JPH0458311B2 - - Google Patents
Info
- Publication number
- JPH0458311B2 JPH0458311B2 JP59258441A JP25844184A JPH0458311B2 JP H0458311 B2 JPH0458311 B2 JP H0458311B2 JP 59258441 A JP59258441 A JP 59258441A JP 25844184 A JP25844184 A JP 25844184A JP H0458311 B2 JPH0458311 B2 JP H0458311B2
- Authority
- JP
- Japan
- Prior art keywords
- carrier
- monomer
- oxirane
- group
- trivinyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 102000004190 Enzymes Human genes 0.000 claims description 31
- 108090000790 Enzymes Proteins 0.000 claims description 31
- YXFVVABEGXRONW-UHFFFAOYSA-N Toluene Natural products CC1=CC=CC=C1 YXFVVABEGXRONW-UHFFFAOYSA-N 0.000 claims description 28
- 239000000178 monomer Substances 0.000 claims description 16
- 239000000203 mixture Substances 0.000 claims description 15
- 239000011324 bead Substances 0.000 claims description 14
- 239000003795 chemical substances by application Substances 0.000 claims description 13
- 238000000034 method Methods 0.000 claims description 12
- 125000000466 oxiranyl group Chemical group 0.000 claims description 12
- 239000012071 phase Substances 0.000 claims description 11
- IAYPIBMASNFSPL-UHFFFAOYSA-N Ethylene oxide Chemical compound C1CO1 IAYPIBMASNFSPL-UHFFFAOYSA-N 0.000 claims description 9
- 239000012074 organic phase Substances 0.000 claims description 8
- VOZRXNHHFUQHIL-UHFFFAOYSA-N glycidyl methacrylate Chemical compound CC(=C)C(=O)OCC1CO1 VOZRXNHHFUQHIL-UHFFFAOYSA-N 0.000 claims description 6
- OKKRPWIIYQTPQF-UHFFFAOYSA-N Trimethylolpropane trimethacrylate Chemical group CC(=C)C(=O)OCC(CC)(COC(=O)C(C)=C)COC(=O)C(C)=C OKKRPWIIYQTPQF-UHFFFAOYSA-N 0.000 claims description 5
- 238000010557 suspension polymerization reaction Methods 0.000 claims description 5
- 238000004519 manufacturing process Methods 0.000 claims description 4
- 239000004215 Carbon black (E152) Substances 0.000 claims description 3
- 229930195733 hydrocarbon Natural products 0.000 claims description 3
- 150000003254 radicals Chemical class 0.000 claims description 3
- 239000007900 aqueous suspension Substances 0.000 claims description 2
- 150000002430 hydrocarbons Chemical class 0.000 claims description 2
- 239000012948 isocyanate Substances 0.000 claims description 2
- 150000002513 isocyanates Chemical class 0.000 claims description 2
- 125000003944 tolyl group Chemical group 0.000 claims description 2
- 238000004132 cross linking Methods 0.000 claims 3
- 238000005191 phase separation Methods 0.000 claims 3
- STMDPCBYJCIZOD-UHFFFAOYSA-N 2-(2,4-dinitroanilino)-4-methylpentanoic acid Chemical compound CC(C)CC(C(O)=O)NC1=CC=C([N+]([O-])=O)C=C1[N+]([O-])=O STMDPCBYJCIZOD-UHFFFAOYSA-N 0.000 claims 2
- RPQRDASANLAFCM-UHFFFAOYSA-N oxiran-2-ylmethyl prop-2-enoate Chemical compound C=CC(=O)OCC1CO1 RPQRDASANLAFCM-UHFFFAOYSA-N 0.000 claims 2
- DAKWPKUUDNSNPN-UHFFFAOYSA-N Trimethylolpropane triacrylate Chemical compound C=CC(=O)OCC(CC)(COC(=O)C=C)COC(=O)C=C DAKWPKUUDNSNPN-UHFFFAOYSA-N 0.000 claims 1
- 125000001183 hydrocarbyl group Chemical group 0.000 claims 1
- 229940088598 enzyme Drugs 0.000 description 27
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 12
- 239000000243 solution Substances 0.000 description 11
- 230000000694 effects Effects 0.000 description 8
- 238000006243 chemical reaction Methods 0.000 description 7
- 108010073038 Penicillin Amidase Proteins 0.000 description 6
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 6
- 239000000969 carrier Substances 0.000 description 6
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 6
- YIVJZNGAASQVEM-UHFFFAOYSA-N Lauroyl peroxide Chemical compound CCCCCCCCCCCC(=O)OOC(=O)CCCCCCCCCCC YIVJZNGAASQVEM-UHFFFAOYSA-N 0.000 description 5
- 230000003100 immobilizing effect Effects 0.000 description 5
- JGSARLDLIJGVTE-MBNYWOFBSA-N Penicillin G Chemical compound N([C@H]1[C@H]2SC([C@@H](N2C1=O)C(O)=O)(C)C)C(=O)CC1=CC=CC=C1 JGSARLDLIJGVTE-MBNYWOFBSA-N 0.000 description 4
- 239000008346 aqueous phase Substances 0.000 description 4
- 239000001257 hydrogen Substances 0.000 description 4
- 229910052739 hydrogen Inorganic materials 0.000 description 4
- 239000003999 initiator Substances 0.000 description 4
- 229920000642 polymer Polymers 0.000 description 4
- 102000004169 proteins and genes Human genes 0.000 description 4
- 108090000623 proteins and genes Proteins 0.000 description 4
- 239000012429 reaction media Substances 0.000 description 4
- 235000011121 sodium hydroxide Nutrition 0.000 description 4
- QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 description 3
- UHOVQNZJYSORNB-UHFFFAOYSA-N Benzene Chemical compound C1=CC=CC=C1 UHOVQNZJYSORNB-UHFFFAOYSA-N 0.000 description 3
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 3
- 108010010803 Gelatin Proteins 0.000 description 3
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 description 3
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 description 3
- 239000008367 deionised water Substances 0.000 description 3
- 229910021641 deionized water Inorganic materials 0.000 description 3
- 239000008273 gelatin Substances 0.000 description 3
- 229920000159 gelatin Polymers 0.000 description 3
- 235000019322 gelatine Nutrition 0.000 description 3
- 235000011852 gelatine desserts Nutrition 0.000 description 3
- -1 glycidyl ester Chemical class 0.000 description 3
- 239000011148 porous material Substances 0.000 description 3
- 239000011780 sodium chloride Substances 0.000 description 3
- 238000003756 stirring Methods 0.000 description 3
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 2
- HEDRZPFGACZZDS-UHFFFAOYSA-N Chloroform Chemical compound ClC(Cl)Cl HEDRZPFGACZZDS-UHFFFAOYSA-N 0.000 description 2
- 239000004593 Epoxy Chemical group 0.000 description 2
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 2
- 108090000604 Hydrolases Proteins 0.000 description 2
- 102000004157 Hydrolases Human genes 0.000 description 2
- LSDPWZHWYPCBBB-UHFFFAOYSA-N Methanethiol Chemical group SC LSDPWZHWYPCBBB-UHFFFAOYSA-N 0.000 description 2
- 239000004372 Polyvinyl alcohol Substances 0.000 description 2
- 150000001412 amines Chemical class 0.000 description 2
- 150000001413 amino acids Chemical group 0.000 description 2
- 230000015572 biosynthetic process Effects 0.000 description 2
- 229920001577 copolymer Polymers 0.000 description 2
- 239000012153 distilled water Substances 0.000 description 2
- HNRMPXKDFBEGFZ-UHFFFAOYSA-N ethyl trimethyl methane Natural products CCC(C)(C)C HNRMPXKDFBEGFZ-UHFFFAOYSA-N 0.000 description 2
- 238000001914 filtration Methods 0.000 description 2
- 239000007788 liquid Substances 0.000 description 2
- 150000002924 oxiranes Chemical class 0.000 description 2
- WLJVXDMOQOGPHL-UHFFFAOYSA-N phenylacetic acid Chemical compound OC(=O)CC1=CC=CC=C1 WLJVXDMOQOGPHL-UHFFFAOYSA-N 0.000 description 2
- 239000008363 phosphate buffer Substances 0.000 description 2
- 229920001495 poly(sodium acrylate) polymer Polymers 0.000 description 2
- 238000006116 polymerization reaction Methods 0.000 description 2
- 229920002451 polyvinyl alcohol Polymers 0.000 description 2
- 239000000376 reactant Substances 0.000 description 2
- 239000011347 resin Substances 0.000 description 2
- 229920005989 resin Polymers 0.000 description 2
- NNMHYFLPFNGQFZ-UHFFFAOYSA-M sodium polyacrylate Chemical compound [Na+].[O-]C(=O)C=C NNMHYFLPFNGQFZ-UHFFFAOYSA-M 0.000 description 2
- AKHNMLFCWUSKQB-UHFFFAOYSA-L sodium thiosulfate Chemical compound [Na+].[Na+].[O-]S([O-])(=O)=S AKHNMLFCWUSKQB-UHFFFAOYSA-L 0.000 description 2
- 235000019345 sodium thiosulphate Nutrition 0.000 description 2
- 239000000126 substance Substances 0.000 description 2
- WSLDOOZREJYCGB-UHFFFAOYSA-N 1,2-Dichloroethane Chemical compound ClCCCl WSLDOOZREJYCGB-UHFFFAOYSA-N 0.000 description 1
- OYKPJMYWPYIXGG-UHFFFAOYSA-N 2,2-dimethylbutane;prop-2-enoic acid Chemical compound OC(=O)C=C.OC(=O)C=C.OC(=O)C=C.CCC(C)(C)C OYKPJMYWPYIXGG-UHFFFAOYSA-N 0.000 description 1
- SMZOUWXMTYCWNB-UHFFFAOYSA-N 2-(2-methoxy-5-methylphenyl)ethanamine Chemical compound COC1=CC=C(C)C=C1CCN SMZOUWXMTYCWNB-UHFFFAOYSA-N 0.000 description 1
- PTTPXKJBFFKCEK-UHFFFAOYSA-N 2-Methyl-4-heptanone Chemical compound CC(C)CC(=O)CC(C)C PTTPXKJBFFKCEK-UHFFFAOYSA-N 0.000 description 1
- FZRCKLPSHGTOAU-UHFFFAOYSA-N 6-amino-1,4-dimethylcyclohexa-2,4-diene-1-carbaldehyde Chemical compound CC1=CC(N)C(C)(C=O)C=C1 FZRCKLPSHGTOAU-UHFFFAOYSA-N 0.000 description 1
- NGHVIOIJCVXTGV-UHFFFAOYSA-N 6beta-amino-penicillanic acid Natural products OC(=O)C1C(C)(C)SC2C(N)C(=O)N21 NGHVIOIJCVXTGV-UHFFFAOYSA-N 0.000 description 1
- 108700023418 Amidases Proteins 0.000 description 1
- 102100026189 Beta-galactosidase Human genes 0.000 description 1
- 229930186147 Cephalosporin Natural products 0.000 description 1
- XFXPMWWXUTWYJX-UHFFFAOYSA-N Cyanide Chemical compound N#[C-] XFXPMWWXUTWYJX-UHFFFAOYSA-N 0.000 description 1
- 108090000371 Esterases Proteins 0.000 description 1
- 108010073178 Glucan 1,4-alpha-Glucosidase Proteins 0.000 description 1
- 102100022624 Glucoamylase Human genes 0.000 description 1
- 108010059881 Lactase Proteins 0.000 description 1
- CERQOIWHTDAKMF-UHFFFAOYSA-N Methacrylic acid Chemical compound CC(=C)C(O)=O CERQOIWHTDAKMF-UHFFFAOYSA-N 0.000 description 1
- NTIZESTWPVYFNL-UHFFFAOYSA-N Methyl isobutyl ketone Chemical compound CC(C)CC(C)=O NTIZESTWPVYFNL-UHFFFAOYSA-N 0.000 description 1
- UIHCLUNTQKBZGK-UHFFFAOYSA-N Methyl isobutyl ketone Natural products CCC(C)C(C)=O UIHCLUNTQKBZGK-UHFFFAOYSA-N 0.000 description 1
- CTQNGGLPUBDAKN-UHFFFAOYSA-N O-Xylene Chemical compound CC1=CC=CC=C1C CTQNGGLPUBDAKN-UHFFFAOYSA-N 0.000 description 1
- 229930182555 Penicillin Natural products 0.000 description 1
- 108700040099 Xylose isomerases Proteins 0.000 description 1
- 238000010521 absorption reaction Methods 0.000 description 1
- 239000008351 acetate buffer Substances 0.000 description 1
- NIXOWILDQLNWCW-UHFFFAOYSA-N acrylic acid group Chemical group C(C=C)(=O)O NIXOWILDQLNWCW-UHFFFAOYSA-N 0.000 description 1
- 238000001042 affinity chromatography Methods 0.000 description 1
- 102000005922 amidase Human genes 0.000 description 1
- 239000007864 aqueous solution Substances 0.000 description 1
- 238000010533 azeotropic distillation Methods 0.000 description 1
- IYNDLOXRXUOGIU-LQDWTQKMSA-M benzylpenicillin potassium Chemical compound [K+].N([C@H]1[C@H]2SC([C@@H](N2C1=O)C([O-])=O)(C)C)C(=O)CC1=CC=CC=C1 IYNDLOXRXUOGIU-LQDWTQKMSA-M 0.000 description 1
- 108010005774 beta-Galactosidase Proteins 0.000 description 1
- 238000009835 boiling Methods 0.000 description 1
- 239000003054 catalyst Substances 0.000 description 1
- 229940124587 cephalosporin Drugs 0.000 description 1
- 150000001875 compounds Chemical class 0.000 description 1
- 238000000354 decomposition reaction Methods 0.000 description 1
- 238000003795 desorption Methods 0.000 description 1
- GYZLOYUZLJXAJU-UHFFFAOYSA-N diglycidyl ether Chemical compound C1OC1COCC1CO1 GYZLOYUZLJXAJU-UHFFFAOYSA-N 0.000 description 1
- 239000002270 dispersing agent Substances 0.000 description 1
- 239000000499 gel Substances 0.000 description 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 description 1
- 230000007062 hydrolysis Effects 0.000 description 1
- 238000006460 hydrolysis reaction Methods 0.000 description 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 description 1
- 229940116108 lactase Drugs 0.000 description 1
- 239000007791 liquid phase Substances 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- QSHDDOUJBYECFT-UHFFFAOYSA-N mercury Chemical compound [Hg] QSHDDOUJBYECFT-UHFFFAOYSA-N 0.000 description 1
- 229910052753 mercury Inorganic materials 0.000 description 1
- AUHZEENZYGFFBQ-UHFFFAOYSA-N mesitylene Substances CC1=CC(C)=CC(C)=C1 AUHZEENZYGFFBQ-UHFFFAOYSA-N 0.000 description 1
- 125000001827 mesitylenyl group Chemical group [H]C1=C(C(*)=C(C([H])=C1C([H])([H])[H])C([H])([H])[H])C([H])([H])[H] 0.000 description 1
- 229910052757 nitrogen Inorganic materials 0.000 description 1
- TVMXDCGIABBOFY-UHFFFAOYSA-N octane Chemical compound CCCCCCCC TVMXDCGIABBOFY-UHFFFAOYSA-N 0.000 description 1
- 230000003287 optical effect Effects 0.000 description 1
- 239000012044 organic layer Substances 0.000 description 1
- CABDEMAGSHRORS-UHFFFAOYSA-N oxirane;hydrate Chemical compound O.C1CO1 CABDEMAGSHRORS-UHFFFAOYSA-N 0.000 description 1
- 229940049954 penicillin Drugs 0.000 description 1
- 229940056360 penicillin g Drugs 0.000 description 1
- 150000002978 peroxides Chemical class 0.000 description 1
- 229960003424 phenylacetic acid Drugs 0.000 description 1
- 239000003279 phenylacetic acid Substances 0.000 description 1
- 238000002360 preparation method Methods 0.000 description 1
- 150000003839 salts Chemical class 0.000 description 1
- 238000000926 separation method Methods 0.000 description 1
- 238000002798 spectrophotometry method Methods 0.000 description 1
- 239000000725 suspension Substances 0.000 description 1
- 239000008096 xylene Substances 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
- C08F216/00—Copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and at least one being terminated by an alcohol, ether, aldehydo, ketonic, acetal or ketal radical
- C08F216/12—Copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and at least one being terminated by an alcohol, ether, aldehydo, ketonic, acetal or ketal radical by an ether radical
- C08F216/14—Monomers containing only one unsaturated aliphatic radical
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
- C08F220/00—Copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and only one being terminated by only one carboxyl radical or a salt, anhydride ester, amide, imide or nitrile thereof
- C08F220/02—Monocarboxylic acids having less than ten carbon atoms; Derivatives thereof
- C08F220/10—Esters
- C08F220/26—Esters containing oxygen in addition to the carboxy oxygen
- C08F220/32—Esters containing oxygen in addition to the carboxy oxygen containing epoxy radicals
- C08F220/325—Esters containing oxygen in addition to the carboxy oxygen containing epoxy radicals containing glycidyl radical, e.g. glycidyl (meth)acrylate
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N11/00—Carrier-bound or immobilised enzymes; Carrier-bound or immobilised microbial cells; Preparation thereof
- C12N11/02—Enzymes or microbial cells immobilised on or in an organic carrier
- C12N11/08—Enzymes or microbial cells immobilised on or in an organic carrier the carrier being a synthetic polymer
- C12N11/082—Enzymes or microbial cells immobilised on or in an organic carrier the carrier being a synthetic polymer obtained by reactions only involving carbon-to-carbon unsaturated bonds
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Wood Science & Technology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Medicinal Chemistry (AREA)
- Polymers & Plastics (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Zoology (AREA)
- Genetics & Genomics (AREA)
- Biotechnology (AREA)
- Microbiology (AREA)
- Biomedical Technology (AREA)
- Biochemistry (AREA)
- General Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Immobilizing And Processing Of Enzymes And Microorganisms (AREA)
- Addition Polymer Or Copolymer, Post-Treatments, Or Chemical Modifications (AREA)
- Peptides Or Proteins (AREA)
Description
ïŒç£æ¥äžã®å©çšåéïŒ
æ¬çºæã¯ãªãã·ã©ã³ãæããããªããŒãããªã
æ äœã«é µçŽ ãåºå®ïŒimmobilizationïŒãããã
ããšã«é¢ãããã®ã§ãããç¹ã«ãªãã·ã©ã³ãã³ã
ã³ãåºãæããé«ãå€åæ§ã倧ããªåŸã®çŽ°ååã³
倧ããªè¡šé¢ç©ãæããæ¹è¯ãããããªããŒåã³ã
ã®è£œé æ¹æ³ã«é¢ãããã®ã§ããã ïŒåŸæ¥ã®æè¡ïŒ é µçŽ ã¯ããããã®åå¿ã«æŒããŠè§ŠåªãšããŠæçš
ã§ãããé µçŽ ã¯é µçŽ ãé ãåºãææ©äœããçŽç²ãª
圢ã§åé¢ããããã®ã®äœ¿çšãæãŸããããã®ãã
ãªçŽç²ãªç¶æ ã§ã¯é µçŽ ã¯æ¯èŒçäžå®ã§å®¹æã«å€æ§
ãããŸãã¯ããã¯æº¶æ¶²åå¿åªäœããååããããš
ãå°é£ã§ããã ããçã®å°é£ãå æããããã«ã¯ãé µçŽ ãäœç
ãã®äžæº¶æ§ã®æ äœã®äžã«åºå®ããããšãæãŸã
ãããã®å Žåãåå¿åªäœäžã§åå¿ç©ãšå®¹æã«æ¥è§Š
ã§ãããããå®å®æ§ã®å¢å€§ãšãçéã®ãããªåçŽ
ãªæ¹æ³ã«ãã€ãŠå®¹æã«åååºæ¥ããšäºãäž¡æ¹ã®å©
ç¹ãåŸãããã æ äœã®äžã«èçœè³ªé µçŽ ãåºå®ããéåžžã®æ©èœ
ã¯ãé µçŽ äžã®æŽ»æ§æ°ŽçŽ ãæã€åºäŸãã°ã¢ã«ã³ãŒ
ã«ãã¢ãã³åã¯ã¡ã«ã«ãã¿ã³åºãšãäžæº¶æ§ã®ããª
ããŒããçªãåºãŠãããªãã·ã©ã³ã€ãŸããšããã·
ç°ãã³ãã¯ãåºãšã®åå¿ã«ããããã®åå¿ã«ãã
ç°ãéããäžèšã®ããã«é µçŽ åºããã®æ°ŽçŽ ããªã
ã·ã©ã³é žçŽ ãšã§ããããã·ã«åºãäœãã ãã®ããã«ããŠãææãªéã®ãªãã·ã©ã³ç°ãå«
æããæ äœã¯ã容æã«èçœè³ªé µçŽ ãåºå®ããããš
ãåºæ¥ãã ãã®ãããªæ äœã¯ãåŸæ¥éåžžã®æžæ¿éåã«ãã
çŽ35ÎŒïœããçŽïŒmmã®çŽåŸã®ããŒãºïŒbeadsïŒã®
圢ã§é ãããŠããã ãã®ãããªæ äœã®ä»£è¡šçãªãã®ã¯ãç±³åœç¹èš±ç¬¬
3844892å·åã³ç±³åœç¹èš±ç¬¬3932557å·æ现æžã«èšèŒ
ãããŠããããããã®æç®ã¯ããªãã·ã©ã³ã€ãŸã
ãšããã·ç°ãå«æããå€ãã®ã¢ãããŒãæ瀺ããŠ
ããã äžèšã®æç®ã«èšèŒãããŠããæ äœã¯ãéåžžã®ã²
ã«ã®ããŒãºã§ããããã®ãããªæ äœã¯ãã®ãŸãŸã§
ã¯ããã¯ã现åãæããããã®ããŒãºãšåãçŽåŸ
ã®çäœã®è¡šé¢ç©ãšã»ãŒåãè¡šé¢ç©ãæãããé µçŽ
ã¯ãæ äœã®è¡šé¢ã§åå¿ããããã«çãåŸåããã
ã®ã§ãè¡šé¢ç©ã¯ãã倧ããããšãæãŸãããæ £çš
ã®æžæ¿éåã«ããããŒãºã®è¡šé¢ç©ã¯ãçžåé¢å€ã
å³ã¡ã¢ãããŒçžããã®ã³ãŒããªããŒã®åé¢ãèµ·ã
ãã液äœãå ããŠãã¯ãåæ§ãå°å ¥ããããšã«ã
ã€ãŠå žåçã«å¢å ãããã ãã®ãããªãã¯ãåæ§ãé µçŽ æ äœã«ãããŠæçš
ã§ããããã«ã¯ãåã¯ãåºå®ãããé µçŽ åã³åå¿
åªäœã®æåããšãã«èªç±ã«ééããã®ã«å åãªå€§
ããã§ãªããã°ãªããªãã æ äœããŒãºã«ãã¯ãåæ§ãå°å ¥ããããã®æ¹æ³
ã¯ãè±åœç¹èš±ç¬¬1512462å·å ¬å ±åã³ç±³åœç¹èš±ç¬¬
4070348å·æ现æžã«æããã«å ±åãããŠãããã
ãããªãããããã®æ¹æ³ã«ãã€ãŠè£œé ãããæ äœ
ã¯ãé µçŽ åºå®ããã»ã¹ã§ã®å©çšã«ããªãã®éçã
æããŠãããäžèšç±³åœã®æç®ã«ããããæ²¹çžäžã«
ã¢ãããŒã®æ°Žæº¶æ¶²ã滎ç¶ã«æžæ¿ããŠããéæžæ¿é
åããã»ã¹ã¯ãæ¯èŒçè¡šé¢ç©ã®å°ããæ äœããŒãº
ãäœããäžæ¹ãè±åœã®æç®ã§çžåé¢å€ãšããŠäœ¿çš
ãããã¢ã«ã³ãŒã«ã¯ããªãã·ã©ã³ç°ãšåå¿ããŠã
é µçŽ ãåºå®ããããã«å©çšåºæ¥ãéšäœã®æ°ãæžå°
ããããã ïŒçºæã解決ãã¹ã課é¡ïŒ æ¬çºæã¯ã倧ããªè¡šé¢ç©åã³é µçŽ åºå®ã®ããã®
é«å¯åºŠã®æŽ»æ§ãªãã·ã©ã³éšäœããã€é µçŽ åºå®åçš
æ äœåã³ãã®è£œé æ³ãæäŸããããšãç®çãšã
ãã ïŒèª²é¡ã解決ããããã®ææ®µïŒ æ¬çºæã®æ äœã¯ããªãã·ã©ã³ç°ãšåå¿ããªãçž
åé¢å€ã®ååšäžã«ãã¢ã¯ãªã«åã¯ã¡ã¿ã¯ãªã«é žã®
ã°ãªã·ãžã«ãšã¹ãã«ãåã¯ã¢ã¯ãªã«ã°ãªã·ãžã«ãš
ãŒãã«ãšã芪氎æ§ãæããããªããã«ã¢ãããŒã
ãšãã°ããªã¡ãã«ãããã³ãããªã¡ã¿ã¯ãªã¬ãŒ
ããããªã¡ãã«ãããã³ ããªã¢ã¯ãªã¬ãŒãåã¯
ããªã¢ãªã« ã€ãœã·ã¢ããŒãåã¯ãããã®æ··åç©
ãšãããªãŒã©ãžã«ã«æžæ¿éåãããããšã«ãã€ãŠ
補é ãããã ã¢ãããã«ã°ãªã·ãžã«ååç©ãšããªããã«åå
ç©ã®ééæ¯ã¯ãçŽïŒïŒ95ã95ïŒïŒã奜ãŸããã¯çŽ
ïŒïŒ95ã50ïŒ50ããã奜ãŸããã¯çŽ10ïŒ90ã30ïŒ
70ã§ããã ãã®é©åœãªæ¯çã¯ã倧ããªè¡šé¢ç©ãåã³é µçŽ ã
åºå®ããã®ã«å©çšã§ãã察å¿ããé«æ¿åºŠã®ãªãã·
ã©ã³åºãæããæ äœã®åœ¢æãä¿é²ããã çžåé¢å€ã¯ãææ©å±€ã®ééïŒ ãåºã«ããŠçŽ20ïŒ
ã90ééïŒ ã®éã§ååšããŠããã æ¬çºæã®è£œé æ¹æ³ã«é©åœãªå±€åé¢å€ã¯ããªãã·
ã©ã³ç°ãšåå¿ããªããã®ã§ããããäžè¿°ã®çžåé¢
å€ã®äžè¬çå®çŸ©ããªãæºãããããã®åé¢å€ã®äŸ
ã«ã¯ããã«ãšã³ããã·ã¬ã³ããã³ãŒã³ãã¡ã·ãã¬
ã³ãã¯ãããã«ã ããšãã¬ã³ãžã¯ãã©ã€ããã¡ã
ã«ã€ãœããã«ã±ãã³ããžã€ãœããã«ã±ãã³ããªã¯
ã¿ã³åã³ãããã®æ··åç©ãå«ãŸãããããæãŸã
ãçžåé¢å€ã¯ãçåæ°ŽçŽ çžåé¢å€ã§ããããã€ãš
ãæãŸããåé¢å€ã¯ãã«ãšã³ã§ããã éåžžã®ããªãŒã©ãžã«ã«éå§å€ãäŸãã°ã¢ãŸåã¯
éé žåç©éå§å€ãéåã®éå§ã®ããã«äœ¿çšããã
ãã®äœ¿çšéã¯ã¢ãããŒã®ééãåºç€ã«ããŠçŽ0.1
ããçŽïŒééïŒ ã§ããã ã¢ãããŒã®æ··åç©åã³çžåé¢å€ãããªãææ©çž
ã¯ãæžæ¿åªäœã®å šééãåºç€ã«ããŠïŒã10ééïŒ
ã®ãã¢ãããŒåã¯éå§å€ãšåå¿ããªãç¡æ©å¡©é¡ã
奜ãŸããã¯å¡©åãããªãŠã ãåã³0.1ã20ééïŒ
ã®éåžžã®æžæ¿å©å€ã奜ãŸããã¯ãŒã©ãã³åã³ïŒå
ã¯ããªã¢ã¯ãªã«é žãããªãŠã ãŸãã¯ããªããã«ã¢
ã«ã³ãŒã«æº¶æ¶²ãå«ãæ°Žæ§æžæ¿åªäœäžã«æ¹æã«ãã
æžæ¿ããããææ©çžã®æ°Žæ§çžã«å¯Ÿããæ¯çã¯çŽ
0.5ïŒïŒããçŽïŒïŒïŒã§ããã éåã¯ãéå§å€ã®å解ããããã®ã«å åãªã»ã©
é«ãããéžæããå§åã§ææ©åã¯æ°Žæ§çžã沞隰ã
ãã®ããµãããããªäœã枩床ã§æ¹æããªããè¡ãª
ãããã奜ãŸãã枩床ã¯çŽ40âããçŽ90âã§ã
ããå§åã¯ãèå§å®¹åšã䜿çšããªããŠããããã
ã«ãæ®éã«ã¯å€§æ°å§ãéžã°ããããæããªãã°æ°
æ°å§ã®äžã§ãè¡ãåŸãã æ¬çºæã¯ãŸãããã®ããã«ããŠäœãããæ äœã«
é¢ããæ äœã¯å¥œãŸããã¯ãäžèšã®å®æœäŸã§ç€ºãã
ãããã«å°ããšã140m2ïŒïœã®è¡šé¢ç©ãå°ããšã
1.14cm3ïŒïœã®å€åçåã³å°ããšã0.18ããªåœéïŒ
ïœã®è¡šé¢ãªãã·ã©ã³ãæããã ïŒäœçšïŒ åŸãããã³ãŒããªããŒã®ããŒãºã¯ããã¯ãåæ§
ã§ããã倧ããªè¡šé¢ç©ãæããŠããããã®ããŒãº
ã¯ãé µçŽ åã¯åå¿ç©ã容æã«äŸµå ¥ããã®ã«å åãª
倧ããã®åãæããé µçŽ åºå®ã®éšäœãšããŠå©çšã§
ããé«å¯åºŠã®ãªãã·ã©ã³åºãæããŠãããããã
ã®æ§è³ªã¯ä»¥äžã«è¿°ã¹ãå®æœäŸã«ãã€ãŠããã«èª¬æ
ããã é µçŽ ã¯èçœè³ªã§ãããç·ãŠã®èçœè³ªã¯æ äœã®ãª
ãã·ã©ã³åºãšåå¿ã§ãã掻æ§æ°ŽçŽ å«æåºãããšã
ã°ã¢ãã³ãã¢ã«ã³ãŒã«ãŸãã¯ã¡ã«ã«ãã¿ã³åºãæ
ããŠããã®ã§ãäºå®äžç·ãŠã®é µçŽ ã¯æ¬çºæã«ãã
æ äœã«åºå®ããã®ã«é©ããŠãããåºå®ã§ããé µçŽ
ã®äŸãšããŠã¯ãããã·ãªã³  ã¢ã·ã©ãŒãŒãã
ãã·ãªã³ã ã¢ã·ã©ãŒãŒãã°ã«ã³ã¢ãã©ãŒãŒã
ã°ã«ã³ãŒã¹ã€ãœã¡ã©ãŒãŒãã©ã¯ã¿ãŒãŒããã«ã¢ã¢
ãŒãŒãã·ã¢ããããããã©ãŒãŒãã»ãã¢ãã¹ããª
ã³ ãããã©ãŒãŒåã³ãšã¹ãã©ãŒãŒãããã æ¬çºæã®æ äœã®ãªãã·ã©ã³ç°ã¯ãé µçŽ ã®åºå®ã«
å ããã«ã掻æ§æ°ŽçŽ ãæããä»ã®ç©è³ªã®åºå®ã«ã
å©çšåºæ¥ããé µçŽ ä»¥å€ã®èçœè³ªããé µçŽ æ·¡çœãšå
æ§ãªåå¿ã«ãã€ãŠåºå®åºæ¥ããã¢ããé žã®ãããª
ãã©ã«ïŒchiralïŒåºããçµåããããããã®çµå
ã¯ãã¢ããé žã®ã©ã»ãæ··åç©ã®åé¢ã«å©çšããã
ããçããŠãã现èã¯ãããã®èçœè³ªã®åå¿ã«ã
ãæ äœã®è¡šé¢ã«åºå®ããããã æ¬çºæã®æ äœãé©ããŠããç¹å®ã®çšéã¯ãæ äœ
ã«çµåããæåãå«æããæ··åç©ããæ äœã®åºäž
ãæµéãããšããã®ã¢ãã€ããã€ã¯ãããã°ã©ã
ã€ãŒã§ãããçµåããæåã¯æ··åç©ããåãé€ã
ããæ®ã€ãæåã¯åŠšããããã«åºãééãããå ¶
ã®ä»ã®åããããªçšéã¯ãåœæ¥è ã«ãšã€ãŠæçœã§
ããã 以äžå®æœäŸã«ããæ¬çºæã説æããããããã
ãã«ãã€ãŠæ¬çºæã®ç¹èš±è«æ±ã®ç¯å²ãéå®ããã
ã®ã§ã¯ãªãã 以äžç¹å¥ã®èšèŒã®ç¡ãå Žåã¯ç·ãŠã®ïŒ ã¯ééïŒ
ãè¡šãããåç·ãŠã®äœ¿çšããè¬åã¯åžè²©ã®è¯å質
ã®ãã®ãçšããã å®æœäŸ ïŒ æ¬å®æœäŸã¯ããªãã·ã©ã³ãæããå€å質ã®ããª
ããŒæ äœã®è£œé ããã³ããã®æ äœäžãã®é µçŽ ã®åº
å®ã«ã€ããŠèª¬æãããšãããã®ã§ããã490mlã®
è±ã€ãªã³æ°Žã16.2ïœã®å¡©åãããªãŠã ã10.5ïœã®
ããªã¢ã¯ãªã«é žãããªãŠã ïŒAcrysolïŒåæšïŒGS
åæ£å€ïŒ12.5ïŒ æº¶æ¶²ãåã³50mlã®è±ã€ãªã³æ°Žã«æº¶
ããã0.9ïœã®ãŒã©ãã³ïŒPharmagelãåæšïŒã®
æ°Žæ§çžãåå¿å®¹åšäžã§10åéæ¹æããããã®å®¹åš
ã«ããªã¡ãããŒã«ãããã³ ããªã¡ã¿ã¯ãªã¬ãŒã
111.4ïœãã°ãªã·ãžã« ã¡ã¿ã¯ãªã¬ãŒã28.0ïœã
ãã«ãšã³314ïœåã³ã©ãŠãã€ã«ããŒãªããµã€ã
1.35ïœã®ææ©çžãå ãããã®æ··åç©ãå転æ°
200RPMã§15åéæ¹æããã次ã«æž©åºŠã65âã«ã
ãã20æéç¶æãããæ··åç©ãæŸå·ããçããçœ
è²ã®ããŒãºãå1000mlã®è±ã€ãªã³æ°Žã§ïŒåæŽæ»
ãã次ã«500mlã®ãã«ãšã³ã§ïŒåæŽæ»ãããã®ã
ãŒãºãç空也ç¥ããã也ç¥ããæš¹èã®è©Šæãåã³
æ¿¡ããããã®ïŒïœãã掻æ§180I.U.ïŒïœãæãã
åçµä¹Ÿç¥ããããã·ãªã³ ã¢ã·ã©ãŒãŒïŒïœãš1M
ã®PHïŒã®é ¢é žå¡©ç·©è¡æ¶²ïŒmlã®æ··åç©ã«å ãããã
ã®æ··åç©ã宀枩ã§ææã«48æéæŸçœ®ããã 次ã«æ¶²çžããã«ã³ãããããŒãºãã¯ãããã°ã©
ãã®ã«ã©ãã«å ¥ãããã«ã©ã ã«1Må¡©åãããªãŠ
ã 氎溶液ã®250mlãæµãã次ã«250mlã®èžçæ°Žãæµ
ããŠãããŒãºãæŽã€ãã å®æœäŸ ïŒ å®æœäŸïŒã§çšããã©ãŠãã€ã«ããŒãªããµã€ãã®
代ãã«ã1.35ïœã®ã¢ãŸã€ãœããããããªã«ãçšã
ã以å€ã¯ãå®æœäŸïŒãç¹°è¿ããã å®æœäŸ ïŒ ææ©çžãšããŠãããªã¡ãããŒã«ãããã³ ããª
ã¡ã¿ã¯ãªã¬ãŒã124ïœãã°ãªã·ãžã«ã¡ã¿ã¯ãªã¬ãŒ
ã14ïœããã«ãšã³314ïœåã³ã©ãŠãã€ã«ããŒãªã
ãµã€ã1.39ïœãããªããã®ã䜿çšãã以å€ã¯ãå®
æœäŸïŒãç¹°è¿ããã å®æœäŸ ïŒ ææ©çžãšããŠããªã¡ãããŒã«ãããã³ ããªã¡
ã¿ã¯ãªã¬ãŒã99.2ïœãã°ãªã·ãžã«ã¡ã¿ã¯ã¬ãŒã
42.2ïœããã«ãšã³314.1ïœåã³ã©ãŠãã€ã«ããŒã¢
ããµã€ã1.35ïœãããªããã®ã䜿çšãã以å€ã¯ã
å®æœäŸïŒãç¹°è¿ããã å®æœäŸ ïŒ 1000mlã®æ°Žã«ããïŒåç®ã®æŽæ»ã®ããšã§ãæ®ç
ãã«ãšã³ãå ±æ²žèžçã«ããåãé€ãã以å€ã¯ãå®
æœäŸïŒãç¹°è¿ããã å®æœäŸ ïŒ ææ©çžãšããŠããªã¡ãããŒã«ãããã³ ããªã¡
ã¿ã¯ãªã¬ãŒã71ïœãã°ãªã·ãžã«ã¡ã¿ã¯ãªã¬ãŒã
71.0ïœããã«ãšã³314.1ïœåã³ã©ãŠãã€ã« ããŒ
ãªããµã€ã1.35ïœãããªããã®ã䜿çšãã以å€
ã¯ãå®æœäŸïŒãç¹°è¿ããã å®æœäŸ ïŒ æ°Žæ§çžãšããŠããªããã«ã¢ã«ã³ãŒã«1.1ïœã
âPharmagelâãŒã©ãã³0.6ïœåã³èžçæ°Ž617ïœã
ããªããã®ã䜿çšãã以å€ã¯ãå®æœäŸïŒãç¹°è¿ã
ãã 以äžã«èšèŒãã第ïŒè¡šã«ã¯ãäžèšã®å®æœäŸã«ã
ã€ãŠè£œé ãããæ äœã®ç©ççãã©ã¡ãŒã¿ãŒåã³æ
äœäžã«åºå®ãããããã·ãªã³ ã¢ã·ã©ãŒãŒé µçŽ ã®
掻æ§ã瀺ãã è¡šé¢ç©åã³å€å床ã¯ãé垞䜿ããããã«ããŠãš
ã«âãšã¡ããâãã©ãŒïŒBETïŒã®è¡šé¢ç©ã®ãã
ã®çªçŽ çæž©è±çè©Šéšåã³å€å床ã®ããã®æ°Žéå§å ¥
ïŒintrusionïŒè©Šéšã«åºã¥ãèšç®ã«ãã決å®ãã
ããè¡šé¢ãªãã·ã©ã³æŽ»æ§ã¯ãäžèšã®æé ã§æž¬å®ã
ããã è¡šé¢ãªãã·ã©ã³ã®æŽ»æ§è©Šéš ïŒïœã®ä¹Ÿç¥æ äœæš¹èããPHã³ã³ãããŒã©ãŒã«æ¥
ç¶ããã容åšäžã§ã1.3Mããªç¡«é žãããªãŠã æ°Ž
溶液100mlã®äžã«æ¹æããªããæžæ¿ããé»æ°çã«
PHã枬å®ããPHãïŒã7.5ã«ç¶æããã«å åãªé
ã®0.1Mã®å¡©é žãèšãå ¥ãããè¡šé¢ãªãã·ã©ã³ã®
éã¯ãåœéã®æ°Žé žåãããªãŠã ãéé¢ããããªç¡«
é žãããªãŠã ãšãªãã·ã©ã³åºã®åå¿ã«åºã¥ããŠèš
ç®ãããã ããã·ãªã³ ã¢ã·ã©ãŒãŒé µçŽ ãæ äœã«åºå®ãã
å Žååã¯ããªãŒã®ç¶æ ã®æŽ»æ§ã¯æ¬¡ã®ãããªæ¹æ³ã§
枬å®ãããã ããã·ãªã³ ã¢ã·ã©ãŒãŒã®æŽ»æ§è©Šéš çŽ50I.U.ã®æŽ»æ§ãå«ãã®ã«ååãªãããªãŒã®å
ã¯æ äœã®äžã«åºå®ãããããã·ãªã³ ã¢ã·ã©ãŒãŒ
é µçŽ ã®ããéããPH7.5ã®çé žå¡©ç·©è¡æ¶²60mlã®äž
ã«æžæ¿ããããæ··åç©ã¯ãé»æ°çã«PHã枬å®ãã
PHã³ã³ãããŒã©ãŒã«æ¥ç¶ããã容åšã®äžã§28âã«
ä¿ãããPHãçŽ8.0ã«ç¶æããã«å åãªéã®0.8N
ã®èæ§ãœãŒã溶液ãã¯ããå ¥ããããã®å®¹åšã«ã
çé žå¡©ç·©è¡æ¶²äžã«ããã·ãªã³ïŒ§ã«ãªãŠã å¡©ïŒïœã
å«æãã溶液ãç¢åŒµã28âã§å ãããããããŠã
ãã·ãªã³ïŒ§ã®é µçŽ 觊åªãããå æ°Žå解ã«ããããš
ãã«é ¢é žã®çæé床ããPHãç¶æããããã®èæ§
ãœãŒã溶液ã®æ·»å é床ãã枬å®ãããããã·ãªã³
塩ãå ãããšãåã³10ååŸã30ååŸã«ã容åšäž
ã®æ¶²äœã®è©Šæããšã€ããããçã®è©ŠæïŒ0.5mlïŒ
ã¯çŽã¡ã«ã0.05Mã®èæ§ãœãŒãïŒmlãšãã¡ã¿ããŒ
ã«100mlåœã20ïœã®é ¢é žåã³0.5ïœã®ãã©ãžã¡ãã«
ã¢ãããã³ãºã¢ã«ããããå«æãã溶液ïŒmlãšã®
溶液ïŒmlãšæ··åããã圢æãããïŒâã¢ãã ã
ãã·ã·ã©ãã㯠ã¢ã·ããã®éã¯415nïœã®æ³¢é·
ã«ããããå·ç©ã®å åžåãåå 枬å ããããšã«ã
ã決å®ãããã
æ äœã«é µçŽ ãåºå®ïŒimmobilizationïŒãããã
ããšã«é¢ãããã®ã§ãããç¹ã«ãªãã·ã©ã³ãã³ã
ã³ãåºãæããé«ãå€åæ§ã倧ããªåŸã®çŽ°ååã³
倧ããªè¡šé¢ç©ãæããæ¹è¯ãããããªããŒåã³ã
ã®è£œé æ¹æ³ã«é¢ãããã®ã§ããã ïŒåŸæ¥ã®æè¡ïŒ é µçŽ ã¯ããããã®åå¿ã«æŒããŠè§ŠåªãšããŠæçš
ã§ãããé µçŽ ã¯é µçŽ ãé ãåºãææ©äœããçŽç²ãª
圢ã§åé¢ããããã®ã®äœ¿çšãæãŸããããã®ãã
ãªçŽç²ãªç¶æ ã§ã¯é µçŽ ã¯æ¯èŒçäžå®ã§å®¹æã«å€æ§
ãããŸãã¯ããã¯æº¶æ¶²åå¿åªäœããååããããš
ãå°é£ã§ããã ããçã®å°é£ãå æããããã«ã¯ãé µçŽ ãäœç
ãã®äžæº¶æ§ã®æ äœã®äžã«åºå®ããããšãæãŸã
ãããã®å Žåãåå¿åªäœäžã§åå¿ç©ãšå®¹æã«æ¥è§Š
ã§ãããããå®å®æ§ã®å¢å€§ãšãçéã®ãããªåçŽ
ãªæ¹æ³ã«ãã€ãŠå®¹æã«åååºæ¥ããšäºãäž¡æ¹ã®å©
ç¹ãåŸãããã æ äœã®äžã«èçœè³ªé µçŽ ãåºå®ããéåžžã®æ©èœ
ã¯ãé µçŽ äžã®æŽ»æ§æ°ŽçŽ ãæã€åºäŸãã°ã¢ã«ã³ãŒ
ã«ãã¢ãã³åã¯ã¡ã«ã«ãã¿ã³åºãšãäžæº¶æ§ã®ããª
ããŒããçªãåºãŠãããªãã·ã©ã³ã€ãŸããšããã·
ç°ãã³ãã¯ãåºãšã®åå¿ã«ããããã®åå¿ã«ãã
ç°ãéããäžèšã®ããã«é µçŽ åºããã®æ°ŽçŽ ããªã
ã·ã©ã³é žçŽ ãšã§ããããã·ã«åºãäœãã ãã®ããã«ããŠãææãªéã®ãªãã·ã©ã³ç°ãå«
æããæ äœã¯ã容æã«èçœè³ªé µçŽ ãåºå®ããããš
ãåºæ¥ãã ãã®ãããªæ äœã¯ãåŸæ¥éåžžã®æžæ¿éåã«ãã
çŽ35ÎŒïœããçŽïŒmmã®çŽåŸã®ããŒãºïŒbeadsïŒã®
圢ã§é ãããŠããã ãã®ãããªæ äœã®ä»£è¡šçãªãã®ã¯ãç±³åœç¹èš±ç¬¬
3844892å·åã³ç±³åœç¹èš±ç¬¬3932557å·æ现æžã«èšèŒ
ãããŠããããããã®æç®ã¯ããªãã·ã©ã³ã€ãŸã
ãšããã·ç°ãå«æããå€ãã®ã¢ãããŒãæ瀺ããŠ
ããã äžèšã®æç®ã«èšèŒãããŠããæ äœã¯ãéåžžã®ã²
ã«ã®ããŒãºã§ããããã®ãããªæ äœã¯ãã®ãŸãŸã§
ã¯ããã¯ã现åãæããããã®ããŒãºãšåãçŽåŸ
ã®çäœã®è¡šé¢ç©ãšã»ãŒåãè¡šé¢ç©ãæãããé µçŽ
ã¯ãæ äœã®è¡šé¢ã§åå¿ããããã«çãåŸåããã
ã®ã§ãè¡šé¢ç©ã¯ãã倧ããããšãæãŸãããæ £çš
ã®æžæ¿éåã«ããããŒãºã®è¡šé¢ç©ã¯ãçžåé¢å€ã
å³ã¡ã¢ãããŒçžããã®ã³ãŒããªããŒã®åé¢ãèµ·ã
ãã液äœãå ããŠãã¯ãåæ§ãå°å ¥ããããšã«ã
ã€ãŠå žåçã«å¢å ãããã ãã®ãããªãã¯ãåæ§ãé µçŽ æ äœã«ãããŠæçš
ã§ããããã«ã¯ãåã¯ãåºå®ãããé µçŽ åã³åå¿
åªäœã®æåããšãã«èªç±ã«ééããã®ã«å åãªå€§
ããã§ãªããã°ãªããªãã æ äœããŒãºã«ãã¯ãåæ§ãå°å ¥ããããã®æ¹æ³
ã¯ãè±åœç¹èš±ç¬¬1512462å·å ¬å ±åã³ç±³åœç¹èš±ç¬¬
4070348å·æ现æžã«æããã«å ±åãããŠãããã
ãããªãããããã®æ¹æ³ã«ãã€ãŠè£œé ãããæ äœ
ã¯ãé µçŽ åºå®ããã»ã¹ã§ã®å©çšã«ããªãã®éçã
æããŠãããäžèšç±³åœã®æç®ã«ããããæ²¹çžäžã«
ã¢ãããŒã®æ°Žæº¶æ¶²ã滎ç¶ã«æžæ¿ããŠããéæžæ¿é
åããã»ã¹ã¯ãæ¯èŒçè¡šé¢ç©ã®å°ããæ äœããŒãº
ãäœããäžæ¹ãè±åœã®æç®ã§çžåé¢å€ãšããŠäœ¿çš
ãããã¢ã«ã³ãŒã«ã¯ããªãã·ã©ã³ç°ãšåå¿ããŠã
é µçŽ ãåºå®ããããã«å©çšåºæ¥ãéšäœã®æ°ãæžå°
ããããã ïŒçºæã解決ãã¹ã課é¡ïŒ æ¬çºæã¯ã倧ããªè¡šé¢ç©åã³é µçŽ åºå®ã®ããã®
é«å¯åºŠã®æŽ»æ§ãªãã·ã©ã³éšäœããã€é µçŽ åºå®åçš
æ äœåã³ãã®è£œé æ³ãæäŸããããšãç®çãšã
ãã ïŒèª²é¡ã解決ããããã®ææ®µïŒ æ¬çºæã®æ äœã¯ããªãã·ã©ã³ç°ãšåå¿ããªãçž
åé¢å€ã®ååšäžã«ãã¢ã¯ãªã«åã¯ã¡ã¿ã¯ãªã«é žã®
ã°ãªã·ãžã«ãšã¹ãã«ãåã¯ã¢ã¯ãªã«ã°ãªã·ãžã«ãš
ãŒãã«ãšã芪氎æ§ãæããããªããã«ã¢ãããŒã
ãšãã°ããªã¡ãã«ãããã³ãããªã¡ã¿ã¯ãªã¬ãŒ
ããããªã¡ãã«ãããã³ ããªã¢ã¯ãªã¬ãŒãåã¯
ããªã¢ãªã« ã€ãœã·ã¢ããŒãåã¯ãããã®æ··åç©
ãšãããªãŒã©ãžã«ã«æžæ¿éåãããããšã«ãã€ãŠ
補é ãããã ã¢ãããã«ã°ãªã·ãžã«ååç©ãšããªããã«åå
ç©ã®ééæ¯ã¯ãçŽïŒïŒ95ã95ïŒïŒã奜ãŸããã¯çŽ
ïŒïŒ95ã50ïŒ50ããã奜ãŸããã¯çŽ10ïŒ90ã30ïŒ
70ã§ããã ãã®é©åœãªæ¯çã¯ã倧ããªè¡šé¢ç©ãåã³é µçŽ ã
åºå®ããã®ã«å©çšã§ãã察å¿ããé«æ¿åºŠã®ãªãã·
ã©ã³åºãæããæ äœã®åœ¢æãä¿é²ããã çžåé¢å€ã¯ãææ©å±€ã®ééïŒ ãåºã«ããŠçŽ20ïŒ
ã90ééïŒ ã®éã§ååšããŠããã æ¬çºæã®è£œé æ¹æ³ã«é©åœãªå±€åé¢å€ã¯ããªãã·
ã©ã³ç°ãšåå¿ããªããã®ã§ããããäžè¿°ã®çžåé¢
å€ã®äžè¬çå®çŸ©ããªãæºãããããã®åé¢å€ã®äŸ
ã«ã¯ããã«ãšã³ããã·ã¬ã³ããã³ãŒã³ãã¡ã·ãã¬
ã³ãã¯ãããã«ã ããšãã¬ã³ãžã¯ãã©ã€ããã¡ã
ã«ã€ãœããã«ã±ãã³ããžã€ãœããã«ã±ãã³ããªã¯
ã¿ã³åã³ãããã®æ··åç©ãå«ãŸãããããæãŸã
ãçžåé¢å€ã¯ãçåæ°ŽçŽ çžåé¢å€ã§ããããã€ãš
ãæãŸããåé¢å€ã¯ãã«ãšã³ã§ããã éåžžã®ããªãŒã©ãžã«ã«éå§å€ãäŸãã°ã¢ãŸåã¯
éé žåç©éå§å€ãéåã®éå§ã®ããã«äœ¿çšããã
ãã®äœ¿çšéã¯ã¢ãããŒã®ééãåºç€ã«ããŠçŽ0.1
ããçŽïŒééïŒ ã§ããã ã¢ãããŒã®æ··åç©åã³çžåé¢å€ãããªãææ©çž
ã¯ãæžæ¿åªäœã®å šééãåºç€ã«ããŠïŒã10ééïŒ
ã®ãã¢ãããŒåã¯éå§å€ãšåå¿ããªãç¡æ©å¡©é¡ã
奜ãŸããã¯å¡©åãããªãŠã ãåã³0.1ã20ééïŒ
ã®éåžžã®æžæ¿å©å€ã奜ãŸããã¯ãŒã©ãã³åã³ïŒå
ã¯ããªã¢ã¯ãªã«é žãããªãŠã ãŸãã¯ããªããã«ã¢
ã«ã³ãŒã«æº¶æ¶²ãå«ãæ°Žæ§æžæ¿åªäœäžã«æ¹æã«ãã
æžæ¿ããããææ©çžã®æ°Žæ§çžã«å¯Ÿããæ¯çã¯çŽ
0.5ïŒïŒããçŽïŒïŒïŒã§ããã éåã¯ãéå§å€ã®å解ããããã®ã«å åãªã»ã©
é«ãããéžæããå§åã§ææ©åã¯æ°Žæ§çžã沞隰ã
ãã®ããµãããããªäœã枩床ã§æ¹æããªããè¡ãª
ãããã奜ãŸãã枩床ã¯çŽ40âããçŽ90âã§ã
ããå§åã¯ãèå§å®¹åšã䜿çšããªããŠããããã
ã«ãæ®éã«ã¯å€§æ°å§ãéžã°ããããæããªãã°æ°
æ°å§ã®äžã§ãè¡ãåŸãã æ¬çºæã¯ãŸãããã®ããã«ããŠäœãããæ äœã«
é¢ããæ äœã¯å¥œãŸããã¯ãäžèšã®å®æœäŸã§ç€ºãã
ãããã«å°ããšã140m2ïŒïœã®è¡šé¢ç©ãå°ããšã
1.14cm3ïŒïœã®å€åçåã³å°ããšã0.18ããªåœéïŒ
ïœã®è¡šé¢ãªãã·ã©ã³ãæããã ïŒäœçšïŒ åŸãããã³ãŒããªããŒã®ããŒãºã¯ããã¯ãåæ§
ã§ããã倧ããªè¡šé¢ç©ãæããŠããããã®ããŒãº
ã¯ãé µçŽ åã¯åå¿ç©ã容æã«äŸµå ¥ããã®ã«å åãª
倧ããã®åãæããé µçŽ åºå®ã®éšäœãšããŠå©çšã§
ããé«å¯åºŠã®ãªãã·ã©ã³åºãæããŠãããããã
ã®æ§è³ªã¯ä»¥äžã«è¿°ã¹ãå®æœäŸã«ãã€ãŠããã«èª¬æ
ããã é µçŽ ã¯èçœè³ªã§ãããç·ãŠã®èçœè³ªã¯æ äœã®ãª
ãã·ã©ã³åºãšåå¿ã§ãã掻æ§æ°ŽçŽ å«æåºãããšã
ã°ã¢ãã³ãã¢ã«ã³ãŒã«ãŸãã¯ã¡ã«ã«ãã¿ã³åºãæ
ããŠããã®ã§ãäºå®äžç·ãŠã®é µçŽ ã¯æ¬çºæã«ãã
æ äœã«åºå®ããã®ã«é©ããŠãããåºå®ã§ããé µçŽ
ã®äŸãšããŠã¯ãããã·ãªã³  ã¢ã·ã©ãŒãŒãã
ãã·ãªã³ã ã¢ã·ã©ãŒãŒãã°ã«ã³ã¢ãã©ãŒãŒã
ã°ã«ã³ãŒã¹ã€ãœã¡ã©ãŒãŒãã©ã¯ã¿ãŒãŒããã«ã¢ã¢
ãŒãŒãã·ã¢ããããããã©ãŒãŒãã»ãã¢ãã¹ããª
ã³ ãããã©ãŒãŒåã³ãšã¹ãã©ãŒãŒãããã æ¬çºæã®æ äœã®ãªãã·ã©ã³ç°ã¯ãé µçŽ ã®åºå®ã«
å ããã«ã掻æ§æ°ŽçŽ ãæããä»ã®ç©è³ªã®åºå®ã«ã
å©çšåºæ¥ããé µçŽ ä»¥å€ã®èçœè³ªããé µçŽ æ·¡çœãšå
æ§ãªåå¿ã«ãã€ãŠåºå®åºæ¥ããã¢ããé žã®ãããª
ãã©ã«ïŒchiralïŒåºããçµåããããããã®çµå
ã¯ãã¢ããé žã®ã©ã»ãæ··åç©ã®åé¢ã«å©çšããã
ããçããŠãã现èã¯ãããã®èçœè³ªã®åå¿ã«ã
ãæ äœã®è¡šé¢ã«åºå®ããããã æ¬çºæã®æ äœãé©ããŠããç¹å®ã®çšéã¯ãæ äœ
ã«çµåããæåãå«æããæ··åç©ããæ äœã®åºäž
ãæµéãããšããã®ã¢ãã€ããã€ã¯ãããã°ã©ã
ã€ãŒã§ãããçµåããæåã¯æ··åç©ããåãé€ã
ããæ®ã€ãæåã¯åŠšããããã«åºãééãããå ¶
ã®ä»ã®åããããªçšéã¯ãåœæ¥è ã«ãšã€ãŠæçœã§
ããã 以äžå®æœäŸã«ããæ¬çºæã説æããããããã
ãã«ãã€ãŠæ¬çºæã®ç¹èš±è«æ±ã®ç¯å²ãéå®ããã
ã®ã§ã¯ãªãã 以äžç¹å¥ã®èšèŒã®ç¡ãå Žåã¯ç·ãŠã®ïŒ ã¯ééïŒ
ãè¡šãããåç·ãŠã®äœ¿çšããè¬åã¯åžè²©ã®è¯å質
ã®ãã®ãçšããã å®æœäŸ ïŒ æ¬å®æœäŸã¯ããªãã·ã©ã³ãæããå€å質ã®ããª
ããŒæ äœã®è£œé ããã³ããã®æ äœäžãã®é µçŽ ã®åº
å®ã«ã€ããŠèª¬æãããšãããã®ã§ããã490mlã®
è±ã€ãªã³æ°Žã16.2ïœã®å¡©åãããªãŠã ã10.5ïœã®
ããªã¢ã¯ãªã«é žãããªãŠã ïŒAcrysolïŒåæšïŒGS
åæ£å€ïŒ12.5ïŒ æº¶æ¶²ãåã³50mlã®è±ã€ãªã³æ°Žã«æº¶
ããã0.9ïœã®ãŒã©ãã³ïŒPharmagelãåæšïŒã®
æ°Žæ§çžãåå¿å®¹åšäžã§10åéæ¹æããããã®å®¹åš
ã«ããªã¡ãããŒã«ãããã³ ããªã¡ã¿ã¯ãªã¬ãŒã
111.4ïœãã°ãªã·ãžã« ã¡ã¿ã¯ãªã¬ãŒã28.0ïœã
ãã«ãšã³314ïœåã³ã©ãŠãã€ã«ããŒãªããµã€ã
1.35ïœã®ææ©çžãå ãããã®æ··åç©ãå転æ°
200RPMã§15åéæ¹æããã次ã«æž©åºŠã65âã«ã
ãã20æéç¶æãããæ··åç©ãæŸå·ããçããçœ
è²ã®ããŒãºãå1000mlã®è±ã€ãªã³æ°Žã§ïŒåæŽæ»
ãã次ã«500mlã®ãã«ãšã³ã§ïŒåæŽæ»ãããã®ã
ãŒãºãç空也ç¥ããã也ç¥ããæš¹èã®è©Šæãåã³
æ¿¡ããããã®ïŒïœãã掻æ§180I.U.ïŒïœãæãã
åçµä¹Ÿç¥ããããã·ãªã³ ã¢ã·ã©ãŒãŒïŒïœãš1M
ã®PHïŒã®é ¢é žå¡©ç·©è¡æ¶²ïŒmlã®æ··åç©ã«å ãããã
ã®æ··åç©ã宀枩ã§ææã«48æéæŸçœ®ããã 次ã«æ¶²çžããã«ã³ãããããŒãºãã¯ãããã°ã©
ãã®ã«ã©ãã«å ¥ãããã«ã©ã ã«1Må¡©åãããªãŠ
ã 氎溶液ã®250mlãæµãã次ã«250mlã®èžçæ°Žãæµ
ããŠãããŒãºãæŽã€ãã å®æœäŸ ïŒ å®æœäŸïŒã§çšããã©ãŠãã€ã«ããŒãªããµã€ãã®
代ãã«ã1.35ïœã®ã¢ãŸã€ãœããããããªã«ãçšã
ã以å€ã¯ãå®æœäŸïŒãç¹°è¿ããã å®æœäŸ ïŒ ææ©çžãšããŠãããªã¡ãããŒã«ãããã³ ããª
ã¡ã¿ã¯ãªã¬ãŒã124ïœãã°ãªã·ãžã«ã¡ã¿ã¯ãªã¬ãŒ
ã14ïœããã«ãšã³314ïœåã³ã©ãŠãã€ã«ããŒãªã
ãµã€ã1.39ïœãããªããã®ã䜿çšãã以å€ã¯ãå®
æœäŸïŒãç¹°è¿ããã å®æœäŸ ïŒ ææ©çžãšããŠããªã¡ãããŒã«ãããã³ ããªã¡
ã¿ã¯ãªã¬ãŒã99.2ïœãã°ãªã·ãžã«ã¡ã¿ã¯ã¬ãŒã
42.2ïœããã«ãšã³314.1ïœåã³ã©ãŠãã€ã«ããŒã¢
ããµã€ã1.35ïœãããªããã®ã䜿çšãã以å€ã¯ã
å®æœäŸïŒãç¹°è¿ããã å®æœäŸ ïŒ 1000mlã®æ°Žã«ããïŒåç®ã®æŽæ»ã®ããšã§ãæ®ç
ãã«ãšã³ãå ±æ²žèžçã«ããåãé€ãã以å€ã¯ãå®
æœäŸïŒãç¹°è¿ããã å®æœäŸ ïŒ ææ©çžãšããŠããªã¡ãããŒã«ãããã³ ããªã¡
ã¿ã¯ãªã¬ãŒã71ïœãã°ãªã·ãžã«ã¡ã¿ã¯ãªã¬ãŒã
71.0ïœããã«ãšã³314.1ïœåã³ã©ãŠãã€ã« ããŒ
ãªããµã€ã1.35ïœãããªããã®ã䜿çšãã以å€
ã¯ãå®æœäŸïŒãç¹°è¿ããã å®æœäŸ ïŒ æ°Žæ§çžãšããŠããªããã«ã¢ã«ã³ãŒã«1.1ïœã
âPharmagelâãŒã©ãã³0.6ïœåã³èžçæ°Ž617ïœã
ããªããã®ã䜿çšãã以å€ã¯ãå®æœäŸïŒãç¹°è¿ã
ãã 以äžã«èšèŒãã第ïŒè¡šã«ã¯ãäžèšã®å®æœäŸã«ã
ã€ãŠè£œé ãããæ äœã®ç©ççãã©ã¡ãŒã¿ãŒåã³æ
äœäžã«åºå®ãããããã·ãªã³ ã¢ã·ã©ãŒãŒé µçŽ ã®
掻æ§ã瀺ãã è¡šé¢ç©åã³å€å床ã¯ãé垞䜿ããããã«ããŠãš
ã«âãšã¡ããâãã©ãŒïŒBETïŒã®è¡šé¢ç©ã®ãã
ã®çªçŽ çæž©è±çè©Šéšåã³å€å床ã®ããã®æ°Žéå§å ¥
ïŒintrusionïŒè©Šéšã«åºã¥ãèšç®ã«ãã決å®ãã
ããè¡šé¢ãªãã·ã©ã³æŽ»æ§ã¯ãäžèšã®æé ã§æž¬å®ã
ããã è¡šé¢ãªãã·ã©ã³ã®æŽ»æ§è©Šéš ïŒïœã®ä¹Ÿç¥æ äœæš¹èããPHã³ã³ãããŒã©ãŒã«æ¥
ç¶ããã容åšäžã§ã1.3Mããªç¡«é žãããªãŠã æ°Ž
溶液100mlã®äžã«æ¹æããªããæžæ¿ããé»æ°çã«
PHã枬å®ããPHãïŒã7.5ã«ç¶æããã«å åãªé
ã®0.1Mã®å¡©é žãèšãå ¥ãããè¡šé¢ãªãã·ã©ã³ã®
éã¯ãåœéã®æ°Žé žåãããªãŠã ãéé¢ããããªç¡«
é žãããªãŠã ãšãªãã·ã©ã³åºã®åå¿ã«åºã¥ããŠèš
ç®ãããã ããã·ãªã³ ã¢ã·ã©ãŒãŒé µçŽ ãæ äœã«åºå®ãã
å Žååã¯ããªãŒã®ç¶æ ã®æŽ»æ§ã¯æ¬¡ã®ãããªæ¹æ³ã§
枬å®ãããã ããã·ãªã³ ã¢ã·ã©ãŒãŒã®æŽ»æ§è©Šéš çŽ50I.U.ã®æŽ»æ§ãå«ãã®ã«ååãªãããªãŒã®å
ã¯æ äœã®äžã«åºå®ãããããã·ãªã³ ã¢ã·ã©ãŒãŒ
é µçŽ ã®ããéããPH7.5ã®çé žå¡©ç·©è¡æ¶²60mlã®äž
ã«æžæ¿ããããæ··åç©ã¯ãé»æ°çã«PHã枬å®ãã
PHã³ã³ãããŒã©ãŒã«æ¥ç¶ããã容åšã®äžã§28âã«
ä¿ãããPHãçŽ8.0ã«ç¶æããã«å åãªéã®0.8N
ã®èæ§ãœãŒã溶液ãã¯ããå ¥ããããã®å®¹åšã«ã
çé žå¡©ç·©è¡æ¶²äžã«ããã·ãªã³ïŒ§ã«ãªãŠã å¡©ïŒïœã
å«æãã溶液ãç¢åŒµã28âã§å ãããããããŠã
ãã·ãªã³ïŒ§ã®é µçŽ 觊åªãããå æ°Žå解ã«ããããš
ãã«é ¢é žã®çæé床ããPHãç¶æããããã®èæ§
ãœãŒã溶液ã®æ·»å é床ãã枬å®ãããããã·ãªã³
塩ãå ãããšãåã³10ååŸã30ååŸã«ã容åšäž
ã®æ¶²äœã®è©Šæããšã€ããããçã®è©ŠæïŒ0.5mlïŒ
ã¯çŽã¡ã«ã0.05Mã®èæ§ãœãŒãïŒmlãšãã¡ã¿ããŒ
ã«100mlåœã20ïœã®é ¢é žåã³0.5ïœã®ãã©ãžã¡ãã«
ã¢ãããã³ãºã¢ã«ããããå«æãã溶液ïŒmlãšã®
溶液ïŒmlãšæ··åããã圢æãããïŒâã¢ãã ã
ãã·ã·ã©ãã㯠ã¢ã·ããã®éã¯415nïœã®æ³¢é·
ã«ããããå·ç©ã®å åžåãåå 枬å ããããšã«ã
ã決å®ãããã
ãè¡šã
ïŒçºæã®å¹æïŒ
æ¬çºæã«ããé
µçŽ ã®åºå®ã®ããã«æå¹ãªãé«è¡š
é¢ç©ã§ãã¯ãåæ§ãæããé µçŽ ã®åºå®ã®çµåç¹ãš
ãªãé«å¯åºŠã®ãªãã·ã©ã³åºãæããããªããŒã®ã
ãŒãºç¶ã®æ äœã補é ããããšãåºãããã€ãã®æ
äœã«åºå®ãããé µçŽ ã¯å®å®æ§ããããå¹åã®æ°žç¶
çãªç¶æãå¯èœã§ããã溶液ã®åå¿åªäœããçé
çã®åçŽãªå·¥çšã«ãã€ãŠå®¹æã«ååã§ããã
é¢ç©ã§ãã¯ãåæ§ãæããé µçŽ ã®åºå®ã®çµåç¹ãš
ãªãé«å¯åºŠã®ãªãã·ã©ã³åºãæããããªããŒã®ã
ãŒãºç¶ã®æ äœã補é ããããšãåºãããã€ãã®æ
äœã«åºå®ãããé µçŽ ã¯å®å®æ§ããããå¹åã®æ°žç¶
çãªç¶æãå¯èœã§ããã溶液ã®åå¿åªäœããçé
çã®åçŽãªå·¥çšã«ãã€ãŠå®¹æã«ååã§ããã
Claims (1)
- ãç¹èš±è«æ±ã®ç¯å²ã ïŒ ã°ãªã·ãžã«ã¢ã¯ãªã¬ãŒããã°ãªã·ãžã«ã¡ã¿ã¯
ãªã¬ãŒããã¢ãªã«ã°ãªã·ãžã«ãšãŒãã«ãåã³ãã
ãã®æ··åç©ãããªã矀ããéžã°ãããªãã·ã©ã³åº
å«æã¢ãããã«ã¢ãããŒãšèŠªæ°Žæ§ãæããããªã
ãã«æ¶æ©æ§ã¢ãããŒãšããééæ¯ã§çŽïŒïŒ95ã
50ïŒ50ã®å²åã§ãæ°Žæ§æžæ¿åªäœäžã§ãææ©çžã«å¯Ÿ
ããŠçŽ20ïŒ ã90ïŒ ã®ããªãã·ã©ã³åºãšåå¿ããªã
çžåé¢å€ã®ååšã®äžã«ããªãŒã©ãžã«ã«æžæ¿éåã
ããããšã«ãããªããé µçŽ åºå®ã®ããã®æ äœã®è£œ
é æ¹æ³ã ïŒ ã¢ãããã«ã¢ãããŒå¯Ÿããªããã«ã¢ãããŒã®
æ¯ãçŽ10ïŒ90ããçŽ30ïŒ70ã§ããç¹èš±è«æ±ã®ç¯å²
第ïŒé èšèŒã®æ¹æ³ã ïŒ æ¶æ©æ§ã¢ãããŒããããªã¡ãããŒã«ãããã³
ããªã¡ã¿ã¯ãªã¬ãŒããããªã¡ãããŒã«ãããã³ã
ãªã¢ã¯ãªã¬ãŒããããªã¢ãªã«ãã€ãœã·ã¢ããŒãå
ã¯ãããã®æ··åç©ãããªã矀ããéžã°ãããã®ã§
ããç¹èš±è«æ±ã®ç¯å²ç¬¬ïŒé èšèŒã®æ¹æ³ã ïŒ çžåé¢å€ãçåæ°ŽçŽ çžåé¢å€ã§ããç¹èš±è«æ±
ã®ç¯å²ç¬¬ïŒé èšèŒã®æ¹æ³ã ïŒ çåæ°ŽçŽ çžåé¢å€ããã«ãšã³ã§ããç¹èš±è«æ±
ã®ç¯å²ç¬¬ïŒé èšèŒã®æ¹æ³ã ïŒ é µçŽ åºå®çšã®æ äœã«ãããŠãæ äœããã°ãªã·
ãžã«ã¢ã¯ãªã¬ãŒããã°ãªã·ãžã«ã¡ã¿ã¯ãªã¬ãŒãã
ã¢ãªã«ã°ãªã·ãžã«ãšãŒãã«åã³ãããã®æ··åç©ã
ããªã矀ããéžã°ãããªãã·ã©ã³åºå«æã¢ããã
ã«ã¢ãããŒåã³èŠªæ°Žæ§ãæããããªããã«æ¶æ©æ§
ã¢ãããŒïŒäœããã¢ãããã«ã¢ãããŒå¯Ÿããªãã
ã«ã¢ãããŒã®ééæ¯ã¯ïŒïŒ95ã50ïŒ50ã§ããïŒã
ãäœãããããªããŒã®ãã¯ãåæ§ããŒãºã§ããã
該ããŒãºã¯å°ããšã140m2ïŒïœã®è¡šé¢ç©ãå°ããš
ã1.14cm3ïŒïœã®å€åçåã³å°ããšã0.18ããªåœ
éïŒïœã®è¡šé¢ãªãã·ã©ã³ãæããããšãç¹åŸŽãšã
ãæ äœã
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US06/561,716 US4582860A (en) | 1983-12-15 | 1983-12-15 | Oxirane resins for enzyme immobilization |
US561716 | 1983-12-15 |
Publications (2)
Publication Number | Publication Date |
---|---|
JPS60221090A JPS60221090A (ja) | 1985-11-05 |
JPH0458311B2 true JPH0458311B2 (ja) | 1992-09-17 |
Family
ID=24243125
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP59258441A Granted JPS60221090A (ja) | 1983-12-15 | 1984-12-06 | é µçŽ åºå®ã®ããã®æ¹è¯ããããªãã·ã©ã³æš¹èåã³ãã®è£œé æ¹æ³ |
Country Status (7)
Country | Link |
---|---|
US (1) | US4582860A (ja) |
EP (1) | EP0146329A3 (ja) |
JP (1) | JPS60221090A (ja) |
BR (1) | BR8406277A (ja) |
CA (1) | CA1228196A (ja) |
ES (1) | ES8800348A1 (ja) |
ZA (1) | ZA849758B (ja) |
Families Citing this family (18)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE3521684A1 (de) * | 1985-06-18 | 1986-12-18 | Dr. MÃŒller-Lierheim KG, Biologische Laboratorien, 8033 Planegg | Verfahren zur beschichtung von polymeren |
DE3537259A1 (de) * | 1985-10-19 | 1987-04-23 | Hoechst Ag | Copolymerisat, verfahren zu seiner herstellung und seine verwendung als enzymtraeger |
DE3629177A1 (de) * | 1986-08-28 | 1988-03-17 | Hoechst Ag | Vernetzte polymerisate und verfahren zu ihrer herstellung |
IL90600A0 (en) * | 1988-06-16 | 1990-01-18 | Du Pont | Polynucleotide phosphorylase immobilized on epoxy-activated beads |
DE3827867A1 (de) * | 1988-08-17 | 1990-02-22 | Hoechst Ag | Verfahren zur herstellung von cyclischen harnstoffen |
ATE115982T1 (de) * | 1988-11-23 | 1995-01-15 | Cytec Tech Corp | Poröse polymerperlen und verfahren. |
US5200471A (en) * | 1990-11-05 | 1993-04-06 | Minnesota Mining And Manufacturing Company | Biomolecules covalently immobilized with a high bound specific biological activity and method of preparing same |
US6465178B2 (en) * | 1997-09-30 | 2002-10-15 | Surmodics, Inc. | Target molecule attachment to surfaces |
US6762019B2 (en) * | 1997-09-30 | 2004-07-13 | Surmodics, Inc. | Epoxide polymer surfaces |
DE10256656A1 (de) * | 2002-12-03 | 2004-06-17 | Röhm GmbH & Co. KG | Verfahren zur Herstellung von Cephalexin |
US7309593B2 (en) * | 2003-10-01 | 2007-12-18 | Surmodics, Inc. | Attachment of molecules to surfaces |
MY144940A (en) * | 2005-01-25 | 2011-11-30 | Avantor Performance Mat Inc | Chromatographic media |
JP5250985B2 (ja) * | 2007-03-19 | 2013-07-31 | æ±ãœãŒæ ªåŒäŒç€Ÿ | å å¡«åºçšæ°èŠå å¡«å€åã³ãã®çšé |
EP2316932B1 (en) * | 2009-10-29 | 2013-05-15 | Gambro Lundia AB | Enzyme-functionalized supports |
FR2953524B1 (fr) * | 2009-12-03 | 2012-12-14 | Arkema France | Systeme de reticulation a haute vitesse |
GB201002824D0 (en) * | 2010-02-19 | 2010-04-07 | Temasek Polytechnic | A method of preparing a substrate for immobilization of functional substances thereon and the substrate obtained therefrom |
CN102505035B (zh) * | 2011-10-25 | 2014-07-09 | ç³è¯éå¢äžè¯ºè¯äžïŒç³å®¶åºïŒæéå ¬åž | äžç§3-å»ä¹é °åº-7-æ°šåºå€Žå¢ç·é žçå¶å€å·¥èº |
US9809706B2 (en) | 2013-08-30 | 2017-11-07 | Council Of Scientific & Industrial Research | Racemic drug resolution using polymer supported chiral selector |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4044196A (en) * | 1972-03-30 | 1977-08-23 | Bayer Aktiengesellschaft | Crosslinked copolymers of α,β-olefinically unsaturated dicarboxylic anhydrides |
US4070348A (en) * | 1973-07-25 | 1978-01-24 | Rohm Gmbh | Water-swellable, bead copolymer |
CH641689A5 (en) * | 1976-10-28 | 1984-03-15 | Asahi Chemical Ind | Process for preparing a protein adsorbent |
DE3106456A1 (de) * | 1981-02-21 | 1982-10-07 | Röhm GmbH, 6100 Darmstadt | Verfahren zur herstellung von perlfoermigen, hydrophilen, gegenueber proteinen bindungsaktiven traegerpolymeren |
-
1983
- 1983-12-15 US US06/561,716 patent/US4582860A/en not_active Expired - Fee Related
-
1984
- 1984-12-03 CA CA000469176A patent/CA1228196A/en not_active Expired
- 1984-12-06 JP JP59258441A patent/JPS60221090A/ja active Granted
- 1984-12-07 BR BR8406277A patent/BR8406277A/pt unknown
- 1984-12-11 EP EP84308588A patent/EP0146329A3/en not_active Ceased
- 1984-12-14 ES ES538624A patent/ES8800348A1/es not_active Expired
- 1984-12-14 ZA ZA849758A patent/ZA849758B/xx unknown
Also Published As
Publication number | Publication date |
---|---|
JPS60221090A (ja) | 1985-11-05 |
BR8406277A (pt) | 1985-10-01 |
ES538624A0 (es) | 1987-11-01 |
ZA849758B (en) | 1986-02-26 |
EP0146329A3 (en) | 1986-08-27 |
EP0146329A2 (en) | 1985-06-26 |
US4582860A (en) | 1986-04-15 |
ES8800348A1 (es) | 1987-11-01 |
CA1228196A (en) | 1987-10-13 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
JPH0458311B2 (ja) | ||
US4486549A (en) | Process for preparing an amino group-containing polyacrylonitrile polymer | |
US5914367A (en) | Polymer protein composites and methods for their preparation and use | |
Nilsson et al. | The use of bead polymerization of acrylic monomers for immobilization of enzymes | |
US7381552B2 (en) | Macroporous material in the form of plastic pearls | |
EP0764047B2 (en) | Polymeric microbeads and method of preparation | |
US6291582B1 (en) | Polymer-protein composites and methods for their preparation and use | |
US4568706A (en) | Macroporous bead polymers, a process for their preparation and their use | |
US4551482A (en) | Macroporous, hydrophilic enzyme carrier | |
US4542069A (en) | Vinylene carbonate polymers, a process for their preparation and their use | |
Bahulekar et al. | Immobilization of penicillin G acylase on functionalized macroporous polymer beads | |
US4931476A (en) | Crosslinked polymers and a process for their preparation | |
Cantarella et al. | Entrapping of acid phosphatase in poly (2âhydroxyethyl methacrylate) matrices: Preparation and kinetic properties | |
CN112980826B (zh) | äžç§èèªé ¶/èäžç¯é °èºæ°Žåè¶åŸ®çå¬åææåå ¶å¶å€æ¹æ³ååºçš | |
US4612288A (en) | Oxirane resins for enzyme immobilization | |
Koilpillai et al. | Immobilization of penicillin G acylase on methacrylate polymers | |
US4767620A (en) | Crosslinked polymers with carbonate ester groups, and a process for their preparation | |
JPH02242833A (ja) | å€åæ§ããªã¢ã¯ãªããããªã«çµæç©ããã®è£œæ³ããã³ãã®çšé | |
JPS62118889A (ja) | çç©åŠçç©è³ªãåºå®åããæ¹æ³åã³ãã®æ¹æ³ã«ãã€ãŠåŸãããåºå®åçç©åŠçç©è³ª | |
JPS6322802A (ja) | æ°èŠãªã¢ããåã¢ã¯ãªããããªã«ç³»ããªãâã®è£œé æ³ | |
JPH09191877A (ja) | é µçŽ åºå®å€åèããã³é µçŽ 觊åªåå¿æ¹æ³ | |
JP2595004B2 (ja) | é µçŽ åºå®åçšæ äœãšãã®é µçŽ åºå®åæ¹æ³ããã³é µçŽ è±çæ¹æ³ | |
JP2795281B2 (ja) | åºå®åé µçŽ | |
JP2660649B2 (ja) | é µçŽ åºå®åçšæ äœã®è£œé æ¹æ³ | |
JPS5858080B2 (ja) | ïŒâã¢ããã»ããšã ååç©ã®è£œé æ³ |