JPH0443074B2 - - Google Patents
Info
- Publication number
- JPH0443074B2 JPH0443074B2 JP59138482A JP13848284A JPH0443074B2 JP H0443074 B2 JPH0443074 B2 JP H0443074B2 JP 59138482 A JP59138482 A JP 59138482A JP 13848284 A JP13848284 A JP 13848284A JP H0443074 B2 JPH0443074 B2 JP H0443074B2
- Authority
- JP
- Japan
- Prior art keywords
- salts
- fosmidomycin
- freeze
- dried powder
- powder
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 150000003839 salts Chemical class 0.000 claims description 22
- GJXWDTUCERCKIX-UHFFFAOYSA-N fosmidomycin Chemical compound O=CN(O)CCCP(O)(O)=O GJXWDTUCERCKIX-UHFFFAOYSA-N 0.000 claims description 21
- 229950006501 fosmidomycin Drugs 0.000 claims description 20
- 239000000843 powder Substances 0.000 claims description 18
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical group [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 claims description 10
- 229910001508 alkali metal halide Inorganic materials 0.000 claims description 7
- 150000008045 alkali metal halides Chemical class 0.000 claims description 7
- 239000008176 lyophilized powder Substances 0.000 claims description 6
- 239000011780 sodium chloride Substances 0.000 claims description 5
- 238000004108 freeze drying Methods 0.000 claims description 4
- 238000004519 manufacturing process Methods 0.000 claims description 2
- 159000000000 sodium salts Chemical class 0.000 claims description 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 7
- 239000003708 ampul Substances 0.000 description 6
- 239000007864 aqueous solution Substances 0.000 description 5
- 238000002360 preparation method Methods 0.000 description 5
- ZZPUYRHMTGOTEU-UHFFFAOYSA-M sodium;3-[formyl(hydroxy)amino]propyl-hydroxyphosphinate Chemical compound [Na+].O=CN(O)CCCP(O)([O-])=O ZZPUYRHMTGOTEU-UHFFFAOYSA-M 0.000 description 4
- 230000000052 comparative effect Effects 0.000 description 3
- 239000012153 distilled water Substances 0.000 description 3
- 238000002347 injection Methods 0.000 description 3
- 239000007924 injection Substances 0.000 description 3
- FBPFZTCFMRRESA-KVTDHHQDSA-N D-Mannitol Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-KVTDHHQDSA-N 0.000 description 2
- 229930195725 Mannitol Natural products 0.000 description 2
- WCUXLLCKKVVCTQ-UHFFFAOYSA-M Potassium chloride Chemical compound [Cl-].[K+] WCUXLLCKKVVCTQ-UHFFFAOYSA-M 0.000 description 2
- 239000000594 mannitol Substances 0.000 description 2
- 235000010355 mannitol Nutrition 0.000 description 2
- 239000000126 substance Substances 0.000 description 2
- QHFBIBHRQPSNPB-UHFFFAOYSA-N BrBr.[K] Chemical compound BrBr.[K] QHFBIBHRQPSNPB-UHFFFAOYSA-N 0.000 description 1
- XBPCUCUWBYBCDP-UHFFFAOYSA-N Dicyclohexylamine Chemical class C1CCCCC1NC1CCCCC1 XBPCUCUWBYBCDP-UHFFFAOYSA-N 0.000 description 1
- 239000005977 Ethylene Substances 0.000 description 1
- ZMANZCXQSJIPKH-UHFFFAOYSA-N Triethylamine Chemical class CCN(CC)CC ZMANZCXQSJIPKH-UHFFFAOYSA-N 0.000 description 1
- 239000003905 agrochemical Substances 0.000 description 1
- AZDRQVAHHNSJOQ-UHFFFAOYSA-N alumane Chemical class [AlH3] AZDRQVAHHNSJOQ-UHFFFAOYSA-N 0.000 description 1
- 150000001413 amino acids Chemical class 0.000 description 1
- 150000003863 ammonium salts Chemical class 0.000 description 1
- 230000000844 anti-bacterial effect Effects 0.000 description 1
- 150000001484 arginines Chemical class 0.000 description 1
- JUHORIMYRDESRB-UHFFFAOYSA-N benzathine Chemical class C=1C=CC=CC=1CNCCNCC1=CC=CC=C1 JUHORIMYRDESRB-UHFFFAOYSA-N 0.000 description 1
- 159000000007 calcium salts Chemical class 0.000 description 1
- 238000007796 conventional method Methods 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 238000001035 drying Methods 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 150000002169 ethanolamines Chemical class 0.000 description 1
- -1 ethylene diane salts Chemical class 0.000 description 1
- 238000005187 foaming Methods 0.000 description 1
- 238000007710 freezing Methods 0.000 description 1
- 230000008014 freezing Effects 0.000 description 1
- 150000007529 inorganic bases Chemical class 0.000 description 1
- 159000000003 magnesium salts Chemical class 0.000 description 1
- 239000011159 matrix material Substances 0.000 description 1
- 150000007530 organic bases Chemical class 0.000 description 1
- 239000000546 pharmaceutical excipient Substances 0.000 description 1
- 239000001103 potassium chloride Substances 0.000 description 1
- 235000011164 potassium chloride Nutrition 0.000 description 1
- 159000000001 potassium salts Chemical class 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
- 239000007921 spray Substances 0.000 description 1
- 239000003381 stabilizer Substances 0.000 description 1
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP13848284A JPS6117596A (ja) | 1984-07-03 | 1984-07-03 | ホスミドマイシンまたはその塩類の凍結乾燥粉体およびその製造法 |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP13848284A JPS6117596A (ja) | 1984-07-03 | 1984-07-03 | ホスミドマイシンまたはその塩類の凍結乾燥粉体およびその製造法 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPS6117596A JPS6117596A (ja) | 1986-01-25 |
| JPH0443074B2 true JPH0443074B2 (de) | 1992-07-15 |
Family
ID=15223108
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP13848284A Granted JPS6117596A (ja) | 1984-07-03 | 1984-07-03 | ホスミドマイシンまたはその塩類の凍結乾燥粉体およびその製造法 |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JPS6117596A (de) |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS5377016A (en) * | 1976-12-16 | 1978-07-08 | Frosst & Co Charles E | Scaffold reflection kit utilizing triethylene tetramine hexa*methylene phosphonate |
-
1984
- 1984-07-03 JP JP13848284A patent/JPS6117596A/ja active Granted
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS5377016A (en) * | 1976-12-16 | 1978-07-08 | Frosst & Co Charles E | Scaffold reflection kit utilizing triethylene tetramine hexa*methylene phosphonate |
Also Published As
| Publication number | Publication date |
|---|---|
| JPS6117596A (ja) | 1986-01-25 |
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