JPH0526775B2 - - Google Patents

Info

Publication number
JPH0526775B2
JPH0526775B2 JP58129255A JP12925583A JPH0526775B2 JP H0526775 B2 JPH0526775 B2 JP H0526775B2 JP 58129255 A JP58129255 A JP 58129255A JP 12925583 A JP12925583 A JP 12925583A JP H0526775 B2 JPH0526775 B2 JP H0526775B2
Authority
JP
Japan
Prior art keywords
formula
hydrogen
lower alkyl
compound according
methyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
JP58129255A
Other languages
English (en)
Japanese (ja)
Other versions
JPS5951246A (ja
Inventor
Ai Natarajan Sasha
Emu Goodon Eritsuku
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bristol Myers Squibb Co
Original Assignee
Bristol Myers Squibb Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bristol Myers Squibb Co filed Critical Bristol Myers Squibb Co
Publication of JPS5951246A publication Critical patent/JPS5951246A/ja
Publication of JPH0526775B2 publication Critical patent/JPH0526775B2/ja
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06086—Dipeptides with the first amino acid being basic
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06008—Dipeptides with the first amino acid being neutral
    • C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
    • C07K5/06026—Dipeptides with the first amino acid being neutral and aliphatic the side chain containing 0 or 1 carbon atom, i.e. Gly or Ala
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06008—Dipeptides with the first amino acid being neutral
    • C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
    • C07K5/06034—Dipeptides with the first amino acid being neutral and aliphatic the side chain containing 2 to 4 carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06008—Dipeptides with the first amino acid being neutral
    • C07K5/06078—Dipeptides with the first amino acid being neutral and aromatic or cycloaliphatic
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06086—Dipeptides with the first amino acid being basic
    • C07K5/06095—Arg-amino acid
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06139—Dipeptides with the first amino acid being heterocyclic
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06191—Dipeptides containing heteroatoms different from O, S, or N
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Pain & Pain Management (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Neurology (AREA)
  • Peptides Or Proteins (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Heterocyclic Compounds Containing Sulfur Atoms (AREA)
  • Pyridine Compounds (AREA)
  • Furan Compounds (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
  • Pyrrole Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Indole Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
JP58129255A 1982-07-19 1983-07-14 置換ペプチド化合物 Granted JPS5951246A (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US39965082A 1982-07-19 1982-07-19
US399650 1982-07-19

Related Child Applications (2)

Application Number Title Priority Date Filing Date
JP3231635A Division JPH0645582B2 (ja) 1982-07-19 1991-09-11 置換ペプチド化合物の中間体
JP3231633A Division JPH0653713B2 (ja) 1982-07-19 1991-09-11 置換ペプチド化合物の中間体

Publications (2)

Publication Number Publication Date
JPS5951246A JPS5951246A (ja) 1984-03-24
JPH0526775B2 true JPH0526775B2 (cs) 1993-04-19

Family

ID=23580391

Family Applications (3)

Application Number Title Priority Date Filing Date
JP58129255A Granted JPS5951246A (ja) 1982-07-19 1983-07-14 置換ペプチド化合物
JP3231635A Expired - Lifetime JPH0645582B2 (ja) 1982-07-19 1991-09-11 置換ペプチド化合物の中間体
JP3231633A Expired - Lifetime JPH0653713B2 (ja) 1982-07-19 1991-09-11 置換ペプチド化合物の中間体

Family Applications After (2)

Application Number Title Priority Date Filing Date
JP3231635A Expired - Lifetime JPH0645582B2 (ja) 1982-07-19 1991-09-11 置換ペプチド化合物の中間体
JP3231633A Expired - Lifetime JPH0653713B2 (ja) 1982-07-19 1991-09-11 置換ペプチド化合物の中間体

Country Status (21)

Country Link
JP (3) JPS5951246A (cs)
KR (1) KR840005709A (cs)
AU (1) AU1643283A (cs)
BE (1) BE897327A (cs)
CA (1) CA1244006A (cs)
CH (1) CH659475A5 (cs)
DE (1) DE3325850A1 (cs)
DK (1) DK330683A (cs)
ES (4) ES8504675A1 (cs)
FI (1) FI832620A7 (cs)
FR (3) FR2530238B1 (cs)
GB (1) GB2123834B (cs)
GR (1) GR79602B (cs)
HU (1) HU187090B (cs)
IE (1) IE55818B1 (cs)
IL (1) IL69136A0 (cs)
IT (1) IT1163800B (cs)
NL (1) NL8302562A (cs)
PT (1) PT77045B (cs)
SE (1) SE8304031L (cs)
ZA (1) ZA834980B (cs)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS55159749A (en) * 1979-05-31 1980-12-12 Takeda Chem Ind Ltd Preparation of dried fish flesh
US4500518A (en) * 1984-04-19 1985-02-19 E. R. Squibb & Sons, Inc. Amino thiol dipeptides
ATE135711T1 (de) * 1984-09-12 1996-04-15 Rhone Poulenc Rorer Pharma Antihypertensive derivate
US4629724A (en) * 1984-12-03 1986-12-16 E. R. Squibb & Sons, Inc. Amino acid ester and amide renin inhibitors
FR2578544A1 (en) * 1985-03-11 1986-09-12 Usv Pharma Corp Antihypertension spirocyclic compounds
FI89058C (fi) * 1987-02-27 1993-08-10 Yamanouchi Pharma Co Ltd Foerfarande foer framstaellning av som remin-inhibitorer anvaenda 2-(l-alanyl-l-histidylamino)-butanol-derivat
US6858565B2 (en) 2001-05-14 2005-02-22 Oji Paper Co., Ltd. Thermosensitive recording material and novel color developer compounds
WO2018130576A1 (en) 2017-01-10 2018-07-19 Mitsubishi Hitec Paper Europe Gmbh Novel colour developer for a thermo-sensitive recording medium, and a heat-sensitive recording material based on pla

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3751239A (en) * 1969-05-29 1973-08-07 Rohm & Haas Herbicidal compositions containing n-(1,1-dialkyl-3-chloroacetonyl) benzamides
JPS5430167A (en) * 1977-08-11 1979-03-06 Mitsubishi Chem Ind Ltd 4-aminomethyl-2-phenyloxazoles and their pharmaceutically acceptable acid salts
IL58849A (en) * 1978-12-11 1983-03-31 Merck & Co Inc Carboxyalkyl dipeptides and derivatives thereof,their preparation and pharmaceutical compositions containing them
FR2480747A1 (fr) * 1980-04-17 1981-10-23 Roques Bernard Derives d'acides amines et leur application therapeutique
IE51409B1 (en) * 1980-07-24 1986-12-24 Ici Ltd Amide derivatives
GR75019B (cs) * 1980-09-17 1984-07-12 Univ Miami
DE19575012I2 (de) * 1980-10-23 2002-01-24 Schering Corp Carboxyalkyl-Dipeptide Verfahren zu ihrer Herstellung und diese enthaltende Arzneimittel
US4462943A (en) * 1980-11-24 1984-07-31 E. R. Squibb & Sons, Inc. Carboxyalkyl amino acid derivatives of various substituted prolines
CY1406A (en) * 1980-12-18 1988-04-22 Schering Corp Substituted dipeptides, processes for their preparation and pharmaceutical compositions containing them and their use in the inhibition of enkephalinase
US4514391A (en) * 1983-07-21 1985-04-30 E. R. Squibb & Sons, Inc. Hydroxy substituted peptide compounds

Also Published As

Publication number Publication date
CH659475A5 (fr) 1987-01-30
FI832620L (fi) 1984-01-20
HUT34040A (en) 1985-01-28
ES539083A0 (es) 1986-04-01
PT77045A (en) 1983-08-01
SE8304031L (sv) 1984-03-30
JPS5951246A (ja) 1984-03-24
JPH0517420A (ja) 1993-01-26
SE8304031D0 (sv) 1983-07-18
FI832620A7 (fi) 1984-01-20
JPH0645582B2 (ja) 1994-06-15
GB2123834A (en) 1984-02-08
KR840005709A (ko) 1984-11-16
FR2540866A1 (fr) 1984-08-17
FR2540867A1 (fr) 1984-08-17
HU187090B (en) 1985-11-28
JPH0532601A (ja) 1993-02-09
FI832620A0 (fi) 1983-07-19
NL8302562A (nl) 1984-02-16
IE55818B1 (en) 1991-01-30
IT1163800B (it) 1987-04-08
ES8707548A1 (es) 1986-05-16
ES524200A0 (es) 1985-04-16
AU1643283A (en) 1984-01-26
BE897327A (fr) 1984-01-19
ES539084A0 (es) 1986-04-01
IT8322114A0 (it) 1983-07-18
DE3325850A1 (de) 1984-01-19
GB8318492D0 (en) 1983-08-10
ES539082A0 (es) 1986-05-16
DK330683A (da) 1984-01-20
ES8707550A1 (es) 1986-04-01
JPH0653713B2 (ja) 1994-07-20
FR2540867B1 (fr) 1987-07-31
GR79602B (cs) 1984-10-31
CA1244006A (en) 1988-11-01
FR2530238B1 (cs) 1989-06-30
IL69136A0 (en) 1983-10-31
FR2530238A1 (cs) 1984-01-20
ES8707549A1 (es) 1986-04-01
PT77045B (en) 1986-02-12
GB2123834B (en) 1986-10-22
ES8504675A1 (es) 1985-04-16
DK330683D0 (da) 1983-07-18
IE831655L (en) 1984-01-19
ZA834980B (en) 1984-03-28

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