JPH0670051B2 - １，２−置換されたエルゴリン誘導体、該製法及び該誘導体を含有する精神分裂同型団精神病及び抑うつ症治療剤 - Google Patents

１，２−置換されたエルゴリン誘導体、該製法及び該誘導体を含有する精神分裂同型団精神病及び抑うつ症治療剤

Info

Publication number
JPH0670051B2
JPH0670051B2 JP61234693A JP23469386A JPH0670051B2 JP H0670051 B2 JPH0670051 B2 JP H0670051B2 JP 61234693 A JP61234693 A JP 61234693A JP 23469386 A JP23469386 A JP 23469386A JP H0670051 B2 JPH0670051 B2 JP H0670051B2
Authority
JP
Japan
Prior art keywords
lower alkyl
ergolinyl
urea
diethyl
methyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
JP61234693A
Other languages
English (en)
Japanese (ja)
Other versions
JPS62174075A (ja
Inventor
アンドレアス・フート
ゲルハルト・ザウアー
ヘルムート・ヴアハテル
Original Assignee
シエ−リング・アクチエンゲゼルシヤフト
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by シエ−リング・アクチエンゲゼルシヤフト filed Critical シエ−リング・アクチエンゲゼルシヤフト
Publication of JPS62174075A publication Critical patent/JPS62174075A/ja
Publication of JPH0670051B2 publication Critical patent/JPH0670051B2/ja
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D457/00—Heterocyclic compounds containing indolo [4, 3-f, g] quinoline ring systems, e.g. derivatives of ergoline, of the formula:, e.g. lysergic acid
    • C07D457/10—Heterocyclic compounds containing indolo [4, 3-f, g] quinoline ring systems, e.g. derivatives of ergoline, of the formula:, e.g. lysergic acid with hetero atoms directly attached in position 8
    • C07D457/12—Nitrogen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/26—Psychostimulants, e.g. nicotine, cocaine

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Neurology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biomedical Technology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Psychiatry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Neurosurgery (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pain & Pain Management (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
JP61234693A 1985-10-04 1986-10-03 １，２−置換されたエルゴリン誘導体、該製法及び該誘導体を含有する精神分裂同型団精神病及び抑うつ症治療剤 Expired - Lifetime JPH0670051B2 (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE19853535929 DE3535929A1 (de) 1985-10-04 1985-10-04 1,2-disubstituierte ergolinderivate
DE3535929.3 1985-10-04

Publications (2)

Publication Number Publication Date
JPS62174075A JPS62174075A (ja) 1987-07-30
JPH0670051B2 true JPH0670051B2 (ja) 1994-09-07

Family

ID=6283084

Family Applications (1)

Application Number Title Priority Date Filing Date
JP61234693A Expired - Lifetime JPH0670051B2 (ja) 1985-10-04 1986-10-03 １，２−置換されたエルゴリン誘導体、該製法及び該誘導体を含有する精神分裂同型団精神病及び抑うつ症治療剤

Country Status (8)

Country Link
US (1) US4874768A (enExample)
EP (1) EP0217736B1 (enExample)
JP (1) JPH0670051B2 (enExample)
AT (1) ATE74919T1 (enExample)
CS (1) CS259893B2 (enExample)
DE (2) DE3535929A1 (enExample)
ES (1) ES2051694T3 (enExample)
GR (1) GR3005135T3 (enExample)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3620293A1 (de) * 1986-06-16 1987-12-17 Schering Ag 1-und/oder 2-substituierte ergolinderivate
DE3824659A1 (de) * 1988-07-15 1990-02-08 Schering Ag 2-, 12- oder 13-substituierte 3-(8'(alpha)-ergolinyl)-1,1-diethylharnstoffe, ihre herstellung und verwendung in arzneimitteln
DK338789A (da) * 1988-07-15 1990-01-16 Schering Ag 2-substituerede ergolinylurinstofderivater og fremgangsmaade til fremstilling deraf, deres anvendelse som laegemidler samt mellemprodukter til fremstilling deraf
TW252979B (enExample) * 1992-12-24 1995-08-01 Erba Carlo Spa
DE10041478A1 (de) 2000-08-24 2002-03-14 Sanol Arznei Schwarz Gmbh Neue pharmazeutische Zusammensetzung
DE10334188B4 (de) * 2003-07-26 2007-07-05 Schwarz Pharma Ag Verwendung von Rotigotin zur Behandlung von Depressionen
DE10334187A1 (de) * 2003-07-26 2005-03-03 Schwarz Pharma Ag Substituierte 2-Aminotetraline zur Behandlung von Depressionen
EP2083008A1 (en) * 2007-12-07 2009-07-29 Axxonis Pharma AG Ergoline derivatives as selective radical scavengers for neurons
BR112017015487A2 (pt) 2015-01-20 2018-01-30 Xoc Pharmaceuticals Inc Composto; composição; método de tratamento e/ou prevenção de enxaqueca, als, doença de alzheimer, doença de parkinson, distúrbios extrapirimidais, depressão, náusea, êmese, síndrome das pernas inquietas, insônia, agressão, doença de huntington, doença cardiopulmonar, fibrogênese, hipertensão arterial pulmonar, ansiedade, dependências a drogas, distonia, parassonia ou hiperlactinemia em um indivíduo; métodos de agonização dos receptores d2, 5-ht1d, 5-ht1a e 5-ht2c, em um indivíduo; método de antagonização do receptor d3 em um indivíduo; métodos de agonização seletiva dos receptores 5 -ht1d, e 5-ht2c, método de fornecimento de atividade de antagonista funcional no receptor 5 -ht2b ou no receptor 5-ht7, ou em ambos, em um indivíduo; método de fornecimento de atividade de antagonista funcional nos receptores adrenérgicos em um indivíduo
CA3064274A1 (en) 2017-06-01 2018-12-06 Xoc Pharmaceuticals, Inc. Ergoline derivatives for use in medicine
EP4423084A4 (en) * 2021-10-26 2025-12-10 Diamond Therapeutics Inc 5-HT2A RECEPTOR ERGOLINE-DERIVED AGONISTS

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2656344A1 (de) * 1975-12-23 1977-07-07 Sandoz Ag Ergolinderivate, ihre verwendung und herstellung
CH622518A5 (en) * 1976-12-14 1981-04-15 Sandoz Ag Process for the preparation of novel ergoline compounds
DE3101535A1 (de) * 1981-01-14 1982-08-12 Schering Ag, 1000 Berlin Und 4619 Bergkamen Neue (2-halogen-ergolinyl)-n'.n'-diethyl-harnstoffderivate, verfahren zu ihrer herstellung und deren verwendung als arzneimittel
DE3151912A1 (de) * 1981-12-23 1983-06-30 Schering Ag, 1000 Berlin Und 4619 Bergkamen Neue ergolin-aminoderivate, verfahren zu ihrer herstellung und deren verwendung als arzneimittel
DE3309493A1 (de) * 1983-03-14 1984-09-20 Schering AG, 1000 Berlin und 4709 Bergkamen Neue ergolin-derivate, verfahren zu ihrer herstellung sowie verwendung als arzneimittel
PH21123A (en) * 1983-04-28 1987-07-27 Erba Farmitalia Ergoline derivatives
DE3413659A1 (de) * 1984-04-09 1985-10-17 Schering AG, 1000 Berlin und 4709 Bergkamen Neue 2-substituierte ergolin-derivate
EP0160842B1 (de) * 1984-04-09 1994-06-22 Schering Aktiengesellschaft 2-substituierte Ergolin-Derivate, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel
DE3533675A1 (de) * 1985-09-19 1987-03-26 Schering Ag Neue 12- und 13-brom-ergolinderivate

Also Published As

Publication number Publication date
ATE74919T1 (de) 1992-05-15
JPS62174075A (ja) 1987-07-30
DE3535929A1 (de) 1987-04-09
DE3684855D1 (de) 1992-05-21
CS259893B2 (en) 1988-11-15
EP0217736A3 (en) 1989-03-22
US4874768A (en) 1989-10-17
ES2051694T3 (es) 1994-07-01
CS715486A2 (en) 1988-03-15
EP0217736A2 (de) 1987-04-08
GR3005135T3 (enExample) 1993-05-24
EP0217736B1 (de) 1992-04-15

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