JPH07502759A - ６，７α−ジフルオロメチレンアンドロスタ−１，４−ジエン−３−オン誘導体及び該誘導体の製造方法 - Google Patents

６，７α−ジフルオロメチレンアンドロスタ−１，４−ジエン−３−オン誘導体及び該誘導体の製造方法

Info

Publication number
JPH07502759A
JPH07502759A JP6510629A JP51062994A JPH07502759A JP H07502759 A JPH07502759 A JP H07502759A JP 6510629 A JP6510629 A JP 6510629A JP 51062994 A JP51062994 A JP 51062994A JP H07502759 A JPH07502759 A JP H07502759A
Authority
JP
Japan
Prior art keywords
formula
formulas
tables
group
compound
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP6510629A
Other languages
English (en)
Japanese (ja)
Inventor
ブツエツテイ，フランコ
ロンゴ，アントニオ
デイ・サーレ，エンリコ
Original Assignee
フアルミタリア・カルロ・エルバ・エツセ・エルレ・エルレ
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by フアルミタリア・カルロ・エルバ・エツセ・エルレ・エルレ filed Critical フアルミタリア・カルロ・エルバ・エツセ・エルレ・エルレ
Publication of JPH07502759A publication Critical patent/JPH07502759A/ja
Pending legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J53/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton has been modified by condensation with a carbocyclic rings or by formation of an additional ring by means of a direct link between two ring carbon atoms, including carboxyclic rings fused to the cyclopenta(a)hydrophenanthrene skeleton are included in this class
    • C07J53/002—Carbocyclic rings fused
    • C07J53/004—3 membered carbocyclic rings
    • C07J53/007—3 membered carbocyclic rings in position 6-7
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/38—Drugs for disorders of the endocrine system of the suprarenal hormones

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Diabetes (AREA)
  • Endocrinology (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Steroid Compounds (AREA)
JP6510629A 1992-10-28 1993-10-18 ６，７α−ジフルオロメチレンアンドロスタ−１，４−ジエン−３−オン誘導体及び該誘導体の製造方法 Pending JPH07502759A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB929222669A GB9222669D0 (en) 1992-10-28 1992-10-28 6,7 alpha-difluoromethylenandrosta-1,4-dien-3-one derivatives and process for their preparation
GB9222669.5 1992-10-28
PCT/EP1993/002864 WO1994010190A1 (fr) 1992-10-28 1993-10-18 DERIVES DE LA 6,7α-DIFLUOROMETHYLENEANDROSTA-1,4-DIEN-3-ONE ET PROCEDES POUR LEUR PREPARATION

Publications (1)

Publication Number Publication Date
JPH07502759A true JPH07502759A (ja) 1995-03-23

Family

ID=10724212

Family Applications (1)

Application Number Title Priority Date Filing Date
JP6510629A Pending JPH07502759A (ja) 1992-10-28 1993-10-18 ６，７α−ジフルオロメチレンアンドロスタ−１，４−ジエン−３−オン誘導体及び該誘導体の製造方法

Country Status (4)

Country Link
EP (1) EP0620823A1 (fr)
JP (1) JPH07502759A (fr)
GB (1) GB9222669D0 (fr)
WO (1) WO1994010190A1 (fr)

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3322285A1 (de) * 1983-06-18 1984-12-20 Schering AG, 1000 Berlin und 4709 Bergkamen 1-alkyl-androsta-1,4-dien-3,17-dione, verfahren zu deren herstellung und diese enthaltende pharmazeutische praeparate
JP2860821B2 (ja) * 1990-05-30 1999-02-24 帝国臓器製薬株式会社 ６，７―メチレンステロイド誘導体

Also Published As

Publication number Publication date
EP0620823A1 (fr) 1994-10-26
GB9222669D0 (en) 1992-12-09
WO1994010190A1 (fr) 1994-05-11

Similar Documents

Publication Publication Date Title
IE69337B1 (en) Phosphonic acid substituted aromatic steroids as inhibitors of steroid 5-alpha-reductase
HU194274B (en) Process for preparing 6-alkylidene-androsta-1,4-dien-3,17-dione derivatives and pharmaceuticals comprising the same
FR2577556A1 (fr) Derives 4-substitues d'androst-4-ene-3, 17-dione utiles notamment comme inhibiteurs d'aromatase et leur fabrication
JPH03504498A (ja) 芳香族ステロイド５‐α‐レダクターゼ抑制剤
JPH06511497A (ja) フッ素化１７β−置換，４−アザ−５α−アンドロスタン−３−オン誘導体
JP2643943B2 (ja) 新規な６−もしくは７−メチレンアンドロスタ−１，４−ジエン−３，１７−ジオン誘導体およびその製造方法
JP2677626B2 (ja) １７−置換アンドロスタ−１，４−ジエン−３−オン誘導体
US4840943A (en) Androst-4-ene-3,17-diones and process for their preparation
AU666433B2 (en) Fluorinated 4-aminoandrostadienone derivatives and process for their preparation
JPH05320189A (ja) ４−アミノ−Δ▲４，６▼−ステロイド類、及び５α−レダクターゼ阻害剤としてのその用途
JPH07502759A (ja) ６，７α−ジフルオロメチレンアンドロスタ−１，４−ジエン−３−オン誘導体及び該誘導体の製造方法
JPH06507181A (ja) ジフルオロメチレンアンドロステノン誘導体およびその調製方法
IE60754B1 (en) Steroidic aromatase inhibitors
EP0608404B1 (fr) DERIVES D'ANDROST-4-ENO[4,5-b]PYRROLE ET LEUR PROCEDE DE PREPARATION
JPH08500609A (ja) フッ素化６−メチレンアンドロスタ−１，４−ジエン−３−オン誘導体及び該誘導体の製造方法
JPH06316591A (ja) ステロイドのレダクターゼ抑制剤として選択される１７β−ポリアロイル−４−アザ−５α−アンドロスト−１−エン−３−オン
JPS635097A (ja) アンドロスト−４−エン−３，１７−ジオンのメチレン誘導体およびその製造方法
GB2284605A (en) 6-or 7-substituted 4-aminoandrostadienone derivatives
JP2557308B2 (ja) 新規なアンドロステンジオン誘導体
JPS62298600A (ja) Ｃ−６またはｃ−７置換ステロイドの４−ヒドロキシ誘導体およびそれらの製造方法
JP2002541154A (ja) エキレニン誘導体、その製造法および該化合物を含有する医薬品