JPH05501208A - 生体部分、特に生物の臓器を作製するための作用物質複合体;この作用物質複合体の製法およびその応用 - Google Patents
生体部分、特に生物の臓器を作製するための作用物質複合体;この作用物質複合体の製法およびその応用Info
- Publication number
- JPH05501208A JPH05501208A JP2513873A JP51387390A JPH05501208A JP H05501208 A JPH05501208 A JP H05501208A JP 2513873 A JP2513873 A JP 2513873A JP 51387390 A JP51387390 A JP 51387390A JP H05501208 A JPH05501208 A JP H05501208A
- Authority
- JP
- Japan
- Prior art keywords
- growth
- component
- agent
- active substance
- biological
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
- A61L27/54—Biologically active materials, e.g. therapeutic substances
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/20—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing organic materials
- A61L2300/252—Polypeptides, proteins, e.g. glycoproteins, lipoproteins, cytokines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
- A61L2300/412—Tissue-regenerating or healing or proliferative agents
- A61L2300/414—Growth factors
Landscapes
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Epidemiology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Dermatology (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Transplantation (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Molecular Biology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Materials For Medical Uses (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Compounds Of Unknown Constitution (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Breeding Of Plants And Reproduction By Means Of Culturing (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Abstract
Description
Claims (11)
- 1.構造成分と、 少なくとも1つの動員成分と、 少なくとも1つの接着成分と、 好ましくは少なくとも1つのサイトカインの形で少なくとも1つの成長および/ または成熟成分と、を含んでいることを特徴とする、生体部分、特に生物の臓器 を製造する作用物質複合体。
- 2.構造成分が、好ましくはプロテオグリカンおよびコラーゲンからなる高分子 ゲルおよび/またはネットワークであることを特徴とする請求項1記載の作用物 質複合体。
- 3.構造成分が金属性および/またはセラミックス性および/またはガラス性お よび/またはポリマー性および/または脂肪含有基体材料を、固体および/また は多孔体および/または膜体および/またはミセルおよび/または塑性体および /または粘性体および/または液体として有していることを特徴とする請求項1 または2記載の作用物質複合体。
- 4.各々の動員成分が化学走性ペプチド、タンパク質および/またはアラキドン 酸代謝物質のグループに属し、または他の同等の化学的構造を有していることを 特徴とする請求項1から3のいずれか1項に記載の作用物質複合体。
- 5.各々の接着成分かフィブロネクチン、テナスキン、サイトタクチン、ラミニ ン、コンドロネクチン、コラーゲンIV、V、VII型、N−CAM、L−CA Mまたはインテグリンなどのタンパク質、これらのタンパク質の組み合わせまた は他の同等の接着物質であることを特徴とする請求項1から4のいずれか1項に 記載の作用物質複合体。
- 6.各々の成長成分および/または成熟成分がコロニー刺激因子(CSF)、イ ンターロイキン(IL)、インシュリン類似成長因子(IGF)、プロスタグラ ンジン(PG)、ロイコトリエン(LT)、形質転換成長因子(TGF)、繊維 芽細胞成長因子(FGF)、インターフェロン(IFN)、上皮成長因子(EG F)、骨由来成長因子(BDGF)、内皮細胞由来成長因子(EDGF)、血小 板由来成長因子(PDGF)のグループに属するか、これらの因子の組み合わせ または他の同等のサイトカインであることを特徴とする請求項1から5のいずれ か1項に記載の作用物質複合体。
- 7.成長成分および/または成熟成分が、製造しようとする生体部分への血管の 成長を促進する因子、たとえば血管形成誘導因子および/または神経の成長を促 進する因子、たとえば神経成長因子を有していることを特徴とする請求項1から 6のいずれか1項に記載の作用物質複合体。
- 8.分解速度が構造成分自体の種々の架橋度および/または(酵素)阻害物質お よび/または免疫抑制物質および/または炎症抑制物質の添加によって制御でき ることを特徴とする請求項1から7のいずれか1項に記載の作用物質複合体。
- 9.目標細胞と一緒に生体部分を、少なくともその構成段階において形成するこ とを特徴とする請求項1から8のいずれか1項に記載の作用物質複合体。
- 10.種々の成分の共同沈降反応または凍結乾燥または個々の成分の共有結合に よって製造できることを特徴とする請求項1から9のいずれか1項に記載の作用 物質複合体の製造法。
- 11.請求項1から9のいずれか1項に記載の作用物質を、生体部分の欠如また はその機能喪失に基づく病気の治療を目的とした生体部分の製造に応用すること 。
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE3936568.9 | 1989-11-03 | ||
DE3936568A DE3936568C2 (de) | 1989-11-03 | 1989-11-03 | Wirkstoffkomplex für die Herstellung von biologischen Teilen in Form von Organen für Lebewesen; Verfahren zum Herstellen desselben und seine Verwendung |
Publications (2)
Publication Number | Publication Date |
---|---|
JPH05501208A true JPH05501208A (ja) | 1993-03-11 |
JP3626178B2 JP3626178B2 (ja) | 2005-03-02 |
Family
ID=6392769
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP51387390A Expired - Fee Related JP3626178B2 (ja) | 1989-11-03 | 1990-10-12 | 生体部分、特に生物の臓器を作製するための作用物質複合体;この作用物質複合体の製法およびその応用 |
Country Status (12)
Country | Link |
---|---|
US (1) | US5932207A (ja) |
EP (1) | EP0500556B1 (ja) |
JP (1) | JP3626178B2 (ja) |
KR (1) | KR100195549B1 (ja) |
AT (1) | ATE188877T1 (ja) |
BR (1) | BR9007808A (ja) |
DE (2) | DE3936568C2 (ja) |
DK (1) | DK0500556T3 (ja) |
ES (1) | ES2142791T3 (ja) |
GR (1) | GR3032800T3 (ja) |
RU (1) | RU2093191C1 (ja) |
WO (1) | WO1991006324A1 (ja) |
Families Citing this family (18)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5071655A (en) * | 1990-01-12 | 1991-12-10 | Baylink David J | Pharmaceutical combination for treatment of bone-wasting diseases |
RU2121370C1 (ru) * | 1992-04-11 | 1998-11-10 | Шмидт Карлхайнц | Способ получения активного комплекса биологического назначения |
US5928635A (en) * | 1994-12-07 | 1999-07-27 | Schmidt; Karlheinz | Process for producing active agent complexes |
US7214654B1 (en) * | 1994-12-07 | 2007-05-08 | Karlheinz Schmidt | Agent for the manufacture of biological parts including an active ingredient complex and carrying materials suitable for the active ingredient complex |
US6989033B1 (en) | 1992-09-17 | 2006-01-24 | Karlheinz Schmidt | Implant for recreating verterbrae and tubular bones |
DE19917696A1 (de) * | 1999-04-20 | 2000-10-26 | Karlheinz Schmidt | Mittel für die Herstellung biologischer Teile mit einem Wirkstoffkomplex und für diesen geeigneten Trägermaterialien |
US6528483B2 (en) | 1995-06-07 | 2003-03-04 | André Beaulieu | Method of producing concentrated non-buffered solutions of fibronectin |
US7067144B2 (en) * | 1998-10-20 | 2006-06-27 | Omeros Corporation | Compositions and methods for systemic inhibition of cartilage degradation |
JP2002306518A (ja) * | 2000-12-21 | 2002-10-22 | Yuichi Mori | 体内留置用具 |
US20020114795A1 (en) * | 2000-12-22 | 2002-08-22 | Thorne Kevin J. | Composition and process for bone growth and repair |
KR100487693B1 (ko) * | 2001-11-27 | 2005-05-06 | (주)리젠메드 | 골아세포의 부착을 촉진하는 자연골 대체용 인공골 구조재료 |
US20050013870A1 (en) * | 2003-07-17 | 2005-01-20 | Toby Freyman | Decellularized extracellular matrix of conditioned body tissues and uses thereof |
US20070178137A1 (en) * | 2006-02-01 | 2007-08-02 | Toby Freyman | Local control of inflammation |
US7556210B2 (en) * | 2006-05-11 | 2009-07-07 | S. C. Johnson & Son, Inc. | Self-contained multi-sprayer |
US7718616B2 (en) | 2006-12-21 | 2010-05-18 | Zimmer Orthobiologics, Inc. | Bone growth particles and osteoinductive composition thereof |
US8114428B2 (en) | 2007-03-08 | 2012-02-14 | Sbf Synthetic Bone Factory Gmbh | Methods for manufacturing a composition for treating bone and/or cartilage defects |
DE102007012276A1 (de) * | 2007-03-08 | 2008-09-11 | Sbf Synthetic Bone Factory Gmbh | Zusammensetzung zur Behandlung von Knochen- und/oder Knorpeldefekten |
US8613938B2 (en) | 2010-11-15 | 2013-12-24 | Zimmer Orthobiologics, Inc. | Bone void fillers |
Family Cites Families (22)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE2929144A1 (de) * | 1979-07-19 | 1981-02-12 | Behringwerke Ag | Verfahren zur herstellung von kollagen |
US4294753A (en) * | 1980-08-04 | 1981-10-13 | The Regents Of The University Of California | Bone morphogenetic protein process |
US4472840A (en) * | 1981-09-21 | 1984-09-25 | Jefferies Steven R | Method of inducing osseous formation by implanting bone graft material |
DE3382031D1 (en) * | 1982-08-04 | 1991-01-10 | Jolla Cancer Res Found | Polypeptide. |
IL68218A (en) * | 1983-03-23 | 1985-12-31 | Univ Ramot | Compositions for cartilage repair comprising embryonal chondrocytes |
US4932973A (en) * | 1983-09-30 | 1990-06-12 | El Gendler | Cartilage and bone induction by artificially perforated organic bone matrix |
US4925924A (en) * | 1984-03-27 | 1990-05-15 | University Of Medicine And Dentistry Of New Jersey | Biocompatible synthetic and collagen compositions having a dual-type porosity for treatment of wounds and pressure ulcers and therapeutic methods thereof |
IL74715A0 (en) * | 1984-03-27 | 1985-06-30 | Univ New Jersey Med | Biodegradable matrix and methods for producing same |
US4681763A (en) * | 1985-06-11 | 1987-07-21 | University Of Medicine And Dentistry Of New Jersey | Composition for stimulating bone growth |
US4732155A (en) * | 1985-08-27 | 1988-03-22 | The Children's Medical Center Corporation | Implantable chemoattractant system |
US4693718A (en) * | 1985-10-31 | 1987-09-15 | University Of Alabama In Birmingham | Stimulation of chemotaxis by chemotactic peptides |
US4832686A (en) * | 1986-06-24 | 1989-05-23 | Anderson Mark E | Method for administering interleukin-2 |
US5019087A (en) * | 1986-10-06 | 1991-05-28 | American Biomaterials Corporation | Nerve regeneration conduit |
WO1993012803A1 (de) * | 1986-10-22 | 1993-07-08 | Krueger Wolfgang | Wachstumstimulierendes material, herstellungsverfahren und therapeutische zusammensetzung |
US5041138A (en) * | 1986-11-20 | 1991-08-20 | Massachusetts Institute Of Technology | Neomorphogenesis of cartilage in vivo from cell culture |
DE3709101A1 (de) * | 1987-03-20 | 1988-09-29 | Mueller Lierheim Kg Biolog Lab | Immobilisierungssubstanz |
US4863732A (en) * | 1987-12-16 | 1989-09-05 | Collagen Corporation | Injectable composition for inductive bone repair |
GB2215209B (en) * | 1988-03-14 | 1992-08-26 | Osmed Inc | Method and apparatus for biodegradable, osteogenic, bone graft substitute device |
US4973466A (en) * | 1988-06-21 | 1990-11-27 | Chiron Ophthalmics, Inc. | Wound-healing dressings and methods |
US4950483A (en) * | 1988-06-30 | 1990-08-21 | Collagen Corporation | Collagen wound healing matrices and process for their production |
US5024841A (en) * | 1988-06-30 | 1991-06-18 | Collagen Corporation | Collagen wound healing matrices and process for their production |
FR2637502A1 (fr) * | 1988-10-12 | 1990-04-13 | Duroselle Patrick | Materiau de xenogreffe osseuse et procede d'obtention |
-
1989
- 1989-11-03 DE DE3936568A patent/DE3936568C2/de not_active Expired - Fee Related
-
1990
- 1990-10-12 AT AT90914898T patent/ATE188877T1/de not_active IP Right Cessation
- 1990-10-12 EP EP90914898A patent/EP0500556B1/de not_active Expired - Lifetime
- 1990-10-12 JP JP51387390A patent/JP3626178B2/ja not_active Expired - Fee Related
- 1990-10-12 DE DE59010894T patent/DE59010894D1/de not_active Expired - Lifetime
- 1990-10-12 DK DK90914898T patent/DK0500556T3/da active
- 1990-10-12 RU SU905011828A patent/RU2093191C1/ru not_active IP Right Cessation
- 1990-10-12 BR BR909007808A patent/BR9007808A/pt not_active Application Discontinuation
- 1990-10-12 WO PCT/DE1990/000782 patent/WO1991006324A1/de active IP Right Grant
- 1990-10-12 KR KR1019920701038A patent/KR100195549B1/ko not_active IP Right Cessation
- 1990-10-12 ES ES90914898T patent/ES2142791T3/es not_active Expired - Lifetime
-
1994
- 1994-12-07 US US08/350,666 patent/US5932207A/en not_active Expired - Fee Related
-
2000
- 2000-02-29 GR GR20000400501T patent/GR3032800T3/el not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
DE59010894D1 (de) | 2000-02-24 |
WO1991006324A1 (de) | 1991-05-16 |
ATE188877T1 (de) | 2000-02-15 |
KR100195549B1 (ko) | 1999-06-15 |
BR9007808A (pt) | 1992-09-29 |
RU2093191C1 (ru) | 1997-10-20 |
EP0500556B1 (de) | 2000-01-19 |
DE3936568C2 (de) | 1997-06-19 |
DE3936568A1 (de) | 1991-05-08 |
KR920703134A (ko) | 1992-12-17 |
GR3032800T3 (en) | 2000-06-30 |
DK0500556T3 (da) | 2000-05-22 |
EP0500556A1 (de) | 1992-09-02 |
ES2142791T3 (es) | 2000-05-01 |
US5932207A (en) | 1999-08-03 |
JP3626178B2 (ja) | 2005-03-02 |
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