JP3216948B2 - Beautiful skin cosmetics - Google Patents

Description

DETAILED DESCRIPTION OF THE INVENTION

[0001]

BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to a cosmetic, and more particularly, to a cosmetic cosmetic containing a wrinkle improving agent.

[0002]

2. Description of the Related Art Beautiful skin has been a desire of all human beings since ancient times.
In boys and girls, wrinkles are formed even when the skin is dull and wet, such as pigmentation occurs over time, and elasticity is lost due to decreased collagen production and qualitative changes. That beauty is lost.

Various cosmetics and cosmetic materials have been developed to combat these problems. For example, it has been found that hydroquinone glycosides have an excellent whitening effect and improve pigmentation. In addition, polysaccharides represented by hyaluronic acid have an excellent water-retaining effect, are known to assist the water-retaining ability of the skin with reduced water-retaining ability due to aging or the like, and give the skin freshness. .

However, among the aging changes of the skin, wrinkles lack a fundamental countermeasure, and there is only a countermeasure to extend the skin with a film-forming agent or the like to make it less noticeable.

[0005] In addition, the essence of guava seeds has not been known to have a wrinkle-reducing effect.

[0006]

That is, an object of the present invention is to provide a wrinkle improving agent capable of improving wrinkles and a cosmetic skin care containing the same.

[0007]

Means for Solving the Problems In view of the above-mentioned circumstances, screening of various natural product extracts using the wrinkle improving effect as an index and intensive research have shown that the essence of guava seeds is remarkably high. They found that they contained wrinkle improving substances and completed the invention.

That is, the present invention relates to a wrinkle improving agent comprising the essence of guava seeds.

[0009] The present invention also relates to a wrinkle improving agent of 0.1 to
It relates to a beautiful skin cosmetic containing 10% by weight.

Hereinafter, the present invention will be described in detail.

The guava referred to in the present invention is a plant belonging to the family Myrtaceae, and its fruits are widely sold and used for food in Japan. In the present invention, the essence of guava seeds is used as a wrinkle improving agent. Examples of methods for obtaining essence from guava seeds include a squeezing method and an extraction method.

This is a method for obtaining the wrinkle improving agent of the present invention from guava seeds by squeezing.
Moreover, you may carry out at room temperature. The squeezing may be performed according to a conventional method using an ordinary squeezing machine.

In order to obtain the wrinkle-reducing agent of the present invention from guava seeds by extraction, it is preferable to extract them with an organic solvent. Examples of the organic solvent used include alcohols such as methanol and ethanol, halogenated hydrocarbons such as chloroform and dichloromethane, ethers such as diethyl ether and isopropyl ether, ketones such as acetone and methyl ethyl ketone, normal hexane, cyclohexane, and petroleum ether. And one or more selected from hydrocarbons and the like. The extraction may be of a continuous type or a batch type, and the temperature may be heated, at room temperature, or under cooling. In addition, stirring may be appropriately added. Further, the guava seeds may be dried before extraction. After extraction, it is also possible to remove insolubles by filtration. The extract thus obtained can be directly used as a wrinkle improver after removing the solvent by concentration under reduced pressure or the like.

For incorporating the guava seed essence of the present invention into a cosmetic as a wrinkle improver, hydrocarbons, esters, oils and fats, oils, fatty acids, alcohols, surfactants,
Thickeners, powders, humectants, preservatives, antioxidants, ultraviolet absorbers, fragrances, various medicinal ingredients and other usual methods,
It can be formulated into various cosmetic forms such as lotion, milky lotion, cream, under-makeup, foundation and the like. At this time, a suitable amount of the wrinkle improving agent of the present invention is 0.1 to 10% by weight based on the total amount of the cosmetic. this is,
If the amount is less than 0.1% by weight, the effect cannot be expected, and if the amount exceeds 10% by weight, the effect reaches a plateau.

As shown in the Examples below, the wrinkle improving agent of the present invention has excellent safety and a wrinkle improving effect.
It is very useful as a component of cosmetics.

[0016]

EXAMPLES Hereinafter, the present invention will be described in more detail with reference to examples, but it goes without saying that the present invention is not limited to these examples.

Embodiment 1 FIG. Production Example 1 After 1 kg of dried guava seeds was finely ground, 2 l of normal hexane was added thereto, and the mixture was heated under reflux with stirring, filtered, and concentrated under reduced pressure to obtain 131 g of a pale yellow liquid.

Embodiment 2 FIG. Production Example 2 After 1 kg of dried guava seeds was finely ground, 2 l of dichloromethane was added thereto, and the mixture was heated under reflux with stirring, filtered, and concentrated under reduced pressure to obtain 145 g of a pale yellow liquid.

Embodiment 3 FIG. Production Example 3 After 1 kg of dried guava seeds was finely ground, 2 l of diethyl ether was added thereto, and the mixture was heated under reflux with stirring, filtered, and concentrated under reduced pressure to obtain 152 g of a pale yellow liquid.

Embodiment 4 FIG. Production Example 4 After 1 kg of dried guava seeds was finely ground, 2 l of acetone was added thereto, and the mixture was heated under reflux with stirring, filtered, and concentrated under reduced pressure to obtain 104 g of a pale yellow liquid.

Embodiment 5 FIG. Production Example 5 After 1 kg of guava seeds were finely ground, 2 l of a 50% ethanol-chloroform solution was added, and the mixture was heated under reflux with stirring, filtered, and concentrated under reduced pressure to obtain 102 g of a pale yellow liquid.

Embodiment 6 FIG. Production Example 6 1 kg of dried guava seeds was squeezed with a press at 450 kg while heating to 80 ° C. to obtain 43 g of a pale yellow liquid.

Embodiment 7 FIG. Acute toxicity Acute toxicity was examined using ICR mice (male, 5 weeks old, 25 to 35 g). That is, 6 animals per group, Production Examples 1 to
Each of 6 wrinkle improvers was orally administered at 1 g / Kg.
On the 14th day after the administration, survival was determined and the LD50 value was determined. None of the animals died, and the LD50 value was 1 g /
It seems to be more than Kg. This indicates that the safety of the present invention is high.

Embodiment 8 FIG. Local toxicity Hartley white guinea pig (female, 300-350
g) The backs of the six animals were shaved to create six 1 mm square parts. The wrinkle improving agent of Examples 1 to 6 was added to each part at 0.
03m was administered once a day for 5 consecutive days, and on the 6th day the skin reaction was determined based on the Japanese patch test criteria. That is,
No response, ±: false positive response, +: positive response, ++: criterion for response with edema. The judgment was that there was no reaction at any site. This indicates that the wrinkle improving agent of the present invention has low local toxicity to the skin.

Embodiment 9 FIG. Keratin turnover speed promotion effect Skin activation, which is an index of wrinkle improvement effect, was measured as turnover promotion effect. After shaving the back of each group of 6 guinea pigs, 10% of Examples 1-6
Apply a liquid paraffin solution and use a BLB lamp for 80W
UV light was applied for 30 minutes at a light intensity of / cm ² . This one
After continuing for 5 days once a day, dansyl chloride was applied and the number of days until the fluorescence of dansyl chloride disappeared was measured. As a comparison, a 10% liquid paraffin solution of vitamin A, which is known as a turnover accelerator, was used. Table 1 shows the results. This indicates that the wrinkle improver of the present invention has an excellent keratin turnover promoting effect. Therefore, it can be expected that this will activate the skin and improve wrinkles.

[0026]

[Table 1]

Embodiment 10 FIG. Formulation Example 1 (Emulsion) An emulsion was prepared according to the following formulation. That is, A, B, C
Were heated and dissolved at 80 ° C., respectively, and B was gradually added to A while stirring, C was further added, and the mixture was cooled with stirring to obtain an emulsion. (A) behenyl alcohol 0.5 synthetic gay wax 2.5 olive oil 1.5 sorbitan monostearate 1.5 POE (20) behenyl ether 2 butyl paraben 0.1 BHT 0.1 liquid paraffin 3.5 wrinkles of Example 1 Improving agent 0.1 Stearic acid 0.5 (B) Propylene glycol 10 Methyl paraben 0.2 Caustic potash 0.1 Water 50 (C) Carbopol 0.2 Water 27.2

Embodiment 11 FIG. Formulation Example 2 (Emulsion) An emulsion was prepared according to the following formulation. That is, A, B, C
Were heated and dissolved at 80 ° C., respectively, and B was gradually added to A while stirring, C was further added, and the mixture was cooled with stirring to obtain an emulsion. (A) behenyl alcohol 0.5 synthetic gay wax 2.5 olive oil 1.5 sorbitan monostearate 1.5 POE (20) behenyl ether 2 butyl paraben 0.1 BHT 0.1 liquid paraffin 3.6 wrinkles of Example 2 Improving agent 5 Stearic acid 0.5 (B) Propylene glycol 10 Methyl paraben 0.2 Caustic potassium 0.1 Water 50 (C) Carbopol 0.2 Water 22.2

Embodiment 12 FIG. Formulation Example 3 (Emulsion) An emulsion was prepared according to the following formulation. That is, A, B, C
Were heated and dissolved at 80 ° C., respectively, and B was gradually added to A while stirring, C was further added, and the mixture was cooled with stirring to obtain an emulsion. (A) behenyl alcohol 0.5 synthetic gay wax 2.5 olive oil 1.5 sorbitan monostearate 1.5 POE (20) behenyl ether 2 butyl paraben 0.1 BHT 0.1 liquid paraffin 3.6 wrinkles of Example 3 Improving agent 1 Stearic acid 0.5 (B) Propylene glycol 10 Methyl paraben 0.2 Caustic potash 0.1 Water 50 (C) Carbopol 0.2 Water 26.2

Embodiment 13 FIG. Formulation Example 4 (Emulsion) An emulsion was prepared according to the following formulation. That is, A, B, C
Were heated and dissolved at 80 ° C., respectively, and B was gradually added to A while stirring, C was further added, and the mixture was cooled with stirring to obtain an emulsion. (A) behenyl alcohol 0.5 synthetic gay wax 2.5 olive oil 1.5 sorbitan monostearate 1.5 POE (20) behenyl ether 2 butyl paraben 0.1 BHT 0.1 liquid paraffin 3.6 wrinkles of Example 4 Improving agent 5 Wrinkle improving agent of Example 5 5 Stearic acid 0.5 (B) Propylene glycol 10 Methylparaben 0.2 Caustic potash 0.1 Water 50 (C) Carbopol 0.2 Water 17.2

Embodiment 14 FIG. Formulation Example 5 (Cream) A cream was prepared according to the following formulation. That is, A, B
Were heated and dissolved at 80 ° C., and B was gradually added to A while stirring, followed by cooling to obtain a cream. (A) behenyl alcohol 6 olive oil 6 hydrogenated tallow 2 microcrystalline wax 6 liquid paraffin 20 stearic acid 4 glyceryl monostearate 2.5 POE (20) behenyl ether 1.5 beeswax 2 benzalkonium chloride 0.1 Example 6 5 (B) Propylene glycol 10 Caustic potassium 0.1 Water 36.8

Embodiment 15 FIG. Use test A use test was performed using the emulsion of Example 10. That is,
Group of 20 female panelists suffering from wrinkles (age 35-70
The wrinkle-reducing effect of the milky lotion of Example 10 and the one obtained by replacing the wrinkle-reducing agent in the milky lotion of Example 10 with water as a comparative example were examined. These emulsions were used twice a day for 30 consecutive days. The skin condition was photographed before and after use, and the degree of improvement was determined according to the following criteria.ー: no change or deterioration, ±: slight improvement, +: obvious improvement, +
+: Significant improvement criterion. Table 2 shows the results. The wrinkle improving effect of the wrinkle improving agent of the present invention is apparent.

[0033]

[Table 2]

Embodiment 16 FIG. Use test For the cream of Example 14, an actual use test was performed.
The effect of wrinkle improvement was confirmed. That is, 20 female panelists (age 40-65 years old) suffering from wrinkles were used, divided into two groups of 10 persons each, one group containing the cream of Example 14, and another group containing the cream of Example 14. The cream of the comparative example in which the wrinkle improver of Example 1 was replaced with olive oil was delivered.
They were used twice a day, twice a month. Thereafter, the degree of wrinkle improvement was examined by a questionnaire. Table 3 shows the results. From this, it can be seen that the cream of the example has better wrinkles than the cream of the comparative example. Therefore, it is clear that the wrinkle improving agent of the present invention has an excellent wrinkle improving effect.

[0035]

[Table 3]

[0036]

EFFECTS OF THE INVENTION The wrinkle improving agent of the present invention is highly useful as a component of cosmetics because it has high safety and excellent wrinkle improving effect.

──────────────────────────────────────────────────続 き Continuing from the front page (72) Inventor Norie Muramatsu 27-1 Takashimadai, Kanagawa-ku, Yokohama-shi, Kanagawa Prefecture Inside the Yokohama Research Laboratory, Polar Research Co., Ltd. Address: POLA KASEI KOGYO CO., LTD. Examiner in the Totsuka Laboratory Ikuji Oya (56) References JP-A-5-246837 (JP, A) JP-A-6-305978 (JP, A) JP-A-60-208920 (JP, A) (58) Field surveyed (Int.Cl. ⁷ , DB name) A61K ^7/ 00-7/035 A61K ⁷ /32-7/44 A61K 7/48

Claims (4)

(57) [Claims] 1. A wrinkle improving agent comprising guava seed essence. 2. A guava seeds essence, is the essence obtained by pressing guava seeds, shea <br/> Wa improving agent according to claim 1 Symbol placement. 3. The wrinkle improving agent according to claim 1, wherein the guava seed essence is an essence obtained by extracting guava seed with an organic solvent and concentrating the extract. 4. The wrinkle improving agent according to claim 1, wherein
A beautiful skin cosmetic containing 10 to 10% by weight.