JPH06502323A - 有機物質あるいは生体物質の電気インピーダンスの測定装置 - Google Patents
有機物質あるいは生体物質の電気インピーダンスの測定装置Info
- Publication number
- JPH06502323A JPH06502323A JP3517772A JP51777291A JPH06502323A JP H06502323 A JPH06502323 A JP H06502323A JP 3517772 A JP3517772 A JP 3517772A JP 51777291 A JP51777291 A JP 51777291A JP H06502323 A JPH06502323 A JP H06502323A
- Authority
- JP
- Japan
- Prior art keywords
- electrodes
- electrode
- impedance
- measuring
- control electrode
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/05—Detecting, measuring or recording for diagnosis by means of electric currents or magnetic fields; Measuring using microwaves or radio waves
- A61B5/053—Measuring electrical impedance or conductance of a portion of the body
- A61B5/0531—Measuring skin impedance
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B3/00—Apparatus for testing the eyes; Instruments for examining the eyes
- A61B3/10—Objective types, i.e. instruments for examining the eyes independent of the patients' perceptions or reactions
- A61B3/16—Objective types, i.e. instruments for examining the eyes independent of the patients' perceptions or reactions for measuring intraocular pressure, e.g. tonometers
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Heart & Thoracic Surgery (AREA)
- Medical Informatics (AREA)
- Physics & Mathematics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Biophysics (AREA)
- Pathology (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Dermatology (AREA)
- Radiology & Medical Imaging (AREA)
- Molecular Biology (AREA)
- Surgery (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Investigating Or Analyzing Materials By The Use Of Electric Means (AREA)
- Measurement And Recording Of Electrical Phenomena And Electrical Characteristics Of The Living Body (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Measurement Of Resistance Or Impedance (AREA)
Abstract
Description
Claims (18)
- 1.有機物質そして生体物質の電気インピーダンスを深部選択性を持ち測定する ことを対象とし、制御電極で隔離された測定電極を有するプローブと、電気イン ピーダンスを測定する機器と、増幅機とから構成された装置において、前記プロ ーブには、増幅機を介し特定の信号を有した制御電極が設けられ、この信号は測 定電極のロードなしに、つまり、高入力インピーダンスによって、測定電極の1 つから得ており、前記増幅機の出力インピーダンスは十分に低く、また、増幅機 の出力は、十分に強く、これらは、試験中の想像できる限り全ての特性に対応し 、制御電極の必要な動的電位を維持するようにしたことを特徴とする装置。
- 2.前記増幅機の周波数応答は、十分に広く、出力信号に、想像できる限りの位 相あるいは振幅エラーをもたらさないことを特徴とする請求項1に記載の装置。
- 3.前記電極に対する振幅は、数十ミリボルトより低く、好ましくは50ミリボ ルトより低く、好ましくは約25ミリボルトより大きいことを特徴とする請求項 1に記載の装置。
- 4.前記増幅機の伝達関数は、外部で制御可能であることを特徴とする請求項1 に記載の装置。
- 5.前記増幅機の外部で制御可能な伝達関数は、手動で選択可能である、あるい は、連続的に変化させることが可能であることを特徴とする請求項1,3及び4 に記載の装置。
- 6.前記増幅機は、測定システムによって、段階的あるいは連続的に制御される ことを特徴とする請求項1,3〜5に記載の装置。
- 7.調整可能な増幅機を有した前記測定電極の信号は、複素数で乗除演算し、実 数部と虚数部は適用例毎に最適化され、前記増幅機から制御電極がフィードされ ることにより、制御電極の電位が測定電極の1つの電位を追従することを特徴と する請求項1に記載の装置。
- 8.前記プローブ先端の接触面は、測定そして制御電極を有し、前記電極と組織 の間には絶縁物質があり、これらは、形状には依存せず、同じ表面レベルにあり 、そして、プローブと試験場所の残留している水層を最小化するようになってお り、この結果、制御電極が、残留している水層の厚みより深いレンズの焦点深度 を得ることを容易にしたことを特徴とする請求項1に記載の装置。
- 9.刺激の測定のために、2種類の周波数で測定されたインピーダンス値が使用 されることで特徴とする請求項1に記載の装置。
- 10.前記刺激の測定には、数百kHzから数MHzまでの領域での一種類の周 波数と、1kHzから100kHzまでの領域での一種類の周波数が使用され、 大きい方の周波数が、試験中の組織の形状の解像度の正規化に使用されることを 特徴とする請求項1と9に記載の装置。
- 11.前記刺激の測定には、制御電極の信号が最適化され、実数部が0.01か ら10の間の値にあり、選択したレンズの焦点深度に依存しており、虚数部は、 使用周波数領域で可能な限りゼロに近くなっていることを特徴とする請求項1と 7に記載の装置。
- 12.制限された周波数、つまり、先行試験で決定された前記周波数が、インピ ーダンスを測定するための装置に供給されることを特徴とする請求項1に記載の 装置。
- 13.ガード、シグナルグラウンド及び駆動用ガードなどを有した付加電極にケ ーブルと任意の適当なシールドとを設けたことを特徴とする請求項1に記載の装 置。
- 14.同心あるいはトポロジー的に等価である配列をし、測定電極が、制御電極 から隔離され、この隔離距離が、目標とする最大のレンズ焦点深度に対応する測 定電極間の距離である電極から構成され、そして、測定電極の1つは中央電極で あり、この中央電極は制御電極で囲まれ、この制御電極は、第2測定電極により 囲まれ、制御電極の電位は、中央電極あるいは第2電極の電位に追従し、調整可 能な増幅機の電位を、複素数で乗除演算することで実施するもので、実数部と虚 数部は適用例毎に最適化され、前記プローブの必須部は、接触面を除き、シグナ ルグラウンドで導電物質から囲まれているか、あるいは中央電極の特定の因子を 利用し、中央電極の電位を追従し、すべての導電部は安定な絶縁物質により隔離 され、接触面のすべての電極と絶縁物質は、試験場所の表面に適応させ、最小の リキッドウェッジを得るために平面あるいは凹面あるいは凸面に配置されている 電気インピーダンスを測定するためのプローブ。
- 15.有機物質あるいは生体物質を深度選択性を有し非破壊的表面キャラクタリ ゼーションを実施する方法において、有機物質あるいは生体物質のインピーダン スは、請求項1と7で定義した装置の適用例により、前記物質の表面から測定さ れることを特徴とする方法。
- 16.刺激効果が原因のインピーダンス、あるいは有機物質あるいは生体物質、 例えば、皮膚や粘膜やその他の外皮のその他の変化が原因で発生したインピーダ ンスは、測定されることを特徴とする請求項15に記載の方法。
- 17.腎臓あるいは目に関し、刺激効果あるいはその他の変化が原因で発生した 前記インピーダンスは、測定されることを特徴とする請求項16に記載の方法。
- 18.粗いレンズの焦点深度調整を、電極をスイッチングし異なる機能を持たせ ることにより実施し、そして、微調整が、湿った表面で測定する可能性があるの と同様に、仮想制御電極を固有電位に駆動することにより実施されるようにした ことを特徴とする汎用プローブ。
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
SE9003336-6 | 1990-10-18 | ||
SE9003336A SE466987B (sv) | 1990-10-18 | 1990-10-18 | Anordning foer djupselektiv icke-invasiv, lokal maetning av elektrisk impedans i organiska och biologiska material samt prob foer maetning av elektrisk impedans |
PCT/SE1991/000703 WO1992006634A1 (en) | 1990-10-18 | 1991-10-18 | A device for measurement of electrical impedance of organic and biological materials |
Publications (2)
Publication Number | Publication Date |
---|---|
JPH06502323A true JPH06502323A (ja) | 1994-03-17 |
JP3320413B2 JP3320413B2 (ja) | 2002-09-03 |
Family
ID=20380684
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP51777291A Expired - Lifetime JP3320413B2 (ja) | 1990-10-18 | 1991-10-18 | 有機物質あるいは生体物質の電気インピーダンスの測定装置 |
Country Status (15)
Country | Link |
---|---|
US (1) | US5353802A (ja) |
EP (1) | EP0553187B1 (ja) |
JP (1) | JP3320413B2 (ja) |
KR (1) | KR100201178B1 (ja) |
AT (1) | ATE167794T1 (ja) |
AU (1) | AU659111B2 (ja) |
CA (1) | CA2093922C (ja) |
DE (1) | DE69129698T2 (ja) |
DK (1) | DK0553187T3 (ja) |
ES (1) | ES2120419T3 (ja) |
FI (1) | FI110304B (ja) |
HU (1) | HU216496B (ja) |
NO (1) | NO307863B1 (ja) |
SE (1) | SE466987B (ja) |
WO (1) | WO1992006634A1 (ja) |
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JP2007282789A (ja) * | 2006-04-14 | 2007-11-01 | Sony Corp | 電界制御装置及び検出装置 |
JP2013521034A (ja) * | 2010-03-02 | 2013-06-10 | コンセホ・スペリオール・デ・インベスティガシオネス・シエンティフィカス | 角膜の機能特性を明らかにするための非侵襲センサ、該センサを備える装置、および該装置の使用 |
JP2015038425A (ja) * | 2013-05-24 | 2015-02-26 | 直之 御法川 | 上皮細胞の異常度合を測定する装置 |
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- 1991-10-18 EP EP91918393A patent/EP0553187B1/en not_active Expired - Lifetime
- 1991-10-18 HU HU9301109A patent/HU216496B/hu not_active IP Right Cessation
- 1991-10-18 DK DK91918393T patent/DK0553187T3/da active
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- 1991-10-18 AT AT91918393T patent/ATE167794T1/de not_active IP Right Cessation
- 1991-10-18 DE DE69129698T patent/DE69129698T2/de not_active Expired - Lifetime
- 1991-10-18 AU AU88499/91A patent/AU659111B2/en not_active Expired
- 1991-10-18 US US08/039,361 patent/US5353802A/en not_active Expired - Lifetime
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- 1991-10-18 WO PCT/SE1991/000703 patent/WO1992006634A1/en active IP Right Grant
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1993
- 1993-04-16 NO NO931415A patent/NO307863B1/no not_active IP Right Cessation
- 1993-04-16 FI FI931730A patent/FI110304B/fi not_active IP Right Cessation
- 1993-04-17 KR KR1019930701152A patent/KR100201178B1/ko not_active IP Right Cessation
Cited By (6)
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JP2005525900A (ja) * | 2002-05-20 | 2005-09-02 | デイヴィス,リチャード・ジェイ | 前癌性および癌性組織を検出するためのシステム |
JP4704031B2 (ja) * | 2002-05-20 | 2011-06-15 | デイヴィス,リチャード・ジェイ | 前癌性および癌性組織を検出するためのシステム |
JP2007282789A (ja) * | 2006-04-14 | 2007-11-01 | Sony Corp | 電界制御装置及び検出装置 |
US8340755B2 (en) | 2006-04-14 | 2012-12-25 | Sony Corporation | Electric field control device and detection device |
JP2013521034A (ja) * | 2010-03-02 | 2013-06-10 | コンセホ・スペリオール・デ・インベスティガシオネス・シエンティフィカス | 角膜の機能特性を明らかにするための非侵襲センサ、該センサを備える装置、および該装置の使用 |
JP2015038425A (ja) * | 2013-05-24 | 2015-02-26 | 直之 御法川 | 上皮細胞の異常度合を測定する装置 |
Also Published As
Publication number | Publication date |
---|---|
DE69129698T2 (de) | 1999-03-11 |
CA2093922C (en) | 2001-07-31 |
HUT66173A (en) | 1994-09-28 |
CA2093922A1 (en) | 1992-04-19 |
AU659111B2 (en) | 1995-05-11 |
FI931730A0 (fi) | 1993-04-16 |
WO1992006634A1 (en) | 1992-04-30 |
US5353802A (en) | 1994-10-11 |
EP0553187A1 (en) | 1993-08-04 |
FI931730A (fi) | 1993-04-16 |
EP0553187B1 (en) | 1998-07-01 |
NO931415D0 (no) | 1993-04-16 |
HU9301109D0 (en) | 1993-08-30 |
JP3320413B2 (ja) | 2002-09-03 |
KR100201178B1 (ko) | 1999-06-15 |
ATE167794T1 (de) | 1998-07-15 |
HU216496B (hu) | 1999-07-28 |
SE9003336A (ja) | 1992-04-19 |
AU8849991A (en) | 1992-05-20 |
SE466987B (sv) | 1992-05-11 |
DK0553187T3 (da) | 1999-06-28 |
NO931415L (no) | 1993-05-13 |
SE9003336D0 (sv) | 1990-10-18 |
NO307863B1 (no) | 2000-06-13 |
DE69129698D1 (de) | 1998-08-06 |
FI110304B (fi) | 2002-12-31 |
ES2120419T3 (es) | 1998-11-01 |
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