JPH08500096A - (3r,4r)−δ▲上6▼−テトラヒドロカンナビノール−7−酸 - Google Patents
(3r,4r)−δ▲上6▼−テトラヒドロカンナビノール−7−酸Info
- Publication number
- JPH08500096A JPH08500096A JP6503574A JP50357494A JPH08500096A JP H08500096 A JPH08500096 A JP H08500096A JP 6503574 A JP6503574 A JP 6503574A JP 50357494 A JP50357494 A JP 50357494A JP H08500096 A JPH08500096 A JP H08500096A
- Authority
- JP
- Japan
- Prior art keywords
- mammal
- administering
- effective amount
- compound
- pharmaceutical composition
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
- C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D311/78—Ring systems having three or more relevant rings
- C07D311/80—Dibenzopyrans; Hydrogenated dibenzopyrans
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pain & Pain Management (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Biomedical Technology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Rheumatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Saccharide Compounds (AREA)
- Fats And Perfumes (AREA)
- Tires In General (AREA)
- Glass Compositions (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
Description
Claims (1)
- 【特許請求の範囲】 1. 式 で、式中のR1が、水素原子、−COCH3あるいは−COCH2CH3であり、R2 が、必要に応じて末端芳香環を有する直鎖あるいは枝分かれC5−C12アルキル ;−(CH2)m−O−R3で、式中のmが0−7の整数、そしてR3が、必要に応 じて末端芳香環を有する、1−12個の炭素原子を含む直鎖あるいは枝分かれの アルキルである基;またはCH−(CH3)−(CH2)n−O−R4で、式中のn が0−7の整数、そしてR4’が、必要に応じて末端芳香環を有する、1−12 個の炭素原子を含む直鎖あるいは枝分かれのアルキルである基である化合物。 2. R1が水素であり、R2が、1、1−ジメチルヘプチルである請求の範囲第 1項に記載の化合物。 3. R1が−COCH3であり、R2が、1,1−ジメチルヘプチルである請求 の範囲第1項に記載の化合物。 4. 請求の範囲第1項に記載の化合物を含有する製剤組成物。 5. 請求の範囲第2項に記載の化合物を含有する製剤組成物。 6. 請求の範囲第3項に記載の化合物を含有する製剤組成物。 7. 哺乳動物の痛みを緩和するにあたって、その動物に、鎮痛有効量の請求の 範囲第1項に記載の化合物を投与する方法。 8. 哺乳動物の痛みを緩和するにあたって、その動物に、鎮痛有効量の請求の 範囲第4項に記載の製剤組成物を投与する方法。 9. 哺乳動物の痛みを緩和するにあたって、その動物に、鎮痛有効量の請求の 範囲第2項に記載の化合物を投与する方法。 10.哺乳動物の痛みを緩和するにあたって、その動物に、鎮痛有効量の請求の 範囲第5項に記載の製剤組成物を投与する方法。 11.哺乳動物の痛みを緩和するにあたって、その動物に、鎮痛有効量の請求の 範囲第3項に記載の化合物を投与する方法。 12.哺乳動物の痛みを緩和するにあたって、その動物に、鎮痛有効量の請求の 範囲第6項に記載の製剤組成物を投与する方法。 13. 哺乳動物の生体組織の炎症を緩和するにあたって、その動物に、抗炎症 有効量の請求の範囲第1項に記載の化合物を投与する方法。 14. 哺乳動物の生体組織の炎症を緩和するにあたって、その動物に、抗炎症 有効量の請求の範囲第4項に記載の製剤組成物を投与する方法。 15. 哺乳動物の生体組織の炎症を緩和するにあたって、その動物に、抗炎症 有効量の請求の範囲第2項に記載の化合物を投与する方法。 16. 哺乳動物の生体組織の炎症を緩和するにあたって、その動物に、抗炎症 有効量の請求の範囲第5項に記載の製剤組成物を投与する方法。 17. 哺乳動物の生体組織の炎症を緩和するにあたって、その動物に、抗炎症 有効量の請求の範囲第3項に記載の化合物を投与する方法。 18. 哺乳動物の生体組織の炎症を緩和するにあたって、その動物に、抗炎症 有効量の請求の範囲第6項に記載の製剤組成物を投与する方法。
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US07/913,096 US5338753A (en) | 1992-07-14 | 1992-07-14 | (3R,4R)-Δ6 -tetrahydrocannabinol-7-oic acids useful as antiinflammatory agents and analgesics |
US913,096 | 1992-07-14 | ||
PCT/US1993/006580 WO1994001429A1 (en) | 1992-07-14 | 1993-07-13 | (3r,4r)-δ6-tetrahydrocannabinol-7-oic acids |
Publications (2)
Publication Number | Publication Date |
---|---|
JPH08500096A true JPH08500096A (ja) | 1996-01-09 |
JP3278159B2 JP3278159B2 (ja) | 2002-04-30 |
Family
ID=25432922
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP50357494A Expired - Fee Related JP3278159B2 (ja) | 1992-07-14 | 1993-07-13 | (3r,4r)−δ▲上6▼−テトラヒドロカンナビノール−7−酸 |
Country Status (13)
Country | Link |
---|---|
US (1) | US5338753A (ja) |
EP (1) | EP0650483B1 (ja) |
JP (1) | JP3278159B2 (ja) |
KR (1) | KR100289202B1 (ja) |
AT (1) | ATE183744T1 (ja) |
AU (1) | AU676845B2 (ja) |
CA (1) | CA2140368C (ja) |
DE (1) | DE69326149T2 (ja) |
DK (1) | DK0650483T3 (ja) |
ES (1) | ES2138626T3 (ja) |
GR (1) | GR3031966T3 (ja) |
HK (1) | HK1010690A1 (ja) |
WO (1) | WO1994001429A1 (ja) |
Families Citing this family (50)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5635530A (en) * | 1991-09-12 | 1997-06-03 | Yissum Research Development Company Of The Hebrew University Of Jerusalem | (3S,4S)-delta-6-tetrahydrocannabinol-7-oic acids and derivatives thereof, processors for their preparation and pharmaceutical compositions containing them |
IL115245A (en) | 1995-09-11 | 2002-12-01 | Yissum Res Dev Co | Tumor necrosis factor inhibiting pharmaceuticals |
US6132762A (en) * | 1997-05-05 | 2000-10-17 | Cristobal; Walter | Transcutaneous application of marijuana |
US6162829A (en) * | 1997-10-17 | 2000-12-19 | Atlantic Pharmaceuticals, Inc. | (3R,4R)-Δ8 -tetrahydrocannabinol-11-oic acids useful as antiinflammatory agents and analgesics |
GB9807639D0 (en) * | 1998-04-14 | 1998-06-10 | Kennedy Rheumatology Inst | Anti-inflammatory agents |
US5847128A (en) * | 1998-05-29 | 1998-12-08 | Virginia Commonwealth University | Water soluble derivatives of cannabinoids |
US6566560B2 (en) | 1999-03-22 | 2003-05-20 | Immugen Pharmaceuticals, Inc. | Resorcinolic compounds |
HUP0203437A3 (en) | 1999-03-22 | 2003-07-28 | Immugen Pharmaceuticals Inc So | Use of resorcinol derivatives for producing pharmaceutical compositions for treatment of immune diseases |
US6448288B1 (en) * | 2000-05-17 | 2002-09-10 | University Of Massachusetts | Cannabinoid drugs |
AU2002213429A1 (en) * | 2000-09-28 | 2002-04-08 | Immugen Pharmaceuticals, Inc. | Antiviral methods and compounds |
AU2001296402A1 (en) * | 2000-09-28 | 2002-04-08 | Immugen Pharmaceuticals, Inc. | Methods and compounds for inhibiting eicosanoid metabolism and platelet aggregation |
US7067539B2 (en) * | 2001-02-08 | 2006-06-27 | Schering Corporation | Cannabinoid receptor ligands |
US7507767B2 (en) * | 2001-02-08 | 2009-03-24 | Schering Corporation | Cannabinoid receptor ligands |
AU2002318427A1 (en) * | 2001-06-25 | 2003-03-03 | University Of Massachusetts | N-fatty acid-amino acid conjugates and therapeutic uses |
DE60234057D1 (de) | 2001-07-25 | 2009-11-26 | Raptor Pharmaceutical Inc | Zusammensetzungen und verfahren zur modulation des transports durch die blut-hirn-schranke |
EP1444203A1 (en) | 2001-11-14 | 2004-08-11 | Schering Corporation | Cannabinoid receptor ligands |
JPWO2003070277A1 (ja) | 2002-02-19 | 2005-06-09 | 塩野義製薬株式会社 | 抗掻痒剤 |
CN1652766A (zh) * | 2002-03-18 | 2005-08-10 | 免疫力药品有限公司 | 间苯二酚和大麻素的局部制剂及其施用方法 |
CA2487346A1 (en) | 2002-06-19 | 2003-12-31 | Schering Corporation | Cannabinoid receptor agonists |
ES2327515T3 (es) | 2002-11-25 | 2009-10-30 | Schering Corporation | Ligandos de receptores de cannabinoides. |
WO2004058251A1 (en) * | 2002-12-19 | 2004-07-15 | University Of Massachusetts | Cannabinoid analogs as peroxisome proliferator activated nuclear receptor gamma activators |
TW200505902A (en) * | 2003-03-20 | 2005-02-16 | Schering Corp | Cannabinoid receptor ligands |
US6916852B2 (en) * | 2003-05-12 | 2005-07-12 | University Of Tennessee Research Foundation | Method for regulation of microvascular tone |
WO2004100893A2 (en) * | 2003-05-12 | 2004-11-25 | Indevus Pharmaceuticals, Inc. | Methods for treatment of inflammatory diseases using ct-3 or analogs thereof |
US20050046848A1 (en) * | 2003-08-26 | 2005-03-03 | Blueshift Biotechnologies, Inc. | Time dependent fluorescence measurements |
WO2005081801A2 (en) * | 2004-02-09 | 2005-09-09 | Blueshift Biotechnologies, Inc. | Methods and apparatus for scanning small sample volumes |
MX2007000015A (es) * | 2004-06-22 | 2007-03-07 | Schering Corp | Ligandos de receptor de canabinoide. |
WO2006014351A2 (en) | 2004-07-02 | 2006-02-09 | Blueshift Biotechnologies, Inc. | Exploring fluorophore microenvironments |
US7544714B2 (en) * | 2004-07-16 | 2009-06-09 | University Of Massachusetts | Lipid-amino acid conjugates and methods of use |
WO2006065792A2 (en) * | 2004-12-13 | 2006-06-22 | Indevus Pharmaceuticals, Inc. | Treatment of interstitial cystitis using cannabinoid analogs |
WO2006065793A2 (en) * | 2004-12-13 | 2006-06-22 | Indevus Pharmaceuticals, Inc. | TREATMENT OF INTERSTITIAL CYSTITIS USING (6aR,10aR)-Δ8-TETRAHYDROCANNABINOL-11-OIC ACIDS |
CN103259027A (zh) | 2005-04-28 | 2013-08-21 | 普罗透斯数字保健公司 | 药物信息系统 |
TWI366460B (en) | 2005-06-16 | 2012-06-21 | Euro Celtique Sa | Cannabinoid active pharmaceutical ingredient for improved dosage forms |
US20070037873A1 (en) * | 2005-08-08 | 2007-02-15 | Zurier Robert B | Airway remodeling treatments |
JP2009510078A (ja) | 2005-09-29 | 2009-03-12 | エーエムアール テクノロジー インコーポレイテッド | Δ−9−テトラヒドロカンナビノールの生成法 |
US20070093519A1 (en) * | 2005-10-20 | 2007-04-26 | Indevus Pharmaceuticals, Inc. | Anti-emetic uses of cannabinoid analogs |
WO2007055806A1 (en) * | 2005-10-31 | 2007-05-18 | Indevus Pharmaceuticals, Inc. | Anti-emetic uses of (3r,4r)-δ8-tetrahydrocannabinol-11-oic acids |
EP2063905B1 (en) | 2006-09-18 | 2014-07-30 | Raptor Pharmaceutical Inc | Treatment of liver disorders by administration of receptor-associated protein (rap)-conjugates |
CA2969926C (en) | 2009-02-20 | 2018-05-15 | 2-Bbb Medicines B.V. | Glutathione-based drug delivery system |
EP2427178B1 (en) | 2009-05-06 | 2023-01-04 | Laboratory Skin Care, Inc. | Dermal delivery compositions comprising active agent-calcium phosphate particle complexes and methods of using the same |
US9066910B2 (en) * | 2010-04-15 | 2015-06-30 | Steven Rosenblatt | Methods and compositions of cannabis extracts |
US20120077778A1 (en) | 2010-09-29 | 2012-03-29 | Andrea Bourdelais | Ladder-Frame Polyether Conjugates |
KR20190139327A (ko) | 2013-02-12 | 2019-12-17 | 코버스 파마수티컬스, 아이엔씨. | 초고순도 테트라하이드로카나비놀-11-오익산 |
US9585867B2 (en) | 2015-08-06 | 2017-03-07 | Charles Everett Ankner | Cannabinod formulation for the sedation of a human or animal |
US10239808B1 (en) | 2016-12-07 | 2019-03-26 | Canopy Holdings, LLC | Cannabis extracts |
WO2019152736A1 (en) | 2018-01-31 | 2019-08-08 | Canopy Holdings, LLC | Hemp powder |
WO2020077153A1 (en) | 2018-10-10 | 2020-04-16 | Canopy Holdings, LLC | Synthesis of cannabigerol |
US20220288015A1 (en) | 2019-08-22 | 2022-09-15 | Epm Group, Inc. | Cannabinoid acid ester compositions and uses thereof |
US20230339880A1 (en) * | 2019-10-11 | 2023-10-26 | Corbus Pharmaceuticals, Inc. | Compositions of ajulemic acid and uses thereof |
US12029718B2 (en) | 2021-11-09 | 2024-07-09 | Cct Sciences, Llc | Process for production of essentially pure delta-9-tetrahydrocannabinol |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4973603A (en) * | 1988-06-16 | 1990-11-27 | Sumner Burstein | Platelet activating factor antagonist and methods of use therefor |
IL99468A (en) * | 1991-09-12 | 1997-09-30 | Yissum Res Dev Co | (3s, 4s)-delta- 6-tetrahydrocannabinol- 7-oic acids and derivatives thereof, processes for their preparation and pharmaceutical compositions containing them |
-
1992
- 1992-07-14 US US07/913,096 patent/US5338753A/en not_active Expired - Lifetime
-
1993
- 1993-07-13 AU AU46759/93A patent/AU676845B2/en not_active Ceased
- 1993-07-13 ES ES93917149T patent/ES2138626T3/es not_active Expired - Lifetime
- 1993-07-13 JP JP50357494A patent/JP3278159B2/ja not_active Expired - Fee Related
- 1993-07-13 DK DK93917149T patent/DK0650483T3/da active
- 1993-07-13 KR KR1019950700133A patent/KR100289202B1/ko not_active IP Right Cessation
- 1993-07-13 AT AT93917149T patent/ATE183744T1/de not_active IP Right Cessation
- 1993-07-13 CA CA002140368A patent/CA2140368C/en not_active Expired - Fee Related
- 1993-07-13 DE DE69326149T patent/DE69326149T2/de not_active Expired - Fee Related
- 1993-07-13 EP EP93917149A patent/EP0650483B1/en not_active Expired - Lifetime
- 1993-07-13 WO PCT/US1993/006580 patent/WO1994001429A1/en active IP Right Grant
-
1998
- 1998-10-29 HK HK98111583A patent/HK1010690A1/xx not_active IP Right Cessation
-
1999
- 1999-11-25 GR GR990403059T patent/GR3031966T3/el unknown
Also Published As
Publication number | Publication date |
---|---|
EP0650483A1 (en) | 1995-05-03 |
ATE183744T1 (de) | 1999-09-15 |
DE69326149D1 (de) | 1999-09-30 |
CA2140368A1 (en) | 1994-01-20 |
GR3031966T3 (en) | 2000-03-31 |
EP0650483B1 (en) | 1999-08-25 |
AU676845B2 (en) | 1997-03-27 |
DK0650483T3 (da) | 2000-03-27 |
HK1010690A1 (en) | 1999-06-25 |
EP0650483A4 (en) | 1995-05-10 |
CA2140368C (en) | 2004-04-27 |
KR100289202B1 (ko) | 2001-05-02 |
KR950702549A (ko) | 1995-07-29 |
DE69326149T2 (de) | 2000-04-27 |
AU4675993A (en) | 1994-01-31 |
US5338753A (en) | 1994-08-16 |
ES2138626T3 (es) | 2000-01-16 |
JP3278159B2 (ja) | 2002-04-30 |
WO1994001429A1 (en) | 1994-01-20 |
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