JPS6253911A - Cosmetic - Google Patents

Abstract

PURPOSE:To obtain a cosmetic having excellent effect to prevent and improve chapped skin, by compounding extract of sponge gourd and a mucopoly saccharide. CONSTITUTION:The objective cosmetic contains 0.05-5wt% mucopolysaccharide (preferably hyaluronic acid, chondroitin-4-sulfate, etc.) and >=1/500pts.(wt) of the extract of sponge gourd (based on 1pt. of the mucopolysaccharide in terms of dried solid). The extract of sponge gourd is preferably the one produced by preparing a water-based dried extract from the whole grass of sponge gourd, extracting with methanol, carrying out the partition of the extract with water- saturated butanol, concentrating the butanol layer, and dissolving the obtained extract in ethanol or hydrated ethanol. The above cosmetic may be compounded further with various conventional cosmetic additives such as polyhydric alcohol, lower alcohol, oil, surfactant, antiseptic preservative, perfume, etc.

Description

DETAILED DESCRIPTION OF THE INVENTION [Industrial Field of Application] The present invention relates to a cosmetic that is highly effective in preventing and improving rough skin.

[Prior art] Conventionally, various raw materials extracted from natural products, such as proteins,
Polysaccharides, extracted extracts, natural polymers, and the like have been incorporated into cosmetics because of their distinctive effects. However, although there has been a long-awaited desire for cosmetics that are effective in preventing and improving skin roughness, there is still not enough of them.

[Problems to be Solved by the Invention] As a result of intensive research into improving the effect of preventing rough skin and improving rough skin as described above, the present inventors have found that when loofah extract and mucopolysaccharide are used together, it is possible to prevent rough skin and improve skin roughness. They found that the improvement effect was improved and completed the present invention.

[Means for solving the interlayer point] That is, the present invention relates to a cosmetic composition characterized by blending a loofah extract and mucopolysaccharide.

Hereinafter, the configuration of the present invention will be explained in detail.

Examples of the mucopolysaccharides used in the present invention include hyaluronic acid, chondroitin-4-sulfate, chondroitin-6-sulfate, dermatan sulfate, keratan sulfate, heparin, etc., and salts thereof, and one or more types thereof are appropriately selected and blended. Preferably hyaluronic acid, chondroitin-4-sulfate, chondroitin-6
- sulfuric acid and their salts.

The blending amount is 0.001 to 15% by weight, preferably 0.01 to 10% by weight, and more preferably 0.001 to 15% by weight based on the total amount of the cosmetic.
05 to 5% by weight. If it is less than 0.001% by weight, the effect of preventing and improving rough skin will be low, and if it exceeds 15% by weight, it will be undesirable because it will cause stickiness in use.

The loofah extract used in the present invention is an extract obtained by a commonly used extraction method using water, an organic solvent, etc. In particular, it is preferable to extract the aqueous dry extract obtained from the whole loofah plant with methanol, distribute the extract in a water-saturated butanol system, concentrate the butanol layer, and dissolve the obtained extract in ethanol or aqueous ethanol. .

The amount of loofah extract blended is preferably at most 1/1000 (by weight) of the mucopolysaccharide as the dry solid content of loofah, and preferably at most 11,500 (by weight).
Less than or equal to the same amount.

In addition to the above-mentioned essential ingredients, the cosmetics of the present invention include polyhydric alcohols and lower alcohols commonly used in cosmetics.
Other components such as oils, surfactants, preservatives, disinfectants, fragrances, and drugs may be added within the range that does not impair the effects of the present invention.

Examples of polyhydric alcohols, lower alcohols, oils, and surfactants are as follows.

Polyhydric alcohols include ethylene glycol, propylene glycol, polypropylene glycol, 1.3-butylene glycol, 1.4-butylene glycol, glycerin, polyglycerin, trimethylolpropane, pentaerythritol, dipentaerythritol, trehalose, and sucrose. , maltose, lactose, cellulose, starch, D-sorbitol, D-mannite, D-mannose, D-gluconic acid, uronic acid, glucose, sorbitan, glucolactone, arbutin,
Examples include monosaccharides such as glucose phosphate, polysaccharides, and derivatives thereof.

Examples of lower alcohols include ethyl alcohol, propyl alcohol, isopropyl alcohol, and the like.

Any oil can be used as long as it is solid, pasty, or liquid at room temperature, such as jojoba oil, sesame oil, triglycerin, castor oil, avocado oil, Japanese wax, hydrogenated castor oil, beeswax, lanolin, guerilla wax, acetic acid lanolin, and carnauba wax. , POE lanolin alcohol ether, liquid paraffin, vaseline, squalane, sericin, paraffin and the like.

The surfactant is polyoxyethylene [hereinafter abbreviated as POE-], POE-branched alkyl ether such as octyldodecyl alcohol, POE-2-decyltetradecyl alcohol, POE-oleyl alcohol ether, POE
- POE-alkyl ethers such as cetyl alcohol, sorbitan esters such as sorbitan monooleate, sorbitan monoisostearate, sorbitan monolaurate, POE-sorbitan monooleate, POE-sorbitan monoisostearate, POE-sorbitan monolaurate POE-sorbitan esters such as glyceryl monooleate, glyceryl monostearate, glycerin fatty acid esters such as glyceryl monomyristate, POE-glyceryl monooleate, POE-glyceryl monostearate, POE-glyceryl monomyristate, etc. POE-glycerin fatty acid ester, POE
POs such as -dihydrocholesterol ether, POE-hydrogenated castor oil, POE-hydrogenated castor oil isostearate, etc.
E-hardened castor oil fatty acid ester, POE-alkylaryl ether such as POE-octylphenol ether, glycerol ether such as glycerol monoisostearate, glycerol monomyristate, POE-
Glycerol monoisostearate, POE-glycerol ether such as POE-glycerol monomyristate, polyglycerol such as diglyceryl monostearate, decaglyceryl decastearate, te'caglyceryl decaisostearate, diglyceryl diisostearate, etc. Nonionic surfactants such as fatty acid esters, salts of higher fatty acids such as myristic acid, stearic acid, palmitic acid, behenic acid, isostearic acid, oleic acid, potassium, sodium, jetanolamine, triethanolamine, amino acids, etc. The above alkali salts of ether carboxylic acids, salts of N-acylamino acids, N-acyl sarconate salts,
Anionic surfactants such as higher alkyl sulfonates,
Cationic surfactants such as alkylamine salts, polyamines, aminoalcohol fatty acid organosilicone resins, quaternary ammonium salts such as stearyltrimethylammonium chloride, lauryltrimethylammonium chloride, and distearyldimethylammonium chloride, betaine series, imidapurine series, and amines. Examples include amphoteric activators such as oxide type activators.

[Effects of the Invention] The cosmetic of the present invention is a cosmetic that has excellent effects on preventing and improving skin roughness by blending loofah extract and mucopolysaccharide.

[Example] Next, the present invention will be roughly described in detail with reference to Examples. Note that the present invention is not limited to this. The blending amount is in weight%.

Example 1 Lotion A, ethanol 10.0PO
E (20) 2-octyl dodecyl ether 0.7 Loofah extract* 0.003 (dry solid content) Flavor 0.1 Preservative
0.1B, glycerin
10.01.3-Butyry6 glycol 5.0 Sodium hyaluronate
0.3 Purified water
Residue *The aqueous dry extract obtained from the whole loofah plant was extracted with methanol, the extract was distributed in a water-saturated butanol system, the butanol layer was concentrated, and the resulting extract was dissolved in ethanol or aqueous ethanol. thing.

(Manufacturing method) After stirring and dissolving the alcohol phase of A and the aqueous phase of B, a lotion was obtained by adding and solubilizing phase A to phase 8.

Comparative Example 1 All the same as Example 1 except that the loofah extract was removed from Example 1.
Comparative Example 1 was obtained in the same manner as above.

Comparative Example 2 Comparative Example 2 was obtained in the same manner as in Example 1 except that sodium hyaluronate was removed.

Skin roughness prevention and skin improvement effect test A replica of the skin surface morphology of a healthy female person (face) was taken using a replica method using myristic resin and examined under a microscope (1
Observation was made at 7x magnification. In other words, rough skin evaluation 1 based on the criteria shown in Table 1 based on the condition of the skin pattern and the peeling condition of the stratum corneum.
．． The lotions obtained in Example 1, Comparative Example 1, and Comparative Example 2 were applied twice a day to the left and right half of the face of 30 people who were judged to have skin irritation of 2 (rough skin panel). Two weeks later, a replica was taken again and the condition of the skin was observed and evaluated according to the criteria in Table 1.

(Margin below) Table-1 The results are shown in Table-2.

(Margins below) Table 2 From these results, facial areas using a lotion containing loofah extract and sodium hyaluronate significantly prevented and improved rough skin compared to facial areas using other lotions. The effect was recognized.

(Left below) Example 2 Aqueous essence A, ethanol 10.0PO
E (60) Hydrogenated castor oil 0.7 Luffa extract* 0.002 (dry solid content) Bantothenyl ethyl ether 0.1 Fragrance
0.1 preservative
0.1B, glycerin
7.01.3-Butylene glycol
8.0 Sodium hyaluronate 0.
5 Purified water remainder *Example 1
Similar extraction method.

(Manufacturing method) After stirring and dissolving the alcohol phase of A and the aqueous phase of B, phase A was added to phase B and solubilized to obtain an aqueous essence.

Example 3 Aqueous essence A, ethanol 8.0POE
(20) 2-Octyldodecyl ether 0.7 Loofah extract* 0.0006 (dry solid content) Vitamin E acetate 0.01 Flavor
0.1 preservative
0.1B, glycerin
10.0 Sodium chondroitin-4-sulfate 3.0 Sodium hyaluronate 0
．． 5 Purified water remainder *Extraction method similar to Example 1.

The manufacturing method is the same as in Example 1.

Example 4 Lime 1.3 Butylene glycol 35.0 Polyethylene glycol 4000 1.0 Glycerin 2.0 Loofah extract* 0.01 (dry solid content) Squalane 20.0 Vaseline 5.0 Cetostearyl alcohol 3. 0 Polyoxyethylene (20 moles) Oleyl alcohol ether 1.5 Glyceryl monostearate 1.5 Sodium hyaluronate 0.2 Urea
2.0 Sodium lactate
2.0 Xanthan gum (Keltrol brand name) 0.05 Methyl paraben
0.1 ethylparaben
0.2 Caustic potash 0.
01E DT A-3N a
O,01 fragrance
0.2 Purified water remainder*
Extraction method similar to Example 1.

The manufacturing method is according to the conventional method.

Example 5 Emulsion 1.3 Butylene glycol 8. O Glycerin 2.0 Squalane 5.0 Vaseline
1.0 Cetostearyl alcohol 0.3 Loofah extract*
0.05 (dry solid content) Polyoxyethylene (20 mol) Oleyl alcohol ether 1.5 Glyceryl monooleate 1.5 Sodium hyaluronate 1.0 Sodium polyglutamate (average molecular weight 70,000) 0.03
Sodium polyacrylate 0.03 Ethylparaben 0.2 Sodium lactate 1.0 Caustic potash
0. IE D T A-3N
a O,03 fragrance
0.2 Purified water
Residue *Extraction method similar to Example 1.

The manufacturing method is according to the conventional method.

Example 6 Pat 1.3 Butylene glycol 10.0
Polyethylene glycol 4000 3.0 Glycerin 15.0 Ethanol 10.0 Loofah extract* 13. O (dry solid content) Polyvinyl alcohol 10.0 Olive oil 3.0 Pyrrolidone carboxylic acid 9.0 Lactic acid
1.0 Sodium chondroitin-6-sulfate 13.0 Carboxymethylcellulose 0.07 Methylparaben
0.1 ethylparaben
0.1 caustic potash
0.02EDTA-3Na
O,01 fragrance. ,
1 Purified water remainder *Extraction method similar to Example 1.

The manufacturing method is according to the conventional method.

Claims (1)

[Claims] A cosmetic comprising a loofah extract and mucopolysaccharide.