JPH0597650A - Whitening cosmetic - Google Patents

Abstract

PURPOSE:To obtain a cosmetic having an excellent whitening activity for skins from the extract of an animal or plant which has been used as a folk medicine, a Chinese medicine or a cosmetic except the whitening cosmetic and whose safety has been guaranteed. CONSTITUTION:A whitening cosmetic having the above-mentioned activity contains one kind or more of extracts in an dry amount of 0.0001-10wt.%, preferably 0.0005-3wt.%, the extracts being obtained by extracting Quercusstenphylla leaves, KAIBO (the bulb of Fritillaria thunbergii) or AKO (a glue) with a mixture of water with a hydrophilic organic solvent such as ethanol, methanol, acetone, propylene glycol, glycerol or 1,3-butylene glycol. The Quercusstenphylla leaves of the raw material are a folk medicine peculiar to Japan and are applied to cholecystitis and nephrolithiasis, and the KAIBO is known to have pharmacological activities such as antitussive, expectorant and antipyretic activities. But both the ingredients are not known as cosmetics. Further, the AKO is used as a hemostatic agent or a clathrating agent, but is not known as a whitening agent. Since the ingredients have been used as folk medicines, galenicals or other cosmetics, the safety of the ingredients are guaranteed.

Description

Detailed Description of the Invention

[0001]

FIELD OF THE INVENTION The present invention relates to a whitening cosmetic composition. More specifically, it relates to a whitening cosmetic composition whose safety is proven.

[0002]

2. Description of the Related Art Vladivore oak is an evergreen tall tree belonging to the dicotyledonous net, the isolated valve sub-net, solanaceae, beech family, Quercus spp. Distributed in. The scientific name is Kerks Stenfila (Q
uercus stenphylla). Vladimir leaf is a folk medicine unique to Japan and is applied to cholelithiasis and nephrolithiasis. Already patented, JP-A-61-118395 and JP-A-2
The former is a method for producing tannin as an astringent or a skin tanning agent,
The latter is a patent for drugs and foods for treating and preventing obesity, and has never been applied to cosmetics.

The shell mother is the bulb of the lily lily. Morel lily is a perennial plant of the monocotyledonous net, liliaceae, and liliaceae, with its origin in China. The scientific name is called Fritillaria thunbergii. Shellfish are known to have antitussive, expectorant, and clear fever effects, but they have never been used in cosmetics.

Ag is a glue made by imitating the skin of donkeys and mules of the horse family, cattle of the cattle family, etc. with water. Glue is mainly collagen and is widely used as a raw material for cosmetics together with gelatin obtained by heat treatment. However, although Ag is used as a hemostatic agent and as an encapsulating agent,
It has never been used as a whitening cosmetic.

[0005]

SUMMARY OF THE INVENTION The object of the present invention is to obtain a cosmetic having a whitening effect from an extract of an animal or plant which is used as a folk medicine, a herbal medicine, or a cosmetic for other purposes and whose safety has been proved. To provide a fee.

[0006]

Means for Solving the Problems As a result of testing a large number of readily available flora and fauna, the present inventors have found that extracts of specific leaves of Vladimir oak, shell mother and Ag are very effective as whitening cosmetics. Therefore, the present invention has been reached. These raw materials are already marketed as crude drugs,
It is easily available.

[0007] That is, the present invention is a whitening cosmetic composition containing one or more selected from the group consisting of an extract of a mixture of a hydrophilic organic solvent of leaves, shellfish and Ag and a water with a hydrophilic organic solvent.

As the extraction solvent, a mixed solution of a hydrophilic organic solvent and water is used. As the hydrophilic organic solvent, ethanol, methanol, acetone, propylene glycol, glycerin, 1,3 butylene glycol or the like is used. Depending on the heating conditions etc., 20-80% by weight of water is used for methanol and 3% for ethanol.
0 to 85% by weight, and in the case of acetone, 50 to 90% by weight of water is suitable.

To make a whitening cosmetic, this substance is used as a raw material for other cosmetics, for example, liquid oil such as squalane and jojoba oil, solid oil such as beeswax and cetyl alcohol, various activators, glycerin and 1,3 butylene glycol. The cosmetics of various dosage forms can be prepared by adding the moisturizers, various drugs and the like. For example, a lotion, a cream, a milky lotion, a pack or the like may be used depending on the purpose. The amount of the extract compounded varies depending on the usage form and purpose, but is 0.0001 to 10% by weight, preferably 0.0005 to 3% by weight in terms of dry matter.

[0010]

The present invention will be described in more detail with reference to the following examples, but the present invention is not limited to these examples.

(Production Example 1) Leaf 2 of dried Vladimir oak
Add 200 ml of 50% ethanol to 0 g and stir 1
I left it all day and night. This was filtered and freeze-dried. The yield is 1.
It was 43 g.

(Production Example 2) Leaf 2 of dried Vladimir oak
Add 200 ml of 50% methanol to 0 g and stir 1
I left it all day and night. This was filtered and freeze-dried. The yield is 1.
It was 76 g.

(Production Example 3) 200 g of 50% aqueous methanol solution was added to 20 g of dried bulbul of Lilium edulis, and the mixture was left to stand for one day with stirring. This was filtered and freeze-dried. The yield was 2.56g.

(Production Example 4) 50% to 20 g of dried Ag
200 ml of an aqueous methanol solution was added, and the mixture was left for one day with stirring. The yield was 0.89 g.

(Example 1) Lotion part by weight 50% ethanol extract of leaves of V. occidentalis of Production Example 1.0 ethanol 80.0Purified water 19.0  100.0

Example 2 Cream A Weight part Squalane 20.0 Jojoba oil 5.0 Beeswax 5.0 Cetostearyl alcohol 2.0 Glycerin monostearate 1.0 Sorbitan monostearate 2.050% methanol extract of leaves of V. occidentalis of Production Example 2 1.0  36.0 B parts by weight Purified water 55.9 Polyoxyethylene (20 E.O.) sorbitan monostearate 2.0 Polyoxyethylene (60 E.O.) hydrogenated castor oil 1.0 Glycerin 5.0Methyl paraoxybenzoate 0.1  64.0 Weigh A and B respectively, heat to 70 ° C, and add A to B
Slowly add with stirring, then slowly with stirring 3
Cooled to 0 ° C.

Example 3 In place of the 50% ethanol extract of the leaves of Vladimella omentum of Example 1 of Example 1, Example 3 of manufacture was used.
Using a 50% methanol extract of the bulb of Lilium lily.

(Example 4) Production Example 3 was used in place of the 50% methanol extract of the leaves of Vladimella oak in Production Example 2 of Production Example 2.
Using a 50% methanol extract of the bulb of Lilium lily.

(Example 5) Production Example 4 was used in place of the 50% ethanol extract of the leaves of Vladimella omentum of Production Example 1 of Example 1.
Using a 50% methanol extract of Agari.

(Example 6) Example 4 was replaced with the 50% methanol extract of the leaves of Vladimella omentum of Example 2 of Example 2.
Using a 50% methanol extract of Agari.

(Example 7) Half the amount of the 50% ethanol extract of the leaves of the white-tailed oak of Example 1 was prepared in Example 3.
Replaced with 50% methanol extract of the bulb of Ligustrum lily.

(Example 8) Half the amount of 50% methanol extract of the leaves of Vladimella oak of Example 2 of Example 2 was produced.
Replaced with 50% methanol extract of Agari.

(Measurement of Tyrosinase Inhibition Rate) (Test Method) Mcllvaln Buffer 0.9 m
l, 1.66 mM Tyrosine solution 1.0 ml, the sample (dry matter) was dissolved in ethanol, water was added, and ethanol was removed by an evaporator, and then 0.1 weight (dry matter) / volume Liquid adjusted to 10% (sample liquid) 1.0 ml
Was placed in a screw vial and heated in a 37 ° C. constant temperature water bath for 5 minutes or more. Add 0.1 ml of tyrosinase solution (Sigma, mushroom-derived, 914 units / ml),
The temperature was kept in a 37 ° C. constant temperature water bath, and after 10 minutes, the absorbance was measured at 475 nm. As a control, pure water was added instead of the sample solution and the same measurement was performed. (Calculation formula) A: Absorbance of sample specimen B: Absorbance of control P: Absorbance due to coloring of sample specimen (3-fold dilution) Tyrosinase activity inhibition rate (%) = {B- (AP)} /
B x 100

(Comparative Production Example 1) A water extract (dried product) of leaves of Vladimir oak.

(Comparative Production Example 2) A methanol extract (dried product) of the leaves of V. occidentalis.

(Comparative Production Example 3) A water extract (dried product) of bulbs of Mytilus edulis.

(Comparative Production Example 4) A methanol extract (dry matter) of bulbs of Lilium edulis.

(Comparative Production Example 5) A methanol extract of Agria (dried product).

The test results are shown in Table 1.

[Table 1]

(Use test) Faces of 10 men were divided into right and left sides, one of which was used as an example and the other was used as a comparative example once or more daily, and a questionnaire was conducted after 2 months. In addition, in the comparative example, various extracts of the production examples from the examples are replaced with water. (Comparative Examples 1 and 2) 40 people were divided into 4 groups, and experiments were conducted using the following samples.

[Table 2] The criteria are as follows, and the results of the questionnaire are summarized in the table below. Example is very good 3 Example is considerably good 2 Example is slightly good 1 No difference 0 Comparative example is slightly good -1 Comparative example is quite good -2 Comparative example Is very good -3

The results are shown in Table 3.

[Table 3]

[0032]

EFFECTS OF THE INVENTION One or more kinds of extracts selected from the leaves, shellfish and Agari extracts of the present invention are clarified by tyrosinase activity inhibition rate test results and sensory test results. No, it has an excellent effect on skin whitening. On the other hand, these flora and fauna are not used as whitening cosmetics, but are used as folk medicines, internal medicines for Chinese herbs, and as cosmetics for other purposes, and their skin safety has been demonstrated.

[Procedure amendment]

[Submission date] December 10, 1991

[Procedure Amendment 1]

[Document name to be amended] Statement

[Name of item to be corrected] 0002

[Correction method] Change

[Correction content]

[0002]

2. Description of the Related Art Vladivore oak is an evergreen tall tree belonging to the dicotyledonous net, the isolated leaflet sub net, beeperaceae, beech family, Quercus spp. Distributed in. The scientific name is Kerks Stenfila (Q
uercus stenphylla). Vladimir leaf is a folk medicine unique to Japan and is applied to cholelithiasis and nephrolithiasis. Already No. Sho 61-118395 as Patent, JP-2-
As disclosed in No. 88525, the former is a method for producing tannin as an astringent or a skin tanning agent, and the latter is a patent for drugs and foods for treating / preventing obesity, which was applied to cosmetics. There is no such thing.

[Procedure Amendment 2]

[Document name to be amended] Statement

[Correction target item name] 0004

[Correction method] Change

[Correction content]

[0004] Aguri refers to glue produced by boiling the skin of donkeys and mules of the equine family and cattle of the bovine family with water. Glue is mainly collagen and is widely used as a raw material for cosmetics together with gelatin obtained by heat treatment. However, although Ag is used as a hemostatic agent and as an encapsulating agent,
It has never been used as a whitening cosmetic.

[Procedure 3]

[Document name to be amended] Statement

[Name of item to be corrected] 0029

[Correction method] Change

[Correction content]

The test results are shown in Table 1.

[Table 1]

 ─────────────────────────────────────────────────── ─── Continuation of the front page (72) Inventor Masao Hattori 2556-4-22-203 Gofuku Suehiro-cho, Toyama City, Toyama Prefecture (72) Inventor Kenji Shimomura 3-16-32 Funae, Ise City, Mie Prefecture (72) Inventor Nakamura Masami 6-32 Ikegami Town, Toba City, Mie Prefecture

Claims (1)

[Claims] 1. A whitening cosmetic composition containing one or more selected from the group consisting of an extract of a mixed solution of a hydrophilic organic solvent such as leaves, shellfish and Ag and the water of Vladimir oak.