JPH08259443A - Dermal composition for external use - Google Patents

Abstract

PURPOSE: To obtain a composition capable of providing improving effects such as an improvement in dermal quality (gloss, texture, etc.) and dermal aging such as fine wrinkles due to keratinous peeling actions, promoting actions on keratinous turnover and regeneration of dermal cells, curing actions on wounds, etc., possessed by a hydroxycarboxylic acid and its salt and suppressing dermal irritation while retaining the usefulness of the hydroxycarboxylic acid and its salt by using a specific seaweed extract. CONSTITUTION: This dermal composition for external use contains at least one selected from a hydroxycarboxylic acid and its salt and at least one selected from an extract from seaweeds belonging to the families Ulvaceae, Gracilariaceae, Gelidiaceae, Solieriaceae, Laminariaceae, Alariariceae, Sargassaceae, Fucaceae, Gloiopeltidaceae, Monostromataceae, Codiaceae, Bangiaceae, Gigartinaceae, Bonnemaisoniaceae, Hypneaceae, Chordariaceae, Nemacystaceae, Durvillaceae, Lessoniaceae and Rhodymeniaceae.

Description

Detailed Description of the Invention

[0001]

BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to a mild external composition for skin.

[0002]

BACKGROUND OF THE INVENTION Hydroxycarboxylic acid and its salts have keratin exfoliating action, keratin turnover promoting action, skin cell regeneration promoting action, wound healing action, etc.
It is known that it has an effect of improving skin aging such as fine wrinkles and the like (texture etc.) (JP-A-63-166837). It is also known that the seaweed extract generally has a moisturizing action.

[0003]

[Problems to be Solved by the Invention] Hydroxycarboxylic acid and salts thereof have a skin irritating effect on some people,
When it is used at a low pH which is known to have a particularly useful effect, skin irritation is increased. As a result, there are problems such as reddening of the skin, itching, tingling, and pain. Therefore, it is an object to suppress skin irritation while maintaining the effectiveness of hydroxycarboxylic acid and its salt, and an object of the present invention is to solve this problem.

[0004]

It has been found in the present invention that certain seaweed extracts alleviate this skin irritation. That is, the external composition for skin of the present invention is characterized by containing the following components (A) and (B). (A) At least one selected from hydroxycarboxylic acids and salts thereof. (B) Ulvaaceae, Larvae (G
raciliariaceae), Agaricaceae (Geli)
diaceae), Myrinaceae (Solieracea)
e), Laminariaceae, Laminariaceae, Alariaceae, Sargassaceae, Himamataceae.
ceae), Funori family (Gloiopeltidace)
ae), Monotromataceae
ae), Milliaceae (Codiaceae), Ushikenori (Bangiaceae), Sugimurai (Gigart)
inaceae), Scutellariae (Bonnemaiso)
niaceae), Iridaceae (Hypneacea)
e), Chordariaceae,
Nedaceaceae (Nemacystaceae), Durvilleaceae (Durvilleaceae), Lessoniaceae (L
Essoniaceae) and the family Dals (Rhody)
at least one selected from the extracts of seaweeds belonging to the genus A. meniaceae).

[0005]

BEST MODE FOR CARRYING OUT THE INVENTION The hydroxycarboxylic acid as the component (A) of the present invention may be any organic acid having at least one hydroxy group and at least one carboxyl group, and has a straight carbon chain or a branched chain. Used, cyclic ones, saturated ones, unsaturated ones and the like. The salts include sodium, potassium, magnesium,
Metal salts such as aluminum, triethanolamine, 2-
Any of organic salts such as amino-2-methyl-1,3-propanebaol may be used.

The hydroxycarboxylic acids include the following. As the one having 2 carbon atoms, glycolic acid can be mentioned. Lactic acid, 3 having 3 carbon atoms
-Hydroxypropanoic acid and 2,3-dihydroxypropanoic acid are exemplified. As those having 4 carbon atoms, methyl lactic acid, malic acid, tartaric acid, oxalacetic acid, 2-hydroxybutanoic acid, 3-hydroxybutanoic acid, 4-hydroxybutanoic acid, 3-hydroxy-2-methylpropanoic acid, 2
-Hydroxy-3-butenoic acid.

[0007] Ittartaric acid, which has 5 carbon atoms,
Examples thereof include itamaric acid, 2-hydroxypentanoic acid, 2,3-dihydroxypentanoic acid, 2-hydroxy-3-methylbutanoic acid, hydroxypivalic acid, and 2-hydroxy-2-methylbutanedicarboxylic acid. Examples of those having 6 carbon atoms include citric acid, isocitric acid, galacturonic acid, 2-keto-galactonic acid, 2-hydroxyhexanoic acid, and 2-hydroxy-2-methylglutaric acid.

As those having 7 carbon atoms, salicylic acid,
Examples include gallic acid, quinic acid, and 2-hydroxyheptanoic acid. As those having 8 carbon atoms, mandelic acid, 4-methylsalicylic acid, 3-methoxysalicylic acid, 2-hydroxyoctanoic acid, 2-hydroxyphenylacetic acid, 3,4
-Dihydroxyphenylacetic acid and 4-hydroxyphthalic acid are mentioned. Examples of those having 9 or more carbon atoms include 3-phenyllactic acid, 3-hydroxy-4-methoxymandelic acid, 4-hydroxydecanoic acid, 12-hydroxydodecanoic acid, 4-hydroxy-2,2-diphenylbutanoic acid and the like. Can be mentioned.

Further, these lactones, halides and sulfides may be used. Of these, the number of carbon atoms is preferably 2
Hydroxycarboxylic acid of No. 8, more preferably glycolic acid, lactic acid, malic acid, tartaric acid, citric acid, isocitric acid and salicylic acid.

The hydroxycarboxylic acid and its salt as the component (A) of the present invention are chemically synthesized, extracted from natural products,
It can be obtained by various methods such as fermentation. The extract or the like from a natural product includes components other than hydroxycarboxylic acid and its salt, but the extract or the like can be used as it is without particular separation and purification. Specific examples of the extraction from natural products include extraction from plants such as aloe (aloe vera, kidachi aloe, etc.), sugar cane, citrus cabbage, cowberry, etc., and the extraction method from aloe will be described below as an example. To do.

There is no limitation on the method of extracting aloe,
An ordinary extraction method is adopted, and extraction is performed using water, a hydrophilic organic solvent, a water-containing hydrophilic organic solvent, another organic solvent or the like. The applicant has made several proposals as an aloe extraction method, and the following method is particularly preferable (the aloe extract by this method is referred to as aloe ECW).

Specifically, the aloe sap is subjected to a first batch of activated carbon treatment by the batch method, then the solution from which the activated carbon has been removed is concentrated, and the concentrated liquid is subjected to a second batch of activated carbon treatment by the batch method. Then, the activated carbon is removed to obtain a solution, and a substance having a physiologically active action is produced from aloe (Japanese Patent Publication No. 5834/1993). The hydroxycarboxylic acid and its salt can be blended at any concentration, but can be 0.
01 to 50% (% is weight%, the same below) is preferable, 0.05 to 20% is more preferable, and 0.1 to 10% is particularly preferable.
Is preferred.

In order to reduce the irritation of hydroxycarboxylic acid and its salt, various seaweed extracts were screened using skin irritation of guinea pigs and humans as an index. As a result, the component (B) of the present invention, Ulvaaceae (Ulvace).
ae), Graciariacea
e), Agaricaceae (Gelidiaceae), Myrrhaceae (Solieriaceae), Laminaria (Lami)
nariaceae), Ainu seaweed (Alaria)
ceae), the family Sargassumacea (Sargassacea)
e), Frucaceae (Fucaceae), Funori (G)
loiopeltidaceae), Astragalus (M)
onostromataceae), Millaceae (Codi
aceae), the genus Orchidaceae (Bangiacea)
e), Family of Gigartinaceae, Family of Kanameori (Bonnemaisoniacee), Family of Hybernaceae (Hypneaceae), Family of Chrysalis (Chordariaceae), Family of Nematode (Nema)
Cystaceae), Dervilleae (Durville)
eaceae), lessonaceae (Lessoniace)
It has been found that the desired effect can be obtained with an extract of seaweed belonging to ae) and the family Rhodymeniaceae.

[0014] On the other hand, it has been conventionally said that seaweed extract is good for the skin such as enhancing the moisturizing property. For example, for example, Cladophoraceae, Chiropodaceae (E
The effect of alleviating the irritation of hydroxycarboxylic acid and its salt was not observed in the extract of Ctocarpaceae), and this effect was specific to the extract of the specific seaweed of the present invention. Seaweeds belonging to the family Ulva family used in the present invention include genus Ulva and genus Enol (En).
thermomorpha), genus Klothiae (Ulvari)
Although a) and the like are used, the genus Ulva and the genus Aeon are preferred.

The seaweeds belonging to the family Scutellariae used in the present invention include the genus Gracilaria, the genus Gracilariaopsis, the genus Tyllotus, and the genus Gelosa.
diopsis) and the like are used, but the genus Ogonori and the genus Tsuriramo are preferred.

The seaweeds belonging to the Agaricaceae family used in the present invention include the genus Gelidium, the genus Beckerella, and the genus Pteroc.
radia), genus Yukiiri (Acanthopelti)
s) and the like are used, but the genus Maxa is preferable. The seaweeds belonging to the family Myrrhaceae used in the present invention include the genus Eucheuma and the genus Toscanori.
stotheca), genus Milinia (Solieria),
The genus Turnerella and the like are used, but the genus Giraffe and the genus Tosakari are preferred.

The seaweeds belonging to the family of kelp family used in the present invention include the genus Laminaria, the genus Kolollum (Kjellmaniella), and the genus Kajime (Ec).
Klonia), genus Eisenia, genus Eckloniopsis, genus Ame
Arum), the genus (Costaria), the cat genus (Arthrothamnus), the genus Heterophyllum (Hedophyllum), and the like are used, but the genus kelp, the trochocomb genus, the genus Amaranth, the genus Antocome are preferable.

The seaweeds belonging to the family Ainu wakame used in the present invention include the genus Undaria, the genus Ainu seaweed (Alaria) and the like, preferably the genus Wakame and the genus Ainu seaweed. The seaweeds belonging to the family Hodwara used in the present invention include the genus Hiziki.
kia), genus Sargassum, genus Turbinaria, genus Yabanemoku (C)
ystoseira), Jolomoku genus (Myagrop)
sis), the genus Coccophora, etc. are used, but the genus Hijiki and the genus Honda Walla are preferred.

As a seaweed belonging to the family Aphididae used in the present invention, the genus Ascophyllum
m), genus Fucus, genus Ezo
lvetia) and the like are used, but Ascophiram and Hibamata are preferred. The seaweeds belonging to the family Funori used in the present invention include the genus Funoli (Gloiopel).
tis) and the like are used, but Funoli is preferred.

The seaweeds belonging to the family Astragalus, which are used in the present invention, include the genus Monostroma,
The genus Kornmannia and the like are used, but the genus Human Exa is preferable. As a seaweed belonging to the family Milaceae used in the present invention, the genus Codiu
m) and the like are used, but preferably of the genus Mill. Examples of seaweeds belonging to the family of the genus Ushikenori used in the present invention include the genus Porphyra and the genus Ushikenori.
ia) and the like are used, but the genus Porphyra is preferred.

As the seaweeds belonging to the family Scutellariae used in the present invention, the genus Gingartina, the genus Rhodoglossum, the genus Chondrus and the like are used, preferably the genus Scutellaria, the genus Acacia vulgaris, It belongs to the genus Tsunomata.

As the seaweed belonging to the family Scutellariae used in the present invention, the genus Asparagopsi
s), and the genus Kabori (Bonnemaisonia) and the like are used, but the genus Kagori is preferred. Examples of the seaweed belonging to the family Corydalidae used in the present invention include the genus Hybara (Hypnea) and the like, and the genus Ivalanori is preferred.

As the seaweeds belonging to the family Noctuidae used in the present invention, the genus Analipus, the genus Cladosiphon and the like are used, and the genus Matsumo and the genus Okinawa are the genus. As the seaweed belonging to the family Mogulaceae used in the present invention, the genus Nemucystis and the like are used, but the genus Modulgum is preferable.

As the seaweed belonging to the family of the family Derviria used in the present invention, the genus Durvillea or the like is used, and the genus Dervillea is preferable. The seaweeds belonging to the Lessonia family used in the present invention include genus Lessonia and genus Macrocystis (M).
acrocystis) and the like are used, but the genus Lessonia and the genus Macrocystis are preferable. As the seaweed belonging to the family Dulceae used in the present invention, the genus Rhul (Rh
Odymenia) and the like are used, but the genus Dhalus is preferable.

When extracting the component (B) of the present invention,
The seaweed may be in an undried state, but it is preferable that the seaweed is dried by a method such as air-drying or freeze-drying before being subjected to extraction from the viewpoint of extraction efficiency. There is no limitation on the method of extracting the component (B) of the present invention, and an ordinary extraction method is adopted, and water, sodium chloride solution, hydrophilic organic solvent, hydrous hydrophilic organic solvent, other organic solvent or the like is used. Extracted from seaweed.

Examples of the hydrophilic organic solvent include lower alcohols such as methanol, ethanol and isopropanol, glycols such as propylene glycol and 1,3-butylene glycol, glycerin, acetone, methylethylketone, acetonitrile, dimethylsulfoxide, dimethylformamide, and the like. And the like. In particular, it is preferable to perform extraction using water or a mixture of water and a lower alcohol such as methanol, ethanol or isopropanol. In that case, the ratio of water to lower alcohol is such that lower alcohol / water is 0/100 to 70/3.
It is preferably 0 (V / V: volume ratio), and more preferably 0/100 to 40/60.

The ratio of dried seaweed to extraction solvent is preferably in the range of 1/50 to 1/2 of dried seaweed / solvent ratio. In addition, as other extraction conditions, the extraction temperature is not particularly limited, but in the range of 5 to 80 ° C, preferably 5 to 50 ° C,
It is preferable to carry out the stirring for 1 to 24 hours, and the extraction pH is not particularly limited as long as it is not extremely acidic or alkaline.

It is also possible to increase the extraction efficiency by repeating the extraction operation on the extraction residue generated by the above extraction operation. The extract may be used as it is, may be used as a dilute solution, or may be a concentrated extract, or may be a dry powder product by freeze-drying or the like, or may be prepared as a paste.

When prepared as a dry powder, it is used by dissolving it in water or a lower alcohol containing water such as methanol, ethanol, and isopropanol in advance, or by solubilizing it in an external composition containing water described later. Is preferred.

The seaweed extract can be blended at any concentration,
0.01 to 50% is preferable, and further 0.05 to 20%
Is preferable, and 0.1 to 10% is particularly preferable. Further, the ratio of the concentrations of the A component and the B component of the present invention is 1: 5000.
〜5000: 1 is preferable, and further 1: 250-25
0: 1 is preferable, and 1: 100 to 100: 1 is particularly preferable.

The external preparation for skin of the present invention contains, in addition to the above-mentioned essential components, raw materials usually used for external preparations such as surfactants, oils, alcohols, humectants, thickeners, preservatives and antioxidants. , Chelating agents, pH adjusters, fragrances, dyes, ultraviolet absorbers / scatterers, vitamins, amino acids, water and the like can be added.

Specifically, the surfactants include lipophilic glycerin monostearate, self-emulsifying glycerin monostearate, polyglycerin monostearate, sorbitan monooleate, polyethylene glycol monostearate, polyoxyethylene sorbitan. Monooleate, polyoxyethylene cetyl ether, polyoxyethylene sterol, polyoxyethylene lanolin,
Nonionic surfactants such as polyoxyethylene beeswax and polyoxyethylene hydrogenated castor oil; sodium stearate, potassium palmitate, sodium cetyl sulfate, sodium lauryl phosphate, triethanolamine palmitate, sodium polyoxyethylene lauryl phosphate, Examples thereof include anionic surfactants such as sodium N-acylglutamate; cationic surfactants such as stearyldimethylbenzylammonium chloride and stearyltrimethylammonium chloride; amphoteric surfactants such as alkylaminoethylglycine hydrochloride liquid and lecithin. .

As the oil, vegetable oils such as castor oil, olive oil, cocoa oil, camellia oil, coconut oil, wax, jojoba oil, grape seed oil, avocado oil and the like; animal oils and fats such as mink oil and egg yolk oil; beeswax , Whale wax, lanolin, carnauba wax, candelilla wax, and other waxes; liquid paraffin, squalane, microcrystalline wax, ceresin wax, paraffin wax, hydrocarbons such as vaseline; lauric acid, myristic acid, stearic acid, oleic acid, Natural and synthetic fatty acids such as isostearic acid and behenic acid; cetanol, stearyl alcohol,
Examples thereof include natural and synthetic higher alcohols such as hexyldecanol, octyldodecanol, and lauryl alcohol; esters such as isopropyl myristate, isopropyl palmitate, octyldodecyl myristate, octyldodecyl oleate, and cholesterol oleate.

As moisturizers, polyhydric alcohols such as glycerin, propylene glycol, 1,3-butylene glycol, sorbitol, polyglycerin, polyethylene glycol, dipropylene glycol; NMF components such as amino acids and sodium pyrrolidonecarboxylate; hyaluronic acid Examples thereof include water-soluble polymer substances such as acids, collagen, mucopolysaccharides and chondroitin sulfate.

As the thickener, sodium alginate,
Natural polymer substances such as xanthan gum, aluminum silicate, quince seed extract, tragacanth gum, starch; semi-synthetic polymer substances such as methyl cellulose, hydroxyethyl cellulose, carboxymethyl cellulose, soluble starch, cationized cellulose; carboxyvinyl polymer, polyvinyl alcohol, etc. The synthetic polymer substance and the like can be exemplified.

Preservatives include benzoate, sorbate, dehydroacetate, paraoxybenzoate,
2,4,4'-trichloro-2'-hydroxydiphenyl ether, 3,4,4'-trichlorocarbanilide,
Benzalkonium chloride, hinokitiol, resorcin,
Ethanol etc. can be illustrated.

Antioxidants include dibutylhydroxytoluene, butylhydroxyanisole, ascorbic acid, etc .; chelating agents include disodium edetate,
Ethylenediaminetetraacetate, pyrophosphate, hexametaphosphate, gluconic acid, etc .; pH adjusters such as sodium hydroxide, potassium hydroxide, triethanolamine, aqueous ammonia, boric acid, borax, potassium hydrogen phosphate, etc. Can be illustrated respectively.

Examples of the ultraviolet absorbing / scattering agent include 2-hydroxy-4-methoxybenzophenone, octyldimethylparaaminobenzoate, ethylhexylparamethoxycinnamate, titanium oxide, kaolin, talc and the like.

As vitamins, vitamin A, vitamin B group, vitamin C, vitamin D, vitamin E, vitamin F, vitamin K, vitamin P, vitamin U, carnitine, ferulic acid, γ-oryzanol, α-lipoic acid, Examples thereof include orotic acid and its derivatives.

Amino acids include glycine, alanine, valine, leucine, isoleucine, phenylalanine, tryptophan, cystine, cysteine, methionine, proline, hydroxyproline, aspartic acid,
Examples thereof include glutamic acid, arginine, histidine, lysine and their derivatives.

The optional components are not limited to these. By appropriately blending the above-mentioned essential components and optional components, for example, the component A of the present invention is 0.01 to 50%,
B component 0.01 to 50%, oil component 0 to 8 as an optional component
It is possible to provide a skin external preparation containing 0%, a surfactant 0 to 12%, a moisturizer 1 to 15%, a purified water balance, and a trace amount of a preservative.

A specific example of use as a skin cosmetic is as follows. (1) Cream for skin 0.1 to 10% of component A of the present invention, 0.1 of component B of the present invention
Composition containing 10%, oil content 10-70%, surfactant 2-7%, moisturizer 1-10%, pH adjuster 0-3%, purified water balance, preservative trace amount, perfume trace amount.

(2) Emulsion 0.1 to 10% of component A of the present invention, 0.1 of component B of the present invention
-10%, oil content 10-40%, alcohols 0-15
%, Surfactant 1-5%, moisturizer 1-10%, thickener 0
A composition containing ˜2%, pH adjuster 0 to 3%, purified water balance, trace amount of preservative, and trace amount of perfume.

(3) Lotion, beauty essence Component A of the present invention 0.1 to 10%, component B of the present invention 0.1
-10%, oil content 0-40%, alcohols 0-20%,
Surfactant 0-2%, moisturizer 2-15%, thickener 0-2
%, Antioxidant 0-0.5%, chelating agent 0-0.1
%, PH adjusting agent 0 to 3%, purified water balance, preservative trace amount, dye 0 to trace amount, and perfume trace amount.

(4) Packing agent Component A of the present invention 0.1 to 10%, component B of the present invention 0.1
-10%, alcohols 2-10%, moisturizer 2-10
%, Inorganic powder 0 to 20%, film forming agent 10 to 20%, purified water balance, preservative trace amount, perfume trace amount composition.

(5) Gel agent 0.1 to 10% of component A of the present invention, 0.1 of component B of the present invention
-10%, alcohols 0-10%, moisturizer 2-20
%, A thickener 1 to 20%, a pH adjuster 0 to 3%, a purified water balance, a preservative trace amount, a pigment 0 to trace amount, and a perfume trace amount.

[0047]

INDUSTRIAL APPLICABILITY According to the present invention, skin qualities (gloss, texture, etc.) are exhibited by the keratin exfoliating action, keratin turnover promoting action, skin cell regeneration promoting action, wound healing action, etc. possessed by hydroxycarboxylic acid and its salts. And the effect of improving skin aging such as fine wrinkles are obtained, and by using a specific seaweed extract, the skin irritation can be suppressed while maintaining the effectiveness of hydroxycarboxylic acid and its salt. By blending these, an external composition for skin such as a drug, a quasi drug, and a cosmetic product, which has excellent effects and is highly safe, is provided.

At least one of the hydroxycarboxylic acids and salts thereof of the present invention and at least one of the specified seaweed extracts
The external composition for skin containing seeds is used for various cosmetic creams,
It can be widely used in various forms such as emulsion, lotion, beauty solution, pack, undermake-up, foundation, gel and ointment.

[0049]

【Example】

Example 1 The degree of irritation was evaluated by the following method, and the effect of alleviating irritation by combining the A component with the B component was examined. <Guinea pig cumulative stimulation test> The body hair of the flank of a Hartley guinea pig (female, body weight 300 to 400 g) is cut with an electric clipper, and further shaved with an electric razor. Hair removal 6
After a period of time, the formulation shown below in a circular shape with a diameter of 2 cm was
It was applied once a day for 4 consecutive days. Then, using a color-difference meter CR-121 (manufactured by Minolta Co., Ltd.), the degree of redness caused by stimulation was evaluated by the a value (red to recording) of the color-difference meter. The results are shown as relative values with the value a in the case of no coating as 1.

Composition of coating preparation A component: component and amount shown in Table 1 B component: component and amount shown in Table 1 1,3-butylene glycol: 10% Purified water: balance (1N sodium hydroxide or hydrochloric acid at pH 4. (Adjusted to 0) The blending amount is shown in% by weight. The seaweed extract was produced by adding 20 times the amount of purified water to the dried product of the specific seaweed shown in the text, extracting at room temperature for 5 hours, and then filtering, concentrating and freeze-drying. The examination results are shown in Tables 1 to 3.

[0051]

[Table 1]Table 1: Composition and evaluation results (1) Compounding amount Compounding color difference meter a value No.A component (%) B component Family name amount(%) (Relative value) Comparative example 1 Glycolic acid 1.0 − − − 1.72 2 Glycolic acid 2.5 − − − 1.81 Aloe ECW 2.5 3 Lactic acid 1.0 − − − 1.70 4 2-Hydroxy-3-butenoic acid 3.0 − − − 1.74 5 Methyl lactic acid 0.1 − − − 1.48 6 Methyl lactic acid 1.0 − − − 1.65 7 Tartaric acid 10.0 − − − 1.73 8 Malic acid / Disodium 4.0 − − − 1.66 9 Citric acid 0.5 − − − 1.55 10 Isocitric acid 20.0 − − − 1.76 11 Galactonic acid 6.0 − − − 1.68 12 Gallic acid 0.05 − − − 1.43 13 Gallic acid 0.1 − − − 1.50 14 2-Hydroxyoctanoic acid 5.0 − − − 1.62 15 Mandelic acid 2.0 − − − 1.57 16 Glycolic acid 1.0 Extract

[0052]

[Table 2]Table 2: Composition and evaluation results (part 2) Blending amount Blending color difference a value No. A component (%) B component Family name amount(%) (Relative value) The present invention 17 Glycolic acid 1.0 Anahaosa Aosa 1.0 1.16 Extract 18 Glycolic acid 1.0 Eucheuma Milin 2.0 1.08 cottonii Extract 19 Glycolic acid 2.5 Hijiki Honda 10.0 1.11 Extract Straw Aloe ECW 2.5 20 Lactic acid 1.0 Ooosa Ooosa 0.5 1.19 Extract 21 2-Hydroxy-3-3.0 Combs Combs 20.0 1.03 Butenoic acid extract 22 Methyl lactic acid 0.1 Kakikenori 5.0 Kakikenori 5.0 0.96 Extract Ibaranori Ibaranori 10.0 Extract 23 Methyl lactic acid 1.0 Human Exa Human Exa 0.05 1.21 Extract 24 Tartaric acid 10.0 Hibamata Hibamata 0.1 1.24 Extract 25 Malic Acid / Disodium 4.0 Mill Extract Mill 4.0 1.13 26 Citric acid 0.5 Wakame Ainu 0.1 1.15 Extract wakame

[0053]

[Table 3]Table 3: Composition and evaluation results (part 3) Blending amount Blending color difference a value No. A component (%) B component Family name amount(%) (Relative value) The present invention 27 Isocitric acid 20.0 Trollocomb 2.0 1.18 Combs Extract 28 Galactonic acid 6.0 Mods Mozuc 4.0 1.08 Extract 29 Gallic acid 0.05 Tochakasuginori 1.0 1.02 Extract 30 Gallic acid 0.1 Kajimekonbu 4.0 0.93 Extract Antokumekonbu 6.0 Extract 31 2-Hydroxyoctanoic acid 5.0 Tosakanomirin 4.0 1.06 Extract 32 Mandelic acid 2.0 Matsumoto Nagamatsu 1.0 1.09 Extract

From the results shown in Tables 1 to 3, it was confirmed that the product of the present invention had a clear decrease in the a value of the colorimeter and a reduction in redness of the skin, as compared with the comparative example. That is, it was found that the skin irritation caused by the A component can be improved by combining the A component with the B component.

Example 2 By the following method, the degree of irritation when applied to humans was evaluated, and the effect of alleviating irritation was examined. That is, the components 1 to 7 and the components 8 to 15 shown in Table 4 were separately dissolved by heating at 70 ° C., mixed and emulsified, and the component 16 was added during cooling.
Was added and the mixture was cooled to room temperature to prepare an emulsion. The components A and B are shown in Tables 5 and 6. In addition, the blending amount is represented by% by weight.

[0056]

[Table 4] Table 4: Ingredient composition Composition of the present invention Comparative Example 1 Liquid paraffin (# 70) 10.0 10.0 2 Isopropyl myristate 1.5 1.5 3 Glycerin monostearate 0.5 0.5 4 Stearic acid 2.0 2.0 5 POE (20) Stearyl alcohol 0.7 0.7 6 Glycyrrhetinic acid 0.1 0.1 7 Butylparaben 0.1 0.1 8 A component (Ingredients in Tables 5 and 6) Amount in Tables 5 and 6 Amount in Tables 5 and 6 9 Component B (Ingredients in Tables 5 and 6) Tables 5 and 6 Amounts in Tables 5 and 6 10 Glycerin 2.0 2.0 11 Carboxyvinyl polymer 0.1 0.1 (Molecular weight 1 million to 1.5 million) 12 Ethanol 2.0 2.0 13 Methylparaben 0.1 0.1 14 Purified water Balance banlas 15 Ammonia water Trace trace 16 Perfume Trace trace

The emulsion thus prepared is shown in Table 4 for 20 female panelists (25-40 years old) twice a day for 7 days (morning and night) per 4 cm x 4 cm on the forearm flexor side. The preparation was applied in an amount of 50 μl, and the number of panelists who felt unpleasant stimuli such as tingling sensation, itchiness and pain was examined. The examination results are shown in Tables 5 and 6.

[0058]

[Table 5]Table 5: Composition and evaluation results thereof (No. 1) Unpleasant stimulus Mixing amountNo. A component (%) B component Family name amount(%) Number of Nellers Comparative example  1 Lactic acid 0.5 − − − 14/20 2 Tartaric acid 5.0 − − − 16/20 3 2-Hydroxyheptanoic acid 4.0 − − − 15/20 4 Sodium citrate 2.0 − − − 13/20 5 Isocitric acid 10.0 − − − 15/20 6-Galactonic acid 4.0 − − − 14/20 7 Salicylic acid 1.0 − − − 13/20 8 Mandelic acid 3.0 − − − 15/20 9 Lactic acid 0.5 Shio Midoro Shio Midoro 2.0 13/20 Extract

[0059]

[Table 6]Table 6: Composition and evaluation results thereof (Part 2) Unpleasant stimulus Mixing amountNo. A component (%) B component Family name amount(%) Number of Nellers Invention product 10 Lactic acid 0.5 Ogonori Ogonori 8.0 1/20 Extract 11 Tartaric acid 5.0 Alamekombe 5.0 3/20 Extract 12 2-Hydroxyheptanoic acid 4.0 Lessonia Lessonia 2.0 2/20 nigrescens extract Dalus dals 2.0 Extract 13 Sodium citrate 2.0 Ainu Waka Ainu 3.0 0/20 Japanese seaweed extract Wakame 14 Isocitric acid 10.0 Asakusano Ushikenori 2.0 2/20 Re-extract 15 Galaconic acid 4.0 Obamamok Honda straw 2.0 0/20 Extract 16 Salicylic Acid 1.0 Notted Hibamata 5.0 1/20 Rack Extract 17 Mandelic Acid 3.0 Durvillea Dervillea 1.0 3/20 antarctica Extract From the results of Table 5 and Table 6, combine A component with B component
By improving the skin irritation caused by the component A
I found out that

Example 3 Components 1 to 7 and components 8 to 15 shown in Table 7 were separately heated to 70 ° C.
After heat-dissolving with, the mixture was emulsified, component 16 was added during cooling and cooled to room temperature to prepare a cream.
In addition, the blending amount is represented by% by weight.

[0061]

Table 7: Composition Ingredient Invention Product Comparative Example 1 Liquid paraffin (# 70) 5.0 5.0 2 Squalane 15.0 15.0 3 cetostearyl alcohol 5.0 5.0 4 Beeswax 2.0 2.0 5 glycerol monostearate 2.0 2.0 6 POE (20 ) Sorbitan monolaurate 2.0 2.0 7 Propylparaben 0.1 0.1 8 Tartaric acid 2.0-9 Aloe ECW 2.0-10 Hyaluronic acid 0.2 0.2 11 Maxa extract (Agaricaceae) 5.0-12 Diglycerin 5.0 5.0 13 Methylparaben 0.2 0.2 14 Sodium hydroxide Trace amount Trace 15 Purified water Balance Balance 16 Fragrance Trace Trace

The effectiveness of the cream thus prepared was evaluated as follows. That is, 20 women aged 35 to 55 were selected twice a day (morning and night) for 3 consecutive months, and the comparative example of the present invention was used on the left and right faces separately by the half-face method. The presence or absence of unpleasant stimuli such as itching and pain, improvement of skin quality (luster, texture, dullness), and degree of improvement of fine wrinkles were examined. Table 8 shows the results.

[0063]

[Table 8]

From the results shown in Table 8, no unpleasant stimuli such as a tingling sensation, itchiness and pain due to the use of the cream of the present invention was observed, and the product of the present invention had a skin quality (gloss, texture, dullness) as compared with Comparative Example. ) And fine wrinkles showed a remarkable improvement effect. The above results show that by using the cream of the present invention in which the components A and B are used in combination,
The skin irritation caused by the A component as shown in the comparative example is relieved, and as a result, the feeling of use is improved, and as shown in Table 8, the A component improves the skin aging symptoms. Shows. No abnormalities such as redness on the skin were observed during and after the use of the cream.

Example 4 Components 1 to 8 and 9 to 12 shown in Table 9 were separately dissolved and then mixed to prepare a beauty essence. The effectiveness of the thus-prepared beauty essence was measured in the same manner as in Example 3.

[0066]

[Table 9] Table 9: Ingredient composition Composition of the present invention Comparative Example 1 Sudiaonori Extract (Liliaceae) 3.0-2 Malic Acid 2.0-3 Glycerin 5.0 5.0 4 1,3-Butylene Glycol 5.0 5.0 5 Carboxyvinyl Polymer 0.5 0.5 6 Potassium hydroxide Trace trace 7 Methylparaben 0.1 0.1 8 Purified water Balance Balance 9 dl-α-tocopherol acetate 0.2 0.2 10 Ethanol 1.0 1.0 11 Polyoxyethylene (40) hydrogenated castor oil 0.5 0.5 12 Fragrance Trace trace results are shown in Table 10. .

[0067]

[Table 10]

From the results shown in Table 10, no unpleasant stimuli such as a tingling sensation, itchiness and pain due to the use of the beauty essence of the present invention was observed, and the product of the present invention showed that the skin quality (gloss, gloss, There was a marked improvement effect on texture, dullness and fine wrinkles. The above results show that the components A and B of the present invention are
By using the beauty essence combined with the ingredients, the skin irritation caused by the ingredient A as shown in the comparative examples of Examples 1 and 2 is alleviated, and as a result, the feeling of use is improved, and in Table 10, As shown, it is shown that the A component improves the skin aging symptoms. No abnormality such as redness on the skin was observed during or after the use of the beauty essence. Example 5 The ingredients shown in Table 11 were mixed to prepare a gel preparation.

[0069]

[Table 11] Table 11: Ingredient composition Composition of the present invention Comparative Example 1 Lactic acid 1.0-2 Citric acid 1.0-3 Fukuro funori extract (Furaceae) 1.0-4 Xanthan gum 1.0 1.0 5 1,3-butylene glycol 5.0 5.0 6 Glycerin 5.0 5.0 7 Methylparaben 0.1 0.1 8 Sodium hydroxide Trace amount 9 Purified water Balance Balance 10 Fragrance Trace amount Trace amount The effectiveness of the gel preparation thus prepared was examined in the same manner as in Example 3. The results are shown in Table 12.

[0070]

[Table 12]

From the results in Table 12, no unpleasant stimuli such as tingling sensation, itchiness, pain, etc. were observed due to the use of the gel preparation of the present invention, and the product of the present invention had a skin quality (gloss, gloss, There was a marked improvement effect on texture, dullness and fine wrinkles. The above results show that the components A and B of the present invention are
By using the gel agent in combination with the components, the skin irritation caused by the component A as shown in the comparative examples of Examples 1 and 2 is reduced, and as a result, the feeling of use is improved, and Table 12 shows As shown, component A improves skin aging symptoms. No abnormalities such as redness on the skin were observed during or after the use of the gel.

Example 6 Components 1 to 4 and components 5 to 10 shown in Table 13 were separately heated at 70 ° C.
After heat-dissolving in (1), the mixture was emulsified, component 11 was added during cooling and cooled to room temperature, and the effectiveness of the prepared emulsion was evaluated in the same manner as in Example 3.

[0073]

[Table 13] Table 13: Ingredient composition Composition of the present invention Comparative Example 1 Lanolin alcohol 5.0 5.0 2 Isopropol myristate 2.0 2.0 3 Stearic acid 5.0 5.0 4 Glycerin monostearate 1.0 1.0 5 Triethanolamine 0.8 0.8 6 Isoprene glycol 6.0 6.0 7 Glycolic acid 0.5-8 Eucheuma spinosum extract (Myrrhaceae) 3.0-9 Methylparaben 0.3 0.3 10 Purified water Balance Balance 11 Fragrance Trace amount Trace amount As a result, tingling sensation, itching, pain etc. No significant irritation was observed, and the product of the present invention showed a remarkable improving effect on skin quality (luster, texture, dullness) and fine wrinkles, as compared with Comparative Example. No abnormalities such as redness on the skin were observed during or after the use of the emulsion.

─────────────────────────────────────────────────── ─── Continuation of the front page (51) Int.Cl. ⁶ Identification code Internal reference number FI Technical display area A61K 31/20 A61K 31/20 35/80 AGZ 35/80 AGZZ 47/46 47/46 Z (72 ) Inventor Tsuneo Miyahara 1-3-7 Honjo, Sumida-ku, Tokyo Inside Lion Co., Ltd.

Claims (1)

[Claims] 1. (A) At least one selected from hydroxycarboxylic acids and salts thereof, and (B) a family of Ulvaaceae and a family of Gourdaceae (G).
raciliariaceae), Agaricaceae (Geli)
diaceae), Myrinaceae (Solieracea)
e), Laminariaceae, Laminariaceae, Alariaceae, Sargassaceae, Himamataceae.
ceae), Funori family (Gloiopeltidace)
ae), Monotromataceae
ae), Milliaceae (Codiaceae), Ushikenori (Bangiaceae), Sugimurai (Gigart)
inaceae), Scutellariae (Bonnemaiso)
niaceae), Iridaceae (Hypneacea)
e), Chordariaceae,
Nedaceaceae (Nemacystaceae), Durvilleaceae (Durvilleaceae), Lessoniaceae (L
Essoniaceae) and the family Dals (Rhody)
A composition for external use for skin, comprising at least one kind selected from the extracts of seaweeds belonging to the group (Meniaceae).