JPH06509812A - 生物人工内分泌装置 - Google Patents
生物人工内分泌装置Info
- Publication number
- JPH06509812A JPH06509812A JP5515019A JP51501993A JPH06509812A JP H06509812 A JPH06509812 A JP H06509812A JP 5515019 A JP5515019 A JP 5515019A JP 51501993 A JP51501993 A JP 51501993A JP H06509812 A JPH06509812 A JP H06509812A
- Authority
- JP
- Japan
- Prior art keywords
- membrane
- xylene
- poly
- thickness
- para
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
- A61K9/0024—Solid, semi-solid or solidifying implants, which are implanted or injected in body tissue
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/022—Artificial gland structures using bioreactors
Landscapes
- Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Transplantation (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Heart & Thoracic Surgery (AREA)
- Medicinal Chemistry (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Cardiology (AREA)
- Neurosurgery (AREA)
- Dermatology (AREA)
- Chemical & Material Sciences (AREA)
- Vascular Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Medicinal Preparation (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Materials For Medical Uses (AREA)
- External Artificial Organs (AREA)
- Prostheses (AREA)
Abstract
Description
Claims (6)
- 1.受容体である患者にホルモンを投与するための装置で、ホルモン産生細胞部 分を含むマトリックスおよび免疫原物質の通過は阻止し、前記細胞部分のための 栄養、およびそれにより化産されたホルモンの通過は可能である多孔をもつポリ −パラ−キシレンの重合膜からなる前記マトリックスを包むカプセル手段からな る装置。
- 2.請求項第1項に記載の装置で、前記重合膜がポリーパラ−キシレン、ポリ− モノクロロ−キシレン、およびポリ−ジクロロ−キシレンからなるグループから 選択される装置。
- 3.請求項第2項に記載の装置で、前記膜が約2000から5000オングスト ロームの厚さをもつ装置。 3.請求項第2項に記載の装置で、前記膜が約2500から3500オングスト ロームの厚さをもつ装置。
- 4.ホルモンを投与するための装置を作製する過程で、ホルモン産生細胞部分を 含むマトリックスを形成する段階、および前記マトリックスを免疫原物質の通過 を阻止し、前記細胞部分のための効果的な栄養、およびそれにより生産されるホ ルモンの通過は可能である前記多孔をもつ膜の形態である少なくとも前記重合物 質部分をもつポリ−パラ−キシレンを含む非免疫原性重合物質でカバーする段階 からなる過程。
- 5.生物人工膵臓で、ポリ−パラ−キシレンで形成される透過膜を含む生物適合 性物質からなるインシュリン産生細胞を含み、および約5000オングストロー ム以下の厚さをもつカプセル手段からなる人工膵臓。
- 6.請求項第5項に記載の生物人工膵臓で、前記カプセル手段が前記透過膜によ りカバーされる開口部をもつ複数の穴をもつ人工膵臓。
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US84197392A | 1992-02-24 | 1992-02-24 | |
US07/841,973 | 1992-02-24 | ||
PCT/US1993/001583 WO1993016685A1 (en) | 1992-02-24 | 1993-02-23 | Bioartificial endocrine device |
Publications (2)
Publication Number | Publication Date |
---|---|
JPH06509812A true JPH06509812A (ja) | 1994-11-02 |
JP3291297B2 JP3291297B2 (ja) | 2002-06-10 |
Family
ID=25286221
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP51501993A Expired - Fee Related JP3291297B2 (ja) | 1992-02-24 | 1993-02-23 | 生物人工内分泌装置 |
Country Status (8)
Country | Link |
---|---|
US (1) | US5614205A (ja) |
EP (1) | EP0587840B1 (ja) |
JP (1) | JP3291297B2 (ja) |
CA (1) | CA2109065C (ja) |
DE (1) | DE69327281T2 (ja) |
FI (1) | FI111335B (ja) |
NO (1) | NO309124B1 (ja) |
WO (1) | WO1993016685A1 (ja) |
Families Citing this family (24)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6231881B1 (en) | 1992-02-24 | 2001-05-15 | Anton-Lewis Usala | Medium and matrix for long-term proliferation of cells |
US5834005A (en) * | 1992-02-24 | 1998-11-10 | Encelle, Inc. | Bioartificial devices and cellular matrices therefor |
US5908633A (en) * | 1992-02-24 | 1999-06-01 | Usala; Anton-Lewis | Bioartificial hormone releasing device |
US5830492A (en) * | 1992-02-24 | 1998-11-03 | Encelle, Inc. | Bioartificial devices and cellular matrices therefor |
US5824331A (en) * | 1992-02-24 | 1998-10-20 | Encelle, Inc. | Bioartificial devices and cellular matrices therefor |
US5776324A (en) * | 1996-05-17 | 1998-07-07 | Encelle, Inc. | Electrochemical biosensors |
US5964261A (en) * | 1996-05-29 | 1999-10-12 | Baxter International Inc. | Implantation assembly |
US5922339A (en) * | 1998-01-27 | 1999-07-13 | Usala; Anton-Lewis | Compositions and methods for biocompatible implants |
SK285392B6 (sk) | 1998-12-15 | 2006-12-07 | Universidad Nacional Autonoma De M�Xico | Zariadenie na uľahčenie implantácie biologického materiálu a/alebo tvorbu materiálu na tkanivové implantáty |
US6365385B1 (en) | 1999-03-22 | 2002-04-02 | Duke University | Methods of culturing and encapsulating pancreatic islet cells |
US6303355B1 (en) | 1999-03-22 | 2001-10-16 | Duke University | Method of culturing, cryopreserving and encapsulating pancreatic islet cells |
US20040115760A1 (en) * | 1999-06-18 | 2004-06-17 | Thomas Metzler | Method and device for carrying out biochemical reactions with a high throughput |
WO2001091774A2 (en) | 2000-05-31 | 2001-12-06 | Encelle, Inc. | Method of treating chronic ulcers |
US20080086792A1 (en) | 2006-10-13 | 2008-04-17 | Thomas Charles Kuracina | Method and apparatus for diverting sweat, liquid, moisture or the like from an eye |
WO2003072157A1 (en) | 2002-02-21 | 2003-09-04 | Encelle, Inc. | Immobilized bioactive hydrogel matrices as surface coatings |
JP4560545B2 (ja) | 2004-07-29 | 2010-10-13 | ユニバーシティ オブ マイアミ | 細胞治療のためのハイブリッドデバイス |
DE102004050457A1 (de) * | 2004-10-12 | 2006-04-13 | Capsulution Nanoscience Ag | Segmentierte Vorrichtung für die verzögerte Freisetzung von Molekülen in tangentialer Richtung durch dünne Filme und Anwendungen derselben |
ES2968634T3 (es) | 2007-02-06 | 2024-05-13 | Pioneer Surgical Tech Inc | Dispositivos de implante intervertebral |
MX2010013135A (es) | 2010-11-30 | 2012-05-31 | Val De Bio S De R L De C V | Procedimiento y dispositivo mejorados para favorecer el trasplante de material biológico. |
US9132021B2 (en) | 2011-10-07 | 2015-09-15 | Pioneer Surgical Technology, Inc. | Intervertebral implant |
WO2013067195A1 (en) | 2011-11-02 | 2013-05-10 | Halscion, Inc. | Methods and compositions for wound treatment |
MX352601B (es) | 2011-12-23 | 2017-11-30 | Pioneer Surgical Tech | Matriz continua con particulas osteoconductoras dispersadas en ella, método para formarla y método para regenerar hueso con ella. |
US11147682B2 (en) | 2017-09-08 | 2021-10-19 | Pioneer Surgical Technology, Inc. | Intervertebral implants, instruments, and methods |
USD907771S1 (en) | 2017-10-09 | 2021-01-12 | Pioneer Surgical Technology, Inc. | Intervertebral implant |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4352883A (en) * | 1979-03-28 | 1982-10-05 | Damon Corporation | Encapsulation of biological material |
EP0147939A2 (en) * | 1983-11-15 | 1985-07-10 | JOHNSON & JOHNSON | Implantable module for gylcemia regulation |
NO166836C (no) * | 1985-03-14 | 1991-09-11 | Univ California | Fremgangsmaate for behandling av et organtransplantat. |
US4861658A (en) * | 1988-05-02 | 1989-08-29 | Barriergen, Inc. | Hypoallergenic jewelry and method of making the same |
-
1993
- 1993-02-23 WO PCT/US1993/001583 patent/WO1993016685A1/en active IP Right Grant
- 1993-02-23 EP EP93906163A patent/EP0587840B1/en not_active Expired - Lifetime
- 1993-02-23 DE DE69327281T patent/DE69327281T2/de not_active Expired - Lifetime
- 1993-02-23 CA CA002109065A patent/CA2109065C/en not_active Expired - Fee Related
- 1993-02-23 JP JP51501993A patent/JP3291297B2/ja not_active Expired - Fee Related
- 1993-10-25 FI FI934702A patent/FI111335B/fi not_active IP Right Cessation
- 1993-10-25 NO NO933844A patent/NO309124B1/no not_active IP Right Cessation
-
1994
- 1994-11-28 US US08/346,340 patent/US5614205A/en not_active Expired - Lifetime
Also Published As
Publication number | Publication date |
---|---|
DE69327281T2 (de) | 2000-08-10 |
NO933844D0 (no) | 1993-10-25 |
WO1993016685A1 (en) | 1993-09-02 |
CA2109065C (en) | 2004-03-30 |
NO309124B1 (no) | 2000-12-18 |
US5614205A (en) | 1997-03-25 |
AU3729693A (en) | 1993-09-13 |
EP0587840B1 (en) | 1999-12-15 |
FI934702A0 (fi) | 1993-10-25 |
FI111335B (fi) | 2003-07-15 |
JP3291297B2 (ja) | 2002-06-10 |
DE69327281D1 (de) | 2000-01-20 |
EP0587840A4 (en) | 1995-06-14 |
NO933844L (no) | 1993-12-23 |
CA2109065A1 (en) | 1993-08-25 |
EP0587840A1 (en) | 1994-03-23 |
AU663938B2 (en) | 1995-10-26 |
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