JPH09194340A - Agent for inhibiting hydrolysis of ester and cosmetic containing the same - Google Patents

Abstract

PROBLEM TO BE SOLVED: To obtain an ester hydrolysis-inhibiting agent, containing a perfume ingradient and capable of inhibiting the release of fatty acids to prevent the body odor, wherein the fatty acids are produced by the hydrolysis of esters and cause the body odor. SOLUTION: This agent for inhibiting the hydrolysis of esters contains one or more kinds of perfume ingredients selected from benzaldehyde, benzyl benzoate, cinnamic aldehyde, ethyl vanillin, phenyl acetate, eugenol acetate, galaxolide, eugenol, hexylcinnamic aldehyde, geranyl formate, iso E super, musk ketone, methyl jasmonate. santalex, santalol, vanillin, vanillal, pennyroyal oil, birch oil and armoise oil in an amount of 0.01-10wt.%. The object of the agent is to prevent the generation of hair odor or body odor, and the agent is used for preparing hair cosmetics such as hair tonics and shampoos and body cosmetics such as body shampoos and body powders.

Description

Detailed Description of the Invention

[0001]

TECHNICAL FIELD The present invention relates to an ester hydrolysis inhibitor useful for suppressing body odor and a cosmetic containing the same for suppressing body odor.

[0002]

2. Description of the Related Art In cosmetics, especially body cosmetics and hair cosmetics, it is important to suppress the generation of body odors such as hair odors and armpits. Since the Japanese originally had a simple diet, and did not ingest foods such as dairy products that promote the production of body odor, it is not necessary to pay attention to the generation of body odor. Although the number was small, the generation of body odor has become a serious problem in recent years due to westernization of eating habits and a rapid increase in the intake of dairy products.

For such body odor, conventionally, antibacterial components such as zinc pyrithione and irgasan have been blended to suppress the growth of microorganisms, which are considered to be the source of body odor, and the generated body odor such as silica gel and talc. , Etc. have been developed by which the adsorbent of (3) suppresses the adsorption and diffusion. However, even if microorganisms are one of the causes of body odor, suppression of microorganisms is not a fundamental solution to the suppression of body odor, and in addition, few antibacterial components have safety problems. There wasn't. Also, the suppression of the diffusion of body odor could not be a fundamental solution as a matter of course.

On the other hand, it has not been known at all that the aroma component has an ester hydrolysis suppressing action, and that the ester hydrolysis suppressing action can suppress body odor.

[0005]

SUMMARY OF THE INVENTION The present invention has been made in view of such circumstances, and an object thereof is to provide an effective material for suppressing body odor.

[0006]

In view of such a situation,
The present inventors have made intensive efforts in search of a mechanism useful for suppressing body odor, and as a result, have found that ester hydrolysis suppression is such a mechanism. As a result of further studies, the inventors found that the following fragrance components of group A are excellent in such action and completed the invention. (A) benzaldehyde, benzyl benzoate, cinnamic aldehyde, ethyl vanillin, phenylacetic acid,
Eugenol acetate, galaxolide, eugenol,
Hexyl cinnamic aldehyde, geranyl formate, iso-E super, musk ketone, methyl jasmonate, Santarex, Sandalore, vanillin, vanillar, peniroyal oil, birch oil, alumoise oil

(1) Ester Hydrolysis Inhibitor of the Present Invention The ester hydrolysis inhibitor of the present invention comprises the aroma components shown in the above-mentioned group A. All of these fragrance components are widely used as fragrance components, and there is no problem in safety in cosmetics. Further, as shown in Examples below, they have an excellent ester hydrolysis inhibitory action, and therefore, the hydrolysis of triglyceride and the like due to the action of esterases such as lipase, which is the fundamental cause of body odor and especially hair odor. Suppresses the generation of fatty acids. All of the fragrance components of the present invention are commercially available and there is no problem in obtaining them. The fragrance component of the present invention may be used alone or in combination of two or more.

(2) Relationship between ester hydrolysis and body odor The present inventors searched for a material that suppresses body odor, and screened a material that does not easily produce body odor using 10 panelists who easily produce body odor. It was As a result, they have found that benzaldehyde is excellent in such action.
Therefore, to investigate the mechanism, we examined how scalp secretion differs depending on the presence or absence of benzaldehyde using gas chromatography. As a result, it was confirmed that the presence of benzaldehyde significantly suppressed the production of fatty acids. Table 1 shows the status of fatty acid generation based on the peak shape. Here, the criteria used were ++: remarkable suppression, +: clear suppression, ±: slight suppression, no suppression or generation promotion:-. This is because it was difficult to quantify the amount of fatty acid generated per se due to changes in the types of fatty acids and peak shapes. On the other hand, the generation status of body odor is as shown in Table 2, and it can be seen that it correlates well with the results in Table 1. This evaluation standard is +
+: Significant body odor generation suppression, +: Clear body odor generation suppression, ±: Slight body odor generation suppression,-: Body odor generation suppression or no body odor generation promotion. From these results, it was speculated that the cause of body odor was the generation of fatty acids due to hydrolysis of ester and especially triglyceride.

[0009]

[Table 1]

[0010]

[Table 2]

Next, the inventors of the present invention considered what caused the hydrolysis of the ester, which is the cause of body odor and hair odor, and thought of esterases such as lipase on the skin, and conducted a model experiment. . That is, to an equal mixture of squalene, cholesterol, glyceryl trioleate and glyceryl tristearate, 0.001% of lipase derived from porcine pancreas was added, and 1% by weight of the test substance was further added to the mixture at 37 ° C. After incubating for one day, four perfumers judged the smell. As a control, a test substance-free one was used. The odor of the control after incubation was said to be very similar to the odor of hair in all four cases. Therefore, using the above-mentioned mixed system as a model of the generation of body odor, the degree of ester hydrolysis was used as an index, and a substance that suppresses this was screened. As a result, as shown in the following examples, the above-mentioned group A substances were found. I arrived. It was found that these substances are excellent in the action of suppressing the hydrolysis of the ester and preventing the generation of body odor such as hair odor, as shown in Examples below. From this, it is understood that the generation of body odor and the hydrolysis of the ester caused by the action of esterase represented by lipase are very closely related.

[0012]

BEST MODE FOR CARRYING OUT THE INVENTION An embodiment of the present invention is a cosmetic characterized in that it contains one or more selected from the ester hydrolysis inhibitors listed in Group A above. The cosmetic of the present invention exerts an excellent effect when used for the purpose of suppressing body odor and especially suppressing hair odor. The preferred content of the ester hydrolysis inhibitor in the cosmetic of the present invention is 0.01 to 10% by weight, more preferably
0.05 to 7% by weight, more preferably 0.05
~ 5% by weight. These can be blended in the cosmetic by a usual method. As the cosmetics of the present invention, cosmetics for hair such as hair creams, hair tonics, shampoos, rinses, treatments, hair oils and the like, and body massages such as body massages, body lotions, body powders and body cleansing are preferable. Of these, cosmetics for hair are preferable. The cosmetics of the present invention may contain any components commonly used in cosmetics other than the ester hydrolysis inhibitor. Examples of such optional components include hydrocarbons such as petrolatum and microcrystalline wax,
Esters such as jojoba oil and gallow, triglycerides such as beef tallow and olive oil, higher alcohols such as cetanol and oleyl alcohol, fatty acids such as stearic acid and oleic acid, and polyhydric alcohols such as glycerin and 1,3-butanediol. , Nonionic surfactants, anionic surfactants, cationic surfactants, amphoteric surfactants, thickeners such as ethanol and carbopol, preservatives, UV absorbers, antioxidants, pigments, fragrances, powders Etc. Further, a deodorant material such as an antibacterial agent may be added. Hereinafter, embodiments of the present invention will be described in more detail with reference to examples.

Example 1 Hair Tonic A hair tonic was prepared according to the following formulation. That is, the formulation components were stirred and solubilized at room temperature to obtain a hair tonic. Ethanol 60 parts by weight Menthol 0.1 parts by weight Benzaldehyde 0.1 parts by weight Capsicum tincture 0.1 parts by weight POE (60) hydrogenated castor oil 0.1 parts by weight Vitamin E nicotinate 0.1 parts by weight water 39.5 parts by weight

Example 2 Hair Tonic A hair tonic was prepared according to the following formulation. That is, the formulation components were stirred and solubilized at room temperature to obtain a hair tonic. Ethanol 60 parts by weight Menthol 0.1 parts by weight Cinnamaldehyde 0.1 parts by weight Capsicum tincture 0.1 parts by weight POE (60) hydrogenated castor oil 0.1 parts by weight Vitamin E nicotinate 0.1 parts by weight water 39.5 parts by weight

Example 3 Hair Tonic A hair tonic was prepared according to the following formulation. That is, the formulation components were stirred and solubilized at room temperature to obtain a hair tonic. Ethanol 60 parts by weight Menthol 0.1 parts by weight Phenylacetic acid 0.1 parts by weight Capsicum tincture 0.1 parts by weight POE (60) hydrogenated castor oil 0.1 parts by weight Vitamin E nicotinate 0.1 parts by weight water 39.5 parts by weight

Example 4 Shampoo A shampoo was prepared according to the following formulation. That is, the prescription ingredients were stirred and solubilized at room temperature to obtain a shampoo. Sodium lauryl sulfate 10 parts by weight POE (20) Sodium lauryl sulfate 10 parts by weight Propylene glycol 10 parts by weight Eugenol 0.1 parts by weight Geranyl formate 0.5 parts by weight Santarex 0.5 parts by weight Vanillin 0.1 parts by weight Vanillar 0 1 part by weight water 68.7 parts by weight

Example 5 Body Shampoo A body shampoo was prepared according to the following formulation. That is, the formulation ingredients were stirred and solubilized at room temperature to obtain a body shampoo. Sodium lauryl sulfate 10 parts by weight Triethanolamine laurate 10 parts by weight Propylene glycol 10 parts by weight Phenylacetic acid 0.1 parts by weight Benzaldehyde 0.5 parts by weight Santarex 0.5 parts by weight Vanillin 0.1 parts by weight Vanillal 0.1 parts by weight Part water 68.7 parts by weight

Example 6 Body Powder The following ingredients were mixed with a Henschel mixer, pulverized with a pulverizer equipped with a 1 mm round hole screen, filled in a gold plate and pressure-molded to obtain a body powder. Squalane 5 parts by weight Talc 49.5 parts by weight Sericite 30 parts by weight Mica 15 parts by weight Benzaldehyde 0.5 parts by weight

(Example 7) Lotion A lotion was prepared according to the following formulation. That is, the formulation ingredients were stirred and solubilized at room temperature to obtain a lotion. Glycerin 5 parts by weight 1,3-butanediol 8 parts by weight Methylparaben 0.2 parts by weight Ethanol 10 parts by weight Cinnamaldehyde 0.2 parts by weight Water 76.5 parts by weight Sodium hyaluronate 0.1 parts by weight

[0020]

EXAMPLES The effects of the present invention will be described in detail below with reference to examples.

Example 1 Inhibition of ester hydrolysis and generation of odor for body odor After incubating a mixture of the following formulations at 37 ° C. for 1 day, gas chromatography (column: HP-5, 15)
m × 0.25 mm, manufactured by Hewlett Packard; carrier gas: helium; flow rate: 1.0 ml / min; oven temperature: 150 → 320 ° C. (8 ° C./min); inlet temperature: 320 ° C., detector temperature: 330 ° C .;
Detection: FID) to measure the amount of ester and free fatty acid,
After that, the perfumer judged the intensity of body odor. The control used was one in which the ester hydrolysis inhibitor was replaced with liquid paraffin. The results are shown in Table 3. From this, it is understood that the ester hydrolysis inhibitor of the present invention suppresses the hydrolysis of the ester and the amount of free fatty acid is suppressed. Further, it is understood that the generation of body odor is suppressed in proportion to this. (Sample prescription) Squalane 25 parts by weight Cholesterol 25 parts by weight Glyceryl trioleate 25 parts by weight Glyceryl tristearate 25 parts by weight Lipase (from pig pancreas) 0.001 parts by weight Ester hydrolysis inhibitor 1 part by weight (residual amount of ester ): Compared with the control)) ++: Very large residual amount, +: Clearly large residual amount, ±: Slightly large residual amount, −: Same as control (standard for determining free fatty acid) ; Compared to the control) ++: Very little fatty acid, +: Clearly small amount of fatty acid, ±: Slightly small amount of fatty acid, −: Same as control (generation of body odor, compared to control ) ++: Very low, +: Clearly low, ±: Slightly low, −: Same as control

[0022]

[Table 3]

Example 2 Sensory test Comparative examples 1 to 7 in which the ester hydrolysis inhibitors were replaced with water in the cosmetics of examples 1 to 7 of the embodiment of the invention were given to 5 specialized panelists. They were used weekly to evaluate the suppression of the generation of body odor. The results are shown in Table 4. From this, it can be seen that the cosmetic containing the ester hydrolysis inhibitor of the present invention suppresses the generation of body odor.

[0024]

[Table 4]

[0025]

EFFECT OF THE INVENTION Since the ester hydrolysis inhibitor of the present invention has an excellent effect of suppressing ester hydrolysis, which is a cause of the generation of body odor, cosmetics containing the same have an excellent effect of suppressing body odor.

─────────────────────────────────────────────────── ─── Continuation of the front page (51) Int.Cl. ⁶ Identification code Internal reference number FI technical display location A61K 7/075 A61K 7/075

Claims (4)

[Claims] 1. An ester hydrolysis inhibitor comprising an aroma component selected from the following group A: (A) benzaldehyde, benzyl benzoate, cinnamic aldehyde, ethyl vanillin, phenylacetic acid,
Eugenol acetate, galaxolide, eugenol,
Hexyl cinnamic aldehyde, geranyl formate, iso-E super, musk ketone, methyl jasmonate, Santarex, Sandalore, vanillin, vanillar, peniroyal oil, birch oil, alumoise oil 2. A cosmetic composition for suppressing body odor, which comprises one or more selected from the ester hydrolysis inhibitors according to claim 1. 3. The cosmetic according to claim 2, wherein the body odor is hair odor or armpit. 4. The cosmetic according to claim 2, wherein the content of the ester hydrolysis inhibitor according to claim 1 is 0.01 to 10% by weight.