JPH07215848A - Skin external agent and skin cosmetic - Google Patents

Abstract

PURPOSE:To obtain a skin external agent and a skin cosmetic capable of imparting skin with refreshing feeling by compounding an anti-inflammatory analgesic agent with a perfume. CONSTITUTION:This skin external agent for an inflammatory and analgesic treatment or a skin cosmetic for imparting the skin with refreshing feeling is composed of an antiflammatory analgesic compound (e.g. methyl salicylate), a surfactant, an absorbefacient, a local irritant, a pH-adjuster, an antiseptic, a perfume, purified water, etc. As the perfume component in these products, a perfumery material of a musk group, a citrus group or a floral group is compounded. Antiinflammatory and analgesic feeling and refreshing feeling are effectively appear in an atmosphere of flavor. In these products, the menthol- like odor which is common in a conventional skin external agent and a skin cosmetic containing a local irritant, e.g. 1-menthol, a peppermint oil, capsaicin or camphor is not persistent for a long time. When applied on the skin, a mint odor appears initially but the odor of the composing perfume prevails after a few minutes.

Description

Detailed Description of the Invention

[0001]

FIELD OF THE INVENTION The present invention relates to a skin external preparation and a skin cosmetic.

[0002]

2. Description of the Related Art Conventionally, there have been external skin preparations and skin cosmetics which use topical stimulants such as l-menthol, peppermint oil, capsaicin, camphor and the like for the purpose of anti-inflammatory and analgesia or to obtain a refreshing feeling of the skin. However, they have a strong peppermint odor that irritates the nose, and also have the purpose of helping antiphlogistic / analgesic as a local stimulant or the purpose of absorption promoter, etc. It was an essential material for skin cosmetics for the purpose of giving a refreshing feeling to the skin.

[0003]

The topical stimulants such as l-menthol, peppermint oil, capsaicin, camphor and the like have a strong effect of promoting absorption on the skin and are useful in that the active ingredient of the anti-inflammatory analgesic can reach the subcutaneous tissue. In the skin external preparation for the purpose of anti-inflammatory analgesia due to its action, the anti-inflammatory analgesic effect can be expected quickly, and in the skin cosmetic for the purpose of giving a refreshing feeling to the skin, suppressing hot flashes of the skin,
It has the effect of tightening the skin, etc., and it was an essential ingredient for external skin preparations for anti-inflammatory and analgesic purposes, skin cosmetics for the purpose of giving a refreshing feeling to the skin, etc. There were problems such as irritation, and as an effect on humans, there were times when it passed the refreshing feeling and gave an unpleasant feeling.

[0004] However, even if it is said that it has a strong odor, it is the main ingredient even when considering skin external preparations for the purpose of anti-inflammatory and analgesia and skin cosmetics for the purpose of giving a refreshing feeling to the skin without using these absorption promoters. It is expected that the action of anti-inflammatory analgesics cannot be fully performed.

Further, the influence of odor on humans is also a big problem, and as a conventional effect of mint smell equal anti-inflammatory and analgesic effect, or the effect of tightening the skin, suppressing hot flash of the skin, etc.,
There is even a feeling that this is a common wisdom. This means that peppermint odor is an indispensable raw material for external skin preparations for anti-inflammatory and analgesic purposes, and skin cosmetics for the purpose of giving a refreshing feeling to the skin.Considerations such as cost and ease of handling. Then it was difficult to refrain from using it.

[0006]

SUMMARY OF THE INVENTION In view of such circumstances, the present inventor has conducted earnest research and, as a result, has produced a method for solving the above-mentioned problems. That is, the present invention is an anti-inflammatory analgesic compound,
A skin external preparation for the purpose of anti-inflammatory and analgesia consisting of a surfactant, an absorption promoter, a local stimulant, a pH adjuster, an antiseptic, a fragrance, purified water, etc., and a skin cosmetic for the purpose of giving a refreshing feeling to the skin. The feature of the present invention will be described in detail with reference to the invention. Preferably, a fragrance of perfume, for example, a musk-based, citrus-based, or floral-based fragrance is used to start the use of the product of the present invention. It emits the scent of l-menthol, camphor, peppermint oil, nonyl acid vanillyl amide, capsaicin, etc., which are blended as a topical stimulant, but a scent of a fragrance that imitates the scent of the perfume of the previous period after one, two or a few minutes. And the scent of the local stimulant disappears. That is, the fragrance of the fragrance imitating the scent of perfume can be maintained without impairing the mint smell that is often present in the external skin preparations for the purpose of anti-inflammatory and analgesia and the skin cosmetics for the purpose of giving the skin a refreshing feeling.

Examples of the anti-inflammatory and analgesic compounds used in the present invention include methyl salicylate, phenyl salicylate, ethylene glycol salicylate and the like, and the compounding amount thereof is 0.1 to 10.0% by weight, preferably 1.0 to 8.
It can be 0% by weight, most preferably 3.0 to 6.0% by weight. In addition to these active ingredient bases, local stimulants include l-menthol, camphor, peppermint oil, nonyl acid vanillyl amide, capsaicin and the like, and these are compounded in amounts of 0.1 to 8.0% by weight, preferably 0.5 to
It can be 5.0% by weight, most preferably 1.0-4.0% by weight. Examples of the absorption enhancer include benzyl alcohol and crotamiton. These absorption enhancers may be contained in an amount of 1 to 25% by weight, preferably 1 to 15% by weight, and most preferably 1 to 10% by weight. is there.

As the surfactant, any of positive ion, negative ion, amphoteric ion and nonionic surfactant may be used, but it is more preferable to use nonionic surfactant. Examples of nonionic surfactants include sorbitan fatty acid ester, glycerin fatty acid ester, polyglycerin fatty acid ester, polyoxyethylene sorbitan fatty acid ester, polyoxyethylene sorbit fatty acid ester, polyoxyethylene glycol fatty acid ester, and polyoxyethylene cured castor. Examples thereof include oil, polyoxyethylene alkyl ether, polyoxyethylene polyoxypropylene alkyl ether, polyoxyethylene phenyl ether, and higher alcohol phosphate ester. These surfactants can be used alone or in combination of two or more, and these are contained in an amount of 0.1 to 15.0% by weight, preferably 0.5 to 10.0% by weight, most preferably Is 1.0-
It is possible to mix in the range of 5.0% by weight.

Further, an emulsification auxiliary agent can be blended for the purpose of assisting the emulsification of these surfactants. Examples of these emulsification auxiliary agents include stearyl alcohol, cetostearyl alcohol, cetanol, cholesterol and behenyl alcohol. To be In addition, it is possible to add a silicone compound for the purpose of facilitating smooth spreading of the anti-inflammatory analgesic compound, topical stimulant, absorption enhancer, etc. to the skin, or for the purpose of gradually volatilizing the compound. It is 1.0% by weight, preferably 0.1 to 0.8% by weight, and most preferably 0.1 to 0.5% by weight.

Examples of the pH adjusting agent include inorganic bases such as sodium hydroxide, potassium hydroxide and aqueous ammonia, and organic bases such as triisopropanolamine, diisopropanolamine, triethanolamine and diethanolamine. The blending amount of these PH adjusting agents is such that the blending amount of 0.01 to 5.0% by weight results in PH4 to 8 of the product. As other preservatives, methylparaben, ethylparaben, propylparaben, thymol, isopropylmethylphenol and the like are used, and the compounding amount is appropriate.
A wetting agent can be added for the purpose of improving the feeling of use, and as the wetting agent, propylene glycol, 1-3 butylene glycol, sodium dl pyrrolidonecarboxylate, glycerin, dsorbitol or the like can be added.

The manufacturing method of the present invention will be described below. In order to produce the skin external preparation and skin cosmetic of the present invention, an absorption enhancer is added to and dissolved in an anti-inflammatory analgesic compound as an active ingredient. Next, after adding a surfactant, an emulsification aid, a local stimulant, an absorption promoter, a fragrance, an antiseptic, a moistening agent, etc., the pH is adjusted with a pH adjuster to a pH of 5-8. After that, it is filled in a container to obtain a product.

[0012]

In the skin external preparation and the skin cosmetic having the above-mentioned structure, the skin external preparation and the skin cosmetic do not linger on the skin for a long period of time without the anti-inflammatory analgesic and the menthol odor that are present in the skin cosmetic. When applied, there is a minty smell at the beginning of application, but after a few minutes, the fragrance of the fragrance that has been blended begins to drift, and since it lasts for a long time, a pleasant scent drifts. Examples of the fragrance include musk-based, floral-based, citrus-based and the like.

[0013]

EXAMPLES Next, as examples of the present invention, the forms of the external preparation for skin and skin cosmetics of the present invention will be shown together with their compositions.

[0014]

[Table 1]

[0015]

[Table 2]

[0016]

[Table 3]

[0017]

EFFECTS OF THE INVENTION As described above, only a few examples are given, and the anti-inflammatory and analgesic sensations, the refreshing sensation, etc. effectively appear while the fragrance of the fragrance is drifting.

A skin irritation test was performed on 30 healthy women. It is a skin irritation test by a closed patch test using the skin external preparations mentioned in the examples as samples.
A sample was dipped in two pieces of 1 cm square gauze and water was dipped in the other two pieces of gauze, and a total of four pieces of gauze were closed-patched inside the anterior bowl of each subject. Gauze was removed after 24 hours and 48 hours, and the skin condition was examined 30 minutes, 24 hours, and 48 hours after the start of the test. As a result, no skin irritation was observed.

─────────────────────────────────────────────────── ─── Continuation of the front page (51) Int.Cl. ⁶ Identification code Internal reference number FI Technical display area A61K 31/165 9454-4C 35/78 C 8217-4C

Claims (1)

[Claims] 1. A skin external preparation or a skin cosmetic, which comprises a perfume in an anti-inflammatory analgesic containing a local stimulant such as l-menthol, peppermint oil, capsaicin, camphor and the like.