JPH04505158A - 非細胞性ワクチン - Google Patents
非細胞性ワクチンInfo
- Publication number
- JPH04505158A JPH04505158A JP2506668A JP50666890A JPH04505158A JP H04505158 A JPH04505158 A JP H04505158A JP 2506668 A JP2506668 A JP 2506668A JP 50666890 A JP50666890 A JP 50666890A JP H04505158 A JPH04505158 A JP H04505158A
- Authority
- JP
- Japan
- Prior art keywords
- antigen
- vaccine
- bordetella pertussis
- pertussis
- vaccines
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/02—Bacterial antigens
- A61K39/099—Bordetella
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- General Health & Medical Sciences (AREA)
- Mycology (AREA)
- Epidemiology (AREA)
- Microbiology (AREA)
- Immunology (AREA)
- General Chemical & Material Sciences (AREA)
- Oncology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Communicable Diseases (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Electrical Discharge Machining, Electrochemical Machining, And Combined Machining (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
- Liquid Crystal Substances (AREA)
- Peptides Or Proteins (AREA)
Abstract
Description
Claims (13)
- 1.百日咳菌の69kDa抗原と百日咳菌の線維状マドグルテニン抗原からなる 相乗性混合物。
- 2.「請求項1」記載の相乗性混合物を医薬的に許される賦形剤と混合してなる 非細胞性ワクチン。
- 3.百日咳菌トキシンを含まない「請求項1」記載ワクチン。
- 4.69kDa抗原と線維状ヘマトグルテニン抗原1:10〜10:1の比で含 有する「請求項2または」記載のワクチン。
- 5.比はほぼ1:1である「請求項4」記載のワクン。
- 6.抗原性蛋白質の濃度は0.0l〜5.0mg/ml範囲である「請求項2〜 5」のいずれかに記載のワクン。
- 7.さらにアジュバントを含有する「請求項2〜」のいずれかに記載のワクチン 。
- 8.医学的治療に使用するための「請求項1」記載相乗性混合物。
- 9.医学的治療に使用するための「請求項2〜7」いずれかに記載のワクチン。
- 10.百日咳菌の感染を受けやすい哺乳動物の予防的置用医薬を製造するための 「請求項1」記載の混合物使用。
- 11.百日咳菌の69kDa抗原と線維状ヘマトグルニチン抗原との、相乗効果 を示す量での混合物を投与することからなる、百日咳菌の感染を受けやすい哺乳 動物の処置方法。
- 12.69kDa抗原と線維状ヘマトグルテニン抗原は同時に投与する「請求項 11」記載の処置方法。
- 13.69kDa抗原と線維状ヘマトグルテニン抗原は連続的に投与する「請求 項11」記載の処置方法。
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB8910570,4 | 1989-05-08 | ||
GB898910570A GB8910570D0 (en) | 1989-05-08 | 1989-05-08 | Acellular vaccine |
Related Child Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2002002530A Division JP2002226397A (ja) | 1989-05-08 | 2002-01-09 | 非細胞性ワクチン |
Publications (2)
Publication Number | Publication Date |
---|---|
JPH04505158A true JPH04505158A (ja) | 1992-09-10 |
JP3281369B2 JP3281369B2 (ja) | 2002-05-13 |
Family
ID=10656410
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP50666890A Expired - Lifetime JP3281369B2 (ja) | 1989-05-08 | 1990-04-26 | 非細胞性ワクチン |
JP2002002530A Pending JP2002226397A (ja) | 1989-05-08 | 2002-01-09 | 非細胞性ワクチン |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2002002530A Pending JP2002226397A (ja) | 1989-05-08 | 2002-01-09 | 非細胞性ワクチン |
Country Status (12)
Country | Link |
---|---|
US (1) | US7479283B1 (ja) |
EP (3) | EP0471726B2 (ja) |
JP (2) | JP3281369B2 (ja) |
AT (3) | ATE147271T1 (ja) |
DE (14) | DE122005000018I1 (ja) |
DK (3) | DK0747058T3 (ja) |
ES (3) | ES2230555T3 (ja) |
FR (1) | FR09C0033I1 (ja) |
GB (1) | GB8910570D0 (ja) |
LU (15) | LU90204I2 (ja) |
NL (13) | NL980007I1 (ja) |
WO (1) | WO1990013313A1 (ja) |
Families Citing this family (14)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB8412207D0 (en) * | 1984-05-12 | 1984-06-20 | Wellcome Found | Antigenic preparations |
GB8910570D0 (en) | 1989-05-08 | 1989-06-21 | Wellcome Found | Acellular vaccine |
EP0484621A3 (en) * | 1990-07-11 | 1992-08-26 | American Cyanamid Company | Efficacious vaccines against bordetella pertussis comprising a combination of individually purified pertussis antigens |
GB9021004D0 (en) * | 1990-09-27 | 1990-11-07 | Wellcome Found | Acellular vaccines |
GB9209118D0 (en) * | 1992-04-28 | 1992-06-10 | Sb 120 Amsterdam Bv | Vaccine compositions |
FR2754543B1 (fr) * | 1996-10-11 | 1998-12-31 | Pasteur Institut | Souche de bordetella deficiente dans la production de toxine et exprimant une proteine hydride, liposomes comprenant de la fha et leurs utilisations comme vaccins, et utilisation de la fha pour stimuler les reponses immunitaires |
US7022522B2 (en) | 1998-11-13 | 2006-04-04 | Limin Guan | Macroporous polymer scaffold containing calcium phosphate particles |
WO2005032584A2 (en) * | 2003-10-02 | 2005-04-14 | Glaxosmithkline Biologicals S.A. | Pertussis antigens and use thereof in vaccination |
WO2009094006A2 (en) | 2007-10-25 | 2009-07-30 | Wake Forest University Health Sciences | Bordetella outer-membrane protein antigens and methods of making and using the same |
JP6134470B2 (ja) | 2008-03-07 | 2017-05-24 | アーケマ・インコーポレイテッド | クロロ−3,3,3−トリフルオロプロペンによる安定した処方系 |
GB201105981D0 (en) | 2011-04-08 | 2011-05-18 | Glaxosmithkline Biolog Sa | Novel process |
ES2597832T3 (es) | 2013-03-08 | 2017-01-23 | Janssen Vaccines & Prevention B.V. | Vacuna acelular contra la tosferina |
MX369534B (es) | 2013-09-08 | 2019-11-11 | Pfizer | Composiciones de neisseria meningitidis y sus metodos. |
CN107249626A (zh) | 2015-02-19 | 2017-10-13 | 辉瑞大药厂 | 脑膜炎奈瑟球菌组合物及其方法 |
Family Cites Families (24)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2047886A1 (en) | 1969-06-30 | 1971-03-19 | Merieux Inst | Non-toxic anti-whooping cough vaccine |
EP0043349B1 (de) | 1980-06-27 | 1987-08-12 | Ciba-Geigy Ag | Synergistisches Mittel und Verfahren zur selektiven Unkrautbekämpfung, insbesondere in Getreide und Sojabohnenkulturen |
JPS5750925A (en) | 1980-09-12 | 1982-03-25 | Takeda Chem Ind Ltd | Preparation of pertussis toxoid |
JPS58222032A (ja) | 1982-06-18 | 1983-12-23 | Teijin Ltd | 百日咳毒素のサブユニツト蛋白 |
GB8412207D0 (en) * | 1984-05-12 | 1984-06-20 | Wellcome Found | Antigenic preparations |
US5237052A (en) * | 1984-05-12 | 1993-08-17 | Burroughs Wellcome Company | Antigenic preparations and isolation of such preparations |
JPS6176422A (ja) * | 1984-09-22 | 1986-04-18 | Chemo Sero Therapeut Res Inst | 百日ぜきコンポ−ネントワクチンおよび百日ぜき・ジフテリア・破傷風混合ワクチンの製造方法 |
FR2590483B1 (fr) | 1985-11-22 | 1988-12-09 | Pasteur Institut | Antigenes purifies ayant des proprietes vaccinantes contre b. pertussis, moyens notamment adns recombinants pour les produire et compositions de vaccins les contenant |
GB8601279D0 (en) * | 1986-01-20 | 1986-02-26 | Public Health Lab Service | Purification of pertussis antigens |
DE3783869D1 (de) * | 1986-11-11 | 1993-03-11 | Siemens Ag | Flusskompensierter stromwandler. |
FR2606789B1 (fr) | 1986-11-17 | 1991-05-31 | Pasteur Institut | Preparations d'adenylate cyclase purifiees, procede d'obtention de ces preparations et leurs applications biologiques |
EP0267998A1 (en) * | 1986-11-17 | 1988-05-25 | Institut Pasteur | Means for protecting against bordetella infections and toxic processes |
US5358868A (en) * | 1987-11-24 | 1994-10-25 | Connaught Laboratories Limited | Genetic detoxification of pertussis toxin |
GB8807860D0 (en) | 1988-04-05 | 1988-05-05 | Connaught Lab | Pertussis vaccine |
US5101014A (en) * | 1989-02-10 | 1992-03-31 | United States Of America | Process for the purification of a 69,000 da outer membrane protein of Bordetella pertussis |
US5162223A (en) * | 1989-02-17 | 1992-11-10 | The United States Of America As Represented By The Secretary Of The Department Of Health And Human Resources | Hybridomas and resulting monoclonal antibodies directed against antigens of Bordetella pertussis |
GB8910570D0 (en) | 1989-05-08 | 1989-06-21 | Wellcome Found | Acellular vaccine |
US5276142A (en) * | 1989-12-11 | 1994-01-04 | American Cyanamid Company | Process for purification of a 69000 dalton antigenic protein from Bordetella pertussis |
GB9007416D0 (en) | 1990-04-02 | 1990-05-30 | Wellcome Found | Expression of heterologous protein in yeast |
GB9007657D0 (en) | 1990-04-04 | 1990-05-30 | Connaught Lab | Purification of a pertussis outer membrane protein(omp69) |
IT1248735B (it) | 1990-06-21 | 1995-01-26 | Sclavo Spa | Vaccini acellulari contro la pertosse |
EP0484621A3 (en) | 1990-07-11 | 1992-08-26 | American Cyanamid Company | Efficacious vaccines against bordetella pertussis comprising a combination of individually purified pertussis antigens |
ATE183194T1 (de) | 1994-04-28 | 1999-08-15 | Takeda Chemical Industries Ltd | Verfahren zur trennung von protektiven verbindungen aus bordetella pertussis |
US5972225A (en) * | 1996-05-07 | 1999-10-26 | Cook Imaging Corporation | Process for remediating endotoxin-contaminated bulk non-ionic contrast media |
-
1989
- 1989-05-08 GB GB898910570A patent/GB8910570D0/en active Pending
-
1990
- 1990-04-26 DE DE200512000018 patent/DE122005000018I1/de active Pending
- 1990-04-26 DK DK96112324T patent/DK0747058T3/da active
- 1990-04-26 AT AT90907222T patent/ATE147271T1/de active
- 1990-04-26 WO PCT/GB1990/000649 patent/WO1990013313A1/en active IP Right Grant
- 1990-04-26 DE DE69029656T patent/DE69029656T3/de not_active Expired - Lifetime
- 1990-04-26 JP JP50666890A patent/JP3281369B2/ja not_active Expired - Lifetime
- 1990-04-26 DE DE200512000020 patent/DE122005000020I1/de active Pending
- 1990-04-26 DE DE200512000017 patent/DE122005000017I1/de active Pending
- 1990-04-26 DE DE69034264T patent/DE69034264D1/de not_active Expired - Lifetime
- 1990-04-26 DK DK90907222T patent/DK0471726T4/da active
- 1990-04-26 EP EP90907222A patent/EP0471726B2/en not_active Expired - Lifetime
- 1990-04-26 ES ES96112324T patent/ES2230555T3/es not_active Expired - Lifetime
- 1990-04-26 DK DK04018329T patent/DK1666057T3/da active
- 1990-04-26 DE DE122009000044C patent/DE122009000044I1/de active Pending
- 1990-04-26 EP EP96112324A patent/EP0747058B1/en not_active Revoked
- 1990-04-26 AT AT96112324T patent/ATE276759T1/de active
- 1990-04-26 EP EP04018329A patent/EP1666057B1/en not_active Expired - Lifetime
- 1990-04-26 DE DE200512000014 patent/DE122005000014I1/de active Pending
- 1990-04-26 DE DE200512000019 patent/DE122005000019I1/de active Pending
- 1990-04-26 DE DE122009000042C patent/DE122009000042I1/de active Pending
- 1990-04-26 DE DE122009000043C patent/DE122009000043I1/de active Pending
- 1990-04-26 AT AT04018329T patent/ATE422900T1/de active
- 1990-04-26 DE DE200512000016 patent/DE122005000016I1/de active Pending
- 1990-04-26 DE DE122009000041C patent/DE122009000041I1/de active Pending
- 1990-04-26 ES ES90907222T patent/ES2095874T5/es not_active Expired - Lifetime
- 1990-04-26 DE DE69034166T patent/DE69034166T2/de not_active Expired - Lifetime
- 1990-04-26 ES ES04018329T patent/ES2322352T3/es not_active Expired - Lifetime
-
1995
- 1995-05-25 US US08/450,336 patent/US7479283B1/en active Active
-
1998
- 1998-01-27 NL NL980007C patent/NL980007I1/nl unknown
- 1998-01-28 LU LU90204C patent/LU90204I2/fr unknown
-
2002
- 2002-01-09 JP JP2002002530A patent/JP2002226397A/ja active Pending
-
2004
- 2004-10-28 DE DE200512000015 patent/DE122005000015I1/de active Pending
-
2005
- 2005-03-22 LU LU91149C patent/LU91149I2/fr unknown
- 2005-03-22 NL NL300187C patent/NL300187I1/nl unknown
- 2005-03-22 LU LU91154C patent/LU91154I2/fr unknown
- 2005-03-22 LU LU91155C patent/LU91155I2/fr unknown
- 2005-03-22 NL NL300185C patent/NL300185I1/nl unknown
- 2005-03-22 NL NL300183C patent/NL300183I1/nl unknown
- 2005-03-22 NL NL300189C patent/NL300189I1/nl unknown
- 2005-03-22 LU LU91150C patent/LU91150I2/fr unknown
- 2005-03-22 LU LU91153C patent/LU91153I2/fr unknown
- 2005-03-22 NL NL300188C patent/NL300188I1/nl unknown
- 2005-03-22 NL NL300184C patent/NL300184I1/nl unknown
- 2005-03-22 LU LU91152C patent/LU91152I2/fr unknown
- 2005-03-22 NL NL300186C patent/NL300186I1/nl unknown
- 2005-03-22 LU LU91151C patent/LU91151I2/fr unknown
-
2009
- 2009-08-11 NL NL300402C patent/NL300402I1/nl unknown
- 2009-08-11 NL NL300401C patent/NL300401I1/nl unknown
- 2009-08-11 NL NL300404C patent/NL300404I1/nl unknown
- 2009-08-11 NL NL300400C patent/NL300400I1/nl unknown
- 2009-08-11 NL NL300403C patent/NL300403I1/nl unknown
- 2009-08-12 LU LU91595C patent/LU91595I2/fr unknown
- 2009-08-12 LU LU91597C patent/LU91597I2/fr unknown
- 2009-08-12 LU LU91594C patent/LU91594I2/fr unknown
- 2009-08-12 LU LU91593C patent/LU91593I2/fr unknown
- 2009-08-12 LU LU91592C patent/LU91592I2/fr unknown
- 2009-08-12 LU LU91596C patent/LU91596I2/fr unknown
- 2009-08-12 LU LU91591C patent/LU91591I2/fr unknown
- 2009-08-13 FR FR09C0033C patent/FR09C0033I1/fr active Active
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