JP3273571B2 - External preparation for skin - Google Patents

Description

DETAILED DESCRIPTION OF THE INVENTION

[0001]

BACKGROUND OF THE INVENTION The present invention is excellent in moisturizing effect, has a rich feeling of use, has no stickiness upon drying, and gives a high smoothness to the skin surface after drying, making it moist and smooth. The present invention relates to a skin external preparation that gives a feeling.

[0002]

2. Description of the Related Art Conventionally, gel cosmetics comprising a carboxyvinyl polymer and a humectant such as glycerin have been generally used for facial, hair and body because of their high moisture content and unique texture. I have been.

[0003] However, high order to have a moisturizing, and to formulate these moisturizing agent in a large amount, stickiness is increased, dry also late, there arises a disadvantage that the bad feeling of use (JP
JP-A-63-270614) .

[0004] In order to solve this problem, attempts have been made to reduce stickiness by blending silicone.
JP-A-1-132680 ). However, it did not have sufficient moisture retention. In addition, a compound containing high viscosity silicone (JP-A-1-250305) has also been tried, but this method has a drawback that the use thereof has a large spread.

[0005]

SUMMARY OF THE INVENTION Accordingly, it is an object of the present invention to provide an external preparation for skin which does not have the above-mentioned drawbacks, has excellent moisturizing effects, and gives an excellent feeling of use.

[0006]

Means for Solving the Problems In view of this situation, the present inventors have conducted intensive studies and have found that a skin containing a specific acidic heteropolysaccharide, a carboxyvinyl polymer, a polyhydric alcohol and a silicone oil having a specific viscosity. The external preparation, in addition to the moisturizing effect and good spreadability, has a rich feeling of use, and there is no stickiness when drying, and after drying, it gives a high smoothness to the skin surface, giving a moist and smooth feel The present invention has been completed.

That is, the present invention provides the following components (A) to
(D): (A) Polyanthes L.
(B) a carboxyvinyl polymer or a salt thereof; (C) a polyhydric alcohol; and (D) a skin external preparation containing a silicone oil having a viscosity of 100 cs or less.

The acidic heteropolysaccharide (hereinafter referred to as "acidic polysaccharide") derived from a plant belonging to the genus Polyantes of the component (A) used in the present invention can be prepared, for example, according to the method described in JP-A-64-10997. Callus derived from plants belonging to the genus can be cultured and collected from the resulting culture. As plants belonging to the genus Polyantes, tuberose (Polianthes)
tuberosa L .; ) Is a preferred example.

As a method for collecting an acidic polysaccharide, for example, in the case of tuberose, the following method can be mentioned. In other words, a part of tuberose flowers and the like are
Callus was induced using a medium supplemented with 10 ⁻⁵ M auxin and 10 ⁻⁶ M cytokinin as plant hormones in a basic medium of nsmeier-skoog, and further supplemented with 3% sucrose as a carbon source. The culture is performed, and the culture is further performed with shaking using a liquid medium containing the same components as the above-described callus culture medium. Thereafter, the cells are removed from the culture solution by centrifugation or filtration, and the culture solution is concentrated using a rotary evaporator or the like, and the concentrated solution is precipitated by adding a solvent such as ethanol or acetone, and the precipitate is freeze-dried. Can separate and obtain acidic polysaccharides. The acidic polysaccharide thus obtained is added to the external preparation for skin of the present invention in an amount of 0.0001 to 10% by weight (hereinafter, referred to as “the external preparation”).
%), Particularly preferably 0.001 to 1%.

The carboxyvinyl polymer (B) used in the present invention or a salt thereof is not particularly limited, but those having a molecular weight in the range of 300,000 to 1,000,000 are particularly preferred. Specific examples of the carboxyvinyl polymer having such a molecular weight include, for example, “Carbopol” (manufactured by Goodrich) having polyacrylic acid as a main component,
"Hibiswako 103", "Hibiswako 10"
4, "Hibiswako 105" (manufactured by Wako Pure Chemical Industries, Ltd.) and "Hispagel" as a carboxyvinyl polymer aqueous solution
(Manufactured by Hispano Kimika) and “U Jerry CP” as an aqueous solution of a polymer similar to carboxyvinyl polymer
(Manufactured by Showa Denko). These are used as they are, or neutralized with alkali, dispersed or dissolved in water, and these can be used alone or in combination of two or more, and the amount of addition is based on the above-mentioned acidic polysaccharide. 0.01 to 10 times, preferably 0.001 to 2%, particularly preferably 0.05 to 2%, based on the total amount of the external preparation for skin of the present invention.

The polyhydric alcohol of the component (C) is not particularly restricted but includes, for example, ethylene glycol, diethylene glycol, triethylene glycol, higher polyethylene glycols, propylene glycol,
Dipropylene glycol, higher polypropylene glycols, butylene glycols such as 1,3-butylene glycol, 1,4-butylene glycol, glycerin, diglycerin, higher polyglycerins, sorbitol, mannitol, xylitol, maltitol Sugar alcohols, glycerin ethylene oxide (hereinafter abbreviated as EO), propylene oxide (hereinafter P)
O) PO, adducts of sugar alcohols, monosaccharides of galactose and fructose sugars and their E
Examples include O, PO adducts, polysaccharides of maltose and lactose sugars and their EO and PO adducts, and polyoxyalkylene alkyl glycosides such as polyoxyethylene methyl glucoside (EO 10 or more). These may be used alone or as a mixture of two or more kinds, and the compounding amount is preferably 1 to 80%, particularly preferably 5 to 50% in the external preparation for skin.

Examples of the silicone oil having a viscosity of component (D) of 100 cs or less include low-polymerized linear dimethylpolysiloxane, methylphenylpolysiloxane, cyclic octamethylcyclotetrasiloxane, and decamethylcyclopentasiloxane. These may be used alone or in combination of two or more. The amount of the component (D) is preferably 0.1 to 6%, particularly preferably 0.1 to 4%, in the external preparation for skin.

The external preparation for skin of the present invention contains, in addition to the above-mentioned essential components, water, oils, waxes, surfactants, lower alcohols within a qualitative and quantitative range which does not impair the effects of the present invention, if necessary. Water-soluble polymer thickeners other than carboxyvinyl polymers, pH regulators, fragrances, antioxidants, chelating agents, pigments, pigments, antiseptics, medicinal ingredients, ultraviolet absorbers, etc. In addition to the components, components such as inorganic or organic powders and granules can also be blended. Although the oil agent used here is not particularly limited, isopropyl palmitate, butyl stearate, isopropyl myristate, diethyl phthalate, myristyl lactate, diisopropyl adipate, cetyl myristate, cetyl lactate, 1-isostearoyl-3-myristoyl glycerol Cholesteryl isostearate, cetyl 2-ethylhexanoate, 2-ethylhexyl palmitate,
2-octyldodecyl myristate, neopentyl glycol di-2-ethylhexanoate, oleic acid-2-
Esters such as octyldodecyl, glycerol triisostearate, glyceryl di-paramethoxycinnamate-mono-2-ethylhexanoate, 2-hexyldecanol, oleyl alcohol, 2-octyldodecanol, batyl alcohol, cetanol, stearyl alcohol and the like Higher alcohols, hydrocarbons such as squalane, liquid paraffin, vaseline, and solid paraffin, eucalyptus oil, peppermint oil, olive oil, camellia oil, macadamia nut oil, jojoba oil, avocado oil, lanolin, tallow, tallow,
Fats and oils such as egg yolk fat, other benzyl alcohol, phenylethyl alcohol, cholesterol, dextrin palmitate, d-δ-tocopherol, JP-A-62-22
An acyl derivative described in JP-A-8048 is used.

The surfactant is not particularly restricted but includes polyoxyethylene (hereinafter abbreviated as POE) hydrogenated castor oil, POE alkyl ether, POE branched alkyl ether, POE fatty acid ester, POE glycerin fatty acid ester, POE sorbitan fatty acid ester, POE
Sorbitol fatty acid ester, POE hydrogenated castor oil alkyl sulfate, POE alkyl sulfate, polyglycerin fatty acid ester, alkyl phosphate,
POE alkyl phosphate, fatty acid alkali metal salt, sorbitan fatty acid ester, glycerin fatty acid ester, alkyl polyglucoside, polyethylene glycol fatty acid ester, α-monoisostearyl glyceryl ether, sodium stearoylmethyltaurine, P
Sodium OE lauryl ether phosphate, ether-modified silicone and the like are used.

The pH adjuster is not particularly restricted but includes metal oxides such as sodium hydroxide, potassium hydroxide and lithium hydroxide, triethanolamine, isopropanolamine, diisopropanolamine, L-arginine,
Basic amino acids such as L-lysine, urea, ε-aminocaproic acid, sodium pyrrolidone carboxylate, sodium hydrogen phosphate, sodium citrate, citric acid, lactic acid, succinic acid, tartaric acid and the like. The pH of the external preparation is desirably in the range of 4 to 10.

[0016]

The external preparation of the present invention is excellent in moisturizing effect, has a rich feeling of use, has no stickiness upon drying, and gives high smoothness to the skin surface after drying, making it moist and smooth. Can give a feel.

[0017]

EXAMPLES Hereinafter, the present invention will be described in more detail with reference to Examples and Comparative Examples of the present invention, but the present invention is not limited thereto. As the acidic polysaccharide in the examples, an acidic heteropolysaccharide derived from the callus of tuberose produced according to Example 1 of JP-A-64-10997 was used. The evaluation method of the external preparation for skin was sensory-evaluated by a specialized panelist according to the following evaluation criteria.

[0018]

[Table 1] 5: fairly good 4: good 3: normal 2: somewhat poor 1: bad In addition, comprehensive evaluation was made according to the following criteria based on the average score of each item.

[0019]

[Table 2] ◎: 5 points or more ○: 4 points or more and less than 5 points ▲: 3 points or more and less than 4 points △: less than 3 points

Example 1 A moisturizing gel shown in Table 3 was produced by the following method. This was evaluated for the items shown in Table 4. Table 4 shows the results.

[0021]

[Table 3]

Production method: 6) to 12) are added to purified water and dissolved. (Aqueous phase) The carboxyvinyl polymer is dispersed in dimethylpolysiloxane and added to the aqueous phase. Where 4) or 12) or 1
After adding 3) and stirring, neutralize with potassium hydroxide.

[0023]

[Table 4]

In the following Examples 2 to 6, external preparations for skin of each composition were produced by each production method. Example 2 Moisturizing essence:

[0025]

(%) 1) Purified water balance 2) Carboxyvinyl polymer (trade name: Carbopol 940) 0.5 3) Potassium hydroxide 0.1 4) Polyethylene glycol 1500 25) Polyoxyethylene (20) Methyl glucoside 156) 1-isostearoyl-3-myristoyl-glycerol 1.5 7) polyoxyethylene (40) hydrogenated castor oil 1.5 8) polyoxyethylene lauryl ether sodium phosphate (4EO) 0. 2 9) Dimethyl polysiloxane (6cs) 1 10) Acidic polysaccharide 0.2 11) Sodium monohydrogen phosphate 0.4 12) Citric acid 0.1 13) Ethanol 4 14) Methyl paraoxybenzoate 0.1

Manufacturing method: 7) to 8) are dissolved by heating and kept at 80 ° C. Heated purified water is added thereto with stirring to obtain an emulsion. 4) to 5) and 11) to 14) are added and dissolved in purified water, and a carboxyvinyl polymer dispersed in dimethylpolysiloxane is added thereto. Further, potassium hydroxide was added, and the acidic polysaccharide and the emulsion were added to obtain a moisturizing essence. Example 3 Lotion:

[0027]

(%) 1) Purified water balance 2) Carboxyvinyl polymer (trade name: Carbopol 941) 0.05 3) Potassium hydroxide 0.01 4) Glycerin 7 5) 1,3-butylene glycol 36 ) Polyoxyethylene (40) hydrogenated castor oil 0.5 7) Dimethyl polysiloxane (6cs) 0.2 8) Acidic polysaccharide 0.05 9) Sodium monohydrogen phosphate 0.75 10) Citric acid 0.25 11 ) Ethanol 4 12) Methyl paraoxybenzoate 0.1

Manufacturing method: 4) to 6) and 9) to 12) are added to purified water and dissolved, and a carboxyvinyl polymer dispersed in dimethylpolysiloxane is added thereto. Further, potassium hydroxide was added, and an acidic polysaccharide was added to obtain a lotion. Example 4 Lotion:

[0029]

(%) 1) Purified water balance 2) Carboxyvinyl polymer (trade name: Carbopol 941) 0.05 3) Potassium hydroxide 0.01 4) Glycerin 7 5) 1,3-butylene glycol 36 ) Polyoxyethylene (40) hydrogenated castor oil 0.5 7) Dimethyl polysiloxane (6cs) 0.2 8) Acid polysaccharide 0.05 9) Urea 1 10) ε-aminocaproic acid 0.3 11) Monophosphate Sodium hydrogen 0.75 12) Citric acid 0.25 13) Ethanol 4 14) Methyl parahydroxybenzoate 0.1

Production method: 4) to 6) and 9) to 14) are added to purified water and dissolved, and a carboxyvinyl polymer dispersed in dimethylpolysiloxane is added thereto. Further, potassium hydroxide was added, and an acidic polysaccharide was added to obtain a lotion. Example 5 Moisturizing Gel:

[0031]

(%) 1) Purified water balance 2) Carboxyvinyl polymer (trade name: Carbopol 940) 0.5 3) Potassium hydroxide 0.15 4) Acidic polysaccharide 0.2 5) Dimethyl polysiloxane ( 50cs) 2 6) Glycerin 15 7) Polyoxyethylene (20) methyl glucoside 10 8) Polyoxyethylene (40) hydrogenated castor oil 19) Sodium monohydrogen phosphate 0.4 10) Citric acid 0.1 11) Ethanol 8 12) Methyl paraoxybenzoate 0.2

Example 6 Moisturizing gel

[0033]

(Table 9) (%) 1) Purified water balance 2) Carboxyvinyl polymer (trade name: Carbopol 940) 0.5 3) Potassium hydroxide 0.15 4) Acidic polysaccharide 0.2 5) Octamethylcyclotetra Siloxane (2.5cs) 2 6) Glycerin 15 7) Dipropylene glycol 10 8) Polyoxyethylene (40) hydrogenated castor oil 19) Sodium monohydrogen phosphate 0.4 10) Citric acid 0.1 11) Ethanol 8 12) Methyl paraoxybenzoate 0.2

────────────────────────────────────────────────── ─── Continuation of the front page (56) References JP-A-1-213213 (JP, A) JP-A-1-250305 (JP, A) (58) Fields investigated (Int. Cl. ⁷ , DB name) A61K 7/00 A61K 7/48

Claims (2)

(57) [Claims] 1. The following components (A) to (D): (A) Polyanthes L.
(C) a polycarboxyvinyl polymer or a salt thereof; (D) a silicone oil having a viscosity of 100 cs or less. 2. The plant belonging to the genus Polyantes is tuberose (Polianthes tuberosa).
L. 2. The external preparation for skin according to claim 1, wherein