JPH05331038A - External preparation for skin - Google Patents

Abstract

PURPOSE:To obtain an external preparation for skin having excellently moisture retaining effects, a feeling of body in use, no greasiness during drying, providing the surface of skin with high evenness, moist and smooth touch. CONSTITUTION:An external preparation for skin comprises (A) an acidic heteropolysaccharide derived from a callus of a plant belonging to the genus Polianthes L., (B) a carboxyvinyl polymer or its salt, (C) a polyhydric alcohol and (D) a silicone oil having <=100cs viscosity.

Description

Detailed Description of the Invention

[0001]

FIELD OF THE INVENTION The present invention has an excellent moisturizing effect, has a rich feeling in use, has no stickiness when dried, and gives a high smoothness to the skin surface after drying, and is moist and smooth. It relates to a skin external preparation that gives a feeling.

[0002]

2. Description of the Related Art Conventionally, gel cosmetics composed of carboxyvinyl polymers and humectants such as glycerin have a high water content and a unique skin feel. Therefore, they are generally used for facials, hair and bodies. Has been.

However, if a large amount of these moisturizers is added in order to impart a high moisturizing power, the stickiness increases, the drying time is slow, and the feeling of use is poor.

In order to solve this problem, an attempt has been made to blend silicone to reduce stickiness (Japanese Patent Laid-Open No. 270614/1988). However, this product was not sufficiently moisturizing. Further, a composition containing a high-viscosity silicone (Japanese Patent Laid-Open No. 1-250305) has been tried, but it has a drawback that it spreads heavily during use.

[0005]

SUMMARY OF THE INVENTION Accordingly, an object of the present invention is to provide an external preparation for skin which is free from such drawbacks and has an excellent moisturizing effect, as well as an excellent feeling of use.

[0006]

[Means for Solving the Problems] In view of such circumstances, the present inventors have conducted diligent research, and as a result, skin containing a specific acidic heteropolysaccharide, a carboxyvinyl polymer, a polyhydric alcohol, and a silicone oil having a specific viscosity. In addition to the moisturizing effect and good spreadability, the external preparation has a rich feeling of use, has no stickiness when dried, and gives high smoothness to the skin surface after drying, giving a moist and smooth feel. The present invention has been completed by discovering that it is a thing.

That is, the present invention provides the following components (A) to
(D): (A) Polyanthes L.
The present invention provides an external skin preparation containing a callus-derived acidic heteropolysaccharide (B) carboxyvinyl polymer or a salt thereof (C) polyhydric alcohol (D) a silicone oil having a viscosity of 100 cs or less.

The component (A) used in the present invention, which is a plant-derived acidic heteropolysaccharide (hereinafter referred to as "acidic polysaccharide") belonging to the genus Polyanthes, can be prepared by the method described in, for example, JP-A No. 64-10997. Callus derived from a plant belonging to the genus can be cultured and collected from the obtained culture. Further, as plants belonging to the genus Polyanthes, there are tuberoses (Polianthes).
tuberosa L .; ) Is mentioned as a preferable example.

As a method of collecting the acidic polysaccharide, for example, in the case of tuberose, the following method can be mentioned. That is, a part of a tuberose flower or the like is used as an explant and Li
After inducing callus using a medium in which 10 ⁻⁵ M auxin and 10 ⁻⁶ M cytokinin were added as plant hormones to the nsmaier-skoo's basal medium, and callus was further induced in the medium containing 3% saccharose as a carbon source, Culturing is carried out, and shaking culture is carried out using a liquid medium containing the same components as the above callus culture medium. After that, remove cells from the culture solution by centrifugation or filtration, concentrate the culture solution using a rotary evaporator, etc., add a solvent such as ethanol or acetone to the concentrated solution for precipitation, and freeze-dry the precipitate. Thus, the acidic polysaccharide can be separated and obtained. The acidic polysaccharide thus obtained is added to the skin external preparation of the present invention in an amount of 0.0001 to 10% by weight (hereinafter,
"%"), Particularly preferably 0.001 to 1%.

The carboxyvinyl polymer or the salt thereof as the component (B) used in the present invention is not particularly limited, but those having a molecular weight of 300,000 to 1,000,000 are particularly preferable. Specific examples of the carboxyvinyl polymer having such a molecular weight include, for example, “Carbopol” (manufactured by Goodrich Co.) having polyacrylic acid as a main constituent,
"Hibis Wako 103", "Hibis Wako 10
4 ”,“ Hibiswako 105 ”(manufactured by Wako Pure Chemical Industries),“ Hispagel ”as an aqueous carboxyvinyl polymer solution
(Manufactured by Hispano Kimika Co., Ltd.) or "U Jelly CP" as an aqueous solution of a polymer similar to carboxyvinyl polymer.
(Manufactured by Showa Denko) and the like. These may be used as they are, or may be neutralized with an alkali, dispersed or dissolved in water, and these may be used alone or in combination of two or more. The addition amount thereof is based on the above-mentioned acidic polysaccharide. It is preferably 0.01 to 10 times, and 0.001 to 2%, particularly 0.05 to 2%, based on the total amount of the skin external preparation of the present invention.

The polyhydric alcohol as the component (C) is not particularly limited, but examples thereof include ethylene glycol, diethylene glycol, triethylene glycol, and further polyethylene glycols, propylene glycol,
Dipropylene glycol, higher polypropylene glycols, butylene glycols such as 1,3-butylene glycol and 1,4-butylene glycol, glycerin, diglycerin, higher polyglycerins, sorbitol, mannitol, xylitol, maltitol And other sugar alcohols, glycerin ethylene oxide (hereinafter abbreviated as EO), propylene oxide (hereinafter P
Abbreviated as O) adduct, EO of sugar alcohol, PO adduct, galactose, monosaccharide of fructose sugar and its E
O, PO adducts, maltose, polysaccharides of lactose sugars and EO and PO adducts thereof, and polyoxyalkylene alkyl glycosides such as polyoxyethylene methyl glucoside (EO 10 or more). These may be used alone or in combination of two or more, and the compounding amount thereof is preferably 1 to 80%, particularly preferably 5 to 50% in the external preparation for skin.

Examples of the silicone oil having a viscosity of the component (D) of 100 cs or less include low-polymerization chain dimethyl polysiloxane, methylphenyl polysiloxane, cyclic octamethylcyclotetrasiloxane, and decamethylcyclopentasiloxane. These may be used alone or in combination of two or more. The content of the component (D) in the external preparation for skin is 0.1 to 6%, preferably 0.1 to 4%.

The external preparation for skin of the present invention contains, in addition to the above-mentioned essential components, water, oils, waxes, surfactants and lower alcohols, if necessary, within a qualitative and quantitative range that does not impair the effects of the present invention. , Water-soluble polymer thickeners other than carboxyvinyl polymer, pH adjusters, fragrances, antioxidants, chelating agents, dyes, pigments, antiseptic agents, medicinal ingredients, UV absorbers, etc., usually used for pharmaceuticals and cosmetics In addition to the components, components such as inorganic or organic powders and granules can be blended. The oil agent used here is not particularly limited, but includes isopropyl palmitate, butyl stearate, isopropyl myristate, diethyl phthalate, myristyl lactate, diisopropyl adipate, cetyl myristate, cetyl lactate, 1-isostearoyl-3-myristoylglycerol. , Cholesteryl isostearate, cetyl 2-ethylhexanoate, 2-ethylhexyl palmitate,
2-Octyldodecyl myristate, neopentyl glycol di-2-ethylhexanoate, oleic acid-2-
Esters such as octyldodecyl, glycerol triisostearate, di-paramethoxycinnamic acid-glyceryl mono-2-ethylhexanoate, 2-hexyldecanol, oleyl alcohol, 2-octyldodecanol, batyl alcohol, cetanol, stearyl alcohol, etc. Hydrocarbons such as higher alcohols, squalane, liquid paraffin, vaseline, solid paraffin, eucalyptus oil, peppermint oil, olive oil, camellia oil, macadamia nut oil, jojoba oil, avocado oil, lanolin, beef tallow, lard,
Fats and oils such as egg yolk fat, benzyl alcohol, phenylethyl alcohol, cholesterol, dextrin palmitate, d-δ-tocopherol, JP-A-62-22
The acyl derivatives and the like described in 8048 are used.

Although the surfactant is not particularly limited, polyoxyethylene (hereinafter abbreviated as POE) hydrogenated castor oil, POE alkyl ether, POE branched alkyl ether, POE fatty acid ester, POE glycerin fatty acid ester, POE sorbitan fatty acid ester, POE
Sorbitol fatty acid ester, POE hydrogenated castor oil alkyl sulfate ester, POE alkyl sulfate ester, polyglycerin fatty acid ester, alkyl phosphate ester,
POE alkyl phosphate ester, fatty acid alkali metal salt, sorbitan fatty acid ester, glycerin fatty acid ester, alkyl polyglucoside, polyethylene glycol fatty acid ester, α-monoisostearyl glyceryl ether, stearoylmethyl taurine sodium, P
OE sodium lauryl ether phosphate, ether-modified silicone, etc. are used.

The pH adjusting agent is not particularly limited, but metal oxides such as sodium hydroxide, potassium hydroxide and lithium hydroxide, triethanolamine, isopropanolamine, diisopropanolamine, L-arginine,
Basic amino acids such as L-lysine, urea, ε-aminocaproic acid, sodium pyrrolidonecarboxylate, sodium hydrogenphosphate, sodium citrate, citric acid, lactic acid, succinic acid, tartaric acid and the like. The pH of the external preparation is preferably in the range of 4-10.

[0016]

Industrial Applicability The external preparation of the present invention has an excellent moisturizing effect, has a rich feeling in use, has no stickiness when dried, and after drying, imparts high smoothness to the skin surface and is moist and smooth. It can give a feel.

[0017]

The present invention will be described in more detail below by showing Examples and Comparative Examples of the present invention, but the present invention is not limited to these. As the acidic polysaccharide in the examples, an acidic heteropolysaccharide derived from callus of tuberose produced according to Example 1 of JP-A-64-10997 was used. In addition, the evaluation method of the external preparation for skin was sensory-evaluated by the following evaluation criteria by a professional panelist.

[0018]

[Table 1] 5: Fairly good 4: Good 3: Normal 2: Fairly bad 1: Poor Also, comprehensive judgment was made according to the following judgment criteria by the average score of each item.

[0019]

[Table 2] ◎: 5 points or more ○: 4 points or more and less than 5 points ▲: 3 points or more and less than 4 points △: Less than 3 points

Example 1 The moisturizing gel shown in Table 3 was produced by the following production method. This was evaluated for the items shown in Table 4. The results are shown in Table 4.

[0021]

[Table 3]

Manufacturing method: 6) to 12) are added to purified water and dissolved. (Aqueous Phase) The carboxyvinyl polymer is dispersed in dimethylpolysiloxane and added to the aqueous phase. Here 4) or 12) or 1
After 3) is added and stirred, it is neutralized with potassium hydroxide.

[0023]

[Table 4]

In Examples 2 to 6 below, external preparations for skin of each composition were produced by each production method. Example 2 Moisturizing essence:

[0025]

[Table 5] (%) 1) Balance of purified water 2) Carboxy vinyl polymer (trade name: Carbopol 940) 0.5 3) Potassium hydroxide 0.1 4) Polyethylene glycol 1500 25 5) Polyoxyethylene (20) Methyl glucoside 156) 1-isostearoyl-3-myristoyl-glycerol 1.5 7) Polyoxyethylene (40) hydrogenated castor oil 1.5 8) Polyoxyethylene lauryl ether sodium phosphate (4EO) 0. 2 9) Dimethylpolysiloxane (6cs) 1 10) Acidic polysaccharide 0.2 11) Sodium monohydrogen phosphate 0.4 12) Citric acid 0.1 13) Ethanol 414) Methyl paraoxybenzoate 0.1

Manufacturing method: 7) to 8) are melted by heating and kept at 80 ° C. To this, heated purified water is added with stirring to obtain an emulsion. 4) to 5) and 11) to 14) are added to purified water and dissolved therein, and a carboxyvinyl polymer dispersed in dimethylpolysiloxane is added thereto. Furthermore, potassium hydroxide was added, an acidic polysaccharide and an emulsion were added to obtain a moisturizing essence. Example 3 Lotion:

[0027]

[Table 6] (%) 1) Balance of purified water 2) Carboxy vinyl polymer (trade name: Carbopol 941) 0.05 3) Potassium hydroxide 0.01 4) Glycerin 75) 1,3-Butylene glycol 36 ) Polyoxyethylene (40) hydrogenated castor oil 0.5 7) Dimethylpolysiloxane (6cs) 0.2 8) Acidic polysaccharide 0.05 9) Sodium monohydrogen phosphate 0.75 10) Citric acid 0.25 11 ) Ethanol 4 12) Methyl paraoxybenzoate 0.1

Manufacturing method: 4) to 6) and 9) to 12) are added to purified water and dissolved therein, and a carboxyvinyl polymer dispersed in dimethylpolysiloxane is added thereto. Furthermore, potassium hydroxide was added and an acidic polysaccharide was added to obtain a lotion. Example 4 Lotion:

[0029]

[Table 7] (%) 1) Balance of purified water 2) Carboxyvinyl polymer (trade name: Carbopol 941) 0.05 3) Potassium hydroxide 0.01 4) Glycerin 75) 1,3-Butylene glycol 36 ) Polyoxyethylene (40) hydrogenated castor oil 0.5 7) Dimethylpolysiloxane (6cs) 0.2 8) Acidic polysaccharide 0.05 9) Urea 1 10) ε-Aminocaproic acid 0.3 11) Phosphoric acid mono Sodium hydrogen 0.75 12) Citric acid 0.25 13) Ethanol 414) Methyl paraoxybenzoate 0.1

Manufacturing method: 4) to 6) and 9) to 14) are added to purified water and dissolved therein, and a carboxyvinyl polymer dispersed in dimethylpolysiloxane is added thereto. Furthermore, potassium hydroxide was added and an acidic polysaccharide was added to obtain a lotion. Example 5 Moisturizing gel:

[0031]

[Table 8] (%) 1) Balance of purified water 2) Carboxyvinyl polymer (trade name: Carbopol 940) 0.5 3) Potassium hydroxide 0.15 4) Acidic polysaccharide 0.25 5) Dimethylpolysiloxane ( 50cs) 2 6) Glycerin 15 7) Polyoxyethylene (20) methyl glucoside 10 8) Polyoxyethylene (40) hydrogenated castor oil 19) Sodium monohydrogen phosphate 0.4 10) Citric acid 0.1 11) Ethanol 8 12) Methyl paraoxybenzoate 0.2

Example 6 Moisturizing gel

[0033]

[Table 9] (%) 1) Balance of purified water 2) Carboxyvinyl polymer (trade name: Carbopol 940) 0.5 3) Potassium hydroxide 0.15 4) Acidic polysaccharide 0.25 5 Octamethylcyclotetra Siloxane (2.5 cs) 26) Glycerin 15 7) Dipropylene glycol 10 8) Polyoxyethylene (40) Hydrogenated castor oil 19) Sodium monohydrogen phosphate 0.4 10) Citric acid 0.1 11) Ethanol 8 12) Methyl paraoxybenzoate 0.2

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[Procedure amendment]

[Submission date] June 10, 1992

[Procedure Amendment 1]

[Document name to be amended] Statement

[Name of item to be corrected] 0003

[Correction method] Change

[Correction content]

[0003] However, high order to have a moisturizing, and to formulate these moisturizing agent in a large amount, stickiness is increased, dry also late, there arises a disadvantage that the bad feeling of use (JP
(Kaisho 63-270614) .

[Procedure Amendment 2]

[Document name to be amended] Statement

[Correction target item name] 0004

[Correction method] Change

[Correction content]

In order to solve this problem, an attempt has been made to reduce the stickiness by blending silicone (Japanese Patent Laid-Open Publication No. 1994-242242).
(Hei 1-132680 gazette). However, this product was not sufficiently moisturizing. Further, a composition containing a high-viscosity silicone (Japanese Patent Laid-Open No. 1-250305) has been tried, but it has a drawback that it spreads heavily during use.

Claims (2)

[Claims] 1. The following components (A) to (D): (A) Polyanthes L.
Callus-derived acidic heteropolysaccharide of plant belonging to (B) Carboxyvinyl polymer or salt thereof (C) Polyhydric alcohol (D) Skin external preparation containing a silicone oil having a viscosity of 100 cs or less. 2. A plant belonging to the genus Polyantes is tuberose (Polianthes tuberosa).
L. ) The external preparation for skin according to claim 1.