ATE48141T1 - Derivatisierte nucleinsaeure-sequenz, verfahren zu deren herstellung sowie deren verwendung zum nachweis von nucleinsaeuren. - Google Patents
Derivatisierte nucleinsaeure-sequenz, verfahren zu deren herstellung sowie deren verwendung zum nachweis von nucleinsaeuren.Info
- Publication number
- ATE48141T1 ATE48141T1 AT85110543T AT85110543T ATE48141T1 AT E48141 T1 ATE48141 T1 AT E48141T1 AT 85110543 T AT85110543 T AT 85110543T AT 85110543 T AT85110543 T AT 85110543T AT E48141 T1 ATE48141 T1 AT E48141T1
- Authority
- AT
- Austria
- Prior art keywords
- nucleic acid
- acid sequence
- preparation
- detection
- cytosine
- Prior art date
Links
- 150000007523 nucleic acids Chemical group 0.000 title abstract 4
- 108091028043 Nucleic acid sequence Proteins 0.000 title abstract 2
- 108020004707 nucleic acids Proteins 0.000 title abstract 2
- 102000039446 nucleic acids Human genes 0.000 title abstract 2
- 238000001514 detection method Methods 0.000 title 1
- 238000000034 method Methods 0.000 title 1
- RYVNIFSIEDRLSJ-UHFFFAOYSA-N 5-(hydroxymethyl)cytosine Chemical compound NC=1NC(=O)N=CC=1CO RYVNIFSIEDRLSJ-UHFFFAOYSA-N 0.000 abstract 2
- LRFVTYWOQMYALW-UHFFFAOYSA-N 9H-xanthine Chemical compound O=C1NC(=O)NC2=C1NC=N2 LRFVTYWOQMYALW-UHFFFAOYSA-N 0.000 abstract 2
- ISAKRJDGNUQOIC-UHFFFAOYSA-N Uracil Chemical compound O=C1C=CNC(=O)N1 ISAKRJDGNUQOIC-UHFFFAOYSA-N 0.000 abstract 2
- OPTASPLRGRRNAP-UHFFFAOYSA-N cytosine Chemical compound NC=1C=CNC(=O)N=1 OPTASPLRGRRNAP-UHFFFAOYSA-N 0.000 abstract 2
- UYTPUPDQBNUYGX-UHFFFAOYSA-N guanine Chemical compound O=C1NC(N)=NC2=C1N=CN2 UYTPUPDQBNUYGX-UHFFFAOYSA-N 0.000 abstract 2
- FDGQSTZJBFJUBT-UHFFFAOYSA-N hypoxanthine Chemical compound O=C1NC=NC2=C1NC=N2 FDGQSTZJBFJUBT-UHFFFAOYSA-N 0.000 abstract 2
- PXQPEWDEAKTCGB-UHFFFAOYSA-N orotic acid Chemical compound OC(=O)C1=CC(=O)NC(=O)N1 PXQPEWDEAKTCGB-UHFFFAOYSA-N 0.000 abstract 2
- RWQNBRDOKXIBIV-UHFFFAOYSA-N thymine Chemical compound CC1=CNC(=O)NC1=O RWQNBRDOKXIBIV-UHFFFAOYSA-N 0.000 abstract 2
- JDBGXEHEIRGOBU-UHFFFAOYSA-N 5-hydroxymethyluracil Chemical compound OCC1=CNC(=O)NC1=O JDBGXEHEIRGOBU-UHFFFAOYSA-N 0.000 abstract 1
- GFFGJBXGBJISGV-UHFFFAOYSA-N Adenine Chemical compound NC1=NC=NC2=C1N=CN2 GFFGJBXGBJISGV-UHFFFAOYSA-N 0.000 abstract 1
- 229930024421 Adenine Natural products 0.000 abstract 1
- UGQMRVRMYYASKQ-UHFFFAOYSA-N Hypoxanthine nucleoside Natural products OC1C(O)C(CO)OC1N1C(NC=NC2=O)=C2N=C1 UGQMRVRMYYASKQ-UHFFFAOYSA-N 0.000 abstract 1
- 229960000643 adenine Drugs 0.000 abstract 1
- -1 alkylene radical Chemical class 0.000 abstract 1
- 239000000427 antigen Substances 0.000 abstract 1
- 102000036639 antigens Human genes 0.000 abstract 1
- 108091007433 antigens Proteins 0.000 abstract 1
- 230000001588 bifunctional effect Effects 0.000 abstract 1
- 229940104302 cytosine Drugs 0.000 abstract 1
- 125000005842 heteroatom Chemical group 0.000 abstract 1
- 229910052757 nitrogen Inorganic materials 0.000 abstract 1
- 125000004433 nitrogen atom Chemical group N* 0.000 abstract 1
- 229960005010 orotic acid Drugs 0.000 abstract 1
- 229940113082 thymine Drugs 0.000 abstract 1
- 229940035893 uracil Drugs 0.000 abstract 1
- 229940075420 xanthine Drugs 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J43/00—Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton
- C07J43/003—Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton not condensed
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6813—Hybridisation assays
- C12Q1/6816—Hybridisation assays characterised by the detection means
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biotechnology (AREA)
- Genetics & Genomics (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Biophysics (AREA)
- Immunology (AREA)
- Microbiology (AREA)
- Analytical Chemistry (AREA)
- Physics & Mathematics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Saccharide Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19843431536 DE3431536A1 (de) | 1984-08-28 | 1984-08-28 | Derivatisierte nucleinsaeure-sequenz, verfahren zu deren herstellung sowie deren verwendung zum nachweis von nucleinsaeuren |
| EP85110543A EP0173251B1 (de) | 1984-08-28 | 1985-08-22 | Derivatisierte Nucleinsäure-Sequenz, Verfahren zu deren Herstellung sowie deren Verwendung zum Nachweis von Nucleinsäuren |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE48141T1 true ATE48141T1 (de) | 1989-12-15 |
Family
ID=6244044
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT85110543T ATE48141T1 (de) | 1984-08-28 | 1985-08-22 | Derivatisierte nucleinsaeure-sequenz, verfahren zu deren herstellung sowie deren verwendung zum nachweis von nucleinsaeuren. |
Country Status (6)
| Country | Link |
|---|---|
| EP (1) | EP0173251B1 (cg-RX-API-DMAC7.html) |
| JP (1) | JPS6160697A (cg-RX-API-DMAC7.html) |
| AT (1) | ATE48141T1 (cg-RX-API-DMAC7.html) |
| AU (1) | AU582380B2 (cg-RX-API-DMAC7.html) |
| CA (1) | CA1242657A (cg-RX-API-DMAC7.html) |
| DE (2) | DE3431536A1 (cg-RX-API-DMAC7.html) |
Families Citing this family (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH02503983A (ja) * | 1987-06-26 | 1990-11-22 | イー・アイ・デュポン・ドゥ・ヌムール・アンド・カンパニー | 捕捉ビーズを用いる組み換えクローン化ｎａからの混入配列のアフイニテイ除去 |
| EP0972779A3 (en) * | 1987-10-28 | 2004-10-20 | Howard Florey Institute Of Experimental Physiology And Medicine | Oligonucleotide-polyamide conjugates |
| US5525465A (en) * | 1987-10-28 | 1996-06-11 | Howard Florey Institute Of Experimental Physiology And Medicine | Oligonucleotide-polyamide conjugates and methods of production and applications of the same |
| DE3813278A1 (de) * | 1988-01-12 | 1989-07-20 | Boehringer Mannheim Gmbh | Verfahren zum nachweis von nukleinsaeuren |
| US5354657A (en) * | 1988-01-12 | 1994-10-11 | Boehringer Mannheim Gmbh | Process for the highly specific detection of nucleic acids in solid |
| DE3800644A1 (de) * | 1988-01-12 | 1989-07-20 | Boehringer Mannheim Gmbh | Verfahren zum hochspezifischen nachweis von nukleinsaeuren in loesung |
| FR2627590A1 (fr) * | 1988-02-24 | 1989-08-25 | Ire Celltarg Sa | Sonde d'acides nucleiques comportant un nucleotide terminal modifie chimiquement en 5(prime) (oh) en vue de son marquage non radioactif et procedes de preparation |
| FR2634211B1 (fr) * | 1988-07-13 | 1992-06-26 | Lebacq Philippe | Procede de marquage d'une sonde nucleique et trousse de reactifs pour la mise en oeuvre de ce procede |
| FR2644163B2 (fr) * | 1988-07-13 | 1994-09-30 | Bioprobe Systems Sa | Procede de marquage d'une sonde nucleique et trousse de reactifs pour la mise en oeuvre de ce procede |
| DE3836656A1 (de) * | 1988-10-27 | 1990-05-03 | Boehringer Mannheim Gmbh | Neue digoxigenin-derivate und ihre verwendung |
| US5356773A (en) * | 1989-05-16 | 1994-10-18 | Kinetic Investments Limited | Generation of unidirectional deletion mutants |
| DE3916595A1 (de) * | 1989-05-22 | 1990-11-29 | Boehringer Mannheim Gmbh | Verfahren zur nichtradioaktiven messung der nucleinsaeuresynthese in eukaryontischen zellen |
| DE3916871A1 (de) * | 1989-05-24 | 1990-11-29 | Boehringer Mannheim Gmbh | Modifiziertes phosphoramidit-verfahren zur herstellung von modifizierten nukleinsaeuren |
| EP0422861B1 (en) * | 1989-10-13 | 2000-05-17 | Zeneca Limited | Probes |
| US5677440A (en) * | 1990-07-16 | 1997-10-14 | Howard Florey Institute Of Experimental Physiology And Medicine | Oligonucleotide-polyamide conjugates |
| EP0752474A1 (en) | 1995-07-07 | 1997-01-08 | Boehringer Mannheim Gmbh | Nucleic acid coding for CMP-N-acetyl-neuraminic acid hydroxylase and its use for the production of modified glycoproteins |
| JPH11509100A (ja) * | 1995-07-13 | 1999-08-17 | イムノロジカル アソシエーツ オブ デンバー | 核酸抽出、増幅および検出を統合する自己充足装置 |
| EP1006184A1 (en) | 1998-12-03 | 2000-06-07 | F. Hoffmann-La Roche Ag | IGF-1 receptor interacting proteins (IIPs) genes coding therefor and uses thereof |
| US20020146728A1 (en) | 1998-12-03 | 2002-10-10 | Tanja Ligensa | IGF-1 receptor interacting proteins |
| EP1099757B1 (en) | 1999-11-11 | 2010-02-24 | F. Hoffmann-La Roche Ag | Process for the determination of CTp11 and for determining whether a tumor sample has metatastic potential |
| US7108977B2 (en) | 2000-05-19 | 2006-09-19 | Hoffmann-La Roche Inc. | Process for determining the tumoricidal potential of a sample the use of a nucleic acid which is downregulated in human tumor cells |
| WO2006054507A1 (ja) | 2004-11-19 | 2006-05-26 | Matsushita Electric Industrial Co., Ltd. | 動画像符号化方法及び動画像復号方法 |
| WO2006098464A1 (ja) | 2005-03-14 | 2006-09-21 | Link Genomics, Inc. | 前立腺がんの診断方法 |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2422956A1 (fr) * | 1978-04-13 | 1979-11-09 | Pasteur Institut | Procede de detection et de caracterisation d'un acide nucleique ou d'une sequence de celui-ci, et reactif enzymatique pour la mise en oeuvre de ce procede |
| CA1219824A (en) * | 1981-04-17 | 1987-03-31 | David C. Ward | Modified nucleotides and methods of preparing and using same |
| FR2519005B1 (fr) * | 1981-12-29 | 1985-10-25 | Pasteur Institut | Fragments d'adn marques a l'une au moins de leurs extremites par des ribonucleotides modifies reconnaissables par des molecules affines et procede pour realiser une analyse de tels fragments d'adn |
| US4490472A (en) * | 1982-06-17 | 1984-12-25 | Imreg, Inc. | Sensitive tests for malignancies based on DNA detection |
| CA1223831A (en) * | 1982-06-23 | 1987-07-07 | Dean Engelhardt | Modified nucleotides, methods of preparing and utilizing and compositions containing the same |
| CA1309672C (en) * | 1983-01-27 | 1992-11-03 | Jannis G. Stavrianopoulos | Methods and structures employing non-radioactive chemically-labeled polynucleotide probes |
| EP0135587B2 (en) * | 1983-02-22 | 2002-12-18 | Syngene, Inc. | Defined sequence single strand oligonucleotides incorporating reporter groups, process for the chemical synthesis thereof, and nucleosides useful in such synthesis |
| US4737454A (en) * | 1983-07-14 | 1988-04-12 | Molecular Diagnostics, Inc. | Fast photochemical method of labelling nucleic acids for detection purposes in hybridization assays |
| US4626501A (en) * | 1983-09-02 | 1986-12-02 | Integrated Genetics, Inc. | Labeled DNA |
| FR2558172B1 (fr) * | 1984-01-16 | 1986-06-13 | Inst Nat Sante Rech Med | Sonde contenant un acide nucleique modifie et reconnaissance par des anticorps specifiques et utilisation de cette sonde et de ces anticorps specifiques pour detecter et caracteriser une sequence d'adn homologue |
-
1984
- 1984-08-28 DE DE19843431536 patent/DE3431536A1/de not_active Withdrawn
-
1985
- 1985-08-21 AU AU46484/85A patent/AU582380B2/en not_active Expired
- 1985-08-22 EP EP85110543A patent/EP0173251B1/de not_active Expired
- 1985-08-22 AT AT85110543T patent/ATE48141T1/de not_active IP Right Cessation
- 1985-08-22 DE DE8585110543T patent/DE3574383D1/de not_active Expired
- 1985-08-22 CA CA000489275A patent/CA1242657A/en not_active Expired
- 1985-08-28 JP JP60187555A patent/JPS6160697A/ja active Granted
Also Published As
| Publication number | Publication date |
|---|---|
| EP0173251A3 (en) | 1986-10-29 |
| CA1242657A (en) | 1988-10-04 |
| JPH0578320B2 (cg-RX-API-DMAC7.html) | 1993-10-28 |
| AU582380B2 (en) | 1989-03-23 |
| EP0173251B1 (de) | 1989-11-23 |
| DE3574383D1 (en) | 1989-12-28 |
| DE3431536A1 (de) | 1986-03-13 |
| AU4648485A (en) | 1986-03-06 |
| JPS6160697A (ja) | 1986-03-28 |
| EP0173251A2 (de) | 1986-03-05 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| EELA | Cancelled due to lapse of time |