JPH06503562A - 置換５−アリールイミダゾール - Google Patents

置換５−アリールイミダゾール

Info

Publication number
JPH06503562A
JPH06503562A JP4501924A JP50192492A JPH06503562A JP H06503562 A JPH06503562 A JP H06503562A JP 4501924 A JP4501924 A JP 4501924A JP 50192492 A JP50192492 A JP 50192492A JP H06503562 A JPH06503562 A JP H06503562A
Authority
JP
Japan
Prior art keywords
alkyl
compound
butyl
methyl
acid
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP4501924A
Other languages
English (en)
Japanese (ja)
Inventor
キーナン，リチャード・マックローチ
モーガン，ティナ
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
SmithKline Beecham Corp
Original Assignee
SmithKline Beecham Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by SmithKline Beecham Corp filed Critical SmithKline Beecham Corp
Publication of JPH06503562A publication Critical patent/JPH06503562A/ja
Pending legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/64—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms, e.g. histidine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/06—Antiglaucoma agents or miotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Ophthalmology & Optometry (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Urology & Nephrology (AREA)
  • Endocrinology (AREA)
  • Reproductive Health (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
JP4501924A 1990-11-30 1991-11-12 置換５−アリールイミダゾール Pending JPH06503562A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US62118890A 1990-11-30 1990-11-30
US621,188 1990-11-30
PCT/US1991/008426 WO1992009278A1 (en) 1990-11-30 1991-11-12 Substituted 5-aryl imidazoles

Publications (1)

Publication Number Publication Date
JPH06503562A true JPH06503562A (ja) 1994-04-21

Family

ID=24489109

Family Applications (1)

Application Number Title Priority Date Filing Date
JP4501924A Pending JPH06503562A (ja) 1990-11-30 1991-11-12 置換５−アリールイミダゾール

Country Status (4)

Country Link
EP (1) EP0559755A1 (enExample)
JP (1) JPH06503562A (enExample)
AU (1) AU9055391A (enExample)
WO (1) WO1992009278A1 (enExample)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5338740A (en) * 1993-07-13 1994-08-16 Pfizer Inc. Angiotensin II receptor antagonists
SE9903028D0 (sv) 1999-08-27 1999-08-27 Astra Ab New use
US6596739B2 (en) 2000-03-29 2003-07-22 The Procter & Gamble Company N-(1-phenylethyl)-5-phenyl-imidazole-2-amine compounds, their compositions and uses
US6552033B1 (en) 2000-05-16 2003-04-22 The Procter & Gamble Co. Imidazo-containing heterocyclic compounds, their compositions and uses
US8969514B2 (en) 2007-06-04 2015-03-03 Synergy Pharmaceuticals, Inc. Agonists of guanylate cyclase useful for the treatment of hypercholesterolemia, atherosclerosis, coronary heart disease, gallstone, obesity and other cardiovascular diseases
MX2009013293A (es) 2007-06-04 2010-02-15 Synergy Pharmaceuticals Inc Agonistas de guanilato ciclasa útiles para el tratamiento de trastornos gastrointestinales, inflamación, cáncer y otros trastornos.
EP2810951B1 (en) 2008-06-04 2017-03-15 Synergy Pharmaceuticals Inc. Agonists of guanylate cyclase useful for the treatment of gastrointestinal disorders, inflammation, cancer and other disorders
CA2730603C (en) 2008-07-16 2019-09-24 Synergy Pharmaceuticals Inc. Agonists of guanylate cyclase useful for the treatment of gastrointestinal disorders, inflammation, cancer and other disorders
US9616097B2 (en) 2010-09-15 2017-04-11 Synergy Pharmaceuticals, Inc. Formulations of guanylate cyclase C agonists and methods of use
JP2016514670A (ja) 2013-03-15 2016-05-23 シナジー ファーマシューティカルズ インコーポレイテッド 他の薬物と組み合わせたグアニル酸シクラーゼ受容体アゴニスト
JP2016514671A (ja) 2013-03-15 2016-05-23 シナジー ファーマシューティカルズ インコーポレイテッド グアニル酸シクラーゼのアゴニストおよびその使用
EA201592263A1 (ru) 2013-06-05 2016-05-31 Синерджи Фармасьютикалз, Инк. Ультрачистые агонисты гуанилатциклазы c, способ их получения и использования

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA1338238C (en) * 1988-01-07 1996-04-09 David John Carini Angiotensin ii receptor blocking imidazoles and combinations thereof with diuretics and nsaids

Also Published As

Publication number Publication date
EP0559755A4 (enExample) 1994-04-27
AU9055391A (en) 1992-06-25
EP0559755A1 (en) 1993-09-15
WO1992009278A1 (en) 1992-06-11

Similar Documents

Publication Publication Date Title
JPH06503834A (ja) アンジオテンシン２受容体遮断組成物
US5294631A (en) Substituted benzimidazoles useful as angiotension II receptor antagonists
US5643906A (en) Method of using N-arylheteroarylalkyl imidazol-2-one compounds for treatment of a glaucoma disorder
DE60315355T2 (de) Piperidinyl-thiazol-carbonsäure-derivate als angiogenese-inhibitoren
JP3883205B2 (ja) アンギオテンシン▲ｉｉ▼レセプタ遮断イミダゾールによるアテローム性動脈硬化症の治療
JPH03115268A (ja) イミダゾリルアルケン酸
JPH03151379A (ja) 置換５―［（テトラゾリル）アルケニル］イミダゾール
BG98454A (bg) Имидазолилалкенови киселини
PT94377B (pt) Processo de preparacao de acidos imidazolilalcenoicos e de composicoes farmaceuticas que os contem
JPH07215944A (ja) 置換５−（アルキル）カルボキシアミドイミダゾール
JPWO1994014769A1 (ja) Ｎ−置換インドール誘導体
EP0504888A1 (en) 5-Arylheteroarylalkyl-1,3,5-trisubstituted-1,2,4-triazole compounds for treatment of circulatory disorders
JPH05508642A (ja) 置換ヒスチジン類
CA2923269A1 (en) Cycloalkyl acid derivative, preparation method thereof, and pharmaceutical application thereof
JP3214856B2 (ja) イミダゾリル−アルケン酸
KR20200091507A (ko) [3-(1-(1h-이미다졸-4-일)에틸)-2-메틸페닐] 메탄올의 에스테르 프로드러그
IE903976A1 (en) Substituted n-(imidazolyl)alkyl alanine derivatives
JPH05509106A (ja) 置換［１ｈ―イミダゾル―５―イル］アルカン酸
US5155117A (en) 1-arylheteroarylalkyl substituted-1h-1,2,4-triazole compounds for treatment of circulatory disorders
US5330989A (en) Heterocycles substituted with biphenyl-3-cyclobutene-1,2-dione derivatives
WO1994020460A1 (en) Chemical compounds
WO1994015926A1 (en) Angiotensin ii inhibitors
JPH0625180A (ja) シクロヘプチミダゾロン化合物，該化合物を含む薬剤組成物及び該化合物を用いた循環器系疾患の治療方法
JPH05504359A (ja) 置換ベンジル部分を含むイミダゾールアンギオテンシン２拮抗物質
JP2010522168A (ja) 鉱質コルチコイドレセプターモジュレータ