JPH05112434A - Hair growing agent - Google Patents

Abstract

PURPOSE:To obtain a hair growing agent having excellently hair growing effects, proved safety, usable with ease, comprising an extract of leaves of mulberry as an active ingredient. CONSTITUTION:A hair growing agent comprising 0.0001-15wt.%, preferably 0.0005-5wt.% calculated as dry base of an extract obtained by extracting leaves of mulberry with an organic solvent such as ethanol, methanol, butanol, acetone, ethyl acetate or dimethyl ether. An ethanol extract is directly used as it is and in the case of an extract with a solvent except ethanol, the solvent is removed to give a dried substance, which is mixed with other cosmetic raw materials and pharmaceutically manufactured into a cosmetic.

Description

Detailed Description of the Invention

[0001]

BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to a hair restorer containing an extract of mulberry leaves.

[0002]

2. Description of the Related Art There are many patents and raw materials for hair-growth products, but generally speaking, when natural products are used as raw materials, the effect is weak, and with synthetic products there is a risk of side effects. is there. Kuwaha is the scientific name of Morus Bombisis.
Bombycis, Morus alba, etc., and refers to the dried leaves of mulberry trees. Morus bombysis is distributed in various parts of Japan, as well as in the southern temperate islands of Korea, China, Vietnam, India, and Kashmir to the subtropics. It is a deciduous tree that is planted in fields in the mountains and is called mulberry or yamawawa. Morus Alba is native to China and the Korean Peninsula and has been introduced to Japan since ancient times. It is a deciduous tree planted in various places for garden trees, street trees, and sericulture, and is called Karagua or Tuguwa.

It has been conventionally applied as an antipyretic, antitussive, bleeding blood, and ophthalmic drug for common cold, cough, headache, eye disease, beriberi, edema, abdominal pain, diarrhea, bleeding blood, etc., and has already been used as a medicine. There is. However, it is not used as a cosmetic.

[0004]

DISCLOSURE OF THE INVENTION The object of the present invention is to use a substance having a hair-growing action from an extract of a plant, which has been proved to be safe and which is used for other purposes such as folk medicine, Chinese medicine, etc. for internal use. To find out.

[0005]

[Means for Solving the Problems] The present inventors
As a result of testing a large number of plants which have been used for other purposes in Kampo or the like, have been proved to be safe, and are easily available, they have found that mulberry leaves are very effective as a hair-growth agent, and arrived at the present invention. . Mulberry leaf is already marketed as a crude drug and is easily available.

That is, the present invention is a hair-growth material containing a solvent extract of mulberry leaves. As mulberry leaves, in order to enhance the extraction effect, it is effective to use dried mulberry leaves and extract with an organic solvent. The organic solvent used is ethanol, methanol, butanol, acetone, ethyl acetate,
Extraction is performed using a solvent such as dimethyl ether, but extraction with ethanol is generally considered to be the easiest method because it does not require removal of the solvent after extraction. In the case of this ethanol extract or other solvent, the solvent is removed to give a dried product (of course, the ethanol extract or ethanol may be removed), and other cosmetic ingredients are blended into a formulation. As the amount of the extract compounded, the usage form, purpose,
The amount is 0.0001 to 15% by weight, preferably 0.0005 to 5% by weight in terms of dry matter, although it varies depending on conditions such as coexistence of other hair-growing raw materials.

[0007]

The present invention will be described in more detail with reference to the following examples, but the present invention is not limited to these examples.

(Production Example 1) 50 g of mulberry leaves (commercially available) was immersed in 1000 ml of ethanol and left for 10 days with occasional stirring. This was filtered, concentrated under reduced pressure, and then freeze-dried.

(Production Example 2) 50 g of mulberry leaves (commercially available) was immersed in 1000 ml of diethyl ether and left for 10 days with occasional stirring. This was filtered, concentrated under reduced pressure, and then freeze-dried.

(Example 1) Hair growth lotion A Vitamin E 0.5 Polyoxyethylene hydrogenated castor oil (60 E.O.) 1.0 Polyoxyethylene sorbitan monostearate (20 E.O.) 2.5 Perfume 0.1 B 1,3 butylene glycol 5.0 Ethanol 70.0 Production Example 1 Extract 1.0 Purified water 19.9 Production method A is weighed and dissolved by heating with stirring. The remaining raw material of B is weighed and added to A while stirring.

(Example 2) Hair-growth lotion The extract of Production Example 1 of Example 1 was replaced with the extract of Production Example 2. (Test method 1) Animal experiment = ddy mouse, male, 4-week-old mouse was preliminarily bred for 1 week and then subjected to the experiment. Breeding condition = MF (Oriental Yeast Co., Ltd.) as feed and tap water as drinking water. Test method = Left and right back skin of the mouse was shaved with electric clippers, then dehaired with a depilatory cream, and the site was thoroughly washed with warm water and then wiped. Then, one side was coated with a sample, and the other side was coated with a 0.2 ml syringe having no coating or having a formulation excluding the evaluation substance. The application was continued twice a day (morning and evening) from the day after hair removal. Judgment = After 28 days, remove hair from the application and control areas (Hair
Tweezers) randomly pulled out, picked 10 hairs out of them randomly, measured the length of the hairs, and calculated the average. This was subjected to Wilcoxon test. The results are shown in Table 1. At the same time, the naked eye was also judged. No. 1 = Ethanol solution containing 1% freeze-dried product prepared in Production Example 1 No. 2 = Ethanol solution containing 1% freeze-dried product prepared in Production Example 2 No. 3 = Example 1 No. 4 = Implementation Example 2 No. 5 = Commercial hair restorer A No. 6 = Commercial hair restorer B No. 7 = Commercial hair restorer C No. 8 = Commercial hair restorer D No. 9 = Commercial hair restorer E No. 10 = Assembly extract No .11 = ginseng extract No.12 = pantothenyl ethyl ether No.13 = tocophenol acetate

[Table 1] (Test Method 2) Twenty men with thin hair were asked to use each of Examples 1 and 2 for 3 months twice in the morning and evening by 10 people each. The results are shown in Table 2.

[Table 2] Became.

EFFECTS OF THE INVENTION By applying a cosmetic containing a solvent extract of mulberry leaves to the skin, it was revealed by both the mouse test and the human sensory test that there was a remarkable hair-growth effect. The extract of mulberry leaves has been used for a long time for internal use such as Chinese herbs, etc., its safety has been proven, and it is easily available. It has excellent effects as a hair restorer and can be used with confidence.

Claims (1)

[Claims] 1. A hair restorer comprising a solvent extract of mulberry leaves.