JPH07501817A - 新規置換オキサジノイソキノリン誘導体，該誘導体を含有する医薬組成物および該誘導体の製法 - Google Patents
新規置換オキサジノイソキノリン誘導体，該誘導体を含有する医薬組成物および該誘導体の製法Info
- Publication number
- JPH07501817A JPH07501817A JP5510763A JP51076393A JPH07501817A JP H07501817 A JPH07501817 A JP H07501817A JP 5510763 A JP5510763 A JP 5510763A JP 51076393 A JP51076393 A JP 51076393A JP H07501817 A JPH07501817 A JP H07501817A
- Authority
- JP
- Japan
- Prior art keywords
- formula
- alkyl
- derivatives
- phenyl
- acid addition
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 238000000034 method Methods 0.000 title claims description 22
- RXINFAULMRJDAU-UHFFFAOYSA-N 7h-pyrido[3,4-f][2,1]benzoxazine Chemical class C1=CC2=CC=NC=C2C2=C1NOC=C2 RXINFAULMRJDAU-UHFFFAOYSA-N 0.000 title claims description 6
- 239000008194 pharmaceutical composition Chemical class 0.000 title claims description 6
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- 125000004178 (C1-C4) alkyl group Chemical group 0.000 claims description 13
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- 150000003839 salts Chemical class 0.000 claims description 12
- 230000003185 calcium uptake Effects 0.000 claims description 11
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- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims description 6
- 239000002904 solvent Substances 0.000 claims description 6
- FYSNRJHAOHDILO-UHFFFAOYSA-N thionyl chloride Chemical compound ClS(Cl)=O FYSNRJHAOHDILO-UHFFFAOYSA-N 0.000 claims description 6
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- 239000011021 lapis lazuli Substances 0.000 description 1
- 230000000670 limiting effect Effects 0.000 description 1
- 235000019359 magnesium stearate Nutrition 0.000 description 1
- JNZGLUUWTFPBKG-UHFFFAOYSA-K magnesium;potassium;trichloride Chemical compound [Mg+2].[Cl-].[Cl-].[Cl-].[K+] JNZGLUUWTFPBKG-UHFFFAOYSA-K 0.000 description 1
- 230000010534 mechanism of action Effects 0.000 description 1
- 230000001404 mediated effect Effects 0.000 description 1
- 238000002844 melting Methods 0.000 description 1
- 230000008018 melting Effects 0.000 description 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 description 1
- 230000025090 microtubule depolymerization Effects 0.000 description 1
- 150000007522 mineralic acids Chemical class 0.000 description 1
- 210000002569 neuron Anatomy 0.000 description 1
- 231100000228 neurotoxicity Toxicity 0.000 description 1
- 230000007135 neurotoxicity Effects 0.000 description 1
- 239000012299 nitrogen atmosphere Substances 0.000 description 1
- JCXJVPUVTGWSNB-UHFFFAOYSA-N nitrogen dioxide Inorganic materials O=[N]=O JCXJVPUVTGWSNB-UHFFFAOYSA-N 0.000 description 1
- 230000036963 noncompetitive effect Effects 0.000 description 1
- 150000007524 organic acids Chemical class 0.000 description 1
- 235000005985 organic acids Nutrition 0.000 description 1
- 230000011164 ossification Effects 0.000 description 1
- 229920002866 paraformaldehyde Polymers 0.000 description 1
- 230000001575 pathological effect Effects 0.000 description 1
- 230000035699 permeability Effects 0.000 description 1
- 230000000144 pharmacologic effect Effects 0.000 description 1
- 229910052697 platinum Inorganic materials 0.000 description 1
- BUKHSQBUKZIMLB-UHFFFAOYSA-L potassium;sodium;dichloride Chemical compound [Na+].[Cl-].[Cl-].[K+] BUKHSQBUKZIMLB-UHFFFAOYSA-L 0.000 description 1
- 229920001592 potato starch Polymers 0.000 description 1
- 239000000843 powder Substances 0.000 description 1
- 230000002265 prevention Effects 0.000 description 1
- 239000000047 product Substances 0.000 description 1
- 230000001681 protective effect Effects 0.000 description 1
- 230000009822 protein phosphorylation Effects 0.000 description 1
- 230000017854 proteolysis Effects 0.000 description 1
- 102000005962 receptors Human genes 0.000 description 1
- 108020003175 receptors Proteins 0.000 description 1
- 238000011160 research Methods 0.000 description 1
- 230000000241 respiratory effect Effects 0.000 description 1
- 235000017557 sodium bicarbonate Nutrition 0.000 description 1
- 229910000030 sodium bicarbonate Inorganic materials 0.000 description 1
- 229940125794 sodium channel blocker Drugs 0.000 description 1
- 239000003195 sodium channel blocking agent Substances 0.000 description 1
- QDRKDTQENPPHOJ-UHFFFAOYSA-N sodium ethoxide Chemical compound [Na+].CC[O-] QDRKDTQENPPHOJ-UHFFFAOYSA-N 0.000 description 1
- 239000012453 solvate Substances 0.000 description 1
- 239000007858 starting material Substances 0.000 description 1
- 239000012089 stop solution Substances 0.000 description 1
- 239000005720 sucrose Substances 0.000 description 1
- 239000000829 suppository Substances 0.000 description 1
- 230000004083 survival effect Effects 0.000 description 1
- 238000003786 synthesis reaction Methods 0.000 description 1
- 235000020357 syrup Nutrition 0.000 description 1
- 239000006188 syrup Substances 0.000 description 1
- 239000003826 tablet Substances 0.000 description 1
- 239000000454 talc Substances 0.000 description 1
- 229910052623 talc Inorganic materials 0.000 description 1
- 210000001519 tissue Anatomy 0.000 description 1
- 231100000419 toxicity Toxicity 0.000 description 1
- 230000001988 toxicity Effects 0.000 description 1
- 239000003053 toxin Substances 0.000 description 1
- 231100000765 toxin Toxicity 0.000 description 1
- 230000002227 vasoactive effect Effects 0.000 description 1
- 238000005406 washing Methods 0.000 description 1
- 210000004885 white matter Anatomy 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D498/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- General Health & Medical Sciences (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Biomedical Technology (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Diabetes (AREA)
- Hospice & Palliative Care (AREA)
- Vascular Medicine (AREA)
- Urology & Nephrology (AREA)
- Psychiatry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Other In-Based Heterocyclic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| HU913906A HU209393B (en) | 1991-12-12 | 1991-12-12 | Process for producing new, substituted oxazinoisoquinoline derivates |
| HU3906/91 | 1991-12-12 | ||
| PCT/HU1992/000053 WO1993012118A1 (en) | 1991-12-12 | 1992-12-11 | Novel substituted oxazinoisoquinoline derivatives, pharmaceutical compositions containing them and process for preparing same |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| JPH07501817A true JPH07501817A (ja) | 1995-02-23 |
Family
ID=10966001
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP5510763A Pending JPH07501817A (ja) | 1991-12-12 | 1992-12-11 | 新規置換オキサジノイソキノリン誘導体，該誘導体を含有する医薬組成物および該誘導体の製法 |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US5494909A (https=) |
| EP (1) | EP0620820A1 (https=) |
| JP (1) | JPH07501817A (https=) |
| AU (1) | AU3170593A (https=) |
| FI (1) | FI942675A7 (https=) |
| HU (1) | HU209393B (https=) |
| NO (1) | NO942181D0 (https=) |
| TW (1) | TW219364B (https=) |
| WO (1) | WO1993012118A1 (https=) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7128759B2 (en) * | 2003-05-19 | 2006-10-31 | Cook Incorporated | Implantable medical device with constrained expansion |
| WO2007022568A1 (en) | 2005-08-25 | 2007-03-01 | Steven Michael Weiss | Reducing myocardial damage and the incidence of arrhythmia arising from loss, reduction or interruption in coronary blood flow |
| CN103651533A (zh) * | 2013-12-30 | 2014-03-26 | 青岛崂乡茶制品有限公司 | 一种新型茶叶种植用农药 |
| CN103651435A (zh) * | 2013-12-30 | 2014-03-26 | 青岛崂乡茶制品有限公司 | 一种环保的茶叶杀虫剂 |
| CN105532682B (zh) * | 2016-02-17 | 2018-03-23 | 陕西先农生物科技有限公司 | 一种含藜芦碱植物源杀虫剂组合物及制备方法 |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| HU191301B (en) * | 1984-03-23 | 1987-02-27 | Richter Gedeon Vegyeszeti Gyar Rt,Hu | Process for preparing 1-/hydroxy-methyl/-1,6,7,11b-tetrahydro-2h,4h-/1,3/-oxazino- or -thiazino/4,3-a/isoquinoline -derivatives |
-
1991
- 1991-12-12 HU HU913906A patent/HU209393B/hu not_active IP Right Cessation
-
1992
- 1992-12-11 JP JP5510763A patent/JPH07501817A/ja active Pending
- 1992-12-11 EP EP93900339A patent/EP0620820A1/en not_active Withdrawn
- 1992-12-11 AU AU31705/93A patent/AU3170593A/en not_active Abandoned
- 1992-12-11 US US08/244,736 patent/US5494909A/en not_active Expired - Fee Related
- 1992-12-11 WO PCT/HU1992/000053 patent/WO1993012118A1/en not_active Ceased
- 1992-12-28 TW TW081110477A patent/TW219364B/zh active
-
1994
- 1994-06-07 FI FI942675A patent/FI942675A7/fi not_active Application Discontinuation
- 1994-06-10 NO NO942181A patent/NO942181D0/no unknown
Also Published As
| Publication number | Publication date |
|---|---|
| HU209393B (en) | 1994-05-30 |
| NO942181L (https=) | 1994-06-10 |
| NO942181D0 (no) | 1994-06-10 |
| US5494909A (en) | 1996-02-27 |
| HUT63427A (en) | 1993-08-30 |
| HU913906D0 (en) | 1992-02-28 |
| EP0620820A1 (en) | 1994-10-26 |
| AU3170593A (en) | 1993-07-19 |
| FI942675A0 (fi) | 1994-06-07 |
| FI942675A7 (fi) | 1994-06-07 |
| WO1993012118A1 (en) | 1993-06-24 |
| TW219364B (https=) | 1994-01-21 |
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