JPH08173437A - 外科用ファスナ付け装置 - Google Patents
外科用ファスナ付け装置Info
- Publication number
- JPH08173437A JPH08173437A JP7198897A JP19889795A JPH08173437A JP H08173437 A JPH08173437 A JP H08173437A JP 7198897 A JP7198897 A JP 7198897A JP 19889795 A JP19889795 A JP 19889795A JP H08173437 A JPH08173437 A JP H08173437A
- Authority
- JP
- Japan
- Prior art keywords
- cartridge housing
- anvil member
- cartridge
- piston
- actuation mechanism
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
- A61B17/068—Surgical staplers, e.g. containing multiple staples or clamps
- A61B17/072—Surgical staplers, e.g. containing multiple staples or clamps for applying a row of staples in a single action, e.g. the staples being applied simultaneously
- A61B17/07207—Surgical staplers, e.g. containing multiple staples or clamps for applying a row of staples in a single action, e.g. the staples being applied simultaneously the staples being applied sequentially
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
- A61B2017/00535—Surgical instruments, devices or methods, e.g. tourniquets pneumatically or hydraulically operated
- A61B2017/00544—Surgical instruments, devices or methods, e.g. tourniquets pneumatically or hydraulically operated pneumatically
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
- A61B17/068—Surgical staplers, e.g. containing multiple staples or clamps
- A61B17/072—Surgical staplers, e.g. containing multiple staples or clamps for applying a row of staples in a single action, e.g. the staples being applied simultaneously
- A61B2017/07214—Stapler heads
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
- A61B17/068—Surgical staplers, e.g. containing multiple staples or clamps
- A61B17/072—Surgical staplers, e.g. containing multiple staples or clamps for applying a row of staples in a single action, e.g. the staples being applied simultaneously
- A61B2017/07214—Stapler heads
- A61B2017/07285—Stapler heads characterised by its cutter
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
- A61B17/28—Surgical forceps
- A61B17/29—Forceps for use in minimally invasive surgery
- A61B2017/2926—Details of heads or jaws
- A61B2017/2927—Details of heads or jaws the angular position of the head being adjustable with respect to the shaft
- A61B2017/2929—Details of heads or jaws the angular position of the head being adjustable with respect to the shaft with a head rotatable about the longitudinal axis of the shaft
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Surgery (AREA)
- Heart & Thoracic Surgery (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Medical Informatics (AREA)
- Molecular Biology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Surgical Instruments (AREA)
Abstract
随物を徐々に接近させ、カートリッジから複数のファス
ナを次々に出すように構成された作動構造を有する内視
鏡ステープル留め装置を提供することである。 【解決手段】 体の組織に外科用ファスナを付ける装置
が提供される。装置は、ハンドル組立体及びハンドル組
立体から遠位に延びる細長い本体を有する。ファスナ付
け組立体は、細長い本体の遠位端に作動的に関連し、カ
ートリッジハウジング、複数のステープル及び開位置と
閉位置との間を移動可能なアンビルを含む。作動組立体
は、アンビルを徐々に閉じ、同時に、カートリッジから
ステープルを次々に出すために、ファスナ付け組立体内
を移動するように構成される。
Description
装置に関し、さらに特定すると、体の組織に複数の外科
用ファスナを次々に付け、任意に、ファスナで留められ
た組織を切開する装置に関する。
掴まれ、又はクランプされ、それから、外科用装置によ
って接合される外科用装置が、この分野で良く知られて
いる。いくつかの器具では、ファスナによって接合され
た組織を切るためのナイフが設けられている。ファスナ
は、典型的には、外科用ステープルの形態であるが、2
部ポリマ(two part polymeric)ファスナも利用される。
この目的のための器具は、組織を掴み、又はクランプす
るために、それぞれ使用される2つの細長い部材を備え
る。典型的には、一方の部材が、少なくとも2つの横列
に配置された複数のステープルを収容する使い捨てカー
トリッジを支持し、他方の部材が、カートリッジから出
されたときにステープルの脚を形成する表面を構成する
アンビルを備える。一般に、ステープル留め操作は、カ
ートリッジ支持部材の中を長手方向に移動する押し子に
よって行われ、押し子は、ステープルをカートリッジか
ら次々に出すようにステープルに作用する。ナイフが、
ステープル列の間を押し子と共に移動し、ステープルの
間でステープル留めされた組織を長手方向に切り、そし
て/又は、開いてもよい。そのような器具が、ボブロブ
等(Bovrov et al)の米国特許第3,079,606 号明細書、グ
リーン(Green) の米国特許第3,490,675 号明細書に開示
されている。
ているその後のステープラは、2列のステープルを切開
の各側に付ける。これは、2組の互い違いにされたステ
ープル支持溝の間の細長い案内通路の中をカム部材が動
くカートリッジ組立体を設けることによって達成され
る。ステープル押しつけ部材は、溝内に配置され、そし
て、長手方向に動くカムに接触されるように位置決めさ
れ、ステープルを出す。このようなステープラの他の例
が、米国特許第4,429,695 号に開示されている。上述の
各器具は、外科医が外科部位に手で直接アクセスする従
来の外科のために設計されたものである。しかしなが
ら、内視鏡又は腹腔鏡を用いた外科では、外科は、小さ
な切開部を通して又は皮膚に明けられた小さな入口を通
して投入された狭いカニューレを通して行われる。内視
鏡外科及び/又は腹腔鏡外科における特有な要求に応え
るために、内視鏡外科用ステープル留め用器具が開発さ
れており、米国特許第5,040,715 号、5,312,023 号、5,
318,221 号、5,318,221 号に開示されている。一般に、
これらの器具は、アンビルの接近を行うためのクランプ
用構造部材と、その間に組織を固定するカートリッジ
と、組織を固定した後にカートリッジから複数のファス
ナを次々に出すステープル押出構造部材とを備える。
ジ付随物を徐々に接近させ、カートリッジから複数のフ
ァスナを次々に出すように構成された作動構造を有する
内視鏡ステープル留め装置を提供することは有益であ
る。
ファスナを次々に付ける外科用装置が提供される。装置
は、ハンドル部分、ハンドル部分から延びる本体部分、
本体部分の遠位端部分に支持され、複数の外科用ファス
ナを収容し、組織接触面を構成するカートリッジハウジ
ング及びカートリッジ組立体から出されたファスナが押
しつけられるファスナ形成面を構成するアンビル部材を
含む。アンビル部材は、ハンドル部分から離れた位置に
取り付けられ、ファスナ形成面が組織接触面から離れて
いる第一位置と、ファスナ形成面と組織接触面がより接
近して協働的に整列した閉位置との間を移動することが
できる。装置は、アンビル部材を開位置から閉位置へ徐
々に動かし、同時に、複数の外科用ファスナを、アンビ
ルに対して形成させるために、カートリッジから出すよ
うにするアクチュエータをさらに含む。アクチュエータ
を駆動する駆動機構が設けられる。駆動機構は、ハンド
ル部分から操作可能であり、本体部分を通って、アンビ
ル部材に延びる。
カートリッジハウジング及びアンビル部材の各々は、ア
クチュエータの移動に順応するために、各々の中に形成
された対応する長手方向に延びるスロットを有する。好
ましくは、アクチュエータは、上カムビーム、横向き中
央部分及び上カムビームに平行な下カムビームを含む。
間隔を隔てた複数のカムプレートが、アクチュエータに
設けられ、カートリッジハウジングから外科用ファスナ
を出すために、カートリッジハウジング内に配置された
複数のステープル押し子に係合するように構成される。
一つの実施形態において、切断刃が、アクチュエータが
ファスナ付け組立体を通って移動すると、ステープルさ
れた組織を切開するために、アクチュエータに取り付け
られる。切断刃は、好ましくは、アクチュエータの中央
部分の先縁に形成される。
ンドル部分内に配置された圧縮流体のキャニスタ、ハン
ドル部分内に構成される、長手方向に延びるピストンチ
ャンバ、ピストンチャンバを通って移動するように構成
されたピストン及びピストンからアクチュエータに延び
る駆動シャフトを有する空気圧式駆動装置を含む。トリ
ガ機構が、好ましくは、流体をキャニスタからピストン
チャンバに解放し、ピストンをチャンバ内で動かすよう
に、空気圧式駆動装置と関連している。別の実施形態に
おいて、ハンドル部分と関連し、アクチュエータに延び
る細長い駆動シャフトと作動的に連結している、回動す
る作動ハンドルを有する手動駆動装置が設けられる。本
外科用装置のさらなる特徴が、図面とともに以下の詳細
な説明から、当業者にとって、より容易に明らかにな
る。
は装置の操作者に最も近い端を指し、「遠位」とは、装
置の操作者から最も遠い端を指す。本装置は、内視鏡に
よる処置と装置の両方について論じられる。しかし、
「内視鏡」、「内視鏡的に」及び「内視鏡部分」などの
用語のここでの使用は、とりわけ、内視鏡管と関連して
の使用のみに限定するものと解釈されるべきではない。
むしろ、装置は、アクセスが、関節鏡処置及び/又は腹
腔鏡処置を含むが、これに限定されるものでない小さな
切開に限定されるような処置における用途を見い出すか
もしれないということが考えられる。今、同じ参照番号
が同じ構造要素を特定する図面を参照すると、図1に
は、好ましい実施形態によって構成され、全体的に、参
照番号10で指定された外科用ステープラが例示されて
いる。簡単に説明すると、外科用ステープラ10は、ハ
ンドル部分12、ハンドル部分12から遠位側に延びる
細長い管状本体部分14及び本体部分14の遠位端と作
動的に関連したファスナ付け組立体16を含む。
ファスナを収容するステープルカートリッジ18及びス
テープルカートリッジ18と回動可能に関連し、カート
リッジ18から出されたとき、ステープルを打ち当てる
形成表面を構成するアンビル部材20を含む。 図1に
最も良く見られるように、回転制御ノブ22が、本体部
分14の近位端に設けられ、本体部分14によって構成
される長手方向軸線を中心とする本体部分14及びファ
スナ付け組立体16の回転を容易にするような方法で取
り付けられる。図2に示すように、内視鏡処置の間、外
科用装置10の本体部分14は、トロカール15を通し
て、患者の腹腔に延びる。組織は、カートリッジ18と
アンビル20の間に掴まれ、ステープルが、組織に付け
られる。外科用装置10の操作は、以下に詳しく説明さ
れる。
ジ18は、向かい合った側壁26及び28と床部30を
有する、細長いカートリッジハウジング24内に支持さ
れる。図4に最も良くわかるように、カートリッジハウ
ジング24は、本体部分14の遠位端で支持される。ノ
ッチ26a及び28aが、側壁26及び28にそれぞれ
形成され、アンビル部材20から外方に延びる一対の対
応するウイングレット36及び38を回動可能に支持す
る。図3及び5に示すように、バネ40及び42が、ア
ンビル部材と関連し、アンビルをカートリッジ18に対
して、開位置に付勢する。別の実施形態では、アンビル
部材20を、本体部分14に直接取り付けてもよい。い
ずれの実施形態においても、アンビル部材20は、ハン
ドル部分の遠位側に位置決めされ、ファスナ付け組立体
は、ハンドル部分によって、遠隔的に作動される。
るバネを設けれもよい。例えば、バネは、アンビル部材
20の近位部分から延び、本体部分14又はハウジング
24に連結される。体の組織がアンビルとカートリッジ
との間に挿入されたとき、体の組織は、アンビルをカー
トリッジ18から遠ざける。それから、アンビルは、組
織に緩くクランプされ、ファスナが押し出されると、以
下に説明される作動機構が作動され、よりしっかり、そ
して徐々に、組織をクランプする。図3及び4を参照す
ると、作動機構50は、ファスナ付け組立体16に関連
し、アンビル20とカートリッジ18を、徐々に接近さ
せて、それらの間に組織をクランプし、同時に、カート
リッジ18から複数の外科用ステープル34を次々に出
す。さらに、作動機構50は、ファスナ付け組立体16
の中、すなわち、アンビル部材20及びカートリッジ1
8の中を、遠位方向に移動するように構成され、カムア
ンビル部材20を閉位置(完全クランプ位置)へ、漸次
移動させ、同時に、複数のステープル押し子を作動して
カートリッジ18からステープル34を押す。適当なス
テープル押し子の例が、米国特許第4,978,049 号に開示
され、その開示を、ここに援用する。
下カムプレート56を、遠位端に配置し、近位端に取付
けブロック58を配置した細長い支持ビーム52を含
む。アンビル部材20には、ステープル留め処置の間、
作動機構50の移動に順応する細長いスロット60が形
成される。対応するスロット62が、カートリッジハウ
ジング24の床部30に形成される。使用中、作動機構
50が、ファスナ付け組立体16の中を、移動すると
き、上カムプレート54は、アンビル部材20の上面
(外面)20aに係合して、アンビル部材をカートリッ
ジ18の方へ押し、下カムプレート56は、床部30の
下面(外面)30aに係合して、上カムプレートによって
アンビルに及ぼされた圧縮力をバランスさせる。図示さ
れるように、上カムプレート54及び下カムプレート5
6は、実質的に平らである。
作動するように構成されたステープル押出バー70a乃
至70dをさらに含む。押出バーは、それらのそれぞれ
の近位端が、対応する係合スロット76に受け入れられ
る係合フック74によって取付けブロック58に係合さ
れる。各押し子の遠位端は、くさび形カム面78を有
し、該カム面は、作動機構50が、ファスナ付け組立体
16の中を移動するとき、ステープル押し子35に係合
する。支持ビーム52の先縁は、組立体16によって付
けられるステープルの平行な列の間に位置した組織に切
開を形成するために作られた切断刃80を構成する。図
6を参照すると、空気圧式駆動装置90が、ハンドル部
分12に作動的に関連し、ステープル留め処置の間、フ
ァスナ付け組立体16の中での作動機構50の移動を制
御する。特に、駆動装置90は、ハンドル部分12か
ら、本体部分14を通して、ファスナ付け組立体16ま
で延びる駆動シャフト92の長手方向移動を行わせるの
に役立つ。駆動シャフト92の遠位端は、取付けブロッ
ク58の対応する受け入れスロット96a及び96bに
係合するように構成された二股フック部分94を含む
(図2及び3に示す)。
から延びる。ピストン98は、ハンドル部分12内に構
成された細長いピストンチャンバ100の中を移動する
ように構成されている。ピストンチャンバ100は、可
撓管104を介してバルブ組立体102と連通してい
る。バルブ組立体102は、比較的低圧の圧縮ガス供給
源を収容する、円筒形キャニスタ106と関連してい
る。回動するトリガ108がハンドル部分112と関連
し、かつバルブ組立体102と相互作用するように構成
され、供給キャニスタ106からピストンチャンバ10
0へのガスの放出を制御する。空気圧式装置の構造及び
作用は、米国特許第5,312,023 号に詳細に記載されてお
り、その開示を、ここに援用する。操作中、図5に示す
ような、矢印Aで指示した方向にトリガ108を操作す
ると、バルブ組立体102により、圧縮ガスをキャニス
タ106から、管104を通って、ピストンチャンバ1
00へ流入させる。チャンバ100内での圧縮ガスの膨
張の結果、ピストン98は、矢印Bで指示したように遠
位方向に駆動される。そのとき、駆動シャフト92は、
遠位方向に押され、作動機構50をファスナ付け組立体
16の中へ押し入れる。作動機構50の、遠位方向の移
動により、カムプレート54は、アンビル部材20を、
カートリッジ18の方へ付勢し、アンビル部材20のフ
ァスナ形成面をカートリッジ18の組織接触面と、より
接近して協働的に整列させ、その間に配置された体の組
織110をクランプする。同時に、ステープル押し子3
5は、各ステープル押出バー70a乃至70dのくさび
形カム面78によって作動され、ステープル34を、掴
まれた体の組織110に押し通す。加えて、切断刃80
が、ステープル押出バーにおくれて移動して、ステープ
ル留めされた組織を切開する。
バ100内での圧縮ガスの膨張により、ピストン98及
び作動機構50を、各ステープルがカートリッジ18か
ら出されるまで、遠位側に移動させる。その後、ピスト
ンチャンバ100内に配置され、ピストン98の遠位側
への移動によって圧縮されたコイル状戻りバネ112
が、ピストンを近位側に押して、駆動シャフト92及び
作動機構50を、最も遠位の位置に戻す。それによっ
て、使用済みステープルカートリッジは、カートリッジ
ハウジング24から取り出され、完全に装填されたカー
トリッジで置き換えられ、装置10を、再度、利用する
ことができる。本装置を、好ましい実施形態について説
明したが、特許請求の範囲によって定められる如き精神
又は範囲から逸脱することなく、これに変更や修正がな
されることを含むことは、当業者にとって、容易に明ら
かになるであろう。
ープル留め装置の斜視図である。
ールを通して患者の腹腔に、延びる、図1の外科用装置
の斜視図である。
体の分解斜視図である。
カートリッジハウジングから取り外した、図1の外科用
装置のファスナ付け組立体の斜視図である。
面図である。
の部分断面の側面図である。
断面の側面図である。
Claims (16)
- 【請求項1】 a)ハンドル部分と、 b)ハンドル部分から遠位側に延びる細長い本体部分と、 c)本体部分の遠位端部分で支持され、組織接触面を構成
し、かつ複数の外科用ファスナを収容するカートリッジ
ハウジングと、 d)カートリッジハウジングから出されたファスナが押し
つけられるファスナ形成面を構成するアンビル部材とを
有し、アンビル部材とカートリッジハウジングは、ハン
ドル部分から間隔を隔てた位置において、第一位置と、
ファスナ形成面及び組織接触面がより接近して協働的に
整列する第二位置との間で相対運動可能に取り付けら
れ、 e)さらに、アンビル部材とカートリッジハウジングを、
第一位置から第二位置まで徐々に接近させ、カートリッ
ジから複数の外科用ファスナをアンビルに向かって形成
されるべく押し出すために、アンビル部材及びカートリ
ッジハウジングの中を移動するように構成された作動機
構と、 f)ハンドル部分から操作可能で、本体部分を通して延
び、作動機構をアンビル部材の中に駆動する駆動機構と
を有する体の組織に外科用ファスナ付け装置。 - 【請求項2】 カートリッジハウジング及びアンビル部
材の各々には、作動機構の移動に順応するための長手方
向に延びるスロットが形成されている請求項1に記載の
装置。 - 【請求項3】 作動機構は、上カムビーム、中央部分及
び上カムビームと平行な下支持ビームを含む前記請求項
のいずれかに記載の装置。 - 【請求項4】 作動機構は、アンビルの第二位置への移
動と同時に、カートリッジハウジングから外科用ファス
ナを出すために、カートリッジハウジング内に配置され
た複数のステープル押し子に係合するように構成された
複数の間隔を隔てたカムバーを含む前記請求項のいずれ
かに記載の装置。 - 【請求項5】 ハンドル組立体と作動的に関連し、ファ
スナ付け組立体の中にアクチュエータを駆動するように
作動される空気圧式駆動装置をさらに備える前記請求項
のいずれかに記載の装置。 - 【請求項6】 空気圧式駆動装置は、ハンドル部分内に
配置された圧縮流体のキャニスタ、ハンドル部分内に構
成された長手方向に延びるピストンチャンバ、ピストン
チャンバの中を移動するように構成されたピストン及び
ピストンからアクチュエータまで延びる駆動シャフトを
含む前記請求項のいずれかに記載の装置。 - 【請求項7】 流体をキャニスタからピストンチャンバ
に解放して、ピストンをチャンバの中を駆動するため
に、空気圧式駆動装置と関連したトリガ機構をさらに備
え、ピストンは、ピストンチャンバの中を一般的に遠位
方向に移動するように構成され、ピストンを近位方向に
付勢するために、ピストンチャンバ内に配置されたコイ
ル状戻りバネをさらに備える請求項7に記載の装置。 - 【請求項8】 作動機構がアクチュエータ部材及びカー
トリッジハウジングの中を移動するとき、ステープル留
めされた組織を切開するために、作動機構に取り付けら
れた切断刃をさらに備える前記請求項のいずれかに記載
の装置。 - 【請求項9】 切断刃は、作動機構がアクチュエータ部
材及びカートリッジハウジングの中を移動するとき、ス
テープル留めされた組織を切開するために、作動機構の
中央部分の先縁に形成される請求項8に記載の装置。 - 【請求項10】 アンビル部材は、第二位置にバネ付勢
される前記請求項のいずれかに記載の装置。 - 【請求項11】 作動機構は、遠位端に上カムプレート
と下カムプレートを、近位端に少なくとも一つのファス
ナ押出バーを受け入れる取付けブロックを含む前記請求
項のいずれかに記載の装置。 - 【請求項12】 アンビル部材は、ファスナ形成面と反
対側の外面部分を有し、作動機構は、該外面部分に係合
する前記請求項のいずれかに記載の装置。 - 【請求項13】 アンビル部材は、長手方向に延びるス
ロットを含み、前記作動機構は、前記外面部分に係合す
るように前記スロットを通して延び、前記作動機構は、
アンビルを第二位置に徐々に移動させるために、前記ア
ンビル部材の前記外面部分に係合するカムプレートを遠
位端に有する請求項12に記載の装置。 - 【請求項14】 カートリッジハウジング組織接触面と
反対側の外面部分及び長手方向に延びるスロットを含
み、前記作動機構は、前記スロットを通って延び、前記
カートリッジハウジングの前記外面部分に係合する前記
請求項のいずれかに記載の装置。 - 【請求項15】 前記作動機構は、前記カートリッジハ
ウジングの外面部分に係合するカムプレートを遠位端に
含む請求項14に記載の装置。 - 【請求項16】 アンビル部材及びカートリッジハウジ
ングに係合するカムプレートは、実質的に平らである請
求項13又は15に記載の装置。
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US08/286851 | 1994-08-05 | ||
US08/286,851 US5507426A (en) | 1994-08-05 | 1994-08-05 | Apparatus for applying surgical fasteners |
Publications (2)
Publication Number | Publication Date |
---|---|
JPH08173437A true JPH08173437A (ja) | 1996-07-09 |
JP3828183B2 JP3828183B2 (ja) | 2006-10-04 |
Family
ID=23100440
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP19889795A Expired - Fee Related JP3828183B2 (ja) | 1994-08-05 | 1995-08-04 | 外科用ファスナ付け装置 |
Country Status (7)
Country | Link |
---|---|
US (2) | US5507426A (ja) |
EP (2) | EP0699417B1 (ja) |
JP (1) | JP3828183B2 (ja) |
AU (1) | AU692572B2 (ja) |
CA (1) | CA2155477C (ja) |
DE (2) | DE69535085T2 (ja) |
ES (2) | ES2264065T3 (ja) |
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JP3828183B2 (ja) | 2006-10-04 |
DE69533016T2 (de) | 2005-05-12 |
CA2155477A1 (en) | 1996-02-06 |
DE69535085D1 (de) | 2006-08-03 |
US5657921A (en) | 1997-08-19 |
ES2218533T3 (es) | 2004-11-16 |
CA2155477C (en) | 2006-07-11 |
US5507426A (en) | 1996-04-16 |
AU692572B2 (en) | 1998-06-11 |
EP1459687A2 (en) | 2004-09-22 |
ES2264065T3 (es) | 2006-12-16 |
EP1459687A3 (en) | 2005-07-20 |
EP0699417B1 (en) | 2004-05-12 |
EP1459687B1 (en) | 2006-06-21 |
AU2831995A (en) | 1996-02-15 |
DE69535085T2 (de) | 2007-01-04 |
DE69533016D1 (de) | 2004-06-17 |
EP0699417A1 (en) | 1996-03-06 |
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