JPH08501075A - ｄｅｓ−Ｔｙｒダイノルフィン類似体 - Google Patents

ｄｅｓ−Ｔｙｒダイノルフィン類似体

Info

Publication number
JPH08501075A
JPH08501075A JP6501537A JP50153794A JPH08501075A JP H08501075 A JPH08501075 A JP H08501075A JP 6501537 A JP6501537 A JP 6501537A JP 50153794 A JP50153794 A JP 50153794A JP H08501075 A JPH08501075 A JP H08501075A
Authority
JP
Japan
Prior art keywords
arg
leu
gly
lys
seq
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP6501537A
Other languages
English (en)
Japanese (ja)
Inventor
リー，ナンシー，エム．
ロー，ホラス，エイチ．
イー． タケモリ，アキラ
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Des Tyr Dynorphin Partnership
Original Assignee
Des Tyr Dynorphin Partnership
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Des Tyr Dynorphin Partnership filed Critical Des Tyr Dynorphin Partnership
Publication of JPH08501075A publication Critical patent/JPH08501075A/ja
Pending legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/665—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans derived from pro-opiomelanocortin, pro-enkephalin or pro-dynorphin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K17/00—Carrier-bound or immobilised peptides; Preparation thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Biophysics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Addiction (AREA)
  • Toxicology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biomedical Technology (AREA)
  • Psychiatry (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Immunology (AREA)
  • Epidemiology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
JP6501537A 1992-06-12 1993-06-01 ｄｅｓ−Ｔｙｒダイノルフィン類似体 Pending JPH08501075A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US89792092A 1992-06-12 1992-06-12
US07/897,920 1992-06-12
PCT/US1993/005161 WO1993025217A1 (en) 1992-06-12 1993-06-01 Des-tyr dynorphin analogues

Publications (1)

Publication Number Publication Date
JPH08501075A true JPH08501075A (ja) 1996-02-06

Family

ID=25408662

Family Applications (1)

Application Number Title Priority Date Filing Date
JP6501537A Pending JPH08501075A (ja) 1992-06-12 1993-06-01 ｄｅｓ−Ｔｙｒダイノルフィン類似体

Country Status (11)

Country Link
EP (1) EP0652765A4 (cs)
JP (1) JPH08501075A (cs)
KR (1) KR950701818A (cs)
AU (1) AU4399093A (cs)
CA (1) CA2137916A1 (cs)
CZ (1) CZ281630B6 (cs)
FI (1) FI945811A7 (cs)
HU (1) HUT70160A (cs)
NO (1) NO944778L (cs)
RU (1) RU95106651A (cs)
WO (1) WO1993025217A1 (cs)

Families Citing this family (29)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5482930A (en) * 1993-06-09 1996-01-09 The Regents Of The University Of California Anti-inflammatory composition and method with des-Tyr dynorphin and analogues
US7220737B1 (en) 1997-09-04 2007-05-22 Novoneuron, Inc Noribogaine in the treatment of pain and drug addiction
IL134796A0 (en) 1997-09-04 2001-04-30 Novoneuron Inc Noribogaine in the treatment of pain and drug addiction
US6437092B1 (en) 1998-11-06 2002-08-20 Conjuchem, Inc. Conjugates of opioids and endogenous carriers
US6849714B1 (en) 1999-05-17 2005-02-01 Conjuchem, Inc. Protection of endogenous therapeutic peptides from peptidase activity through conjugation to blood components
US7601691B2 (en) 1999-05-17 2009-10-13 Conjuchem Biotechnologies Inc. Anti-obesity agents
US6887470B1 (en) 1999-09-10 2005-05-03 Conjuchem, Inc. Protection of endogenous therapeutic peptides from peptidase activity through conjugation to blood components
EP1105409B1 (en) 1999-05-17 2006-03-01 Conjuchem, Inc. Protection of endogenous therapeutic peptides from peptidase activity through conjugation to blood components
US6706892B1 (en) 1999-09-07 2004-03-16 Conjuchem, Inc. Pulmonary delivery for bioconjugation
AU2002233082B2 (en) 2001-02-02 2005-11-10 Conjuchem Biotechnologies Inc. Long lasting growth hormone releasing factor derivatives
US7112567B2 (en) 2001-02-16 2006-09-26 Conjuchem Inc. Long lasting glucagon-like peptide 2 (glp-2) for the treatment of gastrointestinal diseases and disorders
US8765737B1 (en) 2010-05-11 2014-07-01 Demerx, Inc. Methods and compositions for preparing and purifying noribogaine
US9394294B2 (en) 2010-05-11 2016-07-19 Demerx, Inc. Methods and compositions for preparing and purifying noribogaine
US8362007B1 (en) 2010-05-11 2013-01-29 Demerx, Inc. Substituted noribogaine
US9586954B2 (en) 2010-06-22 2017-03-07 Demerx, Inc. N-substituted noribogaine prodrugs
US8802832B2 (en) 2010-06-22 2014-08-12 Demerx, Inc. Compositions comprising noribogaine and an excipient to facilitate transport across the blood brain barrier
US8741891B1 (en) 2010-06-22 2014-06-03 Demerx, Inc. N-substituted noribogaine prodrugs
US8637648B1 (en) 2010-06-22 2014-01-28 Demerx, Inc. Compositions comprising noribogaine and an excipient to facilitate transport across the blood brain barrier
UA111065C2 (uk) 2010-07-23 2016-03-25 Демеркс, Інк. Композиції норибогаїну
EP2481740B1 (en) 2011-01-26 2015-11-04 DemeRx, Inc. Methods and compositions for preparing noribogaine from voacangine
US9617274B1 (en) 2011-08-26 2017-04-11 Demerx, Inc. Synthetic noribogaine
CA2855994A1 (en) 2011-12-09 2013-06-13 Demerx, Inc. Phosphate esters of noribogaine
WO2013112673A1 (en) 2012-01-25 2013-08-01 Demerx, Inc. Synthetic voacangine
US9150584B2 (en) 2012-01-25 2015-10-06 Demerx, Inc. Indole and benzofuran fused isoquinuclidene derivatives and processes for preparing them
US8940728B2 (en) 2012-12-20 2015-01-27 Demerx, Inc. Substituted noribogaine
WO2014098877A1 (en) 2012-12-20 2014-06-26 Demerx, Inc. Substituted noribogaine
US9045481B2 (en) 2012-12-20 2015-06-02 Demerx, Inc. Substituted noribogaine
WO2014190313A2 (en) 2013-05-24 2014-11-27 The Arizona Board Of Regents On Behalf Of The University Of Arizona Dynorphin a analogs with bradykinin receptors specificity for modulation of neuropathic pain
CA2989550C (en) 2014-06-18 2023-08-08 Demerx, Inc. Halogenated indole and benzofuran derivatives of isoquinuclidene and processes for preparing them

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0788371A1 (en) * 1994-08-26 1997-08-13 LEE, Nancy M. Analgesic method with dynorphin analogues truncated at the n-terminus

Also Published As

Publication number Publication date
HU9403563D0 (en) 1995-02-28
NO944778D0 (no) 1994-12-09
WO1993025217A1 (en) 1993-12-23
FI945811A0 (fi) 1994-12-09
EP0652765A1 (en) 1995-05-17
CA2137916A1 (en) 1993-12-23
HUT70160A (en) 1995-09-28
RU95106651A (ru) 1996-12-27
EP0652765A4 (en) 1997-04-09
AU4399093A (en) 1994-01-04
FI945811L (fi) 1995-02-06
FI945811A7 (fi) 1995-02-06
KR950701818A (ko) 1995-05-17
NO944778L (no) 1995-02-10
CZ281630B6 (cs) 1996-11-13
CZ313194A3 (en) 1995-08-16

Similar Documents

Publication Publication Date Title
JPH08501075A (ja) ｄｅｓ−Ｔｙｒダイノルフィン類似体
Frederickson et al. Metkephamid, a systemically active analog of methionine enkephalin with potent opioid δ-receptor activity
Pert et al. Bombesin: receptor distribution in brain and effects on nociception and locomotor activity
Gispen et al. Opiate antagonists suppress ACTH1–24-induced excessive grooming in the rat
JPH0427995B2 (cs)
Stapleton et al. Naloxone reduces fluid consumption in water-deprived and nondeprived rats
JP2004512260A (ja) 局所麻酔／オピオイド製剤およびその使用方法
RU2010135499A (ru) Аналоги адренокортикотропного гормона и относящиеся к ним методы
Fischer et al. β-Endorphin modulates immune functions: A review
Millan et al. Activation of periaqueductal grey pools of β-endorphin by analgetic electrical stimulation in freely moving rats
Zagon et al. Endogenous opioids in the etiology and treatment of multiple sclerosis
EP4431108A1 (en) Use of polypeptide in resistance to addiction and relapse thereof, and complex and polypeptide
JPH10511077A (ja) Ｎ末端基で切断されたダイノルフィン類似体を用いた鎮痛方法
Adams et al. The role of endogenous peptides in the action of opioid analgesics
US5807827A (en) Des-Tyr dynorphin analogues
Friederich et al. Effects of dynorphin (1–8) on movement: Non-opiate effects and structure-activity relationship
WO2014136118A1 (en) Treatment of post-traumatic stress disorder with melanocortin receptor antagonist
Delle et al. Changes in sympathetic nerve activity during morphine abstinence in the rat
EP3765056B1 (en) Compositions, methods and uses of a teneurin c-terminal associated peptide-1 (tcap-1) for treating opioid addiction
US20220056075A1 (en) Method for treating opioid use disorder
Lipkowski et al. Biphalin: a multireceptor opioid ligand
Macia et al. Hypotension induced by growth-hormone-releasing peptide is mediated by mast cell serotonin release in the rat
HK40046105B (en) Compositions, methods and uses of a teneurin c-terminal associated peptide-1 (tcap-1) for treating opioid addiction
HK40046105A (en) Compositions, methods and uses of a teneurin c-terminal associated peptide-1 (tcap-1) for treating opioid addiction
Lang et al. Angiotensin stimulates oxytocin release: impaired response in rats with genetic hypothalamic diabetes insipidus