JP3411146B2 - Body odor generation inhibitor - Google Patents

Description

Detailed Description of the Invention

[0001]

BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to a body odor generation inhibitor useful for suppressing body odor, and a cosmetic containing the same for body odor suppression.

[0002]

2. Description of the Related Art In cosmetics, especially body cosmetics and hair cosmetics, it is important to suppress the generation of body odors such as hair odors and armpits. Since Japanese originally had a simple diet, and did not ingest foods such as dairy products that promote the generation of body odor, it is necessary to be careful about the generation of body odor. However, in recent years, generation of body odor has become a serious problem due to westernization of eating habits and rapid increase in intake of dairy products.

For such body odor, conventionally, antibacterial components such as zinc pyrithione and irgasan have been blended to suppress the growth of microorganisms, which are considered to be the source of body odor, and the generated body odor such as silica gel and talc. , Etc. have been developed by which the adsorbent of (3) suppresses the adsorption and diffusion. However, even if microorganisms are one of the causes of body odor, suppression of microorganisms is not a fundamental solution to the suppression of body odor, and in addition, few antibacterial components have safety problems. There wasn't. Also, the suppression of the diffusion of body odor could not be a fundamental solution as a matter of course.

On the other hand, ester hydrolysis inhibition shown in group A below
It was not known at all that the antibacterial agent had a body odor suppressing effect.

[0005]

SUMMARY OF THE INVENTION The present invention has been made in view of such circumstances, and an object thereof is to provide an effective body odor generation inhibitor .

[0006]

[Means for Solving the Problems] In view of such a situation,
The present inventors have earnestly sought for a mechanism useful for suppressing body odor, and as a result, ester hydrolysis of group A shown below.
The inventors have found that the inhibitor is excellent in such action and completed the invention. These components have the action of suppressing the generation of body odor by suppressing the generation of free fatty acids derived from hydrolysis of esters, which cause body odor such as hair odor as described below. (A) Benzyl alcohol, benzyl acetate, syn
Namyl acetate, Nellore, cinnamon alcohol, Citro
Nellore, phenylethyl alcohol

(1) Body Odor Control Agent of the Present Invention The body odor control agent of the present invention is an ester shown in the above group A.
It consists of a hydrolysis inhibitor . These ester hydrolysis inhibitors
All of the agents are widely used as perfume ingredients, and there is no problem in safety in cosmetics. In addition, as shown in the Examples below, these are the generation of free fatty acids that cause excellent body odor.
It has the effect of suppressing rawness and suppressing the generation of body odor. All of these ester hydrolysis inhibitors of the present invention are commercially available and there is no problem in obtaining them. Inhibition of ester hydrolysis of the present invention
As the agent , only one kind may be used, or two or more kinds may be used.

(2) Relationship between ester hydrolysis and body odor The present inventors searched for a material that suppresses body odor, and screened a material that does not easily produce body odor using 10 panelists who easily produce body odor. It was As a result, they have found that benzyl alcohol is excellent in such action. Therefore, to investigate the mechanism, we investigated how scalp secretions differ depending on the presence or absence of benzyl alcohol using gas chromatography. As a result, it was confirmed that the presence of benzyl alcohol significantly suppressed the production of fatty acids. Table 1 shows the status of fatty acid generation based on the peak shape. Here, the criterion is ++: remarkable suppression, +: clear suppression,
±: Slight suppression, no suppression or accelerated generation:-was used. This is because it was difficult to quantify the amount of fatty acid generated per se due to changes in the types of fatty acids and peak shapes. On the other hand, the generation status of body odor is as shown in Table 2, and it can be seen that it correlates well with the results in Table 1. The evaluation criteria are: ++: Remarkably suppressed body odor generation, +: Clear body odor generation, ±: Slight body odor generation,-: No body odor generation suppression or body odor generation promotion. From these results, it was speculated that the cause of body odor was the generation of fatty acids due to hydrolysis of ester and especially triglyceride. Also, focusing on the peak of benzyl alcohol itself, it was seen that the peak was relatively decreased after administration as compared with that before administration. Also, some new peaks were observed when benzyl alcohol was present. It was speculated that this was an ester in which a fatty acid generated by hydrolysis of triglyceride and benzyl alcohol were bonded.

[0009]

[Table 1]

[0010]

[Table 2]

Next, the inventors of the present invention considered what caused the hydrolysis of the ester, which is the cause of body odor and hair odor, and thought of esterases such as lipase on the skin, and conducted a model experiment. . That is, to an equal mixture of squalene, cholesterol, glyceryl trioleate and glyceryl tristearate, 0.001% of lipase derived from porcine pancreas was added, and 1% by weight of the test substance was further added to the mixture at 37 ° C. After incubation for one day, four perfumers were asked to judge the similarity with the odor of hair. The control was performed without adding the test substance. The results show that for odors, for control sample odors,
It was said that all four had a very similar odor to hair.
In addition, this odor was not observed in the system containing vanzyl alcohol. Therefore, using the above-mentioned mixed system as a model of the generation of body odor, the degree of ester hydrolysis was used as an index, and a substance that suppresses this was screened. As a result, as shown in the following examples, the above-mentioned group A substances were found. I arrived. It was found that these substances are excellent in the action of suppressing the hydrolysis of the ester and preventing the generation of body odor such as hair odor, as shown in Examples below. From this, it is understood that the generation of body odor and the hydrolysis of the ester caused by the action of esterase represented by lipase are very closely related.

[0012]

BEST MODE FOR CARRYING OUT THE INVENTION An embodiment of the present invention is a cosmetic characterized in that it contains one or more selected from the body odor generation inhibitors listed in Group A above. The cosmetic of the present invention exerts an excellent effect when used for the purpose of suppressing body odor and especially suppressing hair odor. The preferable content of the body odor generation inhibitor in the cosmetic of the present invention is 0.01 to 1
0% by weight, more preferably 0.05 to 7% by weight
And more preferably 0.05 to 5% by weight.
These can be blended in the cosmetic by a usual method. The cosmetics of the present invention include hair cream,
Hair tonic, shampoo, conditioner, treatment,
Hair oils and other cosmetics for hair and body massages, body lotions, body powders, body cleansings and other body cosmetics are preferred, and hair cosmetics are particularly preferred. The cosmetics of the present invention may contain any components commonly used in cosmetics other than the ester hydrolysis inhibitor. Such optional components include, for example, hydrocarbons such as petrolatum and microcrystalline wax, esters such as jojoba oil and gallow, beef tallow, triglycerides such as olive oil, cetanol, higher alcohols such as oleyl alcohol, Fatty acids such as stearic acid and oleic acid, polyhydric alcohols such as glycerin and 1,3-butanediol,
Nonionic surfactants, anionic surfactants, cationic surfactants, amphoteric surfactants, thickeners such as ethanol and carbopol, preservatives, ultraviolet absorbers, antioxidants, pigments,
Examples include fragrances and powders. Further, a deodorant material such as an antibacterial agent may be added. Hereinafter, embodiments of the present invention will be described in more detail with reference to examples.

Example 1 Hair Tonic A hair tonic was prepared according to the following formulation. That is, the formulation components were stirred and solubilized at room temperature to obtain a hair tonic. Ethanol 60 parts by weight Menthol 0.1 parts by weight Benzyl alcohol 0.1 parts by weight Capsicum tincture 0.1 parts by weight POE (60) hydrogenated castor oil 0.1 parts by weight Vitamin E nicotinate 0.1 parts by weight water 39.5 parts by weight

Example 2 Hair Tonic A hair tonic was prepared according to the following formulation. That is, the formulation components were stirred and solubilized at room temperature to obtain a hair tonic. Ethanol 60 parts by weight Menthol 0.1 parts by weight Cinnamon alcohol 0.1 parts by weight Capsicum tincture 0.1 parts by weight POE (60) hydrogenated castor oil 0.1 parts by weight Vitamin E nicotinate 0.1 parts by weight water 39.5 parts by weight

Example 3 Hair Tonic A hair tonic was prepared according to the following formulation. That is, the formulation components were stirred and solubilized at room temperature to obtain a hair tonic. Ethanol 60 parts by weight Menthol 0.1 parts by weight Benzyl acetate 0.1 parts by weight Capsicum tincture 0.1 parts by weight POE (60) hydrogenated castor oil 0.1 parts by weight Vitamin E nicotinate 0.1 parts by weight water 39.5 parts by weight

Example 4 Shampoo A shampoo was prepared according to the following formulation. That is, the prescription ingredients were stirred and solubilized at room temperature to obtain a shampoo. Sodium lauryl sulfate 10 parts by weight POE (20) Sodium lauryl sulfate 10 parts by weight Propylene glycol 10 parts by weight Cinnamyl acetate 0.1 parts by weight Citronellol 0.5 parts by weight Geraniol 0.5 parts by weight Nellore 0.1 parts by weight Nonyl acetate 0 .1 part by weight water 68.7 parts by weight

Example 5 Body Shampoo A body shampoo was prepared according to the following formulation. That is, the formulation ingredients were stirred and solubilized at room temperature to obtain a body shampoo. Sodium lauryl sulfate 10 parts by weight Triethanolamine laurate 10 parts by weight Propylene glycol 10 parts by weight Phenylethyl alcohol 0.1 parts by weight Phenylpropyl alcohol 0.5 parts by weight Chamomile oil 0.5 parts by weight Rosed May oil 0.1 parts by weight Geranyl acetate 0.1 part by weight water 68.7 parts by weight

(Example 6) Body powder The following ingredients were mixed in a Henschel mixer, pulverized with a pulverizer equipped with a 1 mm round hole screen, packed in a gold plate and pressure-molded to obtain a body powder. Squalane 5 parts by weight Talc 48.3 parts by weight Sericite 30 parts by weight Mica 15 parts by weight Benzyl alcohol 0.5 parts by weight Citronellyl acetate 0.1 parts by weight Phenylethyl acetate 0.1 parts by weight

(Example 7) Lotion A lotion was prepared according to the following formulation. That is, the formulation ingredients were stirred and solubilized at room temperature to obtain a lotion. Glycerin 5 parts by weight 1,3-butanediol 8 parts by weight Methylparaben 0.2 parts by weight Ethanol 10 parts by weight Cinnamaldehyde 0.2 parts by weight Water 76.5 parts by weight Sodium hyaluronate 0.1 parts by weight

[0020]

EXAMPLES The effects of the present invention will be described in detail below with reference to examples.

Example 1 Release of fatty acid and generation of body odor by hydrolysis of ester The mixture of the following formulation was incubated at 37 ° C. for 1 day and then subjected to gas chromatography (column: HP-5, 15).
m × 0.25 mm, manufactured by Hewlett Packard; carrier gas: helium; flow rate: 1.0 ml / min; oven temperature: 150 → 320 ° C. (8 ° C./min); inlet temperature: 320 ° C., detector temperature: 330 ° C .;
Detection: FID) to measure the amount of ester and free fatty acid,
After that, the perfumer judged the intensity of body odor. As the control, liquid paraffin was used as the body odor generation inhibitor. The results are shown in Table 3. From this, it is understood that the body odor generation inhibitor of the present invention suppresses the hydrolysis of the ester and the free fatty acid is suppressed.
Further, it is understood that the generation of body odor is suppressed in proportion to this. (Sample prescription) Squalane 25 parts by weight Cholesterol 25 parts by weight Glyceryl trioleate 25 parts by weight Glyceryl tristearate 25 parts by weight Lipase (from pig pancreas) 0.001 parts by weight Body odor suppressant 1 part by weight (of residual amount of ester) criterion; compared to controls) ++: remaining amount is very large, +: remaining amount is clearly greater, ±: remaining amount slightly more, -: not different from controls (criteria of free fatty acids; the control ++: Very low amount of fatty acid, +: Clearly low amount of fatty acid, ±: Moderate low amount of fatty acid, −: Same as control (occurrence of body odor-like odor; compared with control) ++: Very few, +: Remarkably less, ±: Somewhat less,-: Same as control

[0022]

[Table 3]

Example 2 Sensory Test For the cosmetics of Examples 1 to 7 of the embodiment of the invention, Comparative Examples 1 to 7 in which these body odor suppressors and inhibitors were replaced with water were designated by 5 specialized panelists. It was used once a week to evaluate the suppression of body odor generation. The results are shown in Table 4. From this, it can be seen that the cosmetic containing the body odor suppressor of the present invention suppresses body odor generation.

[0024]

[Table 4]

[0025]

The body odor suppressor of the present invention is a fatty acid produced by ester hydrolysis, which is a cause of body odor.
Since it has an excellent effect of suppressing the liberation of lactic acid, a cosmetic containing the same has an excellent effect of suppressing body odor.

─────────────────────────────────────────────────── ─── Continuation of the front page (51) Int.Cl. ⁷ Identification code FI A61K 7/075 A61K 7/075 7/50 7/50 (72) Inventor Toyomasa Ishitoya 27 Takashimadai, Kanagawa-ku, Yokohama, Kanagawa Prefecture 1 Pola Chemical Industry Co., Ltd. Yokohama Laboratory (56) Reference JP-A-6-253924 (JP, A) JP-A-5-255689 (JP, A) JP-A-6-179610 (JP, A) JP Flat 9-187297 (JP, A) Special table Flat 11-512132 (JP, A) (58) Fields surveyed (Int.Cl. ⁷ , DB name) A61K 7/32 A61K 7/00 A61K 7/06 A61K 7 / 075 A61K 7/50 CA (STN)

Claims (2)

(57) [Claims] 1. Benzyl alcohol, benzyl acetate
Tomato, cinnamyl acetate, nerol, cinnamon alcohol
From citronellol and phenylethyl alcohol
At least one ester hydrolysis inhibitor selected
A body odor generation inhibitor consisting of . 2. A method according to claim 1 body odor is hair odor or Wakiga
The body odor generation inhibitor described.