CA2143117A1 - Antagonistes du recepteur de l'oxytocine de la tocolyse - Google Patents

Antagonistes du recepteur de l'oxytocine de la tocolyse

Info

Publication number
CA2143117A1
CA2143117A1 CA002143117A CA2143117A CA2143117A1 CA 2143117 A1 CA2143117 A1 CA 2143117A1 CA 002143117 A CA002143117 A CA 002143117A CA 2143117 A CA2143117 A CA 2143117A CA 2143117 A1 CA2143117 A1 CA 2143117A1
Authority
CA
Canada
Prior art keywords
alkyl
mammal
hydrogen
compound
mmol
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA002143117A
Other languages
English (en)
Inventor
Ben E. Evans
Douglas W. Hobbs
Joseph M. Pawluczyk
Peter D. Williams
Kenneth E. Rittle
Douglas J. Pettibone
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck and Co Inc
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of CA2143117A1 publication Critical patent/CA2143117A1/fr
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D221/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
    • C07D221/02—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
    • C07D221/20—Spiro-condensed ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Urology & Nephrology (AREA)
  • Endocrinology (AREA)
  • Reproductive Health (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Plural Heterocyclic Compounds (AREA)
CA002143117A 1992-10-07 1993-09-27 Antagonistes du recepteur de l'oxytocine de la tocolyse Abandoned CA2143117A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US95793892A 1992-10-07 1992-10-07
US957,938 1992-10-07

Publications (1)

Publication Number Publication Date
CA2143117A1 true CA2143117A1 (fr) 1994-04-14

Family

ID=25500372

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002143117A Abandoned CA2143117A1 (fr) 1992-10-07 1993-09-27 Antagonistes du recepteur de l'oxytocine de la tocolyse

Country Status (5)

Country Link
EP (1) EP0663827A4 (fr)
JP (1) JPH08502474A (fr)
AU (1) AU5292393A (fr)
CA (1) CA2143117A1 (fr)
WO (1) WO1994007496A1 (fr)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2166975C (fr) * 1993-07-16 2005-04-05 Mark G. Bock Derives de la benzoxazinone et de la benzopyrimidinone, antagonistes des recepteurs de l'oxytocine et de la vasopressine
JPH09500133A (ja) * 1993-07-16 1997-01-07 メルク エンド カンパニー インコーポレーテッド オキシトシンのアンタゴニストである置換ピペラジニル樟脳誘導体
US5464788A (en) * 1994-03-24 1995-11-07 Merck & Co., Inc. Tocolytic oxytocin receptor antagonists
US5707985A (en) * 1995-06-07 1998-01-13 Tanabe Seiyaku Co. Ltd. Naphthyl-, quinolyl- and isoquinolyl- sulfonamide derivatives as cell adhesion modulators
AU6747498A (en) * 1997-04-11 1998-11-11 Sumitomo Pharmaceuticals Company, Limited Benzene derivatives
GB9819860D0 (en) 1998-09-12 1998-11-04 Zeneca Ltd Chemical compounds
ATE305454T1 (de) 2000-07-05 2005-10-15 Ortho Mcneil Pharm Inc Nichtpeptidische substituierte spirobenzoazepine als vasopressin antagonisten
CA2520114A1 (fr) 2003-04-04 2004-10-21 Merck & Co., Inc. Derives de spiropiperidine acyles utilises comme agonistes vis-a-vis du recepteur de melanocortine-4
BRPI0411598A (pt) * 2003-06-17 2006-08-29 Janssen Pharmaceutica Nv espirobenzazepinas substituìdas
DE102005000666B3 (de) * 2005-01-04 2006-10-05 Sanofi-Aventis Deutschland Gmbh Sulfonylpyrrolidine, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel
CN101541807A (zh) 2006-09-22 2009-09-23 詹森药业有限公司 用作血管升压素拮抗剂的螺环苯并氮杂
EP2078022B1 (fr) 2006-09-22 2011-11-09 Janssen Pharmaceutica N.V. Spirobenzazépines utilisées en tant qu'antagonistes de vasopressine
ATE469900T1 (de) 2006-12-07 2010-06-15 Hoffmann La Roche Spiropiperidinderivate als antagonisten des via- rezeptors
KR101122969B1 (ko) * 2006-12-22 2012-03-22 에프. 호프만-라 로슈 아게 스피로-피페리딘 유도체
EP2535329A3 (fr) * 2006-12-22 2013-03-27 F. Hoffmann-La Roche AG Dérivés de spiro-pipéridine
US20100022572A1 (en) 2008-07-18 2010-01-28 Kowa Company, Ltd. Novel spiro compound and medicine comprising the same
KR101756495B1 (ko) * 2010-03-11 2017-07-10 다이닛본 스미토모 세이야꾸 가부시끼가이샤 Ｎ-아실 시클릭 아민 유도체 또는 이의 의약상 허용되는 염
US11717499B2 (en) * 2011-06-28 2023-08-08 Sandra Eve Reznik Administration of N,N-dimethylacetamide for the treatment of preterm birth
JP5715605B2 (ja) * 2011-09-14 2015-05-07 大日本住友製薬株式会社 Ｎ−アシル環状アミン誘導体またはその医薬上許容される塩からなる医薬
WO2014024993A1 (fr) * 2012-08-09 2014-02-13 国立大学法人京都大学 Dérivé de pipérazine et utilisation de celui-ci

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8917069D0 (en) * 1989-07-26 1989-09-13 Merck Sharp & Dohme Therapeutic agents
EP0444945A3 (en) * 1990-03-02 1992-05-13 Merck & Co. Inc. Use of spirocyclic compounds as oxytocin antagonists
US5091387A (en) * 1990-03-02 1992-02-25 Merck & Co., Inc. Spirocyclic oxytocin antagonists
EP0445974A3 (en) * 1990-03-05 1992-04-29 Merck Sharp & Dohme Ltd. Spirocyclic antipsychotic agents
IL99957A0 (en) * 1990-11-13 1992-08-18 Merck & Co Inc Piperidinylcamphorsulfonyl oxytocin antagonists and pharmaceutical compositions containing them

Also Published As

Publication number Publication date
WO1994007496A1 (fr) 1994-04-14
JPH08502474A (ja) 1996-03-19
EP0663827A1 (fr) 1995-07-26
EP0663827A4 (fr) 1995-11-15
AU5292393A (en) 1994-04-26

Similar Documents

Publication Publication Date Title
CA2143117A1 (fr) Antagonistes du recepteur de l'oxytocine de la tocolyse
US5204349A (en) Amide-substituted derivatives of spiroindanylcamphorsulfonyl oxytocin antagonists
CA2166975C (fr) Derives de la benzoxazinone et de la benzopyrimidinone, antagonistes des recepteurs de l'oxytocine et de la vasopressine
EP0533243B1 (fr) Dérivés de spiroindanylcamphorsulfonyl substitués par un radical hydantoine ou succinimide comme antagonists d'oxytocine
US5464788A (en) Tocolytic oxytocin receptor antagonists
CA2339621C (fr) Composes de 1-piperidyl benzimidazole substitue en 2, agonistes du recepteur orl1
CA2055024A1 (fr) Antagonistes de la n-phenylpiperidinylcamphresulfonyle
US5670509A (en) Tocolytic oxytocin receptor antagonists
JPWO2005115975A1 (ja) アリールアルキルアミン化合物及びその製法
JPH082870B2 (ja) ピペラジニルカンファースルフォニルオキシトシン拮抗物質の置換誘導体
JP2008063256A (ja) β‐アミノ酸誘導体
AU1185295A (en) Piperidinylcamphorsulfonyl oxytocin antagonists
CA2210138A1 (fr) Antagonistes tocolytiques des recepteurs de l'oxytocine
PT1641787E (pt) Dicetopiperazinas substituídas e sua utilização como antagonistas da oxitocina
US20040248931A1 (en) Isoquinoline compound and pharmaceutical use thereof
EA019340B1 (ru) Полиморфные формы ацилсульфонамидов
WO1995019773A1 (fr) Carbostyrile utilise comme antagoniste des recepteurs a l'oxytocine
CA2151821A1 (fr) Derives de substitution hydantoine et succinimide d'antagonistes de spiro-indanylcamphresulfonyle oxytocine
US20030109549A1 (en) 2-Substituted-1-piperidyl benzimidazole compounds as ORL1-receptor agonists
KR19990028759A (ko) 티아졸린 유도체

Legal Events

Date Code Title Description
FZDE Dead