JPH0578320B2 - - Google Patents

Info

Publication number
JPH0578320B2
JPH0578320B2 JP60187555A JP18755585A JPH0578320B2 JP H0578320 B2 JPH0578320 B2 JP H0578320B2 JP 60187555 A JP60187555 A JP 60187555A JP 18755585 A JP18755585 A JP 18755585A JP H0578320 B2 JPH0578320 B2 JP H0578320B2
Authority
JP
Japan
Prior art keywords
nucleic acid
acid sequence
partner
general formula
group
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
JP60187555A
Other languages
English (en)
Japanese (ja)
Other versions
JPS6160697A (ja
Inventor
Guraafu Heruman
Rentsu Herumuuto
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Roche Diagnostics GmbH
Original Assignee
Boehringer Mannheim GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Boehringer Mannheim GmbH filed Critical Boehringer Mannheim GmbH
Publication of JPS6160697A publication Critical patent/JPS6160697A/ja
Publication of JPH0578320B2 publication Critical patent/JPH0578320B2/ja
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J43/00—Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton
    • C07J43/003—Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton not condensed
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6813—Hybridisation assays
    • C12Q1/6816—Hybridisation assays characterised by the detection means

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Biophysics (AREA)
  • Immunology (AREA)
  • Microbiology (AREA)
  • Analytical Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Saccharide Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
JP60187555A 1984-08-28 1985-08-28 新規な誘導体化核酸配列、その製法および核酸ないし核酸配列の検出法 Granted JPS6160697A (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE3431536.5 1984-08-28
DE19843431536 DE3431536A1 (de) 1984-08-28 1984-08-28 Derivatisierte nucleinsaeure-sequenz, verfahren zu deren herstellung sowie deren verwendung zum nachweis von nucleinsaeuren

Publications (2)

Publication Number Publication Date
JPS6160697A JPS6160697A (ja) 1986-03-28
JPH0578320B2 true JPH0578320B2 (cg-RX-API-DMAC7.html) 1993-10-28

Family

ID=6244044

Family Applications (1)

Application Number Title Priority Date Filing Date
JP60187555A Granted JPS6160697A (ja) 1984-08-28 1985-08-28 新規な誘導体化核酸配列、その製法および核酸ないし核酸配列の検出法

Country Status (6)

Country Link
EP (1) EP0173251B1 (cg-RX-API-DMAC7.html)
JP (1) JPS6160697A (cg-RX-API-DMAC7.html)
AT (1) ATE48141T1 (cg-RX-API-DMAC7.html)
AU (1) AU582380B2 (cg-RX-API-DMAC7.html)
CA (1) CA1242657A (cg-RX-API-DMAC7.html)
DE (2) DE3431536A1 (cg-RX-API-DMAC7.html)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH02503983A (ja) * 1987-06-26 1990-11-22 イー・アイ・デュポン・ドゥ・ヌムール・アンド・カンパニー 捕捉ビーズを用いる組み換えクローン化ｎａからの混入配列のアフイニテイ除去
EP0972779A3 (en) * 1987-10-28 2004-10-20 Howard Florey Institute Of Experimental Physiology And Medicine Oligonucleotide-polyamide conjugates
US5525465A (en) * 1987-10-28 1996-06-11 Howard Florey Institute Of Experimental Physiology And Medicine Oligonucleotide-polyamide conjugates and methods of production and applications of the same
DE3813278A1 (de) * 1988-01-12 1989-07-20 Boehringer Mannheim Gmbh Verfahren zum nachweis von nukleinsaeuren
US5354657A (en) * 1988-01-12 1994-10-11 Boehringer Mannheim Gmbh Process for the highly specific detection of nucleic acids in solid
DE3800644A1 (de) * 1988-01-12 1989-07-20 Boehringer Mannheim Gmbh Verfahren zum hochspezifischen nachweis von nukleinsaeuren in loesung
FR2627590A1 (fr) * 1988-02-24 1989-08-25 Ire Celltarg Sa Sonde d'acides nucleiques comportant un nucleotide terminal modifie chimiquement en 5(prime) (oh) en vue de son marquage non radioactif et procedes de preparation
FR2634211B1 (fr) * 1988-07-13 1992-06-26 Lebacq Philippe Procede de marquage d'une sonde nucleique et trousse de reactifs pour la mise en oeuvre de ce procede
FR2644163B2 (fr) * 1988-07-13 1994-09-30 Bioprobe Systems Sa Procede de marquage d'une sonde nucleique et trousse de reactifs pour la mise en oeuvre de ce procede
DE3836656A1 (de) * 1988-10-27 1990-05-03 Boehringer Mannheim Gmbh Neue digoxigenin-derivate und ihre verwendung
US5356773A (en) * 1989-05-16 1994-10-18 Kinetic Investments Limited Generation of unidirectional deletion mutants
DE3916595A1 (de) * 1989-05-22 1990-11-29 Boehringer Mannheim Gmbh Verfahren zur nichtradioaktiven messung der nucleinsaeuresynthese in eukaryontischen zellen
DE3916871A1 (de) * 1989-05-24 1990-11-29 Boehringer Mannheim Gmbh Modifiziertes phosphoramidit-verfahren zur herstellung von modifizierten nukleinsaeuren
EP0422861B1 (en) * 1989-10-13 2000-05-17 Zeneca Limited Probes
US5677440A (en) * 1990-07-16 1997-10-14 Howard Florey Institute Of Experimental Physiology And Medicine Oligonucleotide-polyamide conjugates
EP0752474A1 (en) 1995-07-07 1997-01-08 Boehringer Mannheim Gmbh Nucleic acid coding for CMP-N-acetyl-neuraminic acid hydroxylase and its use for the production of modified glycoproteins
JPH11509100A (ja) * 1995-07-13 1999-08-17 イムノロジカル アソシエーツ オブ デンバー 核酸抽出、増幅および検出を統合する自己充足装置
EP1006184A1 (en) 1998-12-03 2000-06-07 F. Hoffmann-La Roche Ag IGF-1 receptor interacting proteins (IIPs) genes coding therefor and uses thereof
US20020146728A1 (en) 1998-12-03 2002-10-10 Tanja Ligensa IGF-1 receptor interacting proteins
EP1099757B1 (en) 1999-11-11 2010-02-24 F. Hoffmann-La Roche Ag Process for the determination of CTp11 and for determining whether a tumor sample has metatastic potential
US7108977B2 (en) 2000-05-19 2006-09-19 Hoffmann-La Roche Inc. Process for determining the tumoricidal potential of a sample the use of a nucleic acid which is downregulated in human tumor cells
WO2006054507A1 (ja) 2004-11-19 2006-05-26 Matsushita Electric Industrial Co., Ltd. 動画像符号化方法及び動画像復号方法
WO2006098464A1 (ja) 2005-03-14 2006-09-21 Link Genomics, Inc. 前立腺がんの診断方法

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2422956A1 (fr) * 1978-04-13 1979-11-09 Pasteur Institut Procede de detection et de caracterisation d'un acide nucleique ou d'une sequence de celui-ci, et reactif enzymatique pour la mise en oeuvre de ce procede
CA1219824A (en) * 1981-04-17 1987-03-31 David C. Ward Modified nucleotides and methods of preparing and using same
FR2519005B1 (fr) * 1981-12-29 1985-10-25 Pasteur Institut Fragments d'adn marques a l'une au moins de leurs extremites par des ribonucleotides modifies reconnaissables par des molecules affines et procede pour realiser une analyse de tels fragments d'adn
US4490472A (en) * 1982-06-17 1984-12-25 Imreg, Inc. Sensitive tests for malignancies based on DNA detection
CA1223831A (en) * 1982-06-23 1987-07-07 Dean Engelhardt Modified nucleotides, methods of preparing and utilizing and compositions containing the same
CA1309672C (en) * 1983-01-27 1992-11-03 Jannis G. Stavrianopoulos Methods and structures employing non-radioactive chemically-labeled polynucleotide probes
EP0135587B2 (en) * 1983-02-22 2002-12-18 Syngene, Inc. Defined sequence single strand oligonucleotides incorporating reporter groups, process for the chemical synthesis thereof, and nucleosides useful in such synthesis
US4737454A (en) * 1983-07-14 1988-04-12 Molecular Diagnostics, Inc. Fast photochemical method of labelling nucleic acids for detection purposes in hybridization assays
US4626501A (en) * 1983-09-02 1986-12-02 Integrated Genetics, Inc. Labeled DNA
FR2558172B1 (fr) * 1984-01-16 1986-06-13 Inst Nat Sante Rech Med Sonde contenant un acide nucleique modifie et reconnaissance par des anticorps specifiques et utilisation de cette sonde et de ces anticorps specifiques pour detecter et caracteriser une sequence d'adn homologue

Also Published As

Publication number Publication date
ATE48141T1 (de) 1989-12-15
EP0173251A3 (en) 1986-10-29
CA1242657A (en) 1988-10-04
AU582380B2 (en) 1989-03-23
EP0173251B1 (de) 1989-11-23
DE3574383D1 (en) 1989-12-28
DE3431536A1 (de) 1986-03-13
AU4648485A (en) 1986-03-06
JPS6160697A (ja) 1986-03-28
EP0173251A2 (de) 1986-03-05

Similar Documents

Publication Publication Date Title
JPH0578320B2 (cg-RX-API-DMAC7.html)
AU599013B2 (en) Solution-phase dual hybridization assay for detecting polynucleotide sequences
EP0138357B1 (en) Labeled DNA
US5985548A (en) Amplification of assay reporters by nucleic acid replication
US5200313A (en) Nucleic acid hybridization assay employing detectable anti-hybrid antibodies
EP0625211B1 (en) Amplification of assay reporters by nucleic acid replication
US4563417A (en) Nucleic acid hybridization assay employing antibodies to intercalation complexes
CA1336394C (en) Detection and amplification of target nucleic acid sequences
EP0163220B1 (en) Nucleic acid hybridization assay employing detectable anti-hybrid antibodies
US4824775A (en) Cells labeled with multiple Fluorophores bound to a nucleic acid carrier
RU2107730C1 (ru) Молекулярный зонд
JP3093116B2 (ja) 核酸検出方法
US4810638A (en) Enzyme-labeled antibody reagent with polyalkyleneglycol linking group
EP0146815B1 (en) Nucleic acid hybridization assay employing antibodies to intercalation complexes
JP2686729B2 (ja) 核酸プローブ及び蛋白質プローブ
JPH0627740B2 (ja) 抗原の測定方法
JP3400507B2 (ja) 特異的結合パートナーと炭水化物含有蛋白質から構成される複合体の製造方法
JPS63282659A (ja) 核酸の測定方法および測定剤
JP2651317B2 (ja) 核酸の検出法
JPH07508884A (ja) 指示薬として使用するための改善された特異活性を有するアルカリホスファターゼ酵素
HK1003719B (en) Amplification of assay reporters by nucleic acid replication

Legal Events

Date Code Title Description
R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

EXPY Cancellation because of completion of term