JPH08127523A - Skin beautifying cosmetic - Google Patents

Abstract

PURPOSE: To obtain a wrinkle-smoothing agent exhibiting excellent stability and wrinkle-smoothing effect and useful as a cosmetic component and prepare a skin-beautifying cosmetic containing the smoothing agent by using a pear pip essence as an active component. CONSTITUTION: This wrinkle-smoothing agent contains the essence of pips of a pear such as Japanese pear (e.g. Chojurou, Housui, Kousui and Nijusseiki) and common pear (e.g. brandy and francaise) as active component. The essence can be prepared by pressing the pear pips or extracting the pips with an organic solvent and concentrating the extract. A skin beautifying cosmetic can be prepared by incorporating 0.1-10wt.% of the wrinkle-smoothing agent.

Description

Detailed Description of the Invention

[0001]

BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to a cosmetic, and more particularly to a cosmetic for beautiful skin containing a wrinkle improving agent.

[0002]

2. Description of the Related Art Beautiful skin has been a desire of all human beings since ancient times.
In boys and girls' age, wrinkles are formed even if the skin is water-colored, with age-related pigmentation, loss of elasticity due to decreased collagen production and qualitative changes. And the beauty is lost.

To counter these, various cosmetics and cosmetic materials have been developed. For example, it has been found that hydroquinone glycosides have an excellent whitening effect and improve pigmentation. In addition, polysaccharides typified by hyaluronic acid have an excellent water-retaining action, and are known to assist the water-retaining ability of the skin whose water-retaining ability has deteriorated due to aging, etc., and to impart freshness to the skin. .

However, among the changes in the skin with age, a fundamental countermeasure against wrinkles is lacking, and the only countermeasure is to extend the skin by a film-forming agent or the like to make it inconspicuous.

Further, the wrinkle-reducing action of pear seed essence has not been known.

[0006]

That is, an object of the present invention is to provide a wrinkle-improving agent capable of improving wrinkles and a cosmetic for beautiful skin containing the same.

[0007]

In view of the above-mentioned circumstances, various natural product extracts were screened with a wrinkle-improving effect as an index, and as a result of intensive studies, the present inventors found that the essence of pear seeds was significantly wrinkled. The invention was completed by finding out that it contains a substance that improves.

That is, the present invention relates to a wrinkle improving agent consisting of the essence of pear seeds.

Further, the present invention provides the wrinkle improving agent in an amount of 0.1-0.1%.
The present invention relates to a skin cosmetic containing 10% by weight.

The present invention will be described in detail below.

The pear referred to in the present invention is a plant belonging to the family Rosaceae. Specifically, it is a general term for domestic pears such as Chojuro, Hosui, Kosui, 20th century, and pears such as brandy and francaise. Is. These fruits are widely sold even in Japan and are used for food or juice. In the present invention, this pear seed essence is used as a wrinkle improving agent. As a method for obtaining the essence from pear seed, a squeezing method and an extraction method can be exemplified.

This is a method for obtaining the wrinkle improving agent of the present invention from pear seeds by squeezing, which may be carried out under heating or at room temperature. The squeezing may be carried out according to a conventional method using an ordinary squeezing machine.

In order to obtain the wrinkle improving agent of the present invention from pear seeds by extraction, it is preferable to extract them with an organic solvent. Examples of the organic solvent used include alcohols such as methanol and ethanol, halogenated hydrocarbons such as chloroform and dichloromethane, ethers such as diethyl ether and isopropyl ether, ketones such as acetone and methyl ethyl ketone, normal hexane, cyclohexane and petroleum ether. And one or more selected from hydrocarbons and the like. The extraction may be continuous type or batch type, and may be heated at room temperature, at room temperature, or under cooling. Moreover, you may add stirring appropriately. Furthermore, the pear seeds may be pre-dried prior to extraction. It is also possible to remove insoluble matter by filtering after extraction. The extract thus obtained can be directly used as a wrinkle improver after removing the solvent by concentration under reduced pressure or the like.

To mix the pear seed essence of the present invention into a cosmetic as a wrinkle improver, hydrocarbons, esters, oils and fats, oils, fatty acids, alcohols, surfactants, thickeners, powders, moisturizers, etc. It can be formulated into various cosmetic forms such as lotion, emulsion, cream, under make-up, foundation, etc. by a conventional method together with an agent, an antiseptic, an antioxidant, an ultraviolet absorber, a fragrance, various medicinal ingredients and the like. .
At this time, the preferable compounding amount of the wrinkle improving agent of the present invention is 0.1 to 10% by weight based on the total amount of the cosmetic. This is 0.
If less than 1% by weight, no effect can be expected and 10% by weight
This is because the effect will reach the ceiling even if it exceeds.

The wrinkle-improving agent of the present invention has excellent safety and a wrinkle-improving effect, as shown in Examples below.
It is very useful as a cosmetic ingredient.

[0016]

EXAMPLES The present invention will be described in more detail with reference to examples, but it goes without saying that the present invention is not limited to these examples.

Embodiment 1. Production Example 1 1 kg of dried pear seeds was finely crushed, 2 l of normal hexane was added, the mixture was heated under reflux with stirring, filtered and concentrated under reduced pressure to obtain 101 g of a pale yellow liquid.

Example 2. Production Example 2 1 kg of dried pear seeds was finely crushed, 2 l of dichloromethane was added, the mixture was heated under reflux with stirring, filtered, and concentrated under reduced pressure to obtain 153 g of a pale yellow liquid.

Embodiment 3 FIG. Production Example 3 1 kg of dried pear seeds was finely crushed, 2 l of diethyl ether was added, the mixture was heated under reflux with stirring, filtered, and concentrated under reduced pressure to obtain 112 g of a pale yellow liquid.

Example 4. Production Example 4 1 kg of dried pear seeds was finely crushed, and then acetone 2 was added.
1 was added, and the mixture was heated under reflux with stirring, filtered, and concentrated under reduced pressure to obtain 78 g of a pale yellow liquid.

Example 5. Production Example 5 1 kg of pear seeds was finely crushed, 2 l of 50% ethanol-chloroform solution was added, and the mixture was heated under reflux with stirring,
After filtration and concentration under reduced pressure, 111 g of a pale yellow liquid was obtained.

Embodiment 6. 1 Kg of dried pear seeds was put into a press and pressed at 450 Kg while being heated to 80 ° C. to obtain 21 g of a pale yellow liquid.

Example 7. Acute toxicity Acute toxicity was examined using ICR mice (male, 5 weeks old, 25-35 g). That is, one group consists of 6 animals, and Production Examples 1 to
Each of the 6 wrinkle improving agents was orally administered at 1 g / Kg.
On the 14th day after administration, life or death was judged and the LD50 value was calculated. No deaths were observed in any of the animals, so the LD50 value was 1 g /
It seems to be over Kg. From this, it can be seen that the safety of the present invention is high.

Example 8. Local toxicity Hartley white guinea pig (female, 300-350
g) The backs of 6 animals were shaved to create 6 sites of 1 mm square. The wrinkle improving agents of Examples 1 to 6 were applied to each of the parts.
03m was administered once a day for 5 consecutive days, and the skin reaction was evaluated on the 6th day based on Japanese patch test criteria. That is,
No reaction, ±: false positive reaction, +: positive reaction, ++: reaction with edema. The judgment was that there was no reaction at any part. From this, it is understood that the anti-wrinkle agent of the present invention has low local toxicity to the skin.

Example 9. Keratin turnover speed promoting effect The skin activating effect, which is an index of the wrinkle improving effect, was measured as the turnover promoting effect. After shaving the back of each of the six guinea pigs per group, 10% of Examples 1-6
Apply liquid paraffin solution, and use BLB lamp for 80W
Ultraviolet rays were irradiated for 30 minutes at a light amount of / cm ² . This one
After continued once a day for 5 days, dansyl chloride was applied, and the number of days until the fluorescence of dansyl chloride disappeared was measured. For comparison, a 10% liquid paraffin solution of vitamin A, which is known as a turnover accelerator, was used. The results are shown in Table 1. From this, it is understood that the anti-wrinkle agent of the present invention has an excellent effect of promoting keratin turnover. Therefore, this can be expected to activate the skin and improve wrinkles.

[0026]

[Table 1]

Example 10. Formulation Example 1 (Emulsion) An emulsion was prepared according to the following formulation. That is, A, B, C
Was dissolved by heating at 80 ° C., B was gradually added to A with stirring, C was further added, and the mixture was cooled with stirring to obtain an emulsion. (A) Behenyl alcohol 0.5 Synthetic geyrow 2.5 Olive oil 1.5 Sorbitan monostearate 1.5 POE (20) Behenyl ether 2 Butylparaben 0.1 BHT 0.1 Liquid paraffin 3.5 Wrinkles of Example 1 Improver 0.1 Stearic acid 0.5 (B) Propylene glycol 10 Methylparaben 0.2 Caustic potash 0.1 Water 50 (C) Carbopol 0.2 Water 27.2

Example 11. Formulation Example 2 (Emulsion) An emulsion was prepared according to the following formulation. That is, A, B, C
Was dissolved by heating at 80 ° C., B was gradually added to A with stirring, C was further added, and the mixture was cooled with stirring to obtain an emulsion. (A) Behenyl alcohol 0.5 Synthetic gallows 2.5 Olive oil 1.5 Sorbitan monostearate 1.5 POE (20) Behenyl ether 2 Butylparaben 0.1 BHT 0.1 Liquid paraffin 3.6 Wrinkles of Example 2 Improver 5 stearic acid 0.5 (B) propylene glycol 10 methylparaben 0.2 caustic potash 0.1 water 50 (C) carbopol 0.2 water 22.2

Example 12 Formulation Example 3 (Emulsion) An emulsion was prepared according to the following formulation. That is, A, B, C
Was dissolved by heating at 80 ° C., B was gradually added to A with stirring, C was further added, and the mixture was cooled with stirring to obtain an emulsion. (A) Behenyl alcohol 0.5 Synthetic gallows 2.5 Olive oil 1.5 Sorbitan monostearate 1.5 POE (20) Behenyl ether 2 Butylparaben 0.1 BHT 0.1 Liquid paraffin 3.6 Wrinkles of Example 3 Improver 1 Stearic acid 0.5 (B) Propylene glycol 10 Methylparaben 0.2 Caustic potash 0.1 Water 50 (C) Carbopol 0.2 Water 26.2

Example 13 Formulation Example 4 (Emulsion) An emulsion was prepared according to the following formulation. That is, A, B, C
Was dissolved by heating at 80 ° C., B was gradually added to A with stirring, C was further added, and the mixture was cooled with stirring to obtain an emulsion. (A) Behenyl alcohol 0.5 Synthetic geyrow 2.5 Olive oil 1.5 Sorbitan monostearate 1.5 POE (20) Behenyl ether 2 Butylparaben 0.1 BHT 0.1 Liquid paraffin 3.6 Wrinkles of Example 4 Improver 5 Wrinkle improver of Example 5 5 Stearic acid 0.5 (B) Propylene glycol 10 Methylparaben 0.2 Caustic potash 0.1 Water 50 (C) Carbopol 0.2 Water 17.2

Example 14 Formulation Example 5 (Cream) A cream was prepared according to the following formulation. That is, A, B
Were dissolved by heating at 80 ° C., B was gradually added to A while stirring, and cooled to obtain a cream. (A) Behenyl alcohol 6 Olive oil 6 Hydrogenated tallow 2 Microcrystalline wax 6 Liquid paraffin 20 Stearic acid 4 Glyceryl monostearate 2.5 POE (20) Behenyl ether 1.5 Beeswax 2 Benzalkonium chloride 0.1 Example 6 Wrinkle improver 5 (B) propylene glycol 10 caustic potash 0.1 water 36.8

Example 15 Use test A use test was performed using the emulsion of Example 10. That is,
20 female panelists with wrinkles (age 35-70)
The wrinkle-reducing effect of the emulsion of Example 10 and the emulsion of Example 10 in which the wrinkle-improving agent was replaced with water were examined. These emulsions were used twice a day for 30 consecutive days, and the skin condition was photographed before and after use, and the degree of improvement was judged according to the following criteria. -: No change or deterioration, ±: Slight improvement, +: Clear improvement, +
+: A criterion for significant improvement. Table 2 shows the results. The wrinkle reducing effect of the wrinkle reducing agent of the present invention is clear.

[0033]

[Table 2]

Example 16 Usage test The cream of Example 14 was subjected to an actual usage test,
The effect of improving wrinkles was confirmed. That is, 20 female panelists (aged 40 to 65 years old) suffering from wrinkles are used and divided into 2 groups of 10 people, one group is the cream of Example 14 and the other group is the cream of Example 14. The cream of Comparative Example in which the wrinkle improving agent of Example 1 was replaced with olive oil was passed, and 3
I had it used twice a month continuously. Then, the degree of improvement of wrinkles was examined by a questionnaire. The results are shown in Table 3. From this, it can be seen that the cream of the example has improved wrinkles as compared with the cream of the comparative example. Therefore, it is clear that the anti-wrinkle agent of the present invention has an excellent anti-wrinkle action.

[0035]

[Table 3]

[0036]

EFFECT OF THE INVENTION Since the wrinkle improving agent of the present invention is highly safe and has an excellent wrinkle improving action, it is very useful as a component of cosmetics.

 ─────────────────────────────────────────────────── ─── Continuation of the front page (72) Inventor Toshiyuki Fukuda 27-1 Takashimadai, Kanagawa-ku, Yokohama, Kanagawa Pola Chemical Industry Co., Ltd. Yokohama Research Laboratory (72) Masayoshi Yagi 27 Takashimadai, Kanagawa-ku, Yokohama, Kanagawa No. 1 Pola Chemical Industry Co., Ltd. Yokohama Research Center

Claims (4)

[Claims] 1. A wrinkle improving agent comprising pear seed essence. 2. The wrinkle improving agent according to claim 1, wherein the pear seed essence is an essence obtained by pressing pear seeds. 3. The wrinkle improving agent according to claim 1, wherein the pear seed essence is an essence obtained by extracting pear seed with an organic solvent and concentrating the pear seed. 4. The anti-wrinkle agent according to claim 1 is added to 0.1.
Beauty cosmetics containing 10% by weight.