JPH05320023A - Skin cosmetic composition - Google Patents

Abstract

PURPOSE:To provide a skin cosmetic composition effective in suppressing the secretion of sebum, having excellent bactericidal effect and anti-inflammatory action and exhibiting excellent effect on seborrheic diseases caused by the promotion of sebum secretion, e.g. dermatitis. CONSTITUTION:This skin cosmetic composition contains levulinic acid or its salt, glycyrrhizic acid or its salt and resorcin or isopropylmethylphenol.

Description

Detailed Description of the Invention

[0001]

TECHNICAL FIELD The present invention contains levulinic acid or a salt thereof, glycyrrhizic acid or a salt thereof, and resorcin or isopropylmethylphenol as active ingredients, and seborrheic properties such as dermatitis caused by an increase in sebum secretion amount. The present invention relates to a skin cosmetic composition having an excellent effect on diseases, and more specifically to a skin cosmetic composition which suppresses secretion of sebum, has an excellent bactericidal effect, and has an anti-inflammatory effect.

[0002]

BACKGROUND OF THE INVENTION Acne is the most common acne vulgaris (Acne Vulgaris) among acne (acne), and is a skin disease mainly occurring in the pilosebaceous system. is there. It is generally said that the cause of acne onset is the secretion of sex hormones during puberty, and in particular male hormones affect the pilosebaceous system, enlarge the sebaceous glands, and increase sebum secretion. Therefore, indigenous bacteria proliferate in the pores of the pilosebaceous system, and P and ac
The lipase released by nes decomposes triglyceride in sebum to produce free fatty acid. The generated free fatty acid stimulates the opening of the hair follicle, resulting in thickening of the stratum corneum and obstruction of comedones. When the pores are blocked by comedones and sebum accumulates, the stimulation causes inflammation in the surrounding area. In addition, since bacteria easily proliferate in the sebum, the bacteria intensify the inflammation, resulting in small reddish lumps. This is acne papule, and if inflammation becomes stronger, cell infiltration and many white blood cells gather, and yellow pus accumulates and becomes pustule.

Conventionally, keratin exfoliants or keratin softeners such as sulfur, salicylic acid and resorcin have been used in order to open the comedone head and discharge the comedone contents.
The effect is unsatisfactory.

On the other hand, bactericides such as Irgasan DP-300 have been conventionally used for sterilization of skin resident bacteria, but no sufficient effect has been obtained. Further, in the case of acne, the amount of sebum secreted is increased by the influence of the male hormone. Therefore, it is important not only to remove the sebum on the skin surface but also to control the sebum secretion inside the skin.

The present invention has been made in view of such drawbacks of conventional products, and provides a skin cosmetic composition which suppresses secretion of sebum, has an excellent bactericidal effect, and has an anti-inflammatory effect. Has a purpose.

[0006]

The present invention is a skin cosmetic composition comprising levulinic acid or a salt thereof, glycyrrhizic acid or a salt thereof, and resorcin or isopropylmethylphenol.

Levulinic acid in the present invention is a known substance. As the salt, for example, ammonium salt,
Examples thereof include alkanolamine salts such as triethanolamine, alkali metal salts such as sodium salt and potassium salt, and alkaline earth metal salts such as calcium salt and magnesium salt.

The levulinic acid or its salt used in the present invention is
Each may be used alone or in a mixture of both. In any case, the blending amount is 0.0001-0.
04 wt% is preferable, more preferably 0.001 to
It is 0.01% by weight. If the blending amount is less than 0.0001% by weight, the sebum secretion inhibitory effect is insufficient, and if it exceeds 0.04% by weight, it may cause eye mucous membrane irritation when it gets into the eyes, which is not preferable.

Examples of glycyrrhizic acid or a salt thereof in the present invention include monoammonium glycyrrhizinate, sodium glycyrrhizinate, monopotassium glycyrrhizinate, dipotassium glycyrrhizinate, and the like.

Glycyrrhizic acid or a salt thereof used in the present invention may be used alone or as a mixture of both. In any case, the blending amount is 0.00
1 to 2.0% by weight is preferable, and 0.01 is more preferable.
Is about 1.0% by weight. If the content is less than 0.001% by weight, the anti-inflammatory effect is insufficient, and if it exceeds 2.0% by weight, it becomes difficult to obtain a uniform and stable skin cosmetic composition.

The amount of resorcin used in the present invention is
The amount is preferably 0.001 to 1.0% by weight, more preferably 0.01 to 0.5% by weight. If the compounding amount is less than 0.001% by weight, the antibacterial property is poor, and if it exceeds 1.0% by weight,
Discoloration due to exposure to sunlight is not preferable.

The amount of isopropylmethylphenol used in the present invention is preferably 0.001 to 1.0% by weight, more preferably 0.01 to 0.5% by weight. If the blending amount is less than 0.001% by weight, the antibacterial property is poor and 1.0
When the content is more than wt%, it becomes difficult to obtain a uniform and stable skin cosmetic composition.

The skin cosmetic composition of the present invention is used as an aqueous cosmetic such as skin lotion, astringent lotion, body lotion, aftershaving lotion, calamine lotion, makeup lotion, nutritional essence, gel lotion and the like. Is.

The skin cosmetic composition of the present invention contains the above-mentioned components as essential components, but other components can be appropriately added to the composition within a range that achieves the object of the present invention.

That is, anionic surfactants such as alkyl sulfate ester salts, nonionic surfactants such as fatty acid alkanol amides, polyoxyethylene alkyl ethers and alkyl amine oxides, amphoteric surfactants such as alkylamidopropyl betaine, higher alcohols, Silicone oil,
Lanolin derivatives, protein derivatives, oily components such as fatty acid esters of polyethylene glycol, water-soluble polymers such as hydroxypropylmethylcellulose and hydroxycellulose, polymers JR (manufactured by Union Carbide Corporation), polycoat NH (manufactured by Henkel), mercoat 550 (Merck), Gaff Cut 755N (GA
Company F) and other cationic polymers, glycerin, sorbitol, propylene glycol and other polyhydric alcohols, vitamins and other drugs, preservatives, other bactericides, pH adjusters,
Ultraviolet absorbers, polymer fine powders such as lecithin, gelatin and the like can be mentioned, and one or more of these can be blended.

[0016]

The present invention will be described below with reference to examples, but the present invention is not limited to these examples. The test methods used in this example are as follows.

(Measurement Method of Sebum Secretion Inhibition Rate) Panelist 20
Thoroughly wipe the sebum on the forehead of a person with absorbent cotton impregnated with 75% ethanol. Then, the skin cosmetic composition is applied, and 1 cm, 1 c after 1 hour, 2 hours and 3 hours after application.
By pressing a m-sized filter paper (Toyo Roshi No. 6) for about 30 seconds, the sebum secreted on the skin surface (recovered sebum) is adsorbed on the filter paper within this time, and 2 minutes in vapor of osmic acid. After exposing the blackened filter paper to the air for another 24 hours, the absorbance of the blackened filter paper is measured using a spectral reflectometer, and the absorbance of the filter paper that does not adsorb sebum is measured and subtracted. The ratio of the recovered sebum amount of the sample to the saturated sebum amount is obtained from the absorbance, with the recovered sebum amount after 4 hours of the blank being the saturated sebum amount, and the sebum secretion suppression rate is calculated by the following formula. Sebum secretion suppression rate (%) = 100−A / B × 100 A = Absorbance calculated from filter paper on which recovered sebum is adsorbed B = Absorbance calculated from filter paper on which saturated sebum is adsorbed

(Practical Test: Degree of Improvement of Symptoms) Twenty panelists with seborrheic dermatitis evaluated the skin cosmetic composition according to the following criteria after continuously using it for two weeks. Evaluation symbol Evaluation criteria ◎ ………… When there are 18 or more people who answered that the degree of improvement in symptoms was “lightening” ○ …… When there were 14 to 17 people who answered that the degree of improvement in symptoms was “lightening” △ …… When 8 to 13 people answered that the degree of improvement in symptoms was "easy" × ... When there were less than 7 people who answered that the degree of improvement in symptoms was "easy"

(Practical test: eye mucous membrane irritation) 20 women (specialist panelists) evaluated the skin cosmetic composition according to the following evaluation criteria after continuously using it for 1 week. Evaluation symbol Evaluation criteria ◎ ………… When there are 18 or more people who answered that there was no "eye mucous membrane irritation" ○ When there were 14 to 17 people who answered that there was no "eye mucous membrane irritation" △ …… "Eyes 8 to 13 people answered that there was no "mucosal irritation" × ... 7 people or less who answered that there was no "mucosal irritation"

(Light resistance test) 2 in direct sunlight during spring sunny weather
Irradiation was carried out for a day, and the degree of browning was visually observed. The evaluation points are as follows, but as a standard, a skin cosmetic composition (uncolored product), which was produced as a sample at the same time as the sample and stored in a cool dark place, was used.

Examples 1 to 9 and Comparative Examples 1 to 3 Skin cosmetic compositions having the composition shown in Table 1 were prepared by the usual method, the above test was carried out, and the results are shown in Table 2.

[0022]

[Table 1]

[0023]

[Table 2]

As is clear from Examples 1 to 9, the skin cosmetic compositions of the present invention all showed excellent performance.
On the other hand, when levulinic acid or a salt thereof which is an essential component is deficient, when glycyrrhizic acid or a salt thereof is deficient, a comparative example lacking either resorcinol or isopropylmethylphenol shows inferior performance. The purpose of the invention could not be achieved.

[0025]

EFFECTS OF THE INVENTION As described above, the skin cosmetic of the present invention suppresses the secretion of sebum, has an excellent bactericidal effect, has an anti-inflammatory effect, and exhibits an excellent effect on seborrheic diseases such as dermatitis. It is clear to provide a composition.

Claims (1)

[Claims] 1. A skin cosmetic composition comprising levulinic acid or a salt thereof, glycyrrhizic acid or a salt thereof, and resorcin or isopropylmethylphenol.