JPH05213735A - Beautifully whitening cosmetic - Google Patents

Abstract

PURPOSE:To provide the beautifully whitening cosmetic exhibiting an excellent whitening effect, effective for lightening or preventing the blackening or chromatosis of skin caused by UV rays and further having an effect on suppressing affections such as inflammation against the skin by applying the cosmetic to the skin. CONSTITUTION:The beautifully whitening cosmetic comprises isoflavan and one or more kinds of the compounds selected from a 18-22C free fatty acid having two or more unsaturated bonds in the molecular structure, its salt, and its ester with a monohydric or dihydric alcohol.

Description

Detailed Description of the Invention

[0001]

BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to a whitening cosmetic composition which is effective for darkening or preventing skin darkening due to ultraviolet rays or skin pigmentation such as spots and freckles.

[0002]

2. Description of the Related Art When the skin is irradiated with ultraviolet rays from the sun, pigments are formed in pigment cells in the skin, resulting in darkening of the skin and deposition of skin pigments and freckles. Is known to occur. Traditionally,
Various whitening cosmetics have been proposed for the purpose of preventing such blackening of the skin and removing spots and freckles. For example, it is known to use vitamin C and its derivatives, a reducing agent such as glutathione, hydrogen peroxide, a placenta extract, and a melanin production inhibitor such as kojic acid.

[0003] However, vitamin C has a drawback that it is easily oxidized and causes discoloration and odor of cosmetics containing it. It is said that reducing agents such as glutathione have an unpleasant odor and also have a problem of transdermal absorbability, and hydrogen peroxide has a problem of safety and stability. Moreover, the effect of animal tissue extraction system such as placenta extract is not sufficient,
There are also problems in terms of stability, color and odor. Also, since kojic acid has a problem that the effect of preventing blackening of the skin is small when it is in a small amount, it cannot be said that any of them is sufficient as an active ingredient of a whitening cosmetic composition. As described above, these conventionally known melanin production-inhibitory substances are insufficient in terms of effect even if they are used alone, and most of them are practical in various aspects such as safety and stability. The reality is that there is none.

On the other hand, when unsaturated fatty acids are used alone in an amount sufficient to exert their effects, there is concern about their safety.
Therefore, it is an object of the present invention to provide a whitening cosmetic composition which has an excellent whitening effect, has no side effects and is highly safe, and which solves the above conventional problems.

With respect to isoflavans, the whitening effect of glabridin is known (Japanese Patent Laid-Open No. 1-3110).
No. 11, Fragrance Journal 111, 59-66
(1990)), and antibacterial activity is known for hispaglabridin A and hispaglabrizin B (He).
thermocycles9 (11), 1533-1538
(1978)), but no report on suppression of melanin production was found. Therefore, it is an object of the present invention to provide a whitening cosmetic composition which has an excellent whitening effect, has no side effects and is highly safe, and which solves the above conventional problems.

[0006]

The present invention is directed to isoflavans and free fatty acids having 18 to 22 carbon atoms and 2 or more unsaturated bonds in the molecular structure, salts thereof, or esters with monohydric or dihydric alcohols. 1 selected from a group of
The present invention has been completed by discovering that by blending two or more components, a pigmentation of the skin is lightened or a synergistic effect with an excellent preventive effect appears.

That is, the gist of the present invention is (a) isoflavans, (b) free fatty acid having 18 to 22 carbon atoms and 2 or more unsaturated bonds in the molecular structure, a salt thereof, or a monohydric or dihydric alcohol. The present invention relates to a whitening cosmetic composition containing one or more components selected from the ester of

The component (a) used in the present invention, isoflavans, may be either an extract from a plant such as licorice or a synthetic product, and any type may be used as long as it belongs to the isoflavans. Grabridine A, hispaglabridine B, glablysin and phaseolin isoflavan are preferred.

The amount of the isoflavans used in the present invention in the whitening cosmetic composition is usually 0.005% to 1% by weight, although it varies depending on the kind of the cosmetic composition and the expected degree of the whitening effect. .. It is preferably in the range of 0.01 to 0.5% by weight. If the compounding amount is less than 0.005% by weight, the effect is not sufficient, and even if the compounding amount exceeds 1% by weight, the effect commensurate with the amount cannot be expected.
A blending amount of about 1% by weight is sufficient.

As the component (b) used in the present invention,
For example, linoleic acid, linoelaidic acid, α-linolenic acid, γ-linolenic acid, dihomo-γ-linolenic acid, arachidonic acid, eicosapentaenoic acid and the like, and as the salts of these free fatty acids, sodium salts, Examples thereof include metal salts such as potassium salts, amino acid salts such as arginine salts and lysine salts, amine salts such as triethanolamine salts and monoethanolamine salts, and the esters of these free fatty acids include methanol, ethanol and isopropyl. Esters of monohydric alcohols such as alcohol, ethylene glycol, propylene glycol, 1,
Examples thereof include esters with dihydric alcohols such as 3-butylene glycol, and one or more components are used from these components.

In the present invention, by using these active ingredients in combination with the above-mentioned component (a), isoflavans, a synergistic whitening effect on the skin is exhibited. The blending amount of such a component (b) in the cosmetic is usually 0.
It is 1 to 10%. It is preferably 1.0 to 5.0% by weight. If the blending amount is less than 0.1% by weight, the lightening effect of pigmentation is not sufficient, and if the blending amount exceeds 10% by weight, it becomes irritating to the skin.

The whitening cosmetic composition of the present invention is characterized by blending the components (a) and (b) as described above, but the whitening cosmetic composition of the present invention contains these components. In addition to the above, bases and various additives that are usually added to whitening cosmetics may be added. For example, oils, surfactants, fragrances, preservatives and the like are appropriately added.

The whitening cosmetic composition of the present invention can be prepared into a lotion, a cosmetic oil, a cream, an emulsion, a pack, a powder and the like by a conventional method.

The present invention will be described in more detail below with reference to examples and test examples.

【Example】

Example 1 Preparation of lotion: Predetermined amounts of glycerin, citric acid and sodium citrate are dissolved in purified water. Separately from ethanol, a predetermined amount of linoleic acid, α-linolenic acid, hispaglabridine A, polyoxyethylene hydrogenated castor oil (60E.
O. ), The fragrance was dissolved, added to the purified aqueous solution to solubilize it, and filtered to obtain a lotion. [Components] [Blending amount (% by weight)] Hispaglabridin A 0.05 Linoleic acid 1.0 α-Linolenic acid 1.0 Glycerin 6.0 Ethanol 9.0 Polyoxyethylene hydrogenated castor oil (60 EO) 0.8 Methyl paraoxybenzoate 0.05 Citric acid 0.05 Sodium citrate 0.07 Perfume 0.1 Water-soluble placenta extract 2.0 Purified water balance

Example 2 Preparation of Cosmetic Oil: A cosmetic oil was obtained by uniformly dissolving the following other components in squalane in a predetermined amount so as to be the following weight%. [Components] [Compounding amount (wt%)] Hispaglabridine B 0.05 Ethyl linoleate 1.0 γ-Linolenic acid 1.0 Ascorbyl palmitate 0.2 Retinol acetate 0.3 Squalane balance

Example 3 Preparation of cream: Of the following components, the component (A) was mixed in a predetermined amount so that the weight percentage was as follows, and the mixture was heated and dissolved.
Hold at 0 ° C. Separately from this, the component excluding the fragrance (B)
Was mixed in a predetermined amount so as to be the following weight%, heated and dissolved, and kept at 80 ° C. Ingredient (B) excluding the above fragrances
The mixture of the above-mentioned component (A) was added to the above mixture with stirring, mixed well, and then cooled to about 40 ° C. with stirring, and then the fragrance was added. This was further cooled to obtain a cream consisting of the following ingredients. [Components] [Blended amount (wt%)] Component (A) Phaseolin isoflavan 0.1 γ-linolenic acid 2.0 eicosapentaenoic acid 1.0 salami beeswax 4.0 cetanol 2.0 isopropyl myristate 5 0.0 Lanolin 2.0 Liquid paraffin 9.0 Self-emulsifying glyceryl monostearate 3.0 Polyoxy monostearate Ethylene sorbitan (20EO) 1.5 Propyl paraoxybenzoate 0.1 Component (B) Paraoxybenzoic acid Methyl 0.2 Propylene glycol 5.0 Perfume 0.2 Purified water Balance

Example 4 Preparation of Emulsion: Of the following components, a predetermined amount of component (A),
After mixing so as to have the following weight%, the mixture was heated and dissolved, and kept at 80 ° C. Separately from this, a predetermined amount of the component (B) excluding the fragrance was mixed so as to have the following weight%, and the mixture was heated and melted and kept at 80 ° C. The mixture of the component (A) was added to the mixture of the component (B) excluding the above-mentioned fragrance with stirring, mixed well, and then cooled to about 40 ° C. with stirring, and then the fragrance was added. This was further cooled to obtain an emulsion containing the following components. [Components] [Blending amount (% by weight)] Component (A) 1.0 Linoelaidic acid 0.05 Glabridine 2.0 Isopropyl linoleate 5.0 Liquid paraffin 2.0 Vaseline 2.0 Beeswax 1.0 Sesquiolein Acid sorbitan 2.0 Component (B) Epsilon aminocaproic acid 0.2 Polyoxyethylene oleyl ether (20EO) 2.5 Ethyl paraoxybenzoate 0.2 Propylene glycol 5.0 Carboxyvinyl polymer 0.5 Potassium hydroxide 0.5 Perfume 0.2 Purified water balance

Example 5 Preparation of pack: α-linolenic acid, hispaglabridin A, docosahexaenoic acid, perfume and ethanol are uniformly dissolved. This is added to a homogenous blend of vinyl acetate-styrene copolymer, polyvinyl alcohol, sorbit, and kaolin. A solution in which the water-soluble placenta extract and ethyl paraoxybenzoate were uniformly dissolved in purified water was added to this, and the mixture was uniformly mixed to obtain a pack. [Components] [Blending amount (% by weight)] α-linolenic acid 3.0 Hispaglabridin A 0.05 docosahexaenoic acid 0.5 Vinyl acetate / styrene copolymer 10.0 Polyvinyl alcohol 10.0 Solbit 5.0 Kaolin 7.0 Ethanol 5.0 Fragrance 2.0 Ethyl paraoxybenzoate 0.2 Purified water Remainder

Example 6 Preparation of powder: Hispagrabrizin B, linoelaidic acid and ethyl linoleate were melted by heating and kept at 70 ° C., which was gradually added to a mixture of dextrin and talc with stirring to give powder. Obtained. [Components] [Amount (wt%)] Hispaglabridin B 0.05 Linoelaidic acid 2.0 Ethyl linoleate 2.0 Dextrin 2.0 Talc 92.95 Decaglyceryl stearate 1.0 Test Example 1 English system The back of a brown guinea pig is shaved and UV rays (UV
B intensity; 0.8 J / cm ² ) was irradiated. This operation was repeated for 3 days, and pigmentation was obtained after 1 week. Next, a sample prepared by dissolving isoflavans or other components in ethanol was cumulatively applied to this site at an application amount of 10 μl / cm ² for 4 weeks.
As a method of evaluating the lightening of pigmentation, the pigmentation of the site not coated with the sample (non-application) is set to 0, and the degree of the lightening determines the degree of pigmentation with the naked eye according to the criteria shown below. The results are shown in Table 1. The criteria for determining the effect are as follows. 0: No pigmentation is observed 1; Slight pigmentation lightening is observed 2; Moderate pigmentation lightening is observed 3; Intense pigmentation lightening is observed

[0020]

[Table 1]

[0021]

[Table 2]

As is clear from Tables 1 and 2, suppression of pigmentation or lightening is observed even with the active ingredient of isoflavans alone, but it is more remarkable when combined with a component such as linoleic acid. Inhibition of various pigmentation or lightening was observed.

Test Example 2 16 healthy people in their 20s to 40s (8 men and 8 women)
UV of 1.0 mW / cm ² was applied to the 4 adjacent parts of the inner part of the upper arm.
Ultraviolet rays corresponding to 1 to 1.2 MED (Minimal Erytherma Doses) were irradiated for 3 days to obtain uniform pigmentation. Meanwhile, a cream containing no phaseoline isoflavan among the ingredients of Example 3 in each part (abbreviated as cream A), and a cream containing no γ-linolenic acid or eicosapentaenoic acid (cream B) in the same manner. Abbreviated), and a cream comprising the compounding ingredients of Example 3 (abbreviated as Cream C), and among the compounding ingredients of Example 3, any of phaseolin isoflavan, γ-linolenic acid, and eicosapentaenoic acid. No cream (cream D
Abbreviated) was applied three times a day for 4 weeks. The coating amount was 0.5 mg / cm ² . One month after the start of application, the degree of pigmentation of each cream A, B, and C application portion was compared with the degree of pigmentation of cream D application portion, and the results in Table 3 were obtained.

[0024]

[Table 3]

As is clear from Table 3, when the isoflavans alone were blended (cream A) and the unsaturated fatty acids alone were blended (cream B), no noticeable lightening effect of pigmentation was observed. .. On the other hand, when isoflavans and unsaturated fatty acids are used together (cream C)
A remarkable lightening of pigmentation was observed in.

[0026]

By applying the cosmetic composition of the present invention to the skin, the skin blackening or pigmentation caused by ultraviolet rays disappears, becomes lighter in color or is prevented, and exhibits an excellent whitening effect.

Claims (2)

[Claims] 1. (a) Isoflavans, (b) carbon number 1
Characterized by blending one or more components selected from free fatty acids having 8 to 22 and two or more unsaturated bonds in the molecular structure, salts thereof, or esters with monohydric or dihydric alcohols. And whitening cosmetics. 2. The whitening cosmetic composition according to claim 1, wherein the isoflavans are Hispaglabridine A, Hispaglabridine B, Glabridin, and Phaseolin phosphorus.