JPH05239092A - ファルネシル蛋白質トランスフェラーゼの非サブストレート阻害剤 - Google Patents

ファルネシル蛋白質トランスフェラーゼの非サブストレート阻害剤

Info

Publication number
JPH05239092A
JPH05239092A JP4212907A JP21290792A JPH05239092A JP H05239092 A JPH05239092 A JP H05239092A JP 4212907 A JP4212907 A JP 4212907A JP 21290792 A JP21290792 A JP 21290792A JP H05239092 A JPH05239092 A JP H05239092A
Authority
JP
Japan
Prior art keywords
xaa
ras
amino acid
protein transferase
cys
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP4212907A
Other languages
English (en)
Japanese (ja)
Inventor
Jackson B Gibbs
ジヤクソン・ビー・ギブズ
Elaine Rands
エレーヌ・ランドス
David L Pompliano
デイビツド・エル・ポムプリアーノ
Victor M Garsky
ビクター・エム・ガースキイ
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck and Co Inc
Original Assignee
Merck and Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck and Co Inc filed Critical Merck and Co Inc
Publication of JPH05239092A publication Critical patent/JPH05239092A/ja
Pending legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/10—Tetrapeptides
    • C07K5/1002—Tetrapeptides with the first amino acid being neutral
    • C07K5/1005—Tetrapeptides with the first amino acid being neutral and aliphatic
    • C07K5/1013—Tetrapeptides with the first amino acid being neutral and aliphatic the side chain containing O or S as heteroatoms, e.g. Cys, Ser
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
JP4212907A 1991-08-16 1992-08-10 ファルネシル蛋白質トランスフェラーゼの非サブストレート阻害剤 Pending JPH05239092A (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US74638991A 1991-08-16 1991-08-16
US746389 1991-08-16

Publications (1)

Publication Number Publication Date
JPH05239092A true JPH05239092A (ja) 1993-09-17

Family

ID=25000626

Family Applications (1)

Application Number Title Priority Date Filing Date
JP4212907A Pending JPH05239092A (ja) 1991-08-16 1992-08-10 ファルネシル蛋白質トランスフェラーゼの非サブストレート阻害剤

Country Status (3)

Country Link
EP (1) EP0528486A2 (enExample)
JP (1) JPH05239092A (enExample)
CA (1) CA2075678A1 (enExample)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5420245A (en) * 1990-04-18 1995-05-30 Board Of Regents, The University Of Texas Tetrapeptide-based inhibitors of farnesyl transferase
US5976851A (en) * 1990-04-18 1999-11-02 Board Of Regents, The University Of Texas System Methods and compositions for the identification, characterization, and inhibition of farnesyl protein transferase
US6632626B1 (en) 1990-04-18 2003-10-14 Board Of Regents, The University Of Texas System Methods of assaying farnesyl transferase
US5962243A (en) * 1990-04-18 1999-10-05 Board Of Regents, The University Of Texas System Methods for the identification of farnesyltransferase inhibitors
US8003342B1 (en) 1990-04-18 2011-08-23 Board Of Regents, The University Of Texas System Method for identifying farnesyl transferase inhibitors
CA2118985A1 (en) * 1993-04-02 1994-10-03 Dinesh V. Patel Heterocyclic inhibitors of farnesyl protein transferase
US6011175A (en) * 1993-05-18 2000-01-04 University Of Pittsburgh Inhibition of farnesyltransferase
US5965539A (en) * 1993-05-18 1999-10-12 Univeristy Of Pittsburgh Inhibitors of prenyl transferases
US5602098A (en) * 1993-05-18 1997-02-11 University Of Pittsburgh Inhibition of farnesyltransferase
US5834434A (en) * 1993-05-18 1998-11-10 University Of Pittsburgh Inhibitors of farnesyltransferase
US5705686A (en) * 1993-05-18 1998-01-06 University Of Pittsburgh Inhibition of farnesyl transferase
WO1995011917A1 (en) * 1993-10-25 1995-05-04 Parke, Davis & Company Substituted tetra- and pentapeptide inhibitors of protein:farnesyl transferase
US5763577A (en) * 1993-10-25 1998-06-09 Warner-Lambert Company Substituted tetra- and pentapeptide inhibitors of protein: farnesyl transferase
WO1995025086A1 (en) * 1994-03-15 1995-09-21 Eisai Co., Ltd. Isoprenyl transferase inhibitors
US5571792A (en) * 1994-06-30 1996-11-05 Warner-Lambert Company Histidine and homohistidine derivatives as inhibitors of protein farnesyltransferase
IT1273986B (it) * 1994-09-28 1997-07-14 Merck & Co Inc Inibitori peptidici di farnesil proteina transferasi
CA2204144A1 (en) * 1994-12-09 1996-06-13 Francis J. Tinney Substituted tetra- and pentapeptide inhibitors of protein:farnesyl transferase
US6310095B1 (en) 1995-11-06 2001-10-30 University Of Pittsburgh Inhibitors of protein isoprenyl transferases
US6693123B2 (en) 1995-11-06 2004-02-17 University Of Pittsburgh Inhibitors of protein isoprenyl transferases
US6204293B1 (en) 1995-11-06 2001-03-20 University Of Pittsburgh Inhibitors of protein isoprenyl transferases
US6221865B1 (en) 1995-11-06 2001-04-24 University Of Pittsburgh Inhibitors of protein isoprenyl transferases
CA2280752A1 (en) 1997-02-26 1998-09-03 Ariella Paz Drug screen targeting lipoprotein-membrane anchorage

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5141851A (en) * 1990-04-18 1992-08-25 Board Of Regents, The University Of Texas System Isolated farnesyl protein transferase enzyme

Also Published As

Publication number Publication date
CA2075678A1 (en) 1993-02-17
EP0528486A3 (enExample) 1994-04-20
EP0528486A2 (en) 1993-02-24

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