JPH0516413B2 - - Google Patents
Info
- Publication number
- JPH0516413B2 JPH0516413B2 JP60011679A JP1167985A JPH0516413B2 JP H0516413 B2 JPH0516413 B2 JP H0516413B2 JP 60011679 A JP60011679 A JP 60011679A JP 1167985 A JP1167985 A JP 1167985A JP H0516413 B2 JPH0516413 B2 JP H0516413B2
- Authority
- JP
- Japan
- Prior art keywords
- japanese knotweed
- houtt
- substance
- reynoutria
- reynoutria japonica
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 240000001341 Reynoutria japonica Species 0.000 claims description 31
- 235000018167 Reynoutria japonica Nutrition 0.000 claims description 31
- 208000007536 Thrombosis Diseases 0.000 claims description 22
- -1 stilbene compound Chemical class 0.000 claims description 13
- 239000000126 substance Substances 0.000 claims description 12
- PJANXHGTPQOBST-VAWYXSNFSA-N Stilbene Natural products C=1C=CC=CC=1/C=C/C1=CC=CC=C1 PJANXHGTPQOBST-VAWYXSNFSA-N 0.000 claims description 8
- 235000021286 stilbenes Nutrition 0.000 claims description 8
- QNVSXXGDAPORNA-UHFFFAOYSA-N Resveratrol Natural products OC1=CC=CC(C=CC=2C=C(O)C(O)=CC=2)=C1 QNVSXXGDAPORNA-UHFFFAOYSA-N 0.000 claims description 5
- LUKBXSAWLPMMSZ-OWOJBTEDSA-N Trans-resveratrol Chemical compound C1=CC(O)=CC=C1\C=C\C1=CC(O)=CC(O)=C1 LUKBXSAWLPMMSZ-OWOJBTEDSA-N 0.000 claims description 5
- HSTZMXCBWJGKHG-OUUBHVDSSA-N piceide Natural products O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@H]1OC1=CC(O)=CC(C=CC=2C=CC(O)=CC=2)=C1 HSTZMXCBWJGKHG-OUUBHVDSSA-N 0.000 claims description 5
- 235000021283 resveratrol Nutrition 0.000 claims description 5
- 229940016667 resveratrol Drugs 0.000 claims description 5
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 claims description 3
- 239000004615 ingredient Substances 0.000 claims description 3
- YZXBAPSDXZZRGB-DOFZRALJSA-N arachidonic acid Chemical class CCCCC\C=C/C\C=C/C\C=C/C\C=C/CCCC(O)=O YZXBAPSDXZZRGB-DOFZRALJSA-N 0.000 description 14
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 description 12
- 239000000843 powder Substances 0.000 description 10
- 230000000694 effects Effects 0.000 description 8
- 102000003820 Lipoxygenases Human genes 0.000 description 7
- 108090000128 Lipoxygenases Proteins 0.000 description 7
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 6
- 235000013305 food Nutrition 0.000 description 6
- 229940114079 arachidonic acid Drugs 0.000 description 4
- 235000021342 arachidonic acid Nutrition 0.000 description 4
- 210000001772 blood platelet Anatomy 0.000 description 4
- 238000004809 thin layer chromatography Methods 0.000 description 4
- KGIJOOYOSFUGPC-CABOLEKPSA-N 5-HETE Natural products CCCCC\C=C/C\C=C/C\C=C/C=C/[C@H](O)CCCC(O)=O KGIJOOYOSFUGPC-CABOLEKPSA-N 0.000 description 3
- KGIJOOYOSFUGPC-MSFIICATSA-N 5-Hydroxyeicosatetraenoic acid Chemical compound CCCCCC=CCC=CCC=C\C=C\[C@@H](O)CCCC(O)=O KGIJOOYOSFUGPC-MSFIICATSA-N 0.000 description 3
- QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 description 3
- CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 description 3
- 241000196324 Embryophyta Species 0.000 description 3
- XEKOWRVHYACXOJ-UHFFFAOYSA-N Ethyl acetate Chemical compound CCOC(C)=O XEKOWRVHYACXOJ-UHFFFAOYSA-N 0.000 description 3
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 description 3
- 208000025865 Ulcer Diseases 0.000 description 3
- 230000017531 blood circulation Effects 0.000 description 3
- 238000013329 compounding Methods 0.000 description 3
- 239000013078 crystal Substances 0.000 description 3
- 238000004519 manufacturing process Methods 0.000 description 3
- 230000003449 preventive effect Effects 0.000 description 3
- 239000000047 product Substances 0.000 description 3
- 208000024891 symptom Diseases 0.000 description 3
- XNRNNGPBEPRNAR-JQBLCGNGSA-N thromboxane B2 Chemical compound CCCCC[C@H](O)\C=C\[C@H]1OC(O)C[C@H](O)[C@@H]1C\C=C/CCCC(O)=O XNRNNGPBEPRNAR-JQBLCGNGSA-N 0.000 description 3
- 231100000397 ulcer Toxicity 0.000 description 3
- 102000004190 Enzymes Human genes 0.000 description 2
- 108090000790 Enzymes Proteins 0.000 description 2
- 206010061218 Inflammation Diseases 0.000 description 2
- 241000219050 Polygonaceae Species 0.000 description 2
- 244000269722 Thea sinensis Species 0.000 description 2
- 210000004204 blood vessel Anatomy 0.000 description 2
- 210000003989 endothelium vascular Anatomy 0.000 description 2
- 210000003743 erythrocyte Anatomy 0.000 description 2
- 230000004054 inflammatory process Effects 0.000 description 2
- 239000003112 inhibitor Substances 0.000 description 2
- 210000000265 leukocyte Anatomy 0.000 description 2
- 150000002617 leukotrienes Chemical class 0.000 description 2
- 239000007788 liquid Substances 0.000 description 2
- BDAGIHXWWSANSR-UHFFFAOYSA-N methanoic acid Natural products OC=O BDAGIHXWWSANSR-UHFFFAOYSA-N 0.000 description 2
- VLKZOEOYAKHREP-UHFFFAOYSA-N n-Hexane Chemical compound CCCCCC VLKZOEOYAKHREP-UHFFFAOYSA-N 0.000 description 2
- 238000011282 treatment Methods 0.000 description 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 2
- DNIAPMSPPWPWGF-GSVOUGTGSA-N (R)-(-)-Propylene glycol Chemical compound C[C@@H](O)CO DNIAPMSPPWPWGF-GSVOUGTGSA-N 0.000 description 1
- ZNHVWPKMFKADKW-UHFFFAOYSA-N 12-HETE Chemical compound CCCCCC=CCC(O)C=CC=CCC=CCCCC(O)=O ZNHVWPKMFKADKW-UHFFFAOYSA-N 0.000 description 1
- ZNHVWPKMFKADKW-ZYBDYUKJSA-N 12-HETE Natural products CCCCC\C=C/C[C@@H](O)\C=C\C=C/C\C=C/CCCC(O)=O ZNHVWPKMFKADKW-ZYBDYUKJSA-N 0.000 description 1
- OSWFIVFLDKOXQC-UHFFFAOYSA-N 4-(3-methoxyphenyl)aniline Chemical compound COC1=CC=CC(C=2C=CC(N)=CC=2)=C1 OSWFIVFLDKOXQC-UHFFFAOYSA-N 0.000 description 1
- 102000009123 Fibrin Human genes 0.000 description 1
- 108010073385 Fibrin Proteins 0.000 description 1
- BWGVNKXGVNDBDI-UHFFFAOYSA-N Fibrin monomer Chemical compound CNC(=O)CNC(=O)CN BWGVNKXGVNDBDI-UHFFFAOYSA-N 0.000 description 1
- 229920002683 Glycosaminoglycan Polymers 0.000 description 1
- HTTJABKRGRZYRN-UHFFFAOYSA-N Heparin Chemical compound OC1C(NC(=O)C)C(O)OC(COS(O)(=O)=O)C1OC1C(OS(O)(=O)=O)C(O)C(OC2C(C(OS(O)(=O)=O)C(OC3C(C(O)C(O)C(O3)C(O)=O)OS(O)(=O)=O)C(CO)O2)NS(O)(=O)=O)C(C(O)=O)O1 HTTJABKRGRZYRN-UHFFFAOYSA-N 0.000 description 1
- 208000008589 Obesity Diseases 0.000 description 1
- 102000004005 Prostaglandin-endoperoxide synthases Human genes 0.000 description 1
- 108090000459 Prostaglandin-endoperoxide synthases Proteins 0.000 description 1
- 244000184734 Pyrus japonica Species 0.000 description 1
- 241000700159 Rattus Species 0.000 description 1
- 241000227654 Reynoutria Species 0.000 description 1
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 1
- 230000002378 acidificating effect Effects 0.000 description 1
- 230000004931 aggregating effect Effects 0.000 description 1
- 238000004220 aggregation Methods 0.000 description 1
- 230000002776 aggregation Effects 0.000 description 1
- 208000007502 anemia Diseases 0.000 description 1
- 239000005557 antagonist Substances 0.000 description 1
- 230000002785 anti-thrombosis Effects 0.000 description 1
- 210000001367 artery Anatomy 0.000 description 1
- 238000000376 autoradiography Methods 0.000 description 1
- 230000000740 bleeding effect Effects 0.000 description 1
- 210000004369 blood Anatomy 0.000 description 1
- 239000008280 blood Substances 0.000 description 1
- 235000019504 cigarettes Nutrition 0.000 description 1
- 238000004440 column chromatography Methods 0.000 description 1
- 150000001875 compounds Chemical class 0.000 description 1
- 239000012141 concentrate Substances 0.000 description 1
- 235000009508 confectionery Nutrition 0.000 description 1
- 238000007796 conventional method Methods 0.000 description 1
- 230000007812 deficiency Effects 0.000 description 1
- 238000003745 diagnosis Methods 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 208000035475 disorder Diseases 0.000 description 1
- 238000001035 drying Methods 0.000 description 1
- 238000000605 extraction Methods 0.000 description 1
- 229950003499 fibrin Drugs 0.000 description 1
- 239000000945 filler Substances 0.000 description 1
- 239000000706 filtrate Substances 0.000 description 1
- 239000000796 flavoring agent Substances 0.000 description 1
- 235000019634 flavors Nutrition 0.000 description 1
- 235000003599 food sweetener Nutrition 0.000 description 1
- 235000019253 formic acid Nutrition 0.000 description 1
- 238000004108 freeze drying Methods 0.000 description 1
- 239000008187 granular material Substances 0.000 description 1
- 229920000669 heparin Polymers 0.000 description 1
- 229960002897 heparin Drugs 0.000 description 1
- 238000007602 hot air drying Methods 0.000 description 1
- 238000007912 intraperitoneal administration Methods 0.000 description 1
- 230000003211 malignant effect Effects 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 230000004060 metabolic process Effects 0.000 description 1
- 239000002207 metabolite Substances 0.000 description 1
- NIQQIJXGUZVEBB-UHFFFAOYSA-N methanol;propan-2-one Chemical compound OC.CC(C)=O NIQQIJXGUZVEBB-UHFFFAOYSA-N 0.000 description 1
- 238000000034 method Methods 0.000 description 1
- 230000017074 necrotic cell death Effects 0.000 description 1
- 235000020824 obesity Nutrition 0.000 description 1
- 210000005259 peripheral blood Anatomy 0.000 description 1
- 239000011886 peripheral blood Substances 0.000 description 1
- 239000003208 petroleum Substances 0.000 description 1
- 239000000546 pharmaceutical excipient Substances 0.000 description 1
- 230000002265 prevention Effects 0.000 description 1
- 150000003180 prostaglandins Chemical class 0.000 description 1
- 238000010298 pulverizing process Methods 0.000 description 1
- 238000004451 qualitative analysis Methods 0.000 description 1
- 239000000941 radioactive substance Substances 0.000 description 1
- 239000002994 raw material Substances 0.000 description 1
- 238000007670 refining Methods 0.000 description 1
- 239000000741 silica gel Substances 0.000 description 1
- 229910002027 silica gel Inorganic materials 0.000 description 1
- RMAQACBXLXPBSY-UHFFFAOYSA-N silicic acid Chemical compound O[Si](O)(O)O RMAQACBXLXPBSY-UHFFFAOYSA-N 0.000 description 1
- 235000012239 silicon dioxide Nutrition 0.000 description 1
- 239000011780 sodium chloride Substances 0.000 description 1
- 235000014214 soft drink Nutrition 0.000 description 1
- 239000003765 sweetening agent Substances 0.000 description 1
- 239000003826 tablet Substances 0.000 description 1
- 238000007395 thrombosis prophylaxis Methods 0.000 description 1
- 230000001732 thrombotic effect Effects 0.000 description 1
- 210000001519 tissue Anatomy 0.000 description 1
- 238000002525 ultrasonication Methods 0.000 description 1
- 210000003462 vein Anatomy 0.000 description 1
Landscapes
- Saccharide Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines Containing Plant Substances (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP60011679A JPS61171427A (ja) | 1985-01-24 | 1985-01-24 | 血栓等予防物質 |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP60011679A JPS61171427A (ja) | 1985-01-24 | 1985-01-24 | 血栓等予防物質 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPS61171427A JPS61171427A (ja) | 1986-08-02 |
| JPH0516413B2 true JPH0516413B2 (enExample) | 1993-03-04 |
Family
ID=11784678
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP60011679A Granted JPS61171427A (ja) | 1985-01-24 | 1985-01-24 | 血栓等予防物質 |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JPS61171427A (enExample) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2011089168A2 (fr) | 2010-01-21 | 2011-07-28 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Composition particuliere pour son application comme medicament |
| WO2019016153A1 (en) | 2017-07-17 | 2019-01-24 | L'oreal | AQUEOUS COSMETIC COMPOSITION COMPRISING A PYRIDINEDICARBOXYLIC ACID DERIVATIVE AND A HYDROXYSTILBENE |
Families Citing this family (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IT1256354B (it) * | 1992-08-31 | 1995-12-01 | Francesca Pelizzoni | Derivati della combretastatina ad attivita' anti-tumorale e procedimento per la loro preparazione |
| FR2766176B1 (fr) * | 1997-07-15 | 1999-10-29 | Caudalie | Compositions a base de derives de resveratrol |
| AU2003268599B2 (en) * | 1998-05-05 | 2007-03-15 | Casper, Robert Frederic | Arylhydrocarbon Receptor Ligand Antagonists |
| FR2778337B1 (fr) * | 1998-05-05 | 2001-08-31 | Inst Nat Sante Rech Med | Antagonistes des ligands du recepteur des arylhydrocarbures |
| AU4084599A (en) * | 1998-05-18 | 1999-12-06 | Oklahoma Medical Research Foundation | Resveratrol inhibition of myeloperoxidase |
| US6974895B1 (en) | 1999-01-29 | 2005-12-13 | The Samuel Roberts Noble Foundation, Inc. | Transgenic legume plants modified to produce resveratrol glucoside and uses thereof |
| NZ513156A (en) * | 1999-01-29 | 2004-05-28 | Samuel Roberts Noble Found Inc | Transgenic plants modified to contain resveratrol glucoside and uses thereof |
| AU7596100A (en) | 1999-09-21 | 2001-04-24 | Rutgers, The State University | Resveratrol analogs for prevention of disease |
| CN1090603C (zh) * | 1999-09-24 | 2002-09-11 | 四川省凉山州生物研究所 | 一种从中药虎杖中提取白藜芦醇的工艺 |
| JP2002047193A (ja) * | 2000-07-31 | 2002-02-12 | Sunstar Inc | アレルギー性皮膚炎予防または治療用組成物 |
| CN1398838A (zh) * | 2001-07-26 | 2003-02-26 | 中国人民解放军军事医学科学院放射医学研究所 | 二苯乙烯类化合物制备以及它们在治疗和预防糖尿病中的应用 |
| CN105726508B (zh) * | 2016-01-12 | 2019-02-15 | 中国人民解放军第四军医大学 | 新型二苯乙烯苷缓控释制剂及其制备方法 |
| KR102040763B1 (ko) * | 2017-10-27 | 2019-11-05 | 한약진흥재단 | 호장근과 계심을 함유하는 항혈전용 조성물 |
| CN107722079A (zh) * | 2017-10-31 | 2018-02-23 | 桂林纽泰生物科技有限公司 | 从何首乌中提取二苯乙烯苷的方法 |
| CN107903292B (zh) * | 2017-12-26 | 2020-10-30 | 四川文理学院 | 一种何首乌中二苯乙烯苷的提取方法 |
| KR102305237B1 (ko) * | 2019-07-29 | 2021-09-29 | 재단법인 경기도경제과학진흥원 | 이삭여뀌 추출물을 이용한 피부 주름 개선 및 피부 미백용 조성물 |
-
1985
- 1985-01-24 JP JP60011679A patent/JPS61171427A/ja active Granted
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2011089168A2 (fr) | 2010-01-21 | 2011-07-28 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Composition particuliere pour son application comme medicament |
| WO2019016153A1 (en) | 2017-07-17 | 2019-01-24 | L'oreal | AQUEOUS COSMETIC COMPOSITION COMPRISING A PYRIDINEDICARBOXYLIC ACID DERIVATIVE AND A HYDROXYSTILBENE |
Also Published As
| Publication number | Publication date |
|---|---|
| JPS61171427A (ja) | 1986-08-02 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JPH0516413B2 (enExample) | ||
| Akila et al. | Chlorogenic acid ameliorates isoproterenol-induced myocardial injury in rats by stabilizing mitochondrial and lysosomal enzymes | |
| KR101431060B1 (ko) | 바쿠치올의 조성물 및 그것의 제조방법 | |
| KR102246163B1 (ko) | 과실 추출물 | |
| JP4956440B2 (ja) | リグナン系化合物の炎症性疾患の治療又は予防のための使用 | |
| KR20150138068A (ko) | 황칠 나무 추출물을 함유하는 간 기능 개선용 조성물 | |
| JP2009538895A (ja) | トマト抽出物の治療的使用 | |
| JP2008511629A (ja) | 循環器疾患の予防および／または治療のための薬草薬剤組成物ならびにその調製方法 | |
| JP2013530159A (ja) | ホオズキ抽出物を有効成分として含有する炎症性疾患の予防及び治療用組成物 | |
| KR20240095109A (ko) | 구절초 추출물을 포함하는 통증 완화용 또는 항산화용 건강기능식품 | |
| KR100964906B1 (ko) | 리카린 이를 함유하는 염증성 질환의 치료 또는 예방용약학적 조성물 | |
| KR101348729B1 (ko) | 유데스만계 화합물 및 이를 유효성분으로 함유하는 조성물 | |
| JPS61161219A (ja) | アトピ−性皮膚炎症用化粧料組成物 | |
| KR100315000B1 (ko) | 장생도라지추출물을포함하는고지혈증치료용한방제제 | |
| PT1658879E (pt) | Radix salviae miltiorrhizae, o seu extrato e composição para o tratamento de doenças de resistência à aspirina | |
| KR100912735B1 (ko) | 루틴 함유 괴화 추출물을 유효성분으로 하는 소염 진통제조성물 | |
| JP2000191487A (ja) | マトリクスメタロプロテア―ゼ阻害用口腔剤組成物及び飲食品組成物 | |
| JP4708744B2 (ja) | 血小板凝集抑制組成物 | |
| KR101671847B1 (ko) | 땃두릅나무 추출물을 유효성분으로 포함하는 혈전 질환의 예방 또는 치료용 조성물 | |
| KR20180129081A (ko) | 진토닌을 유효성분으로 함유하는 혈전성 질환의 예방 또는 치료용 조성물 | |
| KR101536211B1 (ko) | 길경 추출물 또는 이의 분획물을 함유하는 혈전성 질환의 예방 또는 치료용 조성물 | |
| KR100814949B1 (ko) | 민들레 추출물을 함유하는 지질대사 장애 및 당뇨합병증질환의 예방 및 치료용 조성물 | |
| KR101972080B1 (ko) | 섬말나리 추출물을 유효성분으로 포함하는 약학적 조성물 | |
| Alhazmi | Anticoagulative activity of Commiphora gileadensis, aspirin, and heparin on blood coagulation profiles in naïve mice | |
| JP2000072685A (ja) | 消化器潰瘍を抑制するための食品および医薬組成物 |