JPH0595786A - 変異ヒトプロウロキナーゼ - Google Patents

変異ヒトプロウロキナーゼ

Info

Publication number
JPH0595786A
JPH0595786A JP3289257A JP28925791A JPH0595786A JP H0595786 A JPH0595786 A JP H0595786A JP 3289257 A JP3289257 A JP 3289257A JP 28925791 A JP28925791 A JP 28925791A JP H0595786 A JPH0595786 A JP H0595786A
Authority
JP
Japan
Prior art keywords
amino acid
dna
puk
plasmid
urokinase
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP3289257A
Other languages
English (en)
Japanese (ja)
Inventor
Toshizumi Tanabe
利住 田辺
Masanori Morita
将典 森田
Masaaki Hirose
正明 広瀬
Yasuo Amatsuji
康夫 天辻
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Mitsubishi Tanabe Pharma Corp
GC Biopharma Corp
Original Assignee
Green Cross Corp Japan
Green Cross Corp Korea
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Green Cross Corp Japan, Green Cross Corp Korea filed Critical Green Cross Corp Japan
Priority to JP3289257A priority Critical patent/JPH0595786A/ja
Priority to TW081107912A priority patent/TW215928B/zh
Priority to EP92117000A priority patent/EP0541952A1/en
Priority to US07/957,039 priority patent/US5389538A/en
Priority to KR1019920018372A priority patent/KR930008148A/ko
Publication of JPH0595786A publication Critical patent/JPH0595786A/ja
Pending legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/52—Genes encoding for enzymes or proenzymes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
    • C12N9/6424—Serine endopeptidases (3.4.21)
    • C12N9/6456—Plasminogen activators
    • C12N9/6462—Plasminogen activators u-Plasminogen activator (3.4.21.73), i.e. urokinase
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
    • C12Y304/21—Serine endopeptidases (3.4.21)
    • C12Y304/21073—Serine endopeptidases (3.4.21) u-Plasminogen activator (3.4.21.73), i.e. urokinase
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Biomedical Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Medicinal Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Biophysics (AREA)
  • Plant Pathology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
JP3289257A 1991-10-07 1991-10-07 変異ヒトプロウロキナーゼ Pending JPH0595786A (ja)

Priority Applications (5)

Application Number Priority Date Filing Date Title
JP3289257A JPH0595786A (ja) 1991-10-07 1991-10-07 変異ヒトプロウロキナーゼ
TW081107912A TW215928B (OSRAM) 1991-10-07 1992-10-06
EP92117000A EP0541952A1 (en) 1991-10-07 1992-10-06 Mutant human prourokinase
US07/957,039 US5389538A (en) 1991-10-07 1992-10-06 Mutant human prourokinase
KR1019920018372A KR930008148A (ko) 1991-10-07 1992-10-07 변이 인간 프로우로키나아제

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP3289257A JPH0595786A (ja) 1991-10-07 1991-10-07 変異ヒトプロウロキナーゼ

Publications (1)

Publication Number Publication Date
JPH0595786A true JPH0595786A (ja) 1993-04-20

Family

ID=17740820

Family Applications (1)

Application Number Title Priority Date Filing Date
JP3289257A Pending JPH0595786A (ja) 1991-10-07 1991-10-07 変異ヒトプロウロキナーゼ

Country Status (5)

Country Link
US (1) US5389538A (OSRAM)
EP (1) EP0541952A1 (OSRAM)
JP (1) JPH0595786A (OSRAM)
KR (1) KR930008148A (OSRAM)
TW (1) TW215928B (OSRAM)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6248715B1 (en) * 1993-06-01 2001-06-19 Chiron Corporation Method of treating a urokinase-type plasminogen activator-mediated disorder
JPH08508172A (ja) 1993-06-01 1996-09-03 カイロン コーポレイション ウロキナーゼプラスミノーゲン活性化因子インヒビターの発現
ES2066733B1 (es) * 1993-06-30 1995-11-01 Antibioticos Farma S A Complejo consistente en un activador del plasminogeno y albumina de suero y procedimiento para prepararlo.
ZA976326B (en) 1996-07-19 1998-02-03 Amgen Inc Analogs of cationic proteins.
US6271364B1 (en) 1999-02-23 2001-08-07 Amgen Inc. Analogs of NT-3
US7346518B1 (en) 1999-12-30 2008-03-18 At&T Bls Intellectual Property, Inc. System and method for determining the marketability of intellectual property assets
US7801830B1 (en) 1999-12-30 2010-09-21 At&T Intellectual Property I, L.P. System and method for marketing, managing, and maintaining intellectual property

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5098840A (en) * 1986-07-03 1992-03-24 The Green Cross Corporation Human prourokinase mutants
JPH0761266B2 (ja) * 1986-07-03 1995-07-05 株式会社ミドリ十字 変異ヒトプロウロキナ−ゼ
EP0266032A1 (en) * 1986-08-29 1988-05-04 Beecham Group Plc Modified fibrinolytic enzyme
JPS63105675A (ja) * 1986-10-23 1988-05-10 Green Cross Corp:The ヒトウロキナ−ゼの製造方法
ATE118815T1 (de) * 1987-06-04 1995-03-15 Zymogenetics Inc Gewebs-plasminogen-aktivator-analoge mit modifizierten wachstumsfaktordomänen.
WO1988010119A1 (en) * 1987-06-22 1988-12-29 Genetics Institute, Inc. Novel thrombolytic proteins
GB8721023D0 (en) * 1987-09-07 1987-10-14 Lepetit Spa Modified plasminogen activators
GB8815135D0 (en) * 1988-06-24 1988-08-03 British Bio Technology Proteins & nucleic acids
AU5515790A (en) * 1989-05-18 1990-11-22 Green Cross Corporation, The Human prourokinase variants, methods of producing same, dna sequences, plasmids and hosts therefor

Also Published As

Publication number Publication date
KR930008148A (ko) 1993-05-21
TW215928B (OSRAM) 1993-11-11
EP0541952A1 (en) 1993-05-19
US5389538A (en) 1995-02-14

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