JPH0733635A - Skin external preparation - Google Patents

Abstract

PURPOSE:To obtain a skin external preparation, good in extensibility, having smooth feeling of use and excellent in humectant and softening actions on a horny layer of the skin without changing the appearance with time. CONSTITUTION:This skin external preparation contains (A) one or two or more selected from polysaccharides, e.g. acidic heteropolysaccharides derived from a plant belonging to the genus Polianthes, xanthan gum, cationized cellulose, sodium hyaluronate, alginic acid, CM-chitin, carboxymethyl cellulose and tau- carrageenan and (B) L-arginine. The respective ingredients are blended in amounts within the range of preferably 0.0001-10wt.%, especially 0.001-1wt.% ingredient (A) and preferably 0.0001-10wt.%, especially 0.001-5wt.% ingredient (B).

Description

Detailed Description of the Invention

[0001]

FIELD OF THE INVENTION The present invention relates to an external preparation for skin, more specifically to a skin which has a smooth and smooth feeling of use, an excellent moisturizing and softening effect on the stratum corneum of the skin, and whose appearance does not change with time. Regarding external preparations.

[0002]

2. Description of the Related Art Conventionally, a polysaccharide has been blended in an external preparation for skin for the purpose of giving a good spread and a smooth feeling of use.
For example, an acidic polysaccharide produced by a callus of a plant belonging to the genus Polyantes is added to an external preparation composition without impairing the characteristics of the added external composition, and a smooth and smooth feeling of use is imparted. Are known (Japanese Patent Publication No. 5-29329 and Japanese Patent Laid-Open No. 1-213213).

On the other hand, various moisturizing agents have been incorporated into external skin preparations for the purpose of imparting a large amount of water to the stratum corneum and maintaining it for a long time. Among these moisturizers, amino acids are typical natural moisturizing ingredients. However, for the purpose of improving the feeling of use of an external preparation for skin containing an amino acid, when an amino acid and a polysaccharide are simultaneously added, a Maillard reaction generally occurs between the amino acid and the polysaccharide, and the external preparation for skin is stored during day storage. It had the drawback of turning brown.

Therefore, in order to prevent the Maillard reaction and browning, cysteine (JP-A-57-198066) and sodium bisulfite (JP-A-63-1749).
No. 10) has been carried out, but these methods are weak in efficacy, and if a large amount of cysteine or sodium bisulfite is blended in order to exert the efficacy, an odor unsuitable as an external preparation for skin is produced. There was a problem.

[0005]

SUMMARY OF THE INVENTION Therefore, the object of the present invention is to prevent the skin from changing its appearance such as browning during aging storage, to have a good spread and a smooth feeling of use, and to give an excellent moisturizing effect to the skin. To provide an external preparation.

[0006]

In view of the above circumstances, the present inventors have conducted diligent research and as a result, have found that an external preparation for skin containing a polysaccharide and L-arginine spreads smoothly and has a smooth feeling of use and excellent moisturizing effect. The present invention has been completed by finding that it has an effect and does not change the appearance upon storage over time.

That is, the present invention provides a skin external preparation containing the following components (A) and (B); (A) polysaccharide (B) L-arginine.

Examples of the polysaccharide as the component (A) in the present invention include, for example, Polyanthes.
L. )) Plant-derived acidic heteropolysaccharides (hereinafter referred to as “acidic polysaccharides”), and these are derived from plants belonging to the genus Polyanthes according to the method described in JP-A-64-10997, for example. Callus can be cultured and harvested from the resulting culture. Also,
Preferable examples of the plant belonging to the genus Polyanthes include tubelloses (Polianthes tuberosa L.).

As a method for collecting the acidic polysaccharide, for example, in the case of tuberose, the following method can be mentioned. In other words, a part of flowers such as tuberose is used as an explant and Li
After inducing callus using a medium in which 10 ⁻⁵ M auxin and 10 ⁻⁶ M cytokinin were added as plant hormones to a nsmaier-skoo's basal medium, and callus was further induced using a medium containing 3% saccharose as a carbon source, Culture is performed, and further shake culture is performed using a liquid medium containing the same components as the above callus culture medium. After that, cells are removed from the culture solution by centrifugation or filtration, the culture solution is concentrated using a rotary evaporator, etc., the concentrated solution is added with a solvent such as ethanol or acetone to cause precipitation, and the precipitate is freeze-dried. Thus, the acidic polysaccharide can be separated and obtained.

Examples of the other component (A) include xanthan gum, cationized cellulose, sodium hyaluronate, alginic acid, CM-chitin, carboxymethyl cellulose, and iota carrageenan. As these, commercially available products can be used, and examples of xanthan gum include "SAN ACE CS" (manufactured by Sanei Chemical Co., Ltd.), "Neosoft XK" (manufactured by Taiyo Kagaku), "Echo Gum BT" (manufactured by Dainippon Pharmaceutical), and the like. Cationic cellulose H60 (made by Kao) and the like as cationized cellulose, sodium hyaluronate (made by Chisso) and sodium denka hyaluronic acid (made by Denki Kagaku) as sodium hyaluronate, and Kimitsurugin "I-3F" (manufactured by Kimitsu Chemical Industry Co., Ltd.) and the like, CM-chitin such as "CM-chitin 139T" (manufactured by Katakura Chikkarin), "chitin liquid HV-10" (manufactured by Ichimaru Falcos), and the like, carboxymethyl cellulose " CMC-12M31PTP "(manufactured by Hercules Far East), etc. Carrageenan includes "carrageenin CS-56" and "carrageenin CS".
-222 "(all manufactured by Sanei Chemical Industry Co., Ltd.) and the like.

These components (A) can be used alone or in admixture of two or more, and are used in the external preparation for skin of the present invention in an amount of 0.0001 to 10% by weight (hereinafter referred to as "%"). In particular, 0.001 to 1% is preferable.

The component (B), L-arginine, is contained in the external preparation for skin according to the present invention in an amount of 0.0001 to 10%, particularly 0.0
It is preferably blended in an amount of 01 to 5%.

In addition to the above-mentioned essential components, the external preparation for skin of the present invention may optionally contain water, an oil agent, a wax, a silicone, a surfactant, within a qualitative and quantitative range that does not impair the effects of the present invention. Used in ordinary medicines and cosmetics such as lower alcohols, polyhydric alcohols, water-soluble polymer thickeners, pH adjusters, fragrances, antioxidants, chelating agents, dyes, pigments, antiseptics, medicinal ingredients, UV absorbers, etc. In addition to the above components, inorganic or organic powders, granules, and other components can also be blended.

Of these optional ingredients, the oil agent is not particularly limited, but isopropyl palmitate, butyl stearate, isopropyl myristate, diethyl phthalate, myristyl lactate, diisopropyl adipate,
Cetyl myristate, cetyl lactate, 1-isostearoyl-3-myristoylglycerol, cholesteryl isostearate, cetyl 2-ethylhexanoate, 2-ethylhexyl palmitate, 2-octyldodecyl myristate, di-2-ethylhexane Acid esters such as neopentyl glycol, 2-octyldodecyl oleate, glycerol triisostearate, glyceryl di-2-paramethoxycinnamic acid-mono-2-ethylhexanoate, 2-hexyldecanol, oleyl alcohol,
Higher alcohols such as 2-octyldodecanol, batyl alcohol, cetanol and stearyl alcohol, hydrocarbons such as squalane, liquid paraffin, vaseline and solid paraffin, eucalyptus oil, peppermint oil, olive oil, camellia oil, macadamia nut oil, jojoba oil, Avocado oil, lanolin, beef tallow, lard, egg yolk fat and other oils, benzyl alcohol, phenylethyl alcohol, cholesterol, dextrin palmitate, d-δ-tocopherol, acyl derivatives described in JP-A-62-228048, etc. Is used.

Examples of silicones include low-polymerization chain dimethylpolysiloxane, methylphenylpolysiloxane, cyclic octamethylcyclotetrasiloxane, and decamethylcyclopentasiloxane.

The surfactant is not particularly limited, but polyoxyethylene (hereinafter abbreviated as POE) hydrogenated castor oil, POE alkyl ether, POE branched alkyl ether, POE fatty acid ester, POE glycerin fatty acid ester, POE sorbitan fatty acid ester, POE
Sorbitol fatty acid ester, POE hydrogenated castor oil alkyl sulfate ester, POE alkyl sulfate ester, polyglycerin fatty acid ester, alkyl phosphate ester,
POE alkyl phosphate ester, fatty acid alkali metal salt, sorbitan fatty acid ester, glycerin fatty acid ester, alkyl polyglucoside, polyethylene glycol fatty acid ester, α-monoisostearyl glyceryl ether, stearoylmethyl taurine sodium, P
OE sodium lauryl ether phosphate, ether-modified silicone, etc. are used.

The polyhydric alcohol is not particularly limited, but includes, for example, ethylene glycol, diethylene glycol, triethylene glycol, polyethylene glycols higher than it, propylene glycol, dipropylene glycol, polypropylene glycols higher than it,
Butylene glycols such as 1,3-butylene glycol and 1,4-butylene glycol, glycerin, diglycerin, and more polyglycerins, sorbitol, mannitol, xylitol, maltitol and other sugar alcohols, glycerin ethylene oxide ( Below, EO
Abbreviated), propylene oxide (hereinafter abbreviated as PO) adduct, sugar alcohols EO and PO adducts, monosaccharides such as galactose and fructose, and EO and PO adducts thereof,
EO and PO adducts of polysaccharides such as maltose and lactose, and polyoxyethylene methyl glucoside (EO
10 or more) and the like and polyoxyalkylene alkyl glycosides.

The pH adjusting agent is not particularly limited, but metal hydroxides such as sodium hydroxide, potassium hydroxide and lithium hydroxide, triethanolamine, isopropanolamine, diisopropanolamine, urea, ε-aminocaproic acid, pyrrolidone. Examples thereof include organic acids such as sodium carboxylate, sodium hydrogen phosphate, sodium citrate, citric acid, lactic acid, succinic acid, tartaric acid, and betaines such as glycine betaine and lysine betaine.
The pH of the external preparation for skin of the present invention is preferably in the range of 4 to 10.

The external preparation for skin of the present invention can be prepared by a conventional method using the above-mentioned essential components and optional components as required, and can be liquid, lotion, essence, cream,
It can be made into various dosage forms such as an ointment.

[0020]

EFFECT OF THE INVENTION The external preparation for skin of the present invention has a good spreadability and a smooth feeling of use, an excellent moisturizing and softening effect on the stratum corneum of the skin, and an appearance which does not change with time.

[0021]

EXAMPLES The present invention will be described in more detail below by showing Examples and Comparative Examples of the present invention, but the present invention is not limited to these.

The acidic polysaccharides used in the examples are those described in JP-A-64
The acidic heteropolysaccharide derived from callus of tuberose produced according to Example 1 of JP-10997 was used. The external appearance of the skin external preparation was evaluated by the following evaluation criteria by a specialized panelist after the external storage after storage at 80 ° C. for 1 week.

[0023]

[Table 1] ○: No change ×: Browning

Example 1 A moisturizing lotion having the composition shown in Table 2 was produced by the following production method,
The appearance of each was evaluated. The results are shown in Table 2.
Shown in. Manufacturing method: 1) to 8) are added to 9) and dissolved.

[0025]

[Table 2]

As is clear from Table 2, the moisturizing lotion of the present invention did not change in appearance. Further, the moisturizing lotion of the present invention was excellent in the feeling of use and the moisturizing and softening effect.

Example 2 A moisturizing lotion having the composition shown in Table 3 was produced by the following production method,
The appearance of each was evaluated. The results are shown in Table 3.
Shown in. Manufacturing method: 1) to 8) are added to 9) and dissolved.

[0028]

[Table 3]

As is apparent from Table 3, the moisturizing lotion of the present invention did not cause any change in appearance. Further, the moisturizing lotion of the present invention was excellent in the feeling of use and the moisturizing and softening effect.

In Examples 3 to 5 below, external preparations for skin of each composition were produced by each production method. Example 3

[0031]

[Table 4] Moisturizing lotion (%) 1) Acidic polysaccharide 0.20 2) Aiota carrageenan 0.50 3) Ethanol 6.40 4) L-arginine 2.00 5) Urea 2.50 6) ε-Aminocapron Acid 0.83 7) Succinic acid 1.50 8) Glycerin 3.00 9) Methyl paraoxybenzoate 0.20 10) Purified water balance

Manufacturing method: 2) is added to purified water and dissolved by heating. After cooling to room temperature, 1), 4) to 8) are added and dissolved (water part). 9) is dissolved in 3) (alcohol part).
The alcohol part is added to the water part to obtain a moisturizing lotion.

Example 4

[0034]

Table 5 Moisturizing essence (%) 1) Acidic polysaccharide 0.20 2) Xanthan gum 0.50 3) Ethanol 6.40 4) L-Arginine 2.00 5) Urea 2.50 6) ε-Aminocaproic acid 0 .83 7) Succinic acid 1.55 8) Glycerin 12.0 9) Dipropylene glycol 3.00 10) Methyl paraoxybenzoate 0.20 11) Polyoxyethylene isocetyl ether (20E.O.) 0.30 12 ) Purified water balance

Manufacturing method: 2) is added to purified water and dissolved. After heating and melting, the mixture is cooled to room temperature (water part). 3) to 7) to 1
2) is added and dissolved (alcohol part). After adding the alcohol part to the water part, 1), 4) to 6) are added to obtain a moisturizing essence.

Example 5

[0037]

[Table 6] Moisturizing cream (%) 1) Vaseline 8.0 2) Lanolin 2.0 3) Squalene 20.0 4) Cetanol 5.0 5) Glycerin monostearate 2.0 6) Polyoxyethylene sorbitan monolaurate (20E.O.) 2.0 7) Ethylparaben 0.2 8) L-arginine 0.8 9) Acidic polysaccharide 0.05 10) Succinic acid 0.6 11) Disodium phosphate 0.86 12) Glycerin 5.0 13) 1,3-butylene glycol 5.0 14) Fragrance 15) Purified water balance

Manufacturing method: 1) to 7) and 14) are heated and dissolved,
Keep at 80 ° C. (oil layer). An oil layer is added to a solution of 8) to 13) dissolved in purified water while stirring. After the treatment with a homomixer, the mixture was rapidly cooled to obtain a moisturizing cream.

[Procedure amendment]

[Submission date] August 5, 1993

[Procedure Amendment 1]

[Document name to be amended] Statement

[Correction target item name] 0031

[Correction method] Change

[Correction content]

[0031]

[Table 4] Moisturizing lotion (%) 1) Acidic polysaccharide 0.20 2) Aiota carrageenan 0.05 3) Ethanol 6.40 4) L-arginine 2.00 5) Urea 2.50 6) ε-Aminocapron Acid 0.83 7) Succinic acid 1.50 8) Glycerin 3.00 9) Methyl paraoxybenzoate 0.20 10) Purified water balance

─────────────────────────────────────────────────── ─── Continuation of the front page (51) Int.Cl. ⁶ Identification code Office reference number FI Technical display location A61K 31/195 9454-4C 31/715 ADA 9454-4C 35/78 X 8217-4C

Claims (2)

[Claims] 1. A skin external preparation containing the following components (A) and (B); (A) a polysaccharide (B) L-arginine. 2. The polysaccharide is a genus Polyantes (Polian).
thes. 2. The plant-derived acidic heteropolysaccharide, xanthan gum, cationized cellulose, sodium hyaluronate, alginic acid, CM-chitin, carboxymethylcellulose and one or more selected from the group consisting of aiota carrageenan. Skin external preparation.