrimidinone piperidinyle utiles comme antagonistes tocolytiques du recepteur de l'oxytocine
WO1995002587A1 (fr) * 1993-07-16 1995-01-26 Merck & Co., Inc. Derives de piperazinylcamphre substitues en tant qu'antagonistes de l'ocytocine
US5464788A (en) * 1994-03-24 1995-11-07 Merck & Co., Inc. Tocolytic oxytocin receptor antagonists
US5707985A (en) * 1995-06-07 1998-01-13 Tanabe Seiyaku Co. Ltd. Naphthyl-, quinolyl- and isoquinolyl- sulfonamide derivatives as cell adhesion modulators
WO1998046569A1 (fr) * 1997-04-11 1998-10-22 Sumitomo Pharmaceuticals Co., Ltd. Derives de benzene
GB9819860D0 (en) 1998-09-12 1998-11-04 Zeneca Ltd Chemical compounds
DK1307430T3 (da) 2000-07-05 2006-01-30 Ortho Mcneil Pharm Inc Ikke-peptidsubstituerede spirobenzoazepiner som vasopressin-antagonister
CN1768041A (zh) 2003-04-04 2006-05-03 麦克公司 作为黑皮质素－4受体激动剂的酰化螺哌啶衍生物
EP1633719B1 (fr) 2003-06-17 2009-10-07 Janssen Pharmaceutica N.V. Spirobenzazepines substituees
DE102005000666B3 (de) * 2005-01-04 2006-10-05 Sanofi-Aventis Deutschland Gmbh Sulfonylpyrrolidine, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel
DK2078022T3 (da) 2006-09-22 2012-02-13 Janssen Pharmaceutica Nv Spirobenzazepiner anvendt som vasopressinantagonister
CN101541807A (zh) 2006-09-22 2009-09-23 詹森药业有限公司 用作血管升压素拮抗剂的螺环苯并氮杂
DE602007006990D1 (de) 2006-12-07 2010-07-15 Hoffmann La Roche Spiropiperidinderivate als antagonisten des via-rezeptors
US20100022572A1 (en) 2008-07-18 2010-01-28 Kowa Company, Ltd. Novel spiro compound and medicine comprising the same
US11717499B2 (en) * 2011-06-28 2023-08-08 Sandra Eve Reznik Administration of N,N-dimethylacetamide for the treatment of preterm birth

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8917069D0 (en) * 1989-07-26 1989-09-13 Merck Sharp & Dohme Therapeutic agents
US5091387A (en) * 1990-03-02 1992-02-25 Merck & Co., Inc. Spirocyclic oxytocin antagonists
CA2037357A1 (fr) * 1990-03-02 1991-09-03 Ben E. Evans Methodes d'utilisation d'antagonistes de l'oxytocine spirocyclique
EP0445974A3 (en) * 1990-03-05 1992-04-29 Merck Sharp & Dohme Ltd. Spirocyclic antipsychotic agents
IL99957A0 (en) * 1990-11-13 1992-08-18 Merck & Co Inc Piperidinylcamphorsulfonyl oxytocin antagonists and pharmaceutical compositions containing them

Cited By (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2010513384A (ja) * 2006-12-22 2010-04-30 エフ．ホフマン−ラ ロシュ アーゲー スピロ−ピペリジン誘導体
JP2010513385A (ja) * 2006-12-22 2010-04-30 エフ．ホフマン−ラ ロシュ アーゲー スピロ−ピペリジン誘導体
WO2011111875A1 (fr) * 2010-03-11 2011-09-15 Dainippon Sumitomo Pharma Co., Ltd. Dérivé d'amine n-acyle cyclique ou son sel pharmaceutiquement acceptable
JP2013522165A (ja) * 2010-03-11 2013-06-13 大日本住友製薬株式会社 Ｎ−アシル環状アミン誘導体またはその医薬上許容される塩
US8541585B2 (en) 2010-03-11 2013-09-24 Dainippon Sumitomo Pharma Co., Ltd. N-acyl cyclic amine derivative or pharmaceutically acceptable salt thereof
JP2013075894A (ja) * 2011-09-14 2013-04-25 Dainippon Sumitomo Pharma Co Ltd Ｎ−アシル環状アミン誘導体またはその医薬上許容される塩からなる医薬
WO2014024993A1 (fr) * 2012-08-09 2014-02-13 国立大学法人京都大学 Dérivé de pipérazine et utilisation de celui-ci

Also Published As

Publication number Publication date
EP0663827A1 (fr) 1995-07-26
WO1994007496A1 (fr) 1994-04-14
EP0663827A4 (fr) 1995-11-15
AU5292393A (en) 1994-04-26
CA2143117A1 (fr) 1994-04-14

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