JPH07504908A - ベンゾジアゼピン誘導体，該誘導体を含有する組成物及び治療におけるその使用 - Google Patents

ベンゾジアゼピン誘導体，該誘導体を含有する組成物及び治療におけるその使用

Info

Publication number
JPH07504908A
JPH07504908A JP5516353A JP51635393A JPH07504908A JP H07504908 A JPH07504908 A JP H07504908A JP 5516353 A JP5516353 A JP 5516353A JP 51635393 A JP51635393 A JP 51635393A JP H07504908 A JPH07504908 A JP H07504908A
Authority
JP
Japan
Prior art keywords
formula
alkyl
cck
acid
compound according
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP5516353A
Other languages
English (en)
Japanese (ja)
Inventor
ボツク，マーク・ゲーリー
チエンバーズ，マーク・ステユアート
フレツチヤー・ステフアン・ロバート
マタツサ，ビクトール・ジユリオ
Original Assignee
メルク　シヤープ　エンド　ドーム　リミテツド
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB929205669A external-priority patent/GB9205669D0/en
Priority claimed from GB929223006A external-priority patent/GB9223006D0/en
Application filed by メルク　シヤープ　エンド　ドーム　リミテツド filed Critical メルク　シヤープ　エンド　ドーム　リミテツド
Publication of JPH07504908A publication Critical patent/JPH07504908A/ja
Pending legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing aromatic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/26—Psychostimulants, e.g. nicotine, cocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Psychiatry (AREA)
  • Diabetes (AREA)
  • Pain & Pain Management (AREA)
  • Obesity (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Hematology (AREA)
  • Endocrinology (AREA)
  • Emergency Medicine (AREA)
  • Hospice & Palliative Care (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
JP5516353A 1992-03-16 1993-03-15 ベンゾジアゼピン誘導体，該誘導体を含有する組成物及び治療におけるその使用 Pending JPH07504908A (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
GB9205669.6 1992-03-16
GB929205669A GB9205669D0 (en) 1992-03-16 1992-03-16 Therapeutic agents
GB9223006.9 1992-11-03
GB929223006A GB9223006D0 (en) 1992-11-03 1992-11-03 Therapeutic agents
PCT/GB1993/000535 WO1993019063A1 (fr) 1992-03-16 1993-03-15 Derives de benzodiazepines, compositions les contenant et leur utilisation therapeutique

Publications (1)

Publication Number Publication Date
JPH07504908A true JPH07504908A (ja) 1995-06-01

Family

ID=26300539

Family Applications (1)

Application Number Title Priority Date Filing Date
JP5516353A Pending JPH07504908A (ja) 1992-03-16 1993-03-15 ベンゾジアゼピン誘導体，該誘導体を含有する組成物及び治療におけるその使用

Country Status (6)

Country Link
US (1) US5597915A (fr)
EP (1) EP0637308A1 (fr)
JP (1) JPH07504908A (fr)
AU (1) AU670939B2 (fr)
CA (1) CA2130195A1 (fr)
WO (1) WO1993019063A1 (fr)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2002516313A (ja) * 1997-01-31 2002-06-04 セルジーン・コーポレーシヨン ２−置換ピペリジン立体異性体を製造するための方法及び中間体
JP2009508865A (ja) * 2005-09-16 2009-03-05 ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ ベンゾ［ｅ］［１，２，４］トリアゼピン−２−オン誘導体の製造方法

Families Citing this family (47)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1996005827A1 (fr) * 1994-08-18 1996-02-29 Merck & Co., Inc. N-2,3-dihydro-1-(2-propyl)-2-oxo-5-phenyl-1h-1,4-benzodiazepines
US5428157A (en) * 1993-11-22 1995-06-27 Merck & Co., Inc. 3-acylaminobenzodiazepines
US5438055A (en) * 1993-11-22 1995-08-01 Merck & Co., Inc. Antiarrhythmic benzodiazepines
US5426185A (en) * 1993-11-22 1995-06-20 Merck & Co., Inc. Antiarrhythmic benzodiazepines
US5739129A (en) * 1994-04-14 1998-04-14 Glaxo Wellcome Inc. CCK or gastrin modulating 5-heterocyclic-1, 5 benzodiazepines
HU220635B1 (hu) * 1994-08-18 2002-03-28 Merck & Co. Inc. 2,3-Dihidro-1-(2,2,2-trifluor-etil)-2-oxo-5-fenil-1H-1,4-benzodiazepin-származékok, ezeket tartalmazó gyógyszerkészítmények és alkalmazásuk gyógyszerkészítmények előállítására
US5691331A (en) * 1995-06-07 1997-11-25 Merck & Co., Inc. N-(2,4-Dioxo-2,3,4,5-tetrahydro-1H-1,5-benzodiazepin-3yl) -3- amides
US5631251A (en) * 1995-06-07 1997-05-20 Merck & Co., Inc. 5-cyclopropyl-1,4 benzodiazepine-2-ones
US5700797A (en) * 1995-06-07 1997-12-23 Merck & Co, Inc. N-(2,4-dioxo-2,3,4,5-tetrahydro-1H-1,5-benzodiazepin-3-yl)-3-amides
US5726171A (en) * 1995-06-07 1998-03-10 Merck & Co Inc N-(1-alkyl-5-phenyl-2,3,4,5-tetrahydro-1H-benzo B! 1,4!diazepin-3yl)-acetamides
WO1996040656A1 (fr) * 1995-06-07 1996-12-19 Merck & Co., Inc. Nouveaux n-(2,4-dioxo-2,3,4,5-tetrahydro-1h-1,5-benzodiazepine-3yle)-3-amides
AUPO284396A0 (en) * 1996-10-08 1996-10-31 Fujisawa Pharmaceutical Co., Ltd. Benzodiazepine derivatives
US6635632B1 (en) 1996-12-23 2003-10-21 Athena Neurosciences, Inc. Cycloalkyl, lactam, lactone and related compounds, pharmaceutical compositions comprising same, and methods for inhibiting β-amyloid peptide release and/or its synthesis by use of such compounds
US6683075B1 (en) 1996-12-23 2004-01-27 Athena Neurosciences, Inc. Cycloalkyl, lactam, lactone and related compounds, pharmaceutical compositions comprising same, and methods for inhibiting β-amyloid peptide release and/or its synthesis by use
US6569851B1 (en) 1998-06-22 2003-05-27 Elan Pharmaceutials, Inc. Cycloalkyl, lactam, lactone and related compounds, pharmaceutical compositions comprising same, and methods for inhibiting β-amyloid peptide release and/or its synthesis by use of such compounds
US6774125B2 (en) 1998-06-22 2004-08-10 Elan Pharmaceuticals, Inc. Deoxyamino acid compounds, pharmaceutical compositions comprising same, and methods for inhibiting β-amyloid peptide release and/or its synthesis by use of such compounds
US6958330B1 (en) 1998-06-22 2005-10-25 Elan Pharmaceuticals, Inc. Polycyclic α-amino-ε-caprolactams and related compounds
US6528505B1 (en) 1998-06-22 2003-03-04 Elan Pharmaceuticals, Inc. Cyclic amino acid compounds pharmaceutical compositions comprising same and methods for inhibiting β-amyloid peptide release and/or its synthesis by use of such compounds
US6552013B1 (en) 1998-06-22 2003-04-22 Elan Pharmaceuticals, Inc. Deoxyamino acid compounds, pharmaceutical compositions comprising same, and methods for inhibiting β-amyloid peptide release and/or its synthesis by use of such compounds
US6509331B1 (en) 1998-06-22 2003-01-21 Elan Pharmaceuticals, Inc. Deoxyamino acid compounds, pharmaceutical compositions comprising same, and methods for inhibiting β-amyloid peptide release and/or its synthesis by use of such compounds
US6277844B1 (en) 1998-09-14 2001-08-21 Sydney Spector Compound for selective treatment of malignant cells by inhibiting cell cycle progression, decreasing Bcl2, and increasing apoptosis
US7572788B2 (en) * 1999-04-30 2009-08-11 The Regents Of The University Of Michigan Compositions and methods relating to novel compounds and targets thereof
ES2214273T3 (es) * 1999-04-30 2004-09-16 The Regents Of The University Of Michigan Utilizacion de benzodiazepinas para el tratamiento de enfermedades autoinmunes inducidas por apoptosis.
US20060025388A1 (en) * 1999-04-30 2006-02-02 Glick Gary D Compositions and methods relating to novel compounds and targets thereof
US20030119029A1 (en) * 1999-04-30 2003-06-26 Regents Of The University Of Michigan Compositions and methods relating to novel benzodiazepine compounds and targets thereof
US20040176358A1 (en) * 1999-04-30 2004-09-09 The Regents Of The University Of Michigan Compositions and methods relating to novel compounds and targets thereof
US20050113460A1 (en) 1999-04-30 2005-05-26 The Regents Of The University Of Michigan Compositions and methods relating to novel compounds and targets thereof
US7276348B2 (en) * 1999-04-30 2007-10-02 Regents Of The University Of Michigan Compositions and methods relating to F1F0-ATPase inhibitors and targets thereof
WO2004101533A1 (fr) * 2003-05-12 2004-11-25 Janssen Pharmaceutica, N.V. Sels de 1,3,4-benzotriazepine et leur utilisation comme ligands du recepteur de cck
US20050272723A1 (en) * 2004-04-27 2005-12-08 The Regents Of The University Of Michigan Methods and compositions for treating diseases and conditions associated with mitochondrial function
US20060052369A1 (en) * 2004-09-07 2006-03-09 The Regents Of The University Of Michigan Compositions and methods relating to novel compounds and targets thereof
JP2008528448A (ja) * 2005-01-03 2008-07-31 ザ リージェンツ オブ ザ ユニバーシティ オブ ミシガン 新規化合物に関連する組成物および方法、ならびにその標的
JP2008545757A (ja) * 2005-06-01 2008-12-18 ザ リージェンツ オブ ザ ユニバーシティ オブ ミシガン 溶媒和されていないベンゾジアゼピン組成物および方法
US20070105844A1 (en) * 2005-10-26 2007-05-10 Regents Of The University Of Michigan Therapeutic compositions and methods
JP5241501B2 (ja) 2005-11-01 2013-07-17 ザ リージェンツ オブ ザ ユニバーシティ オブ ミシガン 治療特性を有する新規の１，４−ベンゾジアゼピン−２，５−ジオン
US7759338B2 (en) * 2006-04-27 2010-07-20 The Regents Of The University Of Michigan Soluble 1,4 benzodiazepine compounds and stable salts thereof
EP2037741B1 (fr) 2006-06-09 2013-11-27 The Regents Of The University Of Michigan Dérives de benzodiazépine utiles dans le traitement de pathologies sur une base immune, inflammatoire ou proliferative.
EP2139331B1 (fr) 2007-03-09 2013-02-20 The Regents of the University of Michigan Compositions et procédés en rapport avec de nouveaux composés et cibles de ceux-ci
CN101855203B (zh) 2007-09-14 2014-03-19 密执安州立大学董事会 F1f0-atp合成酶抑制剂以及相关的方法
CA2703005A1 (fr) 2007-11-06 2009-05-14 The Regents Of The University Of Michigan Composes benzodiazepinone utiles dans le traitement d'affections de la peau
WO2010030891A2 (fr) 2008-09-11 2010-03-18 The Regents Of The University Of Michigan Inhibiteurs de f<sb>1</sb>f<sb>0</sb>-atpase à base d’aryle guanidine et procédés associés
WO2010121164A2 (fr) 2009-04-17 2010-10-21 The Regents Of The University Of Michigan Composés de 1,4-benzodiazépinone et leur utilisation dans le traitement du cancer
US8673897B2 (en) 2009-09-18 2014-03-18 The Regents Of The University Of Michigan Benzodiazepinone compounds and methods of treatment using same
JP5856064B2 (ja) 2009-11-17 2016-02-09 ザ リージェンツ オブ ザ ユニバーシティ オブ ミシガン 治療特性を有する１，４−ベンゾジアゼピン−２，５−ジオンおよび関連化合物
CA2915237C (fr) 2009-11-17 2017-10-10 The Regents Of The University Of Michigan 1,4-benzodiazepine-2,5-diones et composes apparentes presentant des proprietes therapeutiques
GB201414116D0 (en) 2014-08-08 2014-09-24 Trio Medicines Ltd Benzodiazepine derivatives
GB201513979D0 (en) 2015-08-07 2015-09-23 Trio Medicines Ltd Synthesis of benzodiazepine derivatives

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA1332410C (fr) * 1984-06-26 1994-10-11 Roger M. Freidinger Analogues de benzodiazepines
IE904560A1 (en) * 1989-12-18 1991-06-19 Merck & Co Inc New benzodiazepine analogs
CA2032226A1 (fr) * 1989-12-18 1991-06-19 Mark G. Bock Analogues de la benzodiazepine
IL96613A0 (en) * 1989-12-18 1991-09-16 Merck & Co Inc Pharmaceutical compositions containing benzodiazepine analogs
IL101514A (en) * 1991-04-10 1996-01-31 Merck & Co Inc History of benzodiazepines and anticoagulants containing cholecystokinin containing them
US5218115A (en) * 1991-04-10 1993-06-08 Merck & Co., Inc. Cholecystokinin antagonists
CA2068355A1 (fr) * 1991-05-14 1992-11-15 Mark S. Chambers Derives de benzodiazepines, compositions les contenant et leur utilisation therapeutique

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2002516313A (ja) * 1997-01-31 2002-06-04 セルジーン・コーポレーシヨン ２−置換ピペリジン立体異性体を製造するための方法及び中間体
JP2009508865A (ja) * 2005-09-16 2009-03-05 ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ ベンゾ［ｅ］［１，２，４］トリアゼピン−２−オン誘導体の製造方法

Also Published As

Publication number Publication date
AU670939B2 (en) 1996-08-08
EP0637308A1 (fr) 1995-02-08
AU3758693A (en) 1993-10-21
CA2130195A1 (fr) 1993-09-30
WO1993019063A1 (fr) 1993-09-30
US5597915A (en) 1997-01-28

Similar Documents

Publication Publication Date Title
JPH07504908A (ja) ベンゾジアゼピン誘導体，該誘導体を含有する組成物及び治療におけるその使用
US5681833A (en) Benzodiazepine derivatives
TW487703B (en) 1,5-benzodiazepine derivatives
EP0652871B1 (fr) Derives de benzodiazepine
AU679085B2 (en) Benzodiazepine analogs
JP2571899B2 (ja) ベンゾジアゼピン誘導体、それを含有する組成物、及び治療に於ける使用
US5360802A (en) Benzodiazepine derivatives, compositions containing them and their use in therapy
US20030232832A1 (en) Pyrrolotriazinone compounds and their use to teat diseases
JPH05178843A (ja) ベンゾジアゼピン誘導体、それらを含有した組成物及びそれらの治療に関する用途
JPH05255279A (ja) コレシストキニン拮抗薬
CA2056809A1 (fr) Analogues de la benzodiazepine
US5302591A (en) Benzodiazepine derivatives
AU667690B2 (en) Benzodiazepine derivatives and their use as antagonists of cholecystokinin and/or gastrin receptors
KR101620115B1 (ko) Ｍｃ5 수용체의 활성을 조절하는 방법 및 이 수용체와 관련된 상태의 치료 방법
JPH0680649A (ja) コレシストキニン拮抗剤
CA2066083C (fr) Analogues de benzodiazepine comme antagonistes de la cholecystokinine
JPH0680650A (ja) コレシストキニン拮抗薬
JPH06509337A (ja) ベンゾジアゼピン誘導体、それらを含有する組成物及び治療におけるそれらの使用
CZ267695A3 (en) 1,5-benzodiazepine derivatives, process of their preparation, their use and pharmaceutical preparations containing thereof
WO2004080965A1 (fr) Antagoniste du recepteur du neuropeptide ff
GB2271991A (en) N-(2-oxo-1H-1,4-benzodiazepin-3-yl)-ureas
GB2266528A (en) Benzodiazepine derivatives
JPS6127982A (ja) ４−オキソ−２−アゼチジニルカルボン酸誘導体及びその製法